Advancing Neurological Health: Insights into Aging, Immunity, and Vascular Dynamics DOI Creative Commons
Tongtong Xu, Jing Ye, Lin Gan

et al.

Aging and Disease, Journal Year: 2024, Volume and Issue: unknown

Published: Jan. 1, 2024

This editorial provides an overview of recent advancements in the understanding and treatment neurological disorders, focusing on aging, immunity, blood flow, as featured this special issue. The first section explores importance identifying biomarkers aging aging-related diseases, such Alzheimer's Disease, highlighting emerging role saliva-based gut-brain axis disease diagnosis management. In subsequent section, dysregulated immune systems associated with are discussed, emphasizing intricate landscape system during its bidirectional relationship neuroinflammation. Additionally, insights into involvement Myeloid-Derived Suppressor Cells (MDSCs) Multiple Sclerosis (MS) pathogenesis presented. third examines microglia neuroinflammation various including age-related macular degeneration (AMD) Tuberculous Meningitis (TBM). Furthermore, therapeutic potential stem cell extracellular vesicle-based therapies for stroke is explored, along molecular mechanism how inflammation regulates cerebral myocardial ischemia. Finally, flow maintaining vascular health impact disorders novel assessment methods optimizing patient care. Overall, issue offers valuable complex mechanisms underlying identifies avenues intervention.

Language: Английский

Inflammatory Pathogenesis of Post-stroke Depression DOI Creative Commons
Xinyu Feng, Xiaojuan Ma, Juan Li

et al.

Aging and Disease, Journal Year: 2024, Volume and Issue: unknown

Published: Jan. 1, 2024

Post-stroke depression (PSD) is a complex mood disorder that emerges in individuals following stroke, characterized by the development of depressive symptoms. The pathogensis PSD diverse, with inflammation playing vital role its onset and progression. Emerging evidence suggests microglial activation, astrocyte responses, nuclear factor κB(NF-κB) signaling, dysregulation hypothalamic pituitary adrenal (HPA) axis, alterations brain-derived neurotrophic (BDNF) expression, neurotransmitter imbalances, adenosine triphosphate (ATP) receptors oxidative stress are intricately linked to pathogenesis PSD. involvement inflammatory cytokines these processes highlights significance pathway. Integrating hypotheses, mechanism offers novel perspective expand therapeutic strategies for

Language: Английский

Citations

13
Exosome-mediated communication between gastric cancer cells and macrophages: implications for tumor microenvironment DOI Creative Commons

Yue Qiu,

Guimei Lu,

Na Li

et al.

Frontiers in Immunology, Journal Year: 2024, Volume and Issue: 15

Published: Feb. 22, 2024

Gastric cancer (GC) is a malignant neoplasm originating from the epithelial cells of gastric mucosa. The pathogenesis GC intricately linked to tumor microenvironment within which reside. Tumor-associated macrophages (TAMs) primarily differentiate peripheral blood monocytes and can be broadly categorized into M1 M2 subtypes. M2-type TAMs have been shown promote growth, tissue remodeling, angiogenesis. Furthermore, they actively suppress acquired immunity, leading poorer prognosis reduced tolerance chemotherapy. Exosomes, contain myriad biologically active molecules including lipids, proteins, mRNA, noncoding RNAs, emerged as key mediators communication between TAMs. exchange these via exosomes markedly influence consequently impact progression. Recent studies elucidated correlation various clinicopathological parameters GC, such size, differentiation, infiltration depth, lymph node metastasis, TNM staging, highlighting pivotal role in development metastasis. In this review, we aim comprehensively examine bidirectional TAMs, implications alterations on immune escape, invasion, metastasis targeted therapeutic approaches for efficacy potential drug resistance strategies.

Language: Английский

Citations

8
From Physiology to Pathology of Astrocytes: Highlighting Their Potential as Therapeutic Targets for CNS Injury DOI Creative Commons
Yimin Yuan, Hong Liu,

Ziwei Dai

et al.

Neuroscience Bulletin, Journal Year: 2024, Volume and Issue: unknown

Published: July 30, 2024

Abstract In the mammalian central nervous system (CNS), astrocytes are ubiquitous glial cells that have complex morphological and molecular characteristics. These fascinating play essential neurosupportive homeostatic roles in healthy CNS undergo morphological, molecular, functional changes to adopt so-called ‘reactive’ states response injury or disease. recent years, interest astrocyte research has increased dramatically some new biological features of physiological pathological conditions been discovered thanks technological advances. Here, we will review discuss well-established emerging astroglial biology functions, with emphasis on their potential as therapeutic targets for injury, including traumatic ischemic injury. This article highlight importance neuropathological process repair

Language: Английский

Citations

7
GFAP as Astrocyte-Derived Extracellular Vesicle Cargo in Acute Ischemic Stroke Patients—A Pilot Study DOI Open Access
Timea Forró, Doina Manu, Ovidiu Båjenaru

et al.

International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(11), P. 5726 - 5726

Published: May 24, 2024

The utility of serum glial fibrillary acidic protein (GFAP) in acute ischemic stroke (AIS) has been extensively studied recent years. Here, we aimed to assess its potential role as a cargo extracellular vesicles (EVs) secreted by astrocytes (ADEVs) response brain ischemia. Plasma samples from eighteen AIS patients at 24 h (D1), 7 days (D7), and one month (M1) post-symptoms onset, nine age, sex, cardiovascular risk factor-matched healthy controls were obtained isolate EVs using the Exoquick ULTRA EV kit. Subsets presumed ADEVs identified further expression glutamate aspartate transporter (GLAST) specific marker with Basic Exo-Flow Capture Western blotting tested presence GFAP ADEV cargo. Post-stroke levels elevated D1 D7 but not M1 compared (p = 0.007, p 0.019, 0.344, respectively). Significant differences highlighted content three time points (n 12, 0.027) between (z 2.65, 0.023). A positive correlation was observed modified Rankin Scale (mRS) (r 0.58, 0.010) 0.57, 0.013), respectively. may dynamically reflect changes during first post-ischemia. Profiling peripheral blood could provide new way central nervous system pathology.

Language: Английский

Citations

4
Astrocyte-Derived Extracellular Vesicles Alleviate Optic Nerve Injury Through Remodeling of Retinal Microenvironmental Homeostasis DOI Creative Commons
Lili Chen, Zhonghao Yu, Senmiao Zhu

et al.

Investigative Ophthalmology & Visual Science, Journal Year: 2025, Volume and Issue: 66(4), P. 16 - 16

Published: April 7, 2025

Traumatic optic neuropathy (TON) leads to the loss of retinal ganglion cells (RGCs) and results in permanent visual impairment. Protecting regenerating RGCs is crucial for treatment TON. Studies have demonstrated that astrocyte-derived extracellular vesicles (ADEVs) exhibit neuroprotective effects models central nervous system (CNS) injury. This study aimed investigate whether ADEVs a similar effect on an nerve crush (ONC) rat model. were collected from primary astrocytes, ONC model was established evaluate structure function using optical coherence tomography (OCT), hematoxylin eosin (H&E) staining, flash evoked potential (f-VEP) analysis. Immunofluorescence used examine reactive gliotic changes. Additionally, miRNA sequencing mRNA performed identify mechanisms involved. protected progressive improved function. also significantly increased expression glial fibrillary acidic protein (GFAP) modulated microglial activation. The miRNAs associated with targeted by signals, such as MAPK, PI3K-AKT, TNF-α, through targeting network generated via sequencing, we found functional genes, THBS1, PAK3, Gstm1, likely participate microenvironmental regulation. We discovered play role Our findings provide new cell-free therapeutic strategy neuropathy.

Language: Английский

Citations

0
Reactive astrocyte-derived exosomes enhance intracranial lymphatic drainage in mice after intracranial hemorrhage DOI Creative Commons
Kexin Li, Yuheng Liu,

Junjie Gong

et al.

Fluids and Barriers of the CNS, Journal Year: 2025, Volume and Issue: 22(1)

Published: April 14, 2025

Language: Английский

Citations

0
Alzheimer’s Disease, Obesity, and Type 2 Diabetes: Focus on Common Neuroglial Dysfunctions (Critical Review and New Data on Human Brain and Models) DOI Creative Commons
A. Tolédano, Arantxa Rodrı́guez-Casado,

María‐Isabel Álvarez

et al.

Brain Sciences, Journal Year: 2024, Volume and Issue: 14(11), P. 1101 - 1101

Published: Oct. 30, 2024

Obesity, type 2 diabetes (T2D), and Alzheimer's disease (AD) are pathologies that affect millions of people worldwide. They have no effective therapy difficult to prevent control when they develop. It has been known for many years these diseases pathogenic aspects in common. We highlight this review neuroglial cells (astroglia, oligodendroglia, microglia) play a vital role the origin, clinical-pathological development, course brain neurodegeneration. Moreover, we include new results T2D-AD mouse model (APP+PS1 mice on high-calorie diet) investigating.

Language: Английский

Citations

3
Astrocyte Dysfunction Reflected in Ischemia-Induced Astrocyte-Derived Extracellular Vesicles: A Pilot Study on Acute Ischemic Stroke Patients DOI Open Access
Timea Forró, Doina Manu, Lucian Barbu–Tudoran

et al.

International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(22), P. 12471 - 12471

Published: Nov. 20, 2024

Extracellular vesicles (EVs) secreted by astrocytes (ADEVs) mediate numerous biological processes, providing insights into damage, repair, and protection following ischemic stroke (IS). This pilot study aimed to broaden the current knowledge on astrocyte response ischemia dynamically assessing aquaporin-4 (AQP4) glial cell line-derived neurotrophic factor (GDNF) as cargo proteins of these in eighteen acute IS patients nine controls. EV were detected Western blotting followed 24 h (D1), 7 days (D7), one month (M1) after symptoms onset. The post-ischemic ADEV AQP4 GDNF levels higher at D1 compared control group (

Language: Английский

Citations

3
Endogenous Extracellular Vesicles Participate in Brain Remodeling after Ischemic Stroke DOI Open Access
Mauricio Muleiro Álvarez, Félipe Esparza Salazar,

Thomas Rodriguez

et al.

International Journal of Molecular Sciences, Journal Year: 2023, Volume and Issue: 24(23), P. 16857 - 16857

Published: Nov. 28, 2023

Brain remodeling after an ischemic stroke represents a promising avenue for exploring the cellular mechanisms of endogenous brain repair. A deeper understanding these is crucial optimizing safety and efficacy neuroprotective treatments patients. Here, we interrogated role extracellular vesicles, particularly exosomes, as potential mediators repair within neurovascular unit (NVU). We hypothesized that vesicles may play in achieving transient neuroprotection. Using established model middle cerebral artery occlusion adult rats, detected surged vesicle marker CD63 peri-infarct area either juxtaposed or co-localized with GFAP-positive glial cells, MAP2-labeled young neurons, VEGF-marked angiogenic cells. This novel observation exosomes spatially temporally approximated activation, neurogenesis, angiogenesis suggests especially contribute to NVU, warranting exploration vesicle-based therapeutics.

Language: Английский

Citations

6
Advancing Neurological Health: Insights into Aging, Immunity, and Vascular Dynamics DOI Creative Commons
Tongtong Xu, Jing Ye, Lin Gan

et al.

Aging and Disease, Journal Year: 2024, Volume and Issue: unknown

Published: Jan. 1, 2024

This editorial provides an overview of recent advancements in the understanding and treatment neurological disorders, focusing on aging, immunity, blood flow, as featured this special issue. The first section explores importance identifying biomarkers aging aging-related diseases, such Alzheimer's Disease, highlighting emerging role saliva-based gut-brain axis disease diagnosis management. In subsequent section, dysregulated immune systems associated with are discussed, emphasizing intricate landscape system during its bidirectional relationship neuroinflammation. Additionally, insights into involvement Myeloid-Derived Suppressor Cells (MDSCs) Multiple Sclerosis (MS) pathogenesis presented. third examines microglia neuroinflammation various including age-related macular degeneration (AMD) Tuberculous Meningitis (TBM). Furthermore, therapeutic potential stem cell extracellular vesicle-based therapies for stroke is explored, along molecular mechanism how inflammation regulates cerebral myocardial ischemia. Finally, flow maintaining vascular health impact disorders novel assessment methods optimizing patient care. Overall, issue offers valuable complex mechanisms underlying identifies avenues intervention.

Language: Английский

Citations

1