Frontiers in Immunology,
Journal Year:
2025,
Volume and Issue:
16
Published: April 7, 2025
Myocardial
infarction
(MI)
is
one
of
the
leading
causes
death
worldwide.
It
triggered
by
thrombosis
or
vascular
occlusion.
After
MI,
damaged
cardiomyocytes
are
replaced
scar
tissue,
to
systolic
and
diastolic
dysfunction,
followed
adverse
remodeling.
Regulatory
T
cells
(Tregs),
as
major
immune
cells,
play
a
crucial
role
in
post-MI
inflammation
immunomodulation.
Tregs
improve
cardiac
remodeling
after
MI
through
various
mechanisms,
including
inhibiting
inflammatory
cell
infiltration,
inducing
anti-inflammatory
macrophages,
suppressing
apoptosis,
regulating
fibroblast
function,
promoting
angiogenesis.
The
modulation
number
function
may
provide
novel
methods
for
improving
This
review
describes
immunoregulatory
roles
Tregs,
their
regulatory
mechanisms
ventricular
remodeling,
prospects
challenges
clinical
application.
However,
exact
molecular
remain
be
investigated.
Although
most
current
studies
at
preclinical
stage,
they
hold
great
potential
further
application
future.
Theranostics,
Journal Year:
2024,
Volume and Issue:
14(5), P. 2099 - 2126
Published: Jan. 1, 2024
Exosomes,
which
are
small
vesicles
enclosed
by
a
lipid
bilayer
and
released
many
cell
types,
widely
dispersed
have
garnered
increased
attention
in
the
field
of
regenerative
medicine
due
to
their
ability
serve
as
indicators
diseases
agents
with
therapeutic
potential.
Exosomes
play
crucial
role
mediating
intercellular
communication
through
transfer
biomolecules,
including
proteins,
lipids,
RNA,
other
molecular
constituents,
between
cells.
The
targeted
transport
proteins
nucleic
acids
specific
cells
has
potential
enhance
or
impair
biological
functions.
applications,
they
can
be
used
alone
combination
approaches.
examination
unique
attributes
functions
these
factors
emerged
prominent
study
realm
biomedical
research.
This
manuscript
summarizes
origins
properties
exosomes,
structural,
biological,
physical,
chemical
aspects.
paper
offers
complete
recent
progress
tissue
repair
medicine,
emphasizing
possible
implications
methods
forthcoming
regeneration
attempts.
Frontiers in Pharmacology,
Journal Year:
2023,
Volume and Issue:
14
Published: March 28, 2023
Cardiac
fibrosis
plays
an
indispensable
role
in
cardiac
tissue
homeostasis
and
repair
after
myocardial
infarction
(MI).
The
fibroblast-to-myofibroblast
differentiation
extracellular
matrix
collagen
deposition
are
the
hallmarks
of
fibrosis,
which
modulated
by
multiple
signaling
pathways
various
types
cells
time-dependent
manners.
Our
understanding
development
MI
has
evolved
basic
clinical
researches,
regulation
fibrotic
remodeling
may
facilitate
novel
diagnostic
therapeutic
strategies,
finally
improve
outcomes.
Here,
we
aim
to
elaborate
pathophysiology,
examination
intervention
MI.
Advanced Science,
Journal Year:
2024,
Volume and Issue:
11(25)
Published: April 26, 2024
Abstract
Myocardial
infarction
(MI),
a
consequence
of
coronary
artery
occlusion,
triggers
the
degradation
ferritin,
resulting
in
elevated
levels
free
iron
heart
and
thereby
inducing
ferroptosis.
Targeting
myocardial
ferroptosis
through
chelation
excess
has
therapeutic
potential
for
MI
treatment.
However,
post
ischemic
injury
areas
using
conventional
iron‐specific
chelators
is
hindered
by
ineffective
intracellular
chelation,
rapid
clearance,
high
systemic
toxicity.
A
chitosan‐desferrioxamine
nanosponge
(CDNS)
designed
co‐crosslinking
chitosan
deferoxamine
noncovalent
gelation
to
address
these
challenges.
This
architecture
facilitates
direct
regardless
(DFO)
release
due
its
sponge‐like
porous
hydrogel
structure.
Upon
cellular
internalization,
CDNS
can
effectively
chelate
facilitate
efflux
captured
iron,
inhibiting
associated
oxidative
stress
lipid
peroxidation.
In
mouse
models,
injection
promotes
sustainable
retention
suppression
infarcted
heart.
intervention
improves
cardiac
function
alleviates
adverse
remodeling
post‐MI,
leading
decreased
promotion
angiogenesis
inhibition
study
reveals
nanosponge‐based
nanomedicine
targeting
with
efficient
efflux,
offering
promising
Sensors,
Journal Year:
2024,
Volume and Issue:
24(3), P. 828 - 828
Published: Jan. 26, 2024
Myocardial
Infarction
(MI),
commonly
known
as
heart
attack,
is
a
cardiac
condition
characterized
by
damage
to
portion
of
the
heart,
specifically
myocardium,
due
disruption
blood
flow.
Given
its
recurring
and
often
asymptomatic
nature,
there
need
for
continuous
monitoring
using
wearable
devices.
This
paper
proposes
single-microcontroller-based
system
designed
automatic
detection
MI
based
on
Edge
Computing
paradigm.
Two
solutions
are
evaluated,
Machine
Learning
(ML)
Deep
(DL)
techniques.
The
developed
algorithms
two
different
approaches
currently
available
in
literature,
they
optimized
deployment
low-resource
hardware.
A
feasibility
assessment
their
implementation
single
32-bit
microcontroller
with
an
ARM
Cortex-M4
core
was
examined,
comparison
terms
accuracy,
inference
time,
memory
usage
detailed.
For
ML
techniques,
significant
data
processing
feature
extraction,
coupled
simpler
Neural
Network
(NN)
involved.
On
other
hand,
second
method,
DL,
employs
Spectrogram
Analysis
extraction
Convolutional
(CNN)
longer
time
higher
utilization.
Both
methods
employ
same
low
power
hardware
reaching
accuracy
89.40%
94.76%,
respectively.
final
prototype
energy-efficient
capable
real-time
without
connect
remote
servers
or
cloud.
All
performed
at
edge,
enabling
NN
microcontroller.
Biomedicines,
Journal Year:
2025,
Volume and Issue:
13(2), P. 259 - 259
Published: Jan. 21, 2025
Background/Objectives:
ST-segment
elevation
acute
coronary
syndrome
(STE-ACS)
represents
a
significant
global
health
challenge,
with
cardiac
remodeling
and
fibrosis
critically
affecting
recovery
after
percutaneous
intervention
(PCI).
Colchicine,
known
for
its
anti-inflammatory
effects,
may
regulate
key
fibrotic
markers
such
as
Procollagen
III
N-terminal
Propeptide
(PIIINP)
Galectin-3.
This
study
assesses
colchicine’s
effect
on
these
biomarkers
in
STE-ACS
patients
undergoing
delayed
PCI.
Methods:
In
this
multicenter,
randomized,
double-blind
trial,
we
examined
impact
Galectin-3
PIIINP
164
early
or
Patients
received
colchicine
shortly
hospital
admission.
Biomarker
changes
were
evaluated
at
24
h
five
days
post-treatment
using
two-way
ANOVA.
Results:
Clinical
trials
the
PCI
group
revealed
that
levels
decreased
significantly
day
one
(p
<
0.01)
further
0.0001),
indicating
Primary
has
benefits
to
inhibition
of
beyond
add-on
treatment.
But,
group,
increased
0.01),
but
decrease
observed
by
was
not
statistically
significant.
It
is
related
treatment
exceed
implantation
preventing
remodeling.
showed
reduction
0.0001).
Conclusions:
Colchicine
demonstrates
novel
efficacy
PCI,
increase
sharp
PIIINP,
ability
control
fibrosis.
positions
breakthrough
therapy
improving
outcomes
intervention.
Antioxidants,
Journal Year:
2024,
Volume and Issue:
13(10), P. 1163 - 1163
Published: Sept. 25, 2024
Precision
medicine
is
envisioned
as
the
future
of
cardiovascular
healthcare,
offering
a
more
tailored
and
effective
method
for
managing
diseases
compared
to
traditional
one-size-fits-all
approaches.
The
complex
role
oxidative
stress
in
chronic
within
framework
precision
was
carefully
explored,
delving
into
cellular
redox
status
its
critical
involvement
pathophysiological
complexity
(CVDs).
review
outlines
mechanisms
reactive
oxygen
species
generation
function
antioxidants
maintaining
balance.
It
emphasizes
elevated
concentrations
observed
heart
failure
their
detrimental
impact
on
health.
Various
sources
ROS
system
are
examined,
including
mitochondrial
dysfunction,
which
contributes
DNA
degradation.
article
also
addresses
stress's
myocardial
remodeling,
process
pivotal
progression
diseases.
By
integrating
these
aspects,
underscores
importance
homeostasis
identifies
molecular
biomarkers
that
can
enhance
therapy
CVDs.
insights
provided
aim
pave
way
targeted
therapeutic
strategies
mitigate
stress,
thereby
improving
patient
outcomes
medicine.
Computational and Structural Biotechnology Journal,
Journal Year:
2023,
Volume and Issue:
21, P. 2717 - 2731
Published: Jan. 1, 2023
Current
transcriptomics
technologies,
including
bulk
RNA-seq,
single-cell
RNA
sequencing
(scRNA-seq),
single-nucleus
RNA-sequencing
(snRNA-seq),
and
spatial
(ST),
provide
novel
insights
into
the
temporal
dynamics
of
gene
expression
during
cardiac
development
disease
processes.
Cardiac
is
a
highly
sophisticated
process
involving
regulation
numerous
key
genes
signaling
pathways
at
specific
anatomical
sites
developmental
stages.
Exploring
cell
biological
mechanisms
involved
in
cardiogenesis
also
contributes
to
congenital
heart
research.
Meanwhile,
severity
distinct
diseases,
such
as
coronary
disease,
valvular
cardiomyopathy,
failure,
associated
with
cellular
transcriptional
heterogeneity
phenotypic
alteration.
Integrating
transcriptomic
technologies
clinical
diagnosis
treatment
diseases
will
aid
advancing
precision
medicine.
In
this
review,
we
summarize
applications
scRNA-seq
ST
field,
organogenesis
promise
translational
research
