Deciphering the Relationship between SARS-CoV-2 and Cancer

International Journal of Molecular Sciences, Journal Year: 2023, Volume and Issue: 24(9), P. 7803 - 7803

Published: April 25, 2023

Some viruses are known to be associated with the onset of specific cancers. These microorganisms, oncogenic or oncoviruses, can convert normal cells into cancer by modulating central metabolic pathways hampering genomic integrity mechanisms, consequently inhibiting apoptotic machinery and/or enhancing cell proliferation. Seven promote tumorigenesis in humans: human papillomavirus (HPV), hepatitis B and C (HBV, HCV), Epstein-Barr virus (EBV), T-cell leukemia 1 (HTLV-1), Kaposi sarcoma-associated herpesvirus (KSHV), Merkel polyomavirus (MCPyV). Recent research indicates that SARS-CoV-2 infection COVID-19 progression may predispose recovered patients accelerate development. This hypothesis is based on growing evidence regarding ability modulate pathways, promoting chronic low-grade inflammation causing tissue damage. Herein, we summarize main relationships date between cancer, providing a summary proposed biochemical mechanisms behind cellular transformation. Mechanistically, DNA (such as HPV, HBV, EBV, MCPyV) encode their oncogenes. In contrast, RNA (like HCV, HTLV-1) oncogenes trigger host through cis-/-trans activation leading different types cancer. As for SARS-CoV-2, its role an seems occur inhibition oncosuppressors controlling autophagy infected cells. However, these effects could significant particular scenarios like those linked severe long COVID. On other hand, looking at SARS-CoV-2─cancer relationship from opposite perspective, oncolytic anti-tumor immune response were triggered some cases. summary, our work aims recall comprehensive attention scientific community elucidate and, more general, β-coronavirus susceptibility prevention supporting therapeutic approaches.

Language: Английский

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Antimicrobial Metabolites of Caucasian Medicinal Plants as Alternatives to Antibiotics

Antibiotics, Journal Year: 2024, Volume and Issue: 13(6), P. 487 - 487

Published: May 24, 2024

This review explores the potential of antimicrobial metabolites derived from Caucasian medicinal plants as alternatives to conventional antibiotics. With rise antibiotic resistance posing a global health threat, there is pressing need investigate alternative sources agents. have traditionally been used for their therapeutic properties, and recent research has highlighted compounds. Representatives 15 families plant extracts (24 species) explored efficacy against these pathogens. The effect on Gram-positive Gram-negative bacteria fungi discussed in this paper. By harnessing bioactive present plants, study aims contribute development new treatments that can effectively combat bacterial infections while minimizing risk emergence. Herein we discuss following classes compounds exhibiting activity: phenolic compounds, flavonoids, tannins, terpenes, saponins, alkaloids, sulfur-containing Allium species. discusses pharmacological properties selected extraction characterization metabolites, mechanisms action antibacterial antifungal applications clinical settings. Additionally, challenges future directions are addressed.

Language: Английский

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Georgian Medicinal Plants as Rich Natural Sources of Antioxidant Derivatives: A Review on the Current Knowledge and Future Perspectives

Current Medicinal Chemistry, Journal Year: 2024, Volume and Issue: 31(28), P. 4407 - 4424

Published: Feb. 12, 2024

Abstract: The study of antioxidants is pivotal importance in biomedicine as these molecules could be involved biological pathways associated with disease. identification new together the acquisition a deeper knowledge on their biology, lead to use compounds drugs for innovative treatments. Plants are an important reservoir phytodrugs that many cases can isolated good extraction yields directly from vegetal source and often endowed low toxicity profile. Georgia, country situated Black Sea coast Caucasus region at intersection Western Asia Eastern Europe, renowned its unique woodland habitats immense diversity due great variety climate zones landscapes. Many wild plants area used remedies number illnesses local traditional medicine. However, scientific sources natural molecular components still far exhaustive. Therefore, present work we reviewed literature some main Georgian medicinal found several species valuable hydrophilic hydrophobic antioxidants, high ROS-scavenging ability. analysis also demonstrated most extracts beneficial suppressing multiple diseases vitro. This review will provide information scientists looking develop secure plant-based pharmaceuticals well rationale using treatment range diseases.

Language: Английский

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Enhancing drug–food interaction prediction with precision representations through multilevel self-supervised learning

Computers in Biology and Medicine, Journal Year: 2024, Volume and Issue: 171, P. 108104 - 108104

Published: Feb. 6, 2024

Language: Английский

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A Survey on Computational Methods in Drug Discovery for Neurodegenerative Diseases

Biomolecules, Journal Year: 2024, Volume and Issue: 14(10), P. 1330 - 1330

Published: Oct. 19, 2024

Currently, the age structure of world population is changing due to declining birth rates and increasing life expectancy. As a result, physicians worldwide have treat an number age-related diseases, which neurological disorders represent significant part. In this context, there urgent need discover new therapeutic approaches counteract effects neurodegeneration on human health, computational science can be pivotal importance for more effective neurodrug discovery. The knowledge molecular receptors other biomolecules involved in pathogenesis facilitates design molecules as potential drugs used fight against diseases high social relevance such dementia, Alzheimer's disease (AD) Parkinson's (PD), cite only few. However, absence comprehensive guidelines regarding strengths weaknesses alternative creates fragmented disconnected field, resulting missed opportunities enhance performance achieve successful applications. This review aims summarize some most innovative strategies based methods development. particular, recent applications state-of-the-art docking artificial intelligence ligand- target-based novel drug were reviewed, highlighting crucial role silico context discovery neurodegenerative diseases.

Language: Английский

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The chemical basis of seawater therapies: a review

Environmental Chemistry Letters, Journal Year: 2024, Volume and Issue: 22(4), P. 2133 - 2149

Published: April 27, 2024

Abstract The rising number of diseases and deaths caused by pollution modern lifestyle habits is a growing societal concern. Marine ecosystems are both victim to this human behaviour as recipient well being source medicinal chemicals which can cure variety diseases. In paper, we review the chemical basis water-based treatments their effects on health, while focusing threats marine potential benefits balneotherapy, thalassotherapy, bioactive species. We found that seawater has for skin demonstrating emollient properties, protection against barrier disruption, inhibition atopic dermatitis-like lesions. present putative mechanisms minerals, salts, organic matter slow down disease progression, through numerous activities, such anti-inflammatory, antioxidant, wound healing properties. Water-living organisms also have an impact producing biologically active compounds with beneficial health.

Language: Английский

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Safety Study and Molecular Docking Analysis of Phyto-Constituents from Withania somnifera Leaves: Insights into Dipeptidyl Peptidase-4 (DPP-4) Inhibition and Therapeutic Potential

Journal of the American Nutrition Association, Journal Year: 2025, Volume and Issue: unknown, P. 1 - 13

Published: May 20, 2025

Medicinal plants form the foundation of healthcare systems and modern medicine, offering powerful therapeutic potential to combat a wide range chronic metabolic disorders. The present study evaluates safety Withania somnifera leaf extracts using rodent modeling for 56 days. It also explores molecular docking interactions (WS) phytoconstituents with dipeptidyl peptidase-4 (DPP-4) receptor. A total 20 rats were divided into 5 groups (G0: Normal diet, G1: 0.25% WS leaves Extract, G3: 0.5% G4: powder, G5: 1% powder) organ-to-body weight ratio, LFTs, RFTs, hematological profile determined in 4th 8th weeks. On other hand, structures compounds identified from methanolic extract W. modified PDBQT format perform docking. results showed that all parameters varied within normal ranges. higher G2 after 28th day compared values 56th day. maximum serum glucose lipid found G3 group as groups, while hepato-renal markers high G0. Molecular revealed binding affinity w-02, w-03, w-04, w-05, w-07 DPP-4 receptors; moreover, w-04 had highest -6.4 kcal/mol. positive effect on biochemical without causing any adverse effects.

Language: Английский

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What Is New about Parsley, a Potential Source of Cardioprotective Therapeutic Substances?

Nutraceuticals, Journal Year: 2024, Volume and Issue: 4(1), P. 104 - 126

Published: Feb. 28, 2024

Petroselinum crispum (Mill.) Fuss (Apiaceae), popularly known as parsley, is a ubiquitous aromatic herb used for culinary and medicinal purposes worldwide. In addition to the richness in nutrients, several bioactive secondary metabolites, especially flavone apigenin its glycosides, have been described this species. Parsley has already shown health-promoting activities, such antithrombotic, antihypertensive, hypolipidemic properties. The multiple studies conducted animal models so far suggest species potential source of cardioprotective agents. This review provides up-to-date information perspectives on parsley compounds development nutraceutical products drugs promoting cardiovascular health. It includes not only discussion parsley’s reported bioactivities but also knowledge supplements food additives developed innovative parsley-based products.

Language: Английский

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Interaction of Laurusides 1 and 2 with the 3C-like Protease (Mpro) from Wild-Type and Omicron Variant of SARS-CoV-2: A Molecular Dynamics Study

International Journal of Molecular Sciences, Journal Year: 2023, Volume and Issue: 24(6), P. 5511 - 5511

Published: March 14, 2023

Laurus nobilis (bay laurel) is a natural source of biological compounds, and some its extracts phytocompounds are also endowed with antiviral activity toward the family severe acute respiratory syndrome (SARS)-associated β-coronaviruses. Some glycosidic laurel compounds such as laurusides were proposed inhibitors important protein targets SARS-CoV-2, which clearly recalls their potential anti-COVID-19 drugs. Due to frequent genomic variations β-coronaviruses consequent importance evaluating new drug candidate respect variants target β-coronavirus, we decided investigate at an atomistic level molecular interactions laurel-derived drugs 1 2 (L01 L02, respectively) well-conserved crucial target, 3C-like protease (Mpro), using enzymes both wild-type SARS-CoV-2 more recent Omicron variant. Thus, performed dynamic (MD) simulations laurusides—SARS-CoV-2 complexes deepen knowledge on stability interaction compare effects targeting among two variants. We found that mutation does not significantly impact lauruside binding L02 connects stably L01 in from variants, even though prevalently interact within same pocket. Although purely silico, current study highlights role bay specifically anti-coronavirus research shows Mpro, corroborating commitment functional food disclosing novel scenarios lauruside-based therapies.

Language: Английский

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Potential Anti-SARS-CoV-2 Molecular Strategies

Molecules, Journal Year: 2023, Volume and Issue: 28(5), P. 2118 - 2118

Published: Feb. 24, 2023

Finding effective antiviral molecular strategies was a main concern in the scientific community when severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) emerged at end of 2019 as an easily transmissible and potentially deadly β-coronavirus able to cause disease 19 (COVID-19), which famously led one most worrying pandemics recent times. Other members this zoonotic pathogenic family were already known before 2019, but apart from SARS-CoV, responsible (SARS) pandemic 2002/2003, Middle East (MERS-CoV), whose impact on humans is geographically restricted Eastern countries, other human β-coronaviruses that time those typically associated with common cold symptoms had not development any specific prophylactic or therapeutic measures. Although SARS-CoV-2 its mutations are still causing illness our communities, COVID-19 less than we returning normality. Overall, lesson learnt after past few years keeping bodies healthy immunity defenses strong using sport, nature-inspired measures, functional foods powerful weapons for preventing more forms caused by and, perspective, finding drugs mechanisms action involving biological targets conserved within different SARS-CoV-2—and possibly entire β-coronaviruses—gives opportunities scenario future based these pathogens. In regard, protease (Mpro), having no homologues, offers lower risk off-target reactivity represents suitable target search efficacious, broad-spectrum anti-β-coronavirus drugs. Herein, discuss above points also report some approaches presented counteract effects β-coronaviruses, special focus MERS-CoV.

Language: Английский

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