The European Physical Journal B,
Journal Year:
2024,
Volume and Issue:
97(6)
Published: June 1, 2024
Abstract
In
functionally
complex
systems,
higher
order
connectivity
is
often
revealed
in
the
underlying
geometry
of
networked
units.
Furthermore,
such
systems
show
signatures
self-organised
criticality,
a
specific
type
non-equilibrium
collective
behaviour
associated
with
an
attractor
internal
dynamics
long-range
correlations
and
scale
invariance,
which
ensures
robust
functioning
as
brain.
Here,
we
highlight
intertwining
features
critical
plausible
mechanism
for
emergence
new
properties
on
larger
scale,
representing
central
paradigm
physical
notion
complexity.
Considering
time-scale
structural
evolution
known
separation
i.e.,
external
driving,
distinguish
three
classes
geometries
that
can
shape
them
differently.
We
provide
overview
current
trends
study
phenomena,
synchronisation
phase
oscillators
discrete
spin
couplings
embedded
faces
simplicial
complexes.
For
representative
example
induced
by
structures,
present
more
detailed
analysis
field-driven
reversal
hysteresis
loops
complexes
composed
triangles.
These
numerical
results
suggest
two
fundamental
interactions
edge-embedded
triangle-embedded
must
be
taken
into
account
theoretical
models
to
describe
influence
dynamics.
Graphical
abstract
Biomedicines,
Journal Year:
2023,
Volume and Issue:
11(9), P. 2488 - 2488
Published: Sept. 7, 2023
Mitochondria
play
a
vital
role
in
maintaining
cellular
energy
homeostasis,
regulating
apoptosis,
and
controlling
redox
signaling.
Dysfunction
of
mitochondria
has
been
implicated
the
pathogenesis
various
brain
diseases,
including
neurodegenerative
disorders,
stroke,
psychiatric
illnesses.
This
review
paper
provides
comprehensive
overview
intricate
relationship
between
disease,
focusing
on
underlying
pathological
mechanisms
exploring
potential
therapeutic
opportunities.
The
covers
key
topics
such
as
mitochondrial
DNA
mutations,
impaired
oxidative
phosphorylation,
dynamics,
calcium
dysregulation,
reactive
oxygen
species
generation
context
disease.
Additionally,
it
discusses
emerging
strategies
targeting
dysfunction,
protective
agents,
metabolic
modulators,
gene
therapy
approaches.
By
critically
analysing
existing
literature
recent
advancements,
this
aims
to
enhance
our
understanding
multifaceted
disease
shed
light
novel
interventions.
International Journal of Molecular Sciences,
Journal Year:
2024,
Volume and Issue:
25(4), P. 2360 - 2360
Published: Feb. 17, 2024
This
review
explores
the
diverse
applications
of
gold
nanoparticles
(AuNPs)
in
neurological
diseases,
with
a
specific
focus
on
Alzheimer's
disease
(AD),
Parkinson's
(PD),
and
stroke.
The
introduction
highlights
pivotal
role
neuroinflammation
these
disorders
introduces
unique
properties
AuNPs.
review's
core
examines
mechanisms
by
which
AuNPs
exert
neuroprotection
anti-neuro-inflammatory
effects,
elucidating
various
pathways
through
they
manifest
properties.
potential
therapeutic
AD
are
discussed,
shedding
light
promising
avenues
for
therapy.
also
prospects
utilizing
PD
interventions,
presenting
hopeful
outlook
future
treatments.
Additionally,
delves
into
providing
after
strokes,
emphasizing
their
significance
mitigating
cerebrovascular
accidents'
aftermath.
Experimental
findings
from
cellular
animal
models
consolidated
to
provide
comprehensive
overview
AuNPs'
effectiveness,
offering
insights
impact
at
both
vivo
levels.
enhances
our
understanding
diseases
lays
groundwork
innovative
strategies
neurology.
Pain and Therapy,
Journal Year:
2024,
Volume and Issue:
13(3), P. 293 - 317
Published: March 2, 2024
Pain
is
a
significant
health
issue,
and
pain
assessment
essential
for
proper
diagnosis,
follow-up,
effective
management
of
pain.
The
conventional
methods
often
suffer
from
subjectivity
variability.
main
issue
to
understand
better
how
people
experience
In
recent
years,
artificial
intelligence
(AI)
has
been
playing
growing
role
in
improving
clinical
diagnosis
decision-making.
application
AI
offers
promising
opportunities
improve
the
accuracy
efficiency
assessment.
This
review
article
provides
an
overview
current
state
explores
its
potential
accuracy,
efficiency,
personalized
care.
By
examining
existing
literature,
research
gaps,
future
directions,
this
aims
guide
further
advancements
field
management.
An
online
database
search
was
conducted
via
multiple
websites
identify
relevant
articles.
inclusion
criteria
were
English
articles
published
between
January
2014
2024).
Articles
that
available
as
full
text
trials,
observational
studies,
articles,
systemic
reviews,
meta-analyses
included
review.
exclusion
not
language,
free
text,
those
involving
pediatric
patients,
case
reports,
editorials.
A
total
(47)
conclusion,
could
present
solutions
can
potentially
increase
precision,
objective
Biomedicines,
Journal Year:
2024,
Volume and Issue:
12(3), P. 613 - 613
Published: March 8, 2024
Neuroscience,
neurology,
and
psychiatry
are
rapidly
evolving
fields
that
aim
to
understand
the
complex
mechanisms
underlying
brain
function
dysfunction,
as
well
develop
effective
interventions
for
various
neurological
psychiatric
disorders
[...]
Cells,
Journal Year:
2024,
Volume and Issue:
13(10), P. 790 - 790
Published: May 7, 2024
Translational
research
in
neurological
and
psychiatric
diseases
is
a
rapidly
advancing
field
that
promises
to
redefine
our
approach
these
complex
conditions
[...]
The
editorial
explores
the
realm
of
emerging
translational
research
in
neurology
and
psychiatry,
providing
insights
into
various
subjects,
including
neurodegenerative
disorders
innovative
therapeutic
methods.
main
objective
is
to
study
neurological
psychiatric
disorders,
such
as
Alzheimer's
disease,
with
a
particular
emphasis
on
techniques
for
neural
regeneration
repair.
highlights
importance
taking
comprehensive
approach
studying
treating
complex
conditions.
This
involves
thoroughly
reviewing
papers
causes,
development,
biomarkers,
treatment
options
these
emphasizes
necessity
using
multidisciplinary
integrative
methods
gain
deeper
understanding
improve
development
an
animal
model
recurrent
primary
dysmenorrhea
showcases
employed
investigation
gynecological
illustrating
capacity
connect
fundamental
scientific
knowledge
practical
medical
applications.
cooperative
endeavors
researchers
clinicians
emphasized
this
lay
foundation
revolutionary
advancements
that
hold
potential
enhance
outcomes
individuals
afflicted
globally.
Delve
into
the
dynamic
realms
of
neuroscience,
neurology,
and
psychiatry
with
this
groundbreaking
editorial,
unveiling
intricate
mechanisms
brain
function
dysfunction.
Explore
latest
advancements
in
molecular
biology,
genetics,
epigenetics,
pharmacology,
neuroimaging
that
are
revolutionizing
our
understanding
neurological
psychiatric
disorders.
Uncover
challenges
gaps
translating
cutting-edge
research
practical
clinical
applications,
aiming
to
enhance
lives
patients
their
families.
Discover
pivotal
role
neuroplasticity
reshaping
brain's
adaptability
throughout
life,
alongside
promising
potential
non-invasive
stimulation
techniques
like
transcranial
magnetic
direct
current
stimulation.
Embark
on
a
journey
innovation
collaboration
as
researchers
clinicians
strive
bridge
gap
between
bench
bedside,
offering
hope
for
improved
diagnosis,
prevention,
treatment
complex
conditions.
Join
us
exploration
transformative
ideas
novel
interventions
hold
key
brighter
future
individuals
society.
Frontiers in Cellular Neuroscience,
Journal Year:
2025,
Volume and Issue:
19
Published: Feb. 19, 2025
The
brain's
complex
organization
spans
from
molecular-level
processes
within
neurons
to
large-scale
networks,
making
it
essential
understand
this
multiscale
structure
uncover
brain
functions
and
address
neurological
disorders.
Multiscale
modeling
has
emerged
as
a
transformative
approach,
integrating
computational
models,
advanced
imaging,
big
data
bridge
these
levels
of
organization.
This
review
explores
the
challenges
opportunities
in
linking
microscopic
phenomena
macroscopic
functions,
emphasizing
methodologies
driving
progress
field.
It
also
highlights
clinical
potential
including
their
role
advancing
artificial
intelligence
(AI)
applications
improving
healthcare
technologies.
By
examining
current
research
proposing
future
directions
for
interdisciplinary
collaboration,
work
demonstrates
how
can
revolutionize
both
scientific
understanding
practice.
