The impact of 17β-estradiol on the estrogen-deficient female brain: from mechanisms to therapy with hot flushes as target symptoms

Frontiers in Endocrinology, Journal Year: 2024, Volume and Issue: 14

Published: Jan. 8, 2024

Sex steroids are essential for whole body development and functions. Among these steroids, 17β-estradiol (E2) has been known as the principal "female" hormone. However, E2's actions not restricted to reproduction, it plays a myriad of important roles throughout including brain. In fact, this hormone also profound effects on female brain life span. The receives gonadal from circulation, local formation E2 testosterone

Language: Английский

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Changes in EEG Activity and Cognition Related to Physical Activity in Older Adults: A Systematic Review

Life, Journal Year: 2024, Volume and Issue: 14(4), P. 440 - 440

Published: March 26, 2024

Aging is generally associated with a decline in important cognitive functions that can be observed EEG. Physical activity older adults should considered one of the main strategies to promote health and prevent disease elderly. The present study aimed systematically review studies EEG function changes physical adults. Records from PubMed, Scopus, EBSCO databases were searched and, following PRISMA guidelines, nine included systematic review. A risk bias assessment was performed using National Institute Health Quality Assessment Tool for Case-control Studies instrument. analyzed used two determine effects on cognition EEG: (1) multiscale entropy power frequencies; (2) event-related potentials. In terms activity, it concluded exercise-induced neuroplasticity underlies improvements healthy

Language: Английский

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U-shaped convolutional transformer GAN with multi-resolution consistency loss for restoring brain functional time-series and dementia diagnosis

Frontiers in Computational Neuroscience, Journal Year: 2024, Volume and Issue: 18

Published: April 17, 2024

The blood oxygen level-dependent (BOLD) signal derived from functional neuroimaging is commonly used in brain network analysis and dementia diagnosis. Missing the BOLD may lead to bad performance misinterpretation of findings when analyzing neurological disease. Few studies have focused on restoration time-series data.

Language: Английский

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A systematic review of the biomarkers associated with cognition and mood state in bipolar disorder

International Journal of Bipolar Disorders, Journal Year: 2024, Volume and Issue: 12(1)

Published: May 17, 2024

Abstract Background Bipolar disorder (BD) is a severe psychiatric characterized by changes in mood that alternate between (hypo) mania or depression and mixed states, often associated with functional impairment cognitive dysfunction. But little known about biomarkers contribute to the development sustainment of deficits. The aim this study was review association neurocognition across different states. Method Search databases were Web Science, Scopus PubMed. A systematic carried out following PRISMA guidelines. Risk bias assessed Newcastle–Ottawa Scale. Studies selected focused on correlation neuroimaging, physiological, genetic peripheral cognition at least two phases BD: depression, (hypo)mania, euthymia mixed. PROSPERO Registration No.: CRD42023410782. Results total 1824 references screened, identifying 1023 published articles, which 336 considered eligible. Only 16 provided information affective states BD. included studies found: (i) Differences levels cholesterol C reactive protein depending state; (ii) There no found biomarkers; (iii) Neuroimaging highlighted hypoactivation frontal areas as distinctive acute state BD; (iv) deactivation failure has been reported ventromedial prefrontal cortex (vmPFC), potentially serving trait marker Conclusion few recent articles have investigated biomarker-cognition associations BD phases. Our findings underline there appear be central regions involved are observed all However, underlying mechanisms dysfunction may vary This highlights importance standardizing data assessment cognition, well need for help prevent symptomatic disease, impairment.

Language: Английский

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Fundamental interactions in self-organised critical dynamics on higher order networks

The European Physical Journal B, Journal Year: 2024, Volume and Issue: 97(6)

Published: June 1, 2024

Abstract In functionally complex systems, higher order connectivity is often revealed in the underlying geometry of networked units. Furthermore, such systems show signatures self-organised criticality, a specific type non-equilibrium collective behaviour associated with an attractor internal dynamics long-range correlations and scale invariance, which ensures robust functioning as brain. Here, we highlight intertwining features critical plausible mechanism for emergence new properties on larger scale, representing central paradigm physical notion complexity. Considering time-scale structural evolution known separation i.e., external driving, distinguish three classes geometries that can shape them differently. We provide overview current trends study phenomena, synchronisation phase oscillators discrete spin couplings embedded faces simplicial complexes. For representative example induced by structures, present more detailed analysis field-driven reversal hysteresis loops complexes composed triangles. These numerical results suggest two fundamental interactions edge-embedded triangle-embedded must be taken into account theoretical models to describe influence dynamics. Graphical abstract

Language: Английский

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