Mechanisms of Regulation Allergic and Autoimmune Reactions by Bacterial Origin Bioregulators DOI Creative Commons
Svetlana V. Guryanova, Ilya A. Sigmatulin, О. О. Гигани

et al.

RUDN Journal of Medicine, Journal Year: 2023, Volume and Issue: 27(4), P. 470 - 482

Published: Dec. 15, 2023

Relevance. The increase in allergic and autoimmune diseases observed recent decades highlights the need for therapy prevention, which requires detailed research into mechanisms of their occurrence. onset progression are influenced by genetic predisposition, lifestyle, environmental factors, disruptions coordinated operation immune system, as a consequence homeostasis. Treatment these is primarily symptomatic often accompanied undesirable side effects. Immune system disorders various pathologies have own characteristics each type disease, at same time common mechanisms. Considering presence large number microorganisms human body, taking influence account paramount importance. Microorganisms source biologically active molecules, action can either prevent reduce severity disease or exacerbate it. aim this study was to analyze cytokine profile effects fragments cell walls Gram-negative Gram-positive bacteria - lipopolysaccharide (LPS) muramyl peptide (MP), well nisin an antimicrobial bacterial origin on mononuclear cells. Materials Methods. Mononuclear cells were obtained from peripheral blood healthy volunteers using Cell separation media Lympholyte CL 5015, cultured LPS, GMDP bacteriocin nisin. activity examined multiplex analysis; analysis surface markers determined flow cytometry. Results Discussion. It shown that wall much greater extent than induce production cytokines, chemokines, growth factors. established LPS MP expression CD11c dendritic cells, while does not affect CD11c+ DCs. conducted ex vivo studies did emergence CCR7. Conclusion. Bacterial bioregulators trigger negative feedback mechanism inducing synthesis anti-inflammatory inflammatory process. Understanding molecular body opens new approaches prevention development personalized strategies.

Language: Английский

Marine Invertebrate Antimicrobial Peptides and Their Potential as Novel Peptide Antibiotics DOI Creative Commons
Svetlana V. Guryanova, Sergey V. Balandin, Oksana Yu. Belogurova-Ovchinnikova

et al.

Marine Drugs, Journal Year: 2023, Volume and Issue: 21(10), P. 503 - 503

Published: Sept. 23, 2023

Marine invertebrates constantly interact with a wide range of microorganisms in their aquatic environment and possess an effective defense system that has enabled existence for millions years. Their lack acquired immunity sets marine apart from other animals. Invertebrates could rely on innate immunity, providing the first line defense, survival, thriving. The immune includes various biologically active compounds, specifically, antimicrobial peptides. Nowadays, there is revive interest these peptides due to urgent need discover novel drugs against antibiotic-resistant bacterial strains, pressing global concern modern healthcare. Modern technologies offer extensive possibilities development innovative based which can act bacteria, fungi, protozoa, viruses. This review focuses structural peculiarities, biological functions, gene expression, biosynthesis, mechanisms action, regulatory activities, prospects therapeutic use derived invertebrates.

Language: Английский

Citations

23
Revisiting the Multifaceted Roles of Bacteriocins DOI Creative Commons
Sara Arbulu, Morten Kjos

Microbial Ecology, Journal Year: 2024, Volume and Issue: 87(1)

Published: Feb. 14, 2024

Abstract Bacteriocins are gene-encoded antimicrobial peptides produced by bacteria. These heterogeneous in terms of structure, activities, biosynthetic clusters, and regulatory mechanisms. widespread nature may contribute to microbial diversity due their capacity target specific Primarily studied as food preservatives therapeutic agents, function natural settings is however less known. This review emphasizes the ecological significance bacteriocins multifunctional exploring bacteriocin distribution, mobility, impact on bacterial population dynamics biofilms.

Language: Английский

Citations

14
Antimicrobial Peptides Derived from Bacteria: Classification, Sources, and Mechanism of Action against Multidrug-Resistant Bacteria DOI Open Access

Raynichka Mihaylova-Garnizova,

Slavena Davidova,

Yordan Hodzhev

et al.

International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(19), P. 10788 - 10788

Published: Oct. 8, 2024

Antimicrobial peptides (AMPs) are short, usually cationic with an amphiphilic structure, which allows them to easily bind and interact the cellular membranes of viruses, bacteria, fungi, other pathogens. Bacterial AMPs, or bacteriocins, can be produced from Gram-negative Gram-positive bacteria via ribosomal synthesis eliminate competing organisms. AMPs vital in addressing increasing antibiotic resistance various pathogens, potentially serving as alternative ineffective antibiotics. Bacteriocins have a narrow spectrum action, making highly specific antibacterial compounds that target particular bacterial This review covers two main groups bacteriocins by their modes classification, sources positive effects they play on human body, limitations future perspectives

Language: Английский

Citations

8
Lactobacillaceae differentially impact butyrate-producing gut microbiota to drive CNS autoimmunity DOI Creative Commons

Theresa L. Montgomery,

Lucinda C. Toppen, Korin Eckstrom

et al.

Gut Microbes, Journal Year: 2024, Volume and Issue: 16(1)

Published: Oct. 27, 2024

Short-chain fatty acids (SCFAs), produced by the gut microbiota, are thought to exert an anti-inflammatory effect on host immune system. The levels of SCFAs and abundance microbiota that produce them depleted in multiple sclerosis (MS), autoimmune disease central nervous system (CNS). mechanisms leading this depletion unknown. Using experimental encephalomyelitis (EAE) as a model for MS, we have previously shown microbiomes divergent their specific commensal

Language: Английский

Citations

8
Effects of dietary Nisin on growth performance, immune function, and gut health of broilers challenged by Clostridium perfringens DOI

Hua Yuan,

Guangdong Bai,

Yu Lin

et al.

Journal of Animal Science, Journal Year: 2024, Volume and Issue: 102

Published: Jan. 1, 2024

Abstract Nisin (Ni) is a polypeptide bacteriocin produced by lactic streptococci (probiotics) that can inhibit the majority of gram-positive bacteria, and improve growth performance broilers, exert antioxidative anti-inflammatory properties. The present study investigated potential preventive effect on necrotic enteritis induced Clostridium perfringens (Cp) challenge. A total 288 Arbor Acres broiler chickens 1-d-olds were allocated using 2 × factorial arrangement into four groups with six replicates (12 per replicate), including: (1) control group (Con, basal diet), (2) Cp challenge (Cp, diet + 1.0 108 CFU/mL Cp), (3) Ni (Ni, 100 mg/kg Ni), (4) (Ni Cp, Cp). results showed decreased average daily gain (ADG) days 15 to 21 (P<0.05) increased interleukin-6 (IL-6) content in serum (P < 0.05), as well significant reduction villus height (VH) ratio VH crypt depth (VCR) increase (CD) jejunum (P<0.05). Furthermore, mRNA expressions Occludin Claudin-1 downregulated (P<0.05), while Caspase3, Caspase9, Bax, Bax/Bcl-2 upregulated jejunum. However, inclusion dietary supplementation significantly improved body weight (BW) 28, ADG CD jejunum, reduced tumor necrosis factor-α (TNF-α) addition levels expression Caspase9 Moreover, altered cecal microbiota composition, which manifested relative abundance phylum Fusobacteriota Shannon index trend Proteobacteria (0.05<P<0.10), Cyanobacteria In conclusion, demonstrated effectively mitigated negative impact challenge-induced damage intestine broilers via reducing inflammatory responses intestinal apoptosis modulating microbial composition.

Language: Английский

Citations

4
Intestinal delivery of encapsulated bacteriocin peptides in cross-linked alginate microcapsules DOI Creative Commons
Lei Wei,

Dana E. Wong,

Tina Jeoh

et al.

Food Research International, Journal Year: 2024, Volume and Issue: 188, P. 114473 - 114473

Published: May 8, 2024

Oral delivery of larger bioactive peptides (>20 amino acids) to the small intestine remains a challenge due their sensitivity proteolytic degradation and chemical denaturation during gastrointestinal transit. In this study, we investigated capacity crosslinked alginate microcapsules (CLAMs) formed by spray drying protect Plantaricin EF (PlnEF) (C-EF) in gastric conditions dissolve release PlnEF intestine. is an unmodified, two-peptide (PlnE: 33 acids; PlnF: 34 bacteriocin produced Lactiplantibacillus plantarum with antimicrobial gut barrier protective properties. After 2 h incubation simulated fluid (SGF) (pH 1.5), 43.39 % ± 8.27 intact was liberated from CLAMs encapsulates, as determined activity assay. Transfer undissolved fraction intestinal (SIF) 7) for another resulted additional 16.13 4.33 %. No active found SGF or sequential SIF incubations when pepsin (2,000 U/ml) added SGF. To test C-EF contained food matrix, mixed peanut butter (PB) (0.15 g 1.5 PB). A total 12.52 9.09 detected after PB + without pepsin, whereas no included. remaining fractions yielded recovery 46.67 13.09 39.42 11.53 following exposure respectively. Upon accounting incubation, fully protected CLAMs-PB mixture there not significant reduction present. These results show that alone do guard conditions, however, mixing them against proteolysis improved release.

Language: Английский

Citations

4
Current challenges and development strategies of bacteriocins produced by lactic acid bacteria applied in the food industry DOI

Qingping Liang,

Zhemin Liu, Ziyu Liang

et al.

Comprehensive Reviews in Food Science and Food Safety, Journal Year: 2024, Volume and Issue: 24(1)

Published: Dec. 14, 2024

Abstract Given the great importance of natural biopreservatives in modern food industry, lactic acid bacteria (LAB)‐producing bacteriocins have gained considerable attention due to their antimicrobial activity against foodborne pathogens and spoilage bacteria. Although numerous LAB‐producing demonstrated efficiency preserving quality various applications, only a limited number these compounds been commercially approved date. The currently unclear gastrointestinal metabolism may pose safety risks, as well cytotoxicity immunogenicity, which need be seriously considered before application. A more noteworthy concern lies whether induce an imbalance gut microbiota, thereby leading alterations abundance health‐associated microorganisms metabolites tract. Accordingly, this review presents unique insights into challenges arising from metabolic interactions between Besides, application industry faces low production yield, weak stability, insufficient activity. corresponding development strategies are proposed for conducting systematic comprehensive evaluation potential risks metabolites. also focus on rational design increase fermentation control enhance hurdle embedding technology improve effects. It definitively discloses perspective become natural, sustainable, safe, eco‐friendly biological preservatives advancement industry.

Language: Английский

Citations

4
Antimicrobial potential and stability of Lactobacillus acidophilus-derived bacteriocins against multidrug-resistant common foodborne pathogens DOI Creative Commons
Md Mahmudul Hasan,

Fahmida Jahan Fahim,

Sohel Rana

et al.

Applied Food Research, Journal Year: 2025, Volume and Issue: unknown, P. 100728 - 100728

Published: Jan. 1, 2025

Language: Английский

Citations

0
Broad-Spectrum Antimicrobial Peptides Suppress Vibrio parahaemolyticus Based on Lactobacillus paracasei A1 Fermentation DOI
Feng Guan, Chen Yu, Yang Lu

et al.

Foodborne Pathogens and Disease, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 11, 2025

Growing evidence supports the efficacy of antimicrobial peptides against foodborne pathogens, though their spectrum and mechanism can vary depending on origin. We investigated derived from Lactobacillus paracasei A1, effects survival rate bactericidal mechanisms Vibrio parahaemolyticus, identified functional short within them. The crude extracts exhibited antibacterial properties 13 pathogenic bacteria, showing strong inhibition V. parahaemolyticus by disrupting structural integrity cell membranes. At minimum inhibitory concentrations, these significantly disrupted initial adhesion, membrane formation, existing biofilms effectively inhibiting pathogen spread, enhancing agents, reducing food safety risks. LC-MS/MS identification revealed four effective peptides, all demonstrating potent bacteriostatic parahaemolyticus. Our findings indicate that destroy bacterial structures as well stability regeneration biofilms, making them promising candidates for use additives to control pathogens.

Language: Английский

Citations

0
Understanding dysbiosis and resilience in the human gut microbiome: biomarkers, interventions, and challenges DOI Creative Commons
Azadeh Safarchi, Ghanyah Al-Qadami, Cuong D. Tran

et al.

Frontiers in Microbiology, Journal Year: 2025, Volume and Issue: 16

Published: March 4, 2025

The healthy gut microbiome is important in maintaining health and preventing various chronic metabolic diseases through interactions with the host via different gut–organ axes, such as gut-brain, gut-liver, gut-immune, gut-lung axes. human relatively stable, yet can be influenced by numerous factors, diet, infections, diseases, medications which may disrupt its composition function. Therefore, microbial resilience suggested one of key characteristics a humans. However, our understanding definition indicators remains unclear due to insufficient experimental data. Here, we review impact drivers including intrinsic extrinsic factors diet antibiotics on microbiome. Additionally, discuss concept resilient highlight potential biomarkers diversity indices some bacterial taxa recovery-associated bacteria, resistance genes, antimicrobial peptides, functional flexibility. These facilitate identification prediction microbiomes, particularly precision medicine, diagnostic tools or machine learning approaches especially after that cause stable dysbiosis. Furthermore, current nutrition intervention strategies maximize resilience, challenges investigating future directions this field research.

Language: Английский

Citations

0