Neuroplasticity of children in autism spectrum disorder

Frontiers in Psychiatry, Journal Year: 2024, Volume and Issue: 15

Published: April 25, 2024

Autism spectrum disorder (ASD) is a neurodevelopmental that encompasses range of symptoms including difficulties in verbal communication, social interaction, limited interests, and repetitive behaviors. Neuroplasticity refers to the structural functional changes occur nervous system adapt respond external environment. In simpler terms, it brain's ability learn new environments. However, individuals with ASD exhibit abnormal neuroplasticity, which impacts information processing, sensory cognition, leading manifestation corresponding symptoms. This paper aims review current research progress on focusing genetics, environment, neural pathways, neuroinflammation, immunity. The findings will provide theoretical foundation insights for intervention treatment pediatric fields related ASD.

Language: Английский

---

Evaluation of S100B, NSE, MBP and GFAP serum levels in children with attention deficit hyperactivity disorder

Pamukkale Medical Journal, Journal Year: 2025, Volume and Issue: 18(2), P. 432 - 443

Published: March 28, 2025

Purpose: This study aimed to investigate serum levels of S100B protein, Neuron Specific Enolase (NSE), Myelin Basic Protein (MBP) and Glial Fibrillary Acidic (GFAP) that reflect glial neural structure. To date, these proteins have been studied in neuropsychiatric diseases relation with neuronal damage has shown. However, there is no simultaneously evaluates the children ADHD compares them healthy controls. Materials methods: 44 37 volunteers participated study. They were selected from adolescents aged 6-18 years who had history other medical or psychiatric not used psychotropic drugs for last six months. Levels assessed by enzyme-linked immunosorbent assay (ELISA). Results: Serum S100B, NSE GFAP found be statistically significantly higher group than control (p=0.012, p=0.000, p=0.001, respectively). No significant difference was intergroup comparison MBP (p=0.181). Conclusion: Increased NSE, may an indicator changes ADHD. Future studies combining serial measurements biochemical genetics neuroimaging data are needed evaluate possible role etiopathogenesis

Language: Английский

---

Neuron-specific enolase in patients with acute and chronic schizophrenia, diversity of approaches: marker of neuronal death, neurodegeneration or neurodevelopmental theory in schizophrenia? a single-center case-control study

Frontiers in Psychiatry, Journal Year: 2025, Volume and Issue: 16

Published: May 6, 2025

Introduction Schizophrenia is a mental illness that affects diverse group of patients, but the underlying causes symptoms can vary. There currently lot research being done on use biomarkers in diagnosis schizophrenia, including neuron-specific enolase (NSE). The aim this study was to evaluate and compare NSE concentrations serum patients with schizophrenia determine possible relationships between duration severity positive negative schizophrenia. Materials methods included 59 60 healthy controls. were assessed all subjects. Scale for Assessment Negative Symptoms (SANS) Positive (SAPS) used assess Results mean concentration statistically significantly lower than A weak correlation levels SANS score SAPS found, results not significant. No relationship reported age, sex, disease duration, dependence others or laboratory findings levels. Discussion found tendency towards decreased observed. In addition, trend noted an increase level symptoms. experiment should be confirmed further studies.

Language: Английский

---

The Dangers of Acetaminophen for Neurodevelopment Outweigh Scant Evidence for Long-Term Benefits

Children, Journal Year: 2023, Volume and Issue: 11(1), P. 44 - 44

Published: Dec. 29, 2023

Based on available data that include approximately 20 lines of evidence from studies in laboratory animal models, observations humans, correlations time, and pharmacological/toxicological considerations, it has been concluded without reasonable doubt with no to the contrary exposure susceptible babies children acetaminophen (paracetamol) induces many, if not most, cases autism spectrum disorder (ASD). However, relative number ASD might be induced by yet estimated. Here, we examine a variety evidence, including acetaminophen-induced reduction social awareness adults, prevalence through crude estimates during various periods neurodevelopment. We conclude very early postpartum period poses greatest risk for ASD, nearly ubiquitous use development could conceivably responsible induction vast majority, perhaps 90% or more, all ASD. Despite over decade accumulating is harmful neurodevelopment, numerous demonstrate frequently administered excess currently approved amounts under conditions which provides benefit. Further, have failed long-term benefits pediatric population, leaving valid rationale continued drug population given its risks

Language: Английский

---

Autologous Cord Blood vs Individualized Supplements in Autistic Spectrum Disease – Results of the CORDUS Study

Published: Jan. 3, 2024

Cellular therapies have started an important new therapeutic direction for Autistic Spectrum Disease (ASD), and the ample diversity of ASD pathophysiology different types cell need equally effort studying applicable causes specific benefits via clinical studies.CORDUS Clinical Study is a crossover study in which autologous cord blood was administered intravenously to 56 patients between January 2019 July 2023, has compared its efficacy versus individualized combination supplements; both treatments were sequence all participants. Treatment evaluated pre- post- by independent psychotherapist with ATEC, Q-CHAT 16-item comparative table score, after interviews children’s parents therapists.Cord beneficial group 3–7-year-old children (n=28; 3 out 4 – 78.57% - improved scores), but much less effective kids older than 8 years or body weight more 35 kg 1 10 scores). Individualized supplements efficacious 5 cases 28, while 23 brought improvement 6 registered minor no improvement. Statistically significant improvements seen infusion on areas such as verbalization social interaction, not irritability aggressive behavior; also individual differences noted. No serious adverse reactions noted during supplement administration.

Language: Английский

---

Research progress of neuron-specific enolase in cognitive disorder: a mini review

Frontiers in Human Neuroscience, Journal Year: 2024, Volume and Issue: 18

Published: July 8, 2024

Numerous studies have demonstrated that neuron-specific enolase (NSE) serves as a distinctive indicator of neuronal injury, with its concentration in blood reflecting the extent and magnitude nervous system damage, expression serum NSE is correlated cognitive dysfunction. The assessment holds significant importance diagnosing dysfunction, assessing disease severity, predicting prognosis, guiding treatment. In this review, research progress dysfunction was reviewed, value level severity prognosis patients discussed.

Language: Английский

---

Molecular Links between Inflammatory Bowel Disease and Mild Cognitive Impairment- a Narrative Review

Published: April 2, 2024

IBD, encompassing CD and UC, are characterized by chronic gastrointestinal inflammation due to abnormal immune responses gut microflora. The bidirectional communication between the brain, known as GBA, is disrupted in leading neurobiological imbalances affective symptoms. Systemic IBD affects brain's inflammatory response system, hormonal axis, BBB integrity, influencing microbiota clinical probiotics. This review aims explore links dysregulations serum biomarkers, development of MCI NDDs. objective identify potential correlations propose future research directions understand impact altered microbiomes intestinal barrier functions on Studies suggest a link extraintestinal complications such Mechanisms include systemic inflammation, dysfunction, autoimmune responses, GBA medication effects, comorbidities. Serum including vitamin D3, C-reactive protein, high-sensitivity B12, homocysteine, amyloid, neuron-specific enolase, neurofilament light chain, S100 proteins, brain-derived neurotrophic factor, IL-6, LP-2 associated phospholipase, prostaglandin E2, IL-1β, TNF-α, have been investigated for their predict but current results lacking clarity.

Language: Английский

---

Evaluating the Role of Susceptibility Inducing Cofactors and of Acetaminophen in the Etiology of Autism

Published: June 4, 2024

More than 20 lines of independent evidence from clinical observations, studies in laboratory animal models, pharmacokinetic considerations, and numerous temporal spatial associations previously indicate that genetic environmental factors leading to inflammation oxidative stress confer vulnerability aberrant metabolism acetaminophen during early development, autism spectrum disorder (ASD). Contrary this conclusion, multivariate analyses cohort data adjusting for inflammation-associated have tended show little no risk use neurodevelopment. To resolve discrepancy, here we in-silico methods create an ideal (virtual) population 120000 individuals which 50% all cases virtual ASD are induced by stress-associated cofactors use. We demonstrate Cox regression analysis set shows if adjusted the analysis. Further, under-reporting is shown be a considerable problem analysis, large erroneously low calculated risks In addition, argue impart susceptibility acetaminophen-induced injury, propensity itself, can shared between prepartum, peripartum, postpartum periods, creating additional difficulty existing datasets determine exposure neurodevelopment specific time frame. It concluded obtained depend on underlying assumptions analyses, other evidence, both abundant robust, critical role etiology ASD.

Language: Английский

---

Evaluating the Role of Susceptibility Inducing Cofactors and of Acetaminophen in the Etiology of Autism Spectrum Disorder

Life, Journal Year: 2024, Volume and Issue: 14(8), P. 918 - 918

Published: July 23, 2024

More than 20 previously reported lines of independent evidence from clinical observations, studies in laboratory animal models, pharmacokinetic considerations, and numerous temporal spatial associations indicate that genetic environmental factors leading to inflammation oxidative stress confer vulnerability the aberrant metabolism acetaminophen during early development, autism spectrum disorder (ASD). Contrary this conclusion, multivariate analyses cohort data adjusting for inflammation-associated have tended show little no risk use neurodevelopment. To resolve discrepancy, here we silico methods create an ideal (virtual) population 120,000 individuals which 50% all cases virtual ASD are induced by stress-associated cofactors use. We demonstrate Cox regression analysis dataset shows if adjusted analysis. Further, under-reporting is shown be a considerable problem analysis, large erroneously low calculated risks In addition, argue impart susceptibility acetaminophen-induced injury, propensity itself, can shared between prepartum, peripartum, postpartum periods, creating additional difficulty existing datasets determine exposure neurodevelopment specific time frame. It concluded obtained depend on underlying assumptions analyses, other evidence, both abundant robust, critical role etiology ASD.

Language: Английский

---

Autologous cord blood vs individualized supplements in autistic spectrum disorder: CORDUS study results

World Journal of Clinical Pediatrics, Journal Year: 2024, Volume and Issue: 14(1)

Published: Dec. 20, 2024

Cellular therapies have started an important new therapeutic direction in autistic spectrum disorder (ASD), and the ample diversity of ASD pathophysiology different types cell prompt equally effort to employ clinical studies for studying causes therapies. Stem cells yielded so far mixed results trials, at patient level varied from impressive no improvement. In this context we administered autologous cord blood (ACB) a non-placebo, material intervention represented by individualized combination supplements (ICS) children. To compare efficacy ACB vs ICS find markers correlated with child's progress order better predict efficacy. CORDUS study is crossover which both oral intravenous were sequentially 56 children; was infused as inpatient procedure. Treatment evaluated pre-treatment post-treatment 6 months independent psychotherapist Autism Evaluation Checklist, Quantitative Checklist Toddlers 16-item comparative table score, after interviewing children's parents therapists. Before each participants had set tests including inflammatory, metabolic oxidative markers, neuronal specific enolase. No serious adverse reactions noted during or supplement administration. improved evaluation scores 78% children age 3-7-years (n = 28), but much less effective kids older than 8 years body weight more 35 kg 28; only 11% scores). 5 cases out 28, while 23 brought improvement (P < 0.05); high initial levels inflammation ferritin associated Ample individual differences progress, statistically significant improvements seen on areas such verbalization social interaction, not irritability aggressive behavior. has superior ASD; inflammation, ferritin, improvement; are needed ASD.

Language: Английский

---