Lesson on obesity and anatomy of adipose tissue: new models of study in the era of clinical and translational research
Journal of Translational Medicine,
Journal Year:
2024,
Volume and Issue:
22(1)
Published: Aug. 14, 2024
Obesity
is
a
serious
global
illness
that
frequently
associated
with
metabolic
syndrome.
Adipocytes
are
the
typical
cells
of
adipose
organ,
which
composed
at
least
two
different
tissues,
white
and
brown
tissue.
They
functionally
cooperate,
interconverting
each
other
under
physiological
conditions,
but
differ
in
their
anatomy,
physiology,
endocrine
functions.
Different
cellular
models
have
been
proposed
to
study
tissue
vitro.
also
useful
for
elucidating
mechanisms
responsible
pathological
condition,
such
as
obesity,
testing
therapeutic
strategies.
Each
cell
model
has
its
own
characteristics,
culture
advantages
disadvantages.
The
choice
one
rather
than
another
depends
on
specific
researcher
conducting.
In
recent
decades,
three-dimensional
cultures,
spheroids,
become
very
attractive
because
they
more
closely
resemble
phenotype
freshly
isolated
cells.
use
developed
parallel
evolution
translational
research,
an
interdisciplinary
branch
biomedical
field,
aims
learn
scientific
approach
improve
human
health
longevity.
focus
present
review
growing
body
data
linking
new
spread
research.
Also,
we
discuss
possibility,
future,
employ
promote
transition
from
benchside
bedsite
vice
versa,
allowing
research
routine,
final
goal
obtaining
clinical
benefits
prevention
treatment
obesity
related
disorders.
Language: Английский
Non-Alcoholic Fatty Liver Disease in Everyday Clinical Practice: From Diagnosis to Therapy
Life,
Journal Year:
2025,
Volume and Issue:
15(3), P. 363 - 363
Published: Feb. 25, 2025
Non-alcoholic
fatty
liver
disease
(NAFLD)
is
currently
one
of
the
most
common
hepatic
disorders
observed
in
daily
medical
practice
[...]
Language: Английский
NPR is an independent risk factor for predicting all-cause mortality in patients with metabolic dysfunction-associated steatotic liver disease: evidence from NHANES 2007–2020
Dan Ye,
No information about this author
Xueying Ji,
No information about this author
Yiming Ma
No information about this author
et al.
Population Health Metrics,
Journal Year:
2025,
Volume and Issue:
23(1)
Published: April 25, 2025
Language: Английский
Hepatocyte Nuclear Factor 4 Alpha: A Key Regulator of Liver Disease Pathology and Haemostatic Disorders
Liver International,
Journal Year:
2025,
Volume and Issue:
45(6)
Published: May 19, 2025
ABSTRACT
Objective
Hepatocyte
nuclear
factor
4
alpha
(HNF4α)
is
a
master
regulator
of
hepatocyte
differentiation
in
fetal
and
adult
liver
exerts
its
transcriptional
role
determining
physiological
functions
the
liver.
The
objective
this
review
to
address
current
knowledge
molecular
mechanisms
involved
HNF4α
regulation
multiple
aspects
disease
pathogenesis.
Methods
Based
on
available
literature,
summarises
state
onthe
mechanism
dysregulation,
activity
inregulating
early
advanced
stages
various
diseases.
Results
Patients
with
deranged
expression
are
at
higher
risk
for
development
diseases
such
as
viral
hepatitis,
alcoholic/nonalcoholic
fatty
disease,
hepatocellular
carcinoma,
haematological
disorders
coagulopathy
bleeding
disorders.
Discussion
interactions
receptors
target
genes
promote
pathology
by
regulating
metabolic
pathways.
strong
correlation
between
severity
suggests
that
targeting
can
offer
potential
therapeutic
strategy
prevention
haemostatic
Language: Английский
Adipocytokines as Predictors of Metabolic Dysfunction-Associated Steatotic Liver Disease (MASLD) Development in Type 2 Diabetes Mellitus Patients
Cureus,
Journal Year:
2024,
Volume and Issue:
unknown
Published: March 6, 2024
Background:
Metabolic
dysfunction-associated
steatotic
liver
disease
(MASLD)
is
a
common
chronic
condition.
Due
to
pathophysiological
processes,
MASLD's
relation
type
2
diabetes
mellitus
(T2DM)
still
unclear,
especially
when
the
role
of
adipocytokines
taken
into
consideration.
Objective:
This
study
aims
examine
potential
predictive
value
adiponectin
and
resistin
for
MASLD
in
T2DM.
Patients
methods:
In
two-year
study,
71
T2DM
patients
were
categorized
MASLD-T2DM
non-MASLD-T2DM
groups
according
development.
Serum
samples
tested
resistin,
adiponectin,
high-density
lipoprotein
cholesterol,
fasting
glucose,
triglycerides.
An
appropriate
equation
used
calculate
adiponectin/resistin
(A/R)
index.
The
optimal
cut-off
values
differentiating
from
non-MASLD
determined
using
receiver
operating
characteristic
(ROC)
curves
corresponding
areas
under
curve
(AUC).
To
predict
onset
with
T2DM,
logistic
regression
analysis
was
performed.
Results:
There
significant
differences
(p<0.001),
A/R
index
(p<0.001)
between
individuals
without
MASLD.
ROC
produced
an
AUC
0.997
sensitivity
96.1%
specificity
100%
point
253.15.
Adiponectin
(OR,
0.054;
95%
CI,
0.011-0.268;
p<0.001)
1.745;
1.195-2,548;
p=0.004)
found
be
independent
predictors
by
analysis.
Conclusion:
confirms
as
development
Language: Английский
Efficacy of liraglutide in pediatric obesity: A review of clinical trial data
Obesity Medicine,
Journal Year:
2024,
Volume and Issue:
48, P. 100545 - 100545
Published: April 26, 2024
Pediatric
obesity
is
steadily
increasing,
and
reaching
alarming
levels;
for
this
reason,
effective
interventions
are
necessary
to
fight
global
health
challenge.
First-line
treatments
based
on
diet
exercise
may
be
ineffective,
resulting
in
common
weight
regain.
Therefore,
second
third-line
alternatives
current
therapies
address
even
the
most
difficult
cases.
Liraglutide,
a
glucagon-like
peptide-1
(GLP-1)
receptor
agonist,
used
past
only
treatment
of
diabetes,
has
shown
promising
results
also
adults.
This
review
aims
explore
potential
liraglutide
as
therapeutic
option
pediatric
obesity,
focusing
its
mechanism
action,
safety
profile,
efficacy
clinical
trials.
Additionally,
discusses
challenges
opportunities
associated
with
liraglutide's
use
population,
such
bariatric
surgery.
Language: Английский
Innovative treatments for obesity and NAFLD: A bibliometric study on antioxidants, herbs, phytochemicals, and natural compounds
Heliyon,
Journal Year:
2024,
Volume and Issue:
10(16), P. e35498 - e35498
Published: Aug. 1, 2024
The
increasing
scientific
interest
in
antioxidants
and
naturally
derived
compounds
as
potential
remedies
for
obesity
non-alcoholic
fatty
liver
disease
(NAFLD)
has
led
to
extensive
research.
objective
of
this
bibliometric
analysis
is
present
an
updated
perspective
on
the
topic
antioxidants,
herbs,
phytochemicals,
natural
compounds,
control
NAFLD,
identify
new
areas
future
Publications
from
years
2012-2022
were
retrieved
using
Scopus
database.
research
trends
analyzed
Biblioshiny
VOSviewer
tools.
field
seen
a
significant
increase
activity,
indicated
by
annual
growth
rate
10
%
number
published
manuscripts.
China,
Korea,
USA
emerged
most
prominent
contributors
specific
field,
supported
their
notable
volumes
publications
citations.
density
revealed
that
frequently
occurring
authors'
keywords
related
herbal
species
are,
rank
order
Language: Английский