Journal of Zhejiang University (Medical Sciences),
Journal Year:
2024,
Volume and Issue:
unknown
Published: Nov. 1, 2024
Neurodegenerative
disorders
are
a
group
of
diseases
caused
by
the
degeneration
and
apoptosis
neurons
in
brain
spinal
cord,
which
seriously
affect
human
ability
motion
perception,
memory
cognition.
Peroxynitrite
can
cause
oxidative
damage
exhibiting
neurotoxicity,
its
excussive
accumulation
is
closely
related
to
neurodegenerative
diseases.
Therefore,
effectively
scavenging
peroxynitrite
may
become
therapeutic
strategy
for
Due
their
high
ability,
some
water-soluble
metalloporphyrins
have
recently
attracted
much
attention.
Metalloporphyrins
such
as
iron
porphyrins
manganese
certain
neuroprotective
effects,
including
inhibiting
amyloid
plaque
accumulation,
alleviating
stress
neuroinflammatory
damage,
improving
mitochondrial
function
reducing
neuronal
apoptosis.
However,
there
limitations
drugs,
metal
poor
blood-brain
barrier
penetration.
To
overcome
obstacle,
addition
traditional
synthesis
processes,
also
be
prepared
into
nanoparticles
improve
bioavailability
Molecular Brain,
Journal Year:
2024,
Volume and Issue:
17(1)
Published: July 17, 2024
Abstract
Alzheimer’s
disease
(AD)
is
a
degenerative
neurological
condition
that
gradually
impairs
cognitive
abilities,
disrupts
memory
retention,
and
impedes
daily
functioning
by
impacting
the
cells
of
brain.
A
key
characteristic
AD
accumulation
amyloid-beta
(Aβ)
plaques,
which
play
pivotal
roles
in
progression.
These
plaques
initiate
cascade
events
including
neuroinflammation,
synaptic
dysfunction,
tau
pathology,
oxidative
stress,
impaired
protein
clearance,
mitochondrial
disrupted
calcium
homeostasis.
Aβ
also
closely
associated
with
other
hallmark
features
AD,
underscoring
its
significance.
generated
through
cleavage
amyloid
precursor
(APP)
plays
dual
role
depending
on
processing
pathway.
The
non-amyloidogenic
pathway
reduces
production
has
neuroprotective
anti-inflammatory
effects,
whereas
amyloidogenic
leads
to
peptides,
Aβ40
Aβ42,
contribute
neurodegeneration
toxic
effects
AD.
Understanding
multifaceted
Aβ,
particularly
crucial
for
developing
effective
therapeutic
strategies
target
metabolism,
aggregation,
clearance
aim
mitigating
detrimental
consequences
disease.
This
review
aims
explore
mechanisms
functions
under
normal
abnormal
conditions,
examining
both
beneficial
effects.
GeroScience,
Journal Year:
2024,
Volume and Issue:
46(5), P. 4275 - 4314
Published: April 1, 2024
Down
syndrome
(DS)
is
a
genetic
condition
where
the
person
born
with
an
extra
chromosome
21.
DS
associated
accelerated
aging;
people
are
prone
to
age-related
neurological
conditions
including
early-onset
Alzheimer's
disease.
Using
Dp(17)3Yey/
+
mice,
which
overexpresses
portion
of
mouse
17,
encodes
for
transsulfuration
enzyme
cystathionine
β-synthase
(CBS),
we
investigated
functional
role
CBS/hydrogen
sulfide
(H
International Journal of Molecular Sciences,
Journal Year:
2024,
Volume and Issue:
25(18), P. 9950 - 9950
Published: Sept. 15, 2024
This
survey
reviews
modern
ideas
on
the
structure
and
functions
of
mitochondrial
cytosolic
aconitase
isoenzymes
in
eukaryotes.
Cumulative
experimental
evidence
about
aconitases
(Aco2)
as
one
main
targets
reactive
oxygen
nitrogen
species
is
generalized.
The
important
role
Aco2
maintenance
homeostasis
intracellular
iron
pool
DNA
discussed.
pathogenesis
some
neurodegenerative
diseases
highlighted.
Inactivation
or
dysfunction
well
mutations
found
ACO2
gene
appear
to
be
significant
factors
development
promotion
various
types
diseases.
A
restoration
efficient
functioning
a
source
energy
for
cell
by
targeting
seems
promising
therapeutic
directions
minimize
progressive
disorders.
Current Treatment Options in Psychiatry,
Journal Year:
2024,
Volume and Issue:
12(1)
Published: Nov. 21, 2024
This
review
explores
the
evidence
for
using
a
ketogenic
diet
as
transdiagnostic
treatment
mental
health
disorders.
We
examine
biological
pathophysiologic
mechanisms
that
underlie
many
neuropsychiatric
disorders—such
mitochondrial
dysfunction,
oxidative
stress,
inflammation,
glucose
hypometabolism,
and
glutamate/GABA
imbalance—that
can
be
ameliorated
by
diet.
Additionally,
literature
summarizes
clinical
trials
case
reports
on
various
psychiatric
Recent
research
provides
may
an
effective
schizophrenia/schizoaffective
disorder,
bipolar
depression,
anxiety
disorders,
Alzheimer's
disease,
autism
spectrum
somatic
eating
alcohol
use
disorder.
Many
disorders
have
shared
metabolic
pathways
exacerbate
or
cause
psychopathology.
The
is
not
only
address
but
also
ameliorate
symptoms
like
anxiety,
mania,
psychosis,
cognitive
impairment.
These
effects
suggest
has
potential
to
serve
non-pharmacological
option
ease
global
disease
burden
of
Ageing Research Reviews,
Journal Year:
2024,
Volume and Issue:
102, P. 102578 - 102578
Published: Nov. 13, 2024
Alzheimer's
Disease
(AD)
is
the
most
common
form
of
dementia
among
elderly
people.
This
disease
imposes
a
significant
burden
on
healthcare
system,
society,
and
economy
due
to
increasing
global
aging
population.
Current
trials
with
drugs
or
bioactive
compounds
aimed
at
reducing
cerebral
Amyloid
beta
(Aβ)
plaques
tau
protein
neurofibrillary
tangles,
which
are
two
main
hallmarks
this
devastating
neurodegenerative
disease,
have
not
provided
results
in
terms
their
neuropathological
outcomes
nor
met
expected
clinical
end-points.
Ageing,
genetic
environmental
risk
factors,
along
different
symptoms
suggest
that
AD
complex
heterogeneous
disorder
multiple
interconnected
pathological
pathways
rather
than
single
entity.
In
present
review,
we
highlight
discuss
various
non-canonical,
Aβ-independent
mechanisms,
like
gliosis,
unhealthy
dietary
intake,
lipid
sugar
signaling,
cerebrovascular
damage
contribute
onset
development
AD.
We
emphasize
challenging
traditional
"amyloid
cascade
hypothesis"
may
improve
our
understanding
age-related
syndrome
help
fight
progressive
cognitive
decline
