Advancements in periodontal pathology: A systematic review and meta-analysis of molecular diagnostics, imaging techniques, regenerative therapies, and artificial intelligence DOI Open Access

V. Manjunatha

Journal of Oral Medicine Oral Surgery Oral Pathology and Oral Radiology, Journal Year: 2024, Volume and Issue: 10(4), P. 231 - 237

Published: Dec. 15, 2024

: Periodontal diseases, such as gingivitis and periodontitis, are prevalent conditions that adversely affect the supporting structures of teeth. Recent advancements in field periodontal pathology have enhanced understanding disease mechanisms improved diagnostic therapeutic strategies. To provide a comprehensive review current innovations explore emerging technologies future directions could revolutionize care. This synthesizes findings from recent literature on pathology, including molecular diagnostics, imaging techniques, regenerative therapies, application artificial intelligence (AI). A systematic approach was adopted to identify analyze relevant studies, focusing their clinical relevance potential for transforming Key include: 1. Molecular Diagnostics: Improved identification biomarkers early detection progression monitoring. 2. Imaging Techniques: Enhanced visualization using advanced modalities like cone-beam computed tomography (CBCT) optical coherence (OCT). 3. Regenerative Therapies: Breakthroughs tissue engineering, stem cell therapy, biomaterials regeneration. 4. Artificial Intelligence: Integration AI predictive modeling, support, personalized treatment planning. significantly expanded possibilities. Emerging technologies, approaches, hold immense advancements. Continued research integration these critical enhancing care improving patient outcomes.

Language: Английский

Beyond hype: unveiling the Real challenges in clinical translation of 3D printed bone scaffolds and the fresh prospects of bioprinted organoids DOI Creative Commons
Xiangyu Zhao, Na Li, Ziqi Zhang

et al.

Journal of Nanobiotechnology, Journal Year: 2024, Volume and Issue: 22(1)

Published: Aug. 21, 2024

Bone defects pose significant challenges in healthcare, with over 2 million bone repair surgeries performed globally each year. As a burgeoning force the field of tissue engineering, 3D printing offers novel solutions to traditional transplantation procedures. However, current 3D-printed scaffolds still face three critical material selection, methods, cellular self-organization and co-culture, significantly impeding their clinical application. In this comprehensive review, we delve into performance criteria that ideal should possess, particular focus on core faced by technology during translation. We summarize latest advancements non-traditional materials advanced techniques, emphasizing importance integrating organ-like technologies bioprinting. This combined approach enables more precise simulation natural structure function. Our aim writing review is propose effective strategies address these promote translation for defect treatment.

Language: Английский

Citations

13
Emerging roles of hydrogel in promoting periodontal tissue regeneration and repairing bone defect DOI Creative Commons
Wendi Guo, Hongbin Dong, Xing Wang

et al.

Frontiers in Bioengineering and Biotechnology, Journal Year: 2024, Volume and Issue: 12

Published: April 24, 2024

Periodontal disease is the most common type of oral disease. bone defect clinical outcome advanced periodontal disease, which seriously affects quality life patients. Promoting tissue regeneration and repairing defects ultimate treatment goal for but means methods are very limited. Hydrogels a class highly hydrophilic polymer networks, their good biocompatibility has made them popular research material in field medicine recent years. This paper reviews current mainstream types characteristics hydrogels, summarizes relevant basic on hydrogels promoting repair The possible mechanisms action efficacy evaluation discussed depth, application prospects also discussed.

Language: Английский

Citations

5
Bone Tissue Engineering: From Biomaterials to Clinical Trials DOI

Swapnali Jagadale,

Mrunal N. Damle, Meghnad G. Joshi

et al.

Advances in experimental medicine and biology, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 1, 2025

Language: Английский

Citations

0
Betaine enhances SCAPs chondrogenic differentiation and promotes cartilage repair in TMJOA through WDR81 DOI Creative Commons
Meiyue Wang, Zhaoming Wu, Xiaoyu Zheng

et al.

Stem Cell Research & Therapy, Journal Year: 2025, Volume and Issue: 16(1)

Published: Feb. 7, 2025

The cartilage tissue regeneration mediated with mesenchymal stem cells (MSCs) is considered as a viable strategy for temporomandibular joint osteoarthritis (TMJOA). Betaine has been confirmed to modulate the multidirectional differentiation of MSCs, while its effect on chondrogenic Stem Cells from Apical Papilla (SCAPs) unknown. Here, we explored effects and underlying mechanisms betaine SCAPs. was added SCAPs induction. potential assessed using Alcian Blue staining, Sirius Red staining main markers. In vivo were evaluated by rat TMJOA model. RNA-sequencing biological analyses performed select target genes processes involved. mechanism acts further explored. Betain-treated demonstrated stronger in vitro promoted repair vivo. enhanced expression WDR81 during chondrogenesis. overexpression SCAPs, depletion inhibited differentiation. addition, both treatment reduced intracellular reactive oxygen species levels increased mitochondrial membrane promotes provided an effective candidate treatment. may serve drug through mitophagy.

Language: Английский

Citations

0
Artificial Bone Materials for Infected Bone Defects: Advances in Antimicrobial Functions DOI

Di Ying,

Tianshou Zhang, Manlin Qi

et al.

ACS Biomaterials Science & Engineering, Journal Year: 2025, Volume and Issue: unknown

Published: March 14, 2025

Infected bone defects, caused by bacterial contamination following disease or injury, result in the partial loss destruction of tissue. Traditional transplantation and other clinical approaches often fail to address therapeutic complexities these conditions effectively. In recent years, advanced biomaterials have attracted significant attention for their potential enhance treatment outcomes. This review explores pathogenic mechanisms underlying infected including biofilm formation internalization into cells, which allow bacteria evade host immune system. To control infection facilitate repair, we focus on antibacterial materials regeneration. A detailed introduction is given intrinsically (e.g., metal alloys, oxide materials, carbon-based hydroxyapatite, chitosan, Sericin). The functionality repair can be enhanced through strategies such as incorporation antimicrobial ions, surface modification, combined use multiple treat defects. Key innovations discussed include that release agents, functional contact biomaterials, bioresponsive collectively efficacy. Research translation has also facilitated practical application prevention healing. conclusion, advancements provide promising pathways developing more biocompatible, effective, personalized therapies reconstruct

Language: Английский

Citations

0
The bone microenvironment: new insights into the role of stem cells and cell communication in bone regeneration DOI Creative Commons
Luca Dalle Carbonare, Mattia Cominacini, Elisabetta Trabetti

et al.

Stem Cell Research & Therapy, Journal Year: 2025, Volume and Issue: 16(1)

Published: April 12, 2025

Mesenchymal stem cells (MSCs) play a crucial role in bone formation and remodeling. Intrinsic genetic factors extrinsic environmental cues regulate their differentiation into osteoblasts. Within the microenvironment, complex network of biochemical biomechanical signals orchestrates homeostasis regeneration. In addition, crosstalk among MSCs, immune cells, neighboring cells-mediated by extracellular vesicles non-coding RNAs (such as circular micro RNAs) -profoundly influences osteogenic Recent studies have explored specific signaling pathways that contribute to effective regeneration, highlighting potential manipulating microenvironment enhance MSC functionality. The integration advanced biomaterials, gene editing techniques, controlled delivery systems is paving way for more targeted efficient regenerative therapies. Furthermore, artificial intelligence could improve tissue engineering, optimize biomaterial design, enable personalized treatment strategies. This review explores latest advancements emphasizing intricate interplay molecules. By providing comprehensive overview these mechanisms clinical implications, we aim shed light on future research directions this rapidly evolving field.

Language: Английский

Citations

0
Biomaterials for Nonunion of Fractures Management DOI
Madhan Jeyaraman, Naveen Jeyaraman, Swaminathan Ramasubramanian

et al.

Published: Jan. 1, 2025

Language: Английский

Citations

0
Regenerative Aesthetics: A Genuine Frontier or Just a Facet of Regenerative Medicine: A Systematic Review DOI
Eqram Rahman, Jean Carruthers,

Parinitha Rao

et al.

Aesthetic Plastic Surgery, Journal Year: 2024, Volume and Issue: unknown

Published: Aug. 28, 2024

Language: Английский

Citations

2
Clinical challenges in bone tissue engineering - A narrative review DOI
Amir Human Hoveidaei, Mehdi Sadat‐Shojai, Sara Sadat Nabavizadeh

et al.

Bone, Journal Year: 2024, Volume and Issue: 192, P. 117363 - 117363

Published: Dec. 3, 2024

Language: Английский

Citations

1
Depletion of MicroRNA-100-5p Promotes Osteogenesis Via Lysine(K)-Specific Demethylase 6B DOI
Xiaokang Gong, Xi Chen,

Zhulong Meng

et al.

Tissue Engineering Part A, Journal Year: 2024, Volume and Issue: unknown

Published: Dec. 24, 2024

Senescence and osteogenic differentiation potential loss limited bone nonunion treatment effects of marrow-derived mesenchymal stem cells (BMSCs). MiR-100-5p/Lysine(K)-specific demethylase 6B (KDM6B) can inhibit osteogenesis, but their on union remain unclear. This study aims to investigate the miR-100-5p/KDM6B defects. Wild-type or microRNA 100 (miR-100) knockdown mice underwent critical-size defect (CSD) cranial surgery collagen I/poly-γ-glutamic acid scaffold treatment. The crania was observed using microcomputed tomography, hematoxylin eosin staining, Masson alkaline phosphatase (ALP) immunohistochemistry, immunofluorescence. Primary-cultured BMSCs transfected with miR-100-5p mimic/inhibitor KDM6B cDNA were evaluated for Alizarin Red ALP activity detection, Western blot analysis. Genetic transcription levels detected quantitative reverse polymerase chain reaction. found that miR-100 depletion promotes healing in mouse calvaria, increases proportion new osteoblasts activates expression osteocalcin (OCN) proteins, promoting morphogenetic protein-2, Runt-related factor 2 (Runx2), OCN, KDM6B, while methylation lysine 27 histone H3 (H3K27me3) decreased. Furthermore, mimics suppressed by inhibiting increased H3K27me3, ALP, Runx2, osteopontin protein expression, inhibitors have opposite effects. Moreover, mimic Notably, scaffolds carrying mimics/inhibitors placed CSD a better effect increase without inflammatory cell infiltration. proved via KDM6B/H3K27me3.

Language: Английский

Citations

1