Review on Ginseng and its Potential Active Substance G-Rg2 Against Age-Related Diseases: Traditional Efficacy and Mechanism

Journal of Ethnopharmacology, Journal Year: 2024, Volume and Issue: unknown, P. 118781 - 118781

Published: Sept. 1, 2024

Language: Английский

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Monitoring physiological processes of fast-growing broilers during the whole life cycle: Changes of redox-homeostasis effected to trassulfuration pathway predicting the development of non-alcoholic fatty liver disease

PLoS ONE, Journal Year: 2023, Volume and Issue: 18(8), P. e0290310 - e0290310

Published: Aug. 17, 2023

In the broiler industry, average daily gain and feed conversion ratio are extremely favorable, but birds beginning to approach maximum of their genetic capacity. However, as a consequence strong selection, occurrence certain metabolic diseases, such myopathies, ascites, sudden cardiac death tibial dyschondroplasia, is increasing. These diseases can greatly affect health status welfare birds, well quality meat. The main goal this study was investigate changes in parameters redox homeostasis during rearing (1–42 days age) broilers with high capacity, concentrations malondialdehyde, vitamin C, E, reduced glutathione, activities glutathione peroxidase reductase, inhibition rate superoxide dismutase. Damage transsulfuration pathway growth reason for level homocysteine were investigated. Further, that characterize biochemical occurring examined. Our first plasma albumin saturation. A method developed measure levels other small molecule thiol components plasma. Changes induce increases tumor necrosis factor alpha inflammatory interleukins interleukin 2, 6 8 reared according current large-scale husbandry technology feeding protocols. significant difference all tested observed on 21st day. cytokines increased, while cysteine decreased. findings suggest abovementioned indices have negative effect poultry health.

Language: Английский

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Hypothalamic JNK1-hepatic fatty acid synthase axis mediates a metabolic rewiring that prevents hepatic steatosis in male mice treated with olanzapine via intraperitoneal: Additional effects of PTP1B inhibition

Redox Biology, Journal Year: 2023, Volume and Issue: 63, P. 102741 - 102741

Published: May 16, 2023

Olanzapine (OLA), a widely used second-generation antipsychotic (SGA), causes weight gain and metabolic alterations when administered orally to patients. Recently, we demonstrated that, contrarily the oral treatment which induces gain, OLA via intraperitoneal (i.p.) in male mice resulted body loss. This protection was due an increase energy expenditure (EE) through mechanism involving modulation of hypothalamic AMPK activation by higher levels reaching this brain region compared those treatment. Since clinical studies have shown hepatic steatosis upon chronic with OLA, herein further investigated role hypothalamus-liver interactome administration wild-type (WT) protein tyrosine phosphatase 1B knockout (PTP1B–KO) mice, preclinical model protected against syndrome. WT PTP1B–KO were fed OLA-supplemented diet or treated i.p. Mechanistically, found that mild oxidative stress inflammation hypothalamus JNK1-independent dependent manner, respectively, without features cell dead. Hypothalamic JNK up-regulated lipogenic gene expression liver though vagus nerve. effect concurred unexpected rewiring ATP depletion increased AMPK/ACC phosphorylation. starvation-like signature prevented steatosis. By contrast, intrahepatic lipid accumulation observed OLA; being absent mice. We also additional benefit PTP1B inhibition activation, induced treatment, thereby preventing lipogenesis. The conferred deficiency neuroinflammation strongly suggests targeting might be therapeutic strategy prevent comorbidities patients under personalized manner.

Language: Английский

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Silymarin and management of liver function in nonalcoholic steatohepatitis: a case report

Drugs in Context, Journal Year: 2023, Volume and Issue: 12, P. 1 - 5

Published: May 30, 2023

Non-alcoholic fatty liver disease (NAFLD) and its progressive form (non-alcoholic steatohepatitis; NASH) are the main reason for chronic in general population, characterized by fat accumulation hepatocytes (steatosis) anomalies biochemical analyses. To date, no pharmacological agents have been approved NAFLD or NASH treatment. However, silymarin, active ingredient milk thistle, has used last decades treatment of several diseases. In this case report, with silymarin 140 mg three-times daily highlighted moderate efficacy a good safety profile management function, as it decreased serum AST ALT levels over period side-effects, supporting promising supplemental intervention that can normalize activity NASH. This article is part Current clinical use toxic diseases: series. Special Issue: https://www.drugsincontext.com/special_issues/current-clinical-use-of-silymarin-in-the-treatment-of-toxic-liver-diseases-a-case-series.

Language: Английский

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Role of Oxidative Stress and Carcinoembryonic Antigen-Related Cell Adhesion Molecule 1 in Nonalcoholic Fatty Liver Disease

International Journal of Molecular Sciences, Journal Year: 2023, Volume and Issue: 24(14), P. 11271 - 11271

Published: July 10, 2023

Nonalcoholic fatty liver disease (NAFLD) has become a widely studied subject due to its increasing prevalence and links diseases such as type 2 diabetes obesity. It severe complications, including nonalcoholic steatohepatitis, cirrhosis, hepatocellular carcinoma, portal hypertension that can lead transplantation in some cases. To better prevent treat this pathology, it is important understand underlying physiology. Here, we identify two main factors play crucial role the pathophysiology of NAFLD: oxidative stress key carcinoembryonic antigen-related cell adhesion molecule 1 (CEACAM1). We discuss linking these NAFLD pathophysiology.

Language: Английский

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