Effects of Probiotics on Gut Microbiota: An Overview
International Journal of Molecular Sciences,
Journal Year:
2024,
Volume and Issue:
25(11), P. 6022 - 6022
Published: May 30, 2024
The
role
of
probiotics
in
regulating
intestinal
flora
to
enhance
host
immunity
has
recently
received
widespread
attention.
Altering
the
human
gut
microbiota
may
increase
predisposition
several
disease
phenotypes
such
as
inflammation
and
metabolic
disorders.
converts
dietary
nutrients
into
metabolites
that
serve
biologically
active
molecules
modulating
regulatory
functions
host.
Probiotics,
which
are
microorganisms,
play
a
versatile
restoring
composition
microbiota,
helping
improve
prevent
phenotypes.
This
comprehensive
review
provides
firsthand
information
on
their
influence
health,
effects
diet
how
alter
function
along
with
corresponding
building
healthy
intestine.
We
also
discuss
implications
some
most
important
diseases.
In
summary,
significant
boosting
overall
immunity,
increasing
abundance
beneficial
bacteria,
ameliorate
symptoms
multiple
Language: Английский
The signaling pathways in obesity‐related complications
Journal of Cell Communication and Signaling,
Journal Year:
2024,
Volume and Issue:
18(2)
Published: June 1, 2024
Abstract
Obesity,
a
rapidly
expanding
epidemic
worldwide,
is
known
to
exacerbate
many
medical
conditions,
making
it
significant
factor
in
multiple
diseases
and
their
associated
complications.
This
threatening
linked
various
harmful
conditions
such
as
type
2
diabetes
mellitus,
hypertension,
metabolic
dysfunction‐associated
steatotic
liver
disease,
polycystic
ovary
syndrome,
cardiovascular
(CVDs),
dyslipidemia,
cancer.
The
rise
urbanization
sedentary
lifestyles
creates
an
environment
that
fosters
obesity,
leading
both
psychosocial
To
identify
individuals
at
risk
ensure
timely
treatment,
crucial
have
better
understanding
of
the
pathophysiology
obesity
its
comorbidities.
comprehensive
review
highlights
relationship
between
obesity‐associated
complications,
including
diabetes,
gastrointestinal
obstructive
sleep
apnea.
It
also
explores
potential
mechanisms
underlying
these
associations.
A
thorough
analysis
interplay
complications
vital
developing
effective
therapeutic
strategies
combat
exponential
increase
global
rates
mitigate
deadly
consequences
this
polygenic
condition.
Language: Английский
Perilipins: A family of five fat‐droplet storing proteins that play a significant role in fat homeostasis
Journal of Cellular Biochemistry,
Journal Year:
2024,
Volume and Issue:
125(6)
Published: May 15, 2024
Abstract
Lipid
droplets
are
organelles
with
unique
spherical
structures.
They
consist
of
a
hydrophobic
neutral
lipid
core
that
varies
depending
on
the
cell
type
and
tissue.
These
surrounded
by
phospholipid
monolayers,
along
heterogeneous
proteins
responsible
for
synthesis
metabolism.
Additionally,
there
specialized
droplet‐associated
surface
proteins.
Recent
evidence
suggests
from
perilipin
family
(PLIN)
associated
involved
in
their
formation.
have
specific
roles
hepatic
droplet
metabolism,
such
as
protecting
lipase
action
maintaining
balance
between
storage
utilization
cells.
Metabolic
dysfunction‐associated
steatotic
liver
disease
(MASLD)
is
characterized
accumulation
more
than
5%
hepatocytes.
This
can
progress
into
metabolic
steatohepatitis,
fibrosis,
cirrhosis,
hepatocellular
carcinoma.
The
progression
MASLD
other
diseases
sarcopenic
obesity.
Therefore,
it
crucial
to
understand
role
perilipins
this
accumulation,
these
key
targets
developing
novel
therapeutic
strategies.
comprehensive
review
aims
summarize
structure
characteristics
PLIN
proteins,
well
pathogenic
development
steatosis
fatty
diseases.
Language: Английский
PNPLA3 as a driver of steatotic liver disease: navigating from pathobiology to the clinics via epidemiology
Journal of Translational Genetics and Genomics,
Journal Year:
2024,
Volume and Issue:
8(4), P. 355 - 77
Published: Dec. 7, 2024
Steatotic
liver
disease
(SLD),
particularly
metabolic
dysfunction-associated
SLD,
represents
a
significant
public
health
concern
worldwide.
Among
the
various
factors
implicated
in
development
and
progression
of
this
condition,
patatin-like
phospholipase
domain-containing
protein
3
(PNPLA3
)
gene
has
emerged
as
critical
player.
Variants
PNPLA3
are
associated
with
altered
lipid
metabolism,
leading
to
increased
hepatic
fat
accumulation
subsequent
inflammation
fibrosis.
Understanding
role
not
only
enhances
our
comprehension
pathomechanisms
driving
SLD
but
also
informs
potential
therapeutic
strategies.
The
molecular
mechanisms
through
which
variants
contribute
dysregulation
hepatocyte
injury
critically
discussed
present
review
article.
We
extensively
analyze
clinical
cohorts
population-based
studies
underpinning
association
between
polymorphisms
risk
developing
its
liver-related
protean
extrahepatic
outcomes,
concert
other
modifiers,
notably
including
age,
sex,
ethnicity
adults
children.
discuss
increasingly
recognized
played
by
transplantation,
autoimmune
hepatitis,
acquired
immunodeficiency
syndrome.
Finally,
we
examine
implications
diagnostics
regarding
stratification
targeted
therapies
for
patients
affected
context
precision
medicine
approaches.
Language: Английский