Microorganisms,
Journal Year:
2025,
Volume and Issue:
13(4), P. 721 - 721
Published: March 24, 2025
Probiotics
are
increasingly
used
to
promote
oral
health,
with
Lacticaseibacillus
rhamnosus
demonstrating
proven
effectiveness.
Additionally,
Heyndrickxia
coagulans
shows
promising
potential
in
this
field.
Chewing
gum
has
recently
been
proposed
as
an
innovative
delivery
method
for
probiotics.
This
study
aimed
evaluate
the
kinetics
saliva
of
SNZ1969®
and
GG
microencapsulated
non-microencapsulated
forms
(LGG®)
following
their
administration
via
sugar-free
chewing
gums.
A
randomized
cross-over
trial
was
conducted
involving
10
volunteers.
Participants
chewed
gums
containing
one
probiotic
strains
min.
Saliva
samples
were
collected
at
baseline
(T0)
six
subsequent
time
points
over
2
h
(T1–T6).
Colony-forming
units
(CFUs)
identified
quantified.
The
Tukey’s
range
test
applied
make
pairwise
comparisons
between
different
probiotics
every
point,
same
probiotic,
area
under
curve
describing
saliva.
At
T1,
all
exhibited
peak
counts,
followed
by
a
gradual
decline
until
T6.
H.
achieved
highest
counts
T2,
T3
(mean
log10
CFU/mL:
6.1
±
0.5;
5.8
5.6
0.5,
respectively),
while
form
LGG®
peaked
T4,
T5,
T6
4.0
0.7;
3.8
0.9;
3.3
1.3,
respectively).
participants
reported
no
adverse
effects.
detectable
up
post-administration
gum,
indicating
its
suitability
vehicle.
However,
significant
variability
observed
among
participants.
International Journal of Molecular Sciences,
Journal Year:
2024,
Volume and Issue:
25(17), P. 9715 - 9715
Published: Sept. 8, 2024
The
gut
microbiota
is
one
of
the
most
critical
factors
in
human
health.
It
involves
numerous
physiological
processes
impacting
host
health,
mainly
via
immune
system
modulation.
A
balanced
microbiome
contributes
to
gut’s
barrier
function,
preventing
invasion
pathogens
and
maintaining
integrity
lining.
Dysbiosis,
or
an
imbalance
microbiome’s
composition
disrupts
essential
various
diseases.
This
narrative
review
summarizes
key
findings
related
modern
multifactorial
inflammatory
conditions
such
as
ulcerative
colitis
Crohn’s
disease.
addresses
challenges
posed
by
antibiotic-driven
dysbiosis,
particularly
context
C.
difficile
infections,
development
novel
therapies
like
fecal
transplantation
biotherapeutic
drugs
combat
these
infections.
An
emphasis
given
restoration
healthy
through
dietary
interventions,
probiotics,
prebiotics,
approaches
for
managing
gut-related
Nutrients,
Journal Year:
2025,
Volume and Issue:
17(5), P. 842 - 842
Published: Feb. 28, 2025
Background:
The
human
gastrointestinal
tract
is
home
to
a
wide
variety
of
microorganisms.
For
some
decades
now,
bacteria
known
as
probiotics
have
been
added
various
foods
because
their
beneficial
effects
for
health.
Evidence
indicates
that
significantly
regulate
gut
microbiota,
which
vital
digestion,
metabolism,
immune
function,
and
mental
Methods:
We
conducted
narrative
review
available
original
research
published
in
PubMed
the
past
ten
years
focusing
on
recent
advancements
provide
thorough
understanding
relationship
between
system
brain.
Results:
Recent
advances
focused
importance
microbiota
influencing
microbiota-gut-brain
axis
complex,
bidirectional
communication
network
linking
central
nervous
tract,
highlights
how
brain
are
deeply
interconnected
influence
each
other
ways
affect
our
overall
health,
emotions,
behavior.
This
powerful
link
major
area
scientists
discover
more
about
health
can
impact
well-being.
Conclusions:
A
comprehensive
composition
mechanisms
involved
these
interactions
could
shape
future
medical
therapeutic
approaches.
It
would
balance
scientific
explanation
with
clinical
relevance,
offering
insights
into
brain-gut
revolutionize
approach
treating
disorders.
Life,
Journal Year:
2024,
Volume and Issue:
14(10), P. 1279 - 1279
Published: Oct. 9, 2024
The
human
gut
microbiota
is
a
complex
ecosystem
harboring
thousands
of
microbial
strains
that
play
crucial
role
in
maintaining
the
overall
well-being
its
host.
composition
varies
with
age
from
infancy
to
adulthood
and
influenced
by
dietary
habits,
environment,
genetic
disposition.
Recent
advances
culture-independent
techniques
nucleic
acid
sequencing
have
improved
our
understanding
diversity
microbiota.
species
present
release
short-chain
fatty
acids
(SCFAs),
which
anti-inflammatory
properties.
also
plays
substantial
modulating
host's
immune
system,
promoting
tolerance,
homeostasis.
impact
on
health
host
quite
evident,
as
dysbiosis
has
been
linked
various
diseases,
including
metabolic
disorders,
autoimmune
allergies,
inflammatory
bowel
diseases.
bidirectional
communication
respiratory
creating
gut-lung
axis,
associated
different
Therapeutic
approaches
targeting
microbiota,
such
probiotics,
prebiotics,
interventions,
fecal
transplantation
(FMT),
aim
restore
balance
promote
growth
beneficial
gut.
Nonetheless,
gaining
knowledge
interactions
between
necessary
develop
personalized
medicine
microbiota-based
therapies
for
conditions.
This
review
summarizes
studies
related
axis
particular
emphasis
Future
research
directions
are
discussed.
Designed Monomers & Polymers,
Journal Year:
2024,
Volume and Issue:
28(1), P. 1 - 34
Published: Dec. 31, 2024
This
review
paper
analyzes
recent
advancements
in
bio-polymer
coatings
for
probiotic
microencapsulation,
with
a
particular
emphasis
on
chitosan
and
its
synergistic
combinations
other
materials.
Probiotic
microencapsulation
is
essential
protecting
probiotics
from
environmental
stresses,
enhancing
their
stability,
ensuring
effective
delivery
to
the
gut.
The
begins
an
overview
of
highlighting
significance
safeguarding
through
processing,
storage,
gastrointestinal
transit.
Advances
chitosan-based
encapsulation
are
explored,
including
integration
bio-polymers
such
as
alginate,
gelatin,
pectin,
well
application
nanotechnology
innovative
techniques
like
spray
drying
layer-by-layer
assembly.
Detailed
mechanistic
insights
integrated,
illustrating
how
influences
gut
microbiota
by
promoting
beneficial
bacteria
suppressing
pathogens,
thus
role
prebiotic
or
synbiotic.
Furthermore,
delves
into
chitosan's
immunomodulatory
effects,
particularly
context
inflammatory
bowel
disease
(IBD)
autoimmune
diseases,
describing
immune
signaling
pathways
influenced
linking
changes
improvements
systemic
immunity.
Recent
clinical
trials
human
studies
assessing
efficacy
chitosan-coated
presented,
alongside
discussion
practical
applications
comparison
vitro
vivo
findings
highlight
real-world
relevance.
sustainability
sources
impact
addressed,
along
novel
concept
gut-brain
axis.
Finally,
emphasizes
future
research
needs,
development
personalized
therapies
exploration
techniques.
Diagnostics,
Journal Year:
2024,
Volume and Issue:
15(1), P. 21 - 21
Published: Dec. 25, 2024
The
gut–kidney
axis
represents
the
complex
interactions
between
gut
microbiota
and
kidney,
which
significantly
impact
progression
of
chronic
kidney
disease
(CKD)
overall
patient
health.
In
CKD
patients,
imbalances
in
promote
production
uremic
toxins,
such
as
indoxyl
sulfate
p-cresyl
sulfate,
impair
renal
function
contribute
to
systemic
inflammation.
Mechanisms
like
endotoxemia,
immune
activation
oxidative
stress
worsen
damage
by
activating
pro-inflammatory
pathways.
Insights
into
these
mechanisms
highlight
gut-derived
metabolites,
bacterial
translocation,
response
changes
on
health,
suggesting
new
potential
approaches
for
treatment.
Clinical
applications,
dietary
interventions,
prebiotics,
probiotics
fecal
transplantation,
are
promising
adjusting
alleviate
symptoms
slow
progression.
Current
research
highlights
clinical
relevance
axis,
but
further
study
is
essential
clarify
mechanisms’
diagnostic
biomarkers
optimize
therapeutic
interventions.
This
review
emphasizes
importance
an
integrated
approach
management,
focusing
a
target
limit
injury.
Journal of Experimental Pharmacology,
Journal Year:
2025,
Volume and Issue:
Volume 17, P. 1 - 14
Published: Jan. 1, 2025
Abstract:
Acne
vulgaris
is
a
prevalent
dermatological
condition
characterized
by
comedones,
papules,
and
pustules,
with
significant
physical
psychological
implications.
Conventional
treatments
for
this
condition,
including
antibiotics
retinoids,
face
challenges,
such
as
side
effects
antibiotic
resistance,
necessitating
alternative
treatments.
Recent
studies
show
the
potential
of
probiotics
to
modulate
skin
microbiome
alleviate
acne
symptoms.
Therefore,
study
aimed
consolidate
evidence
from
randomized
controlled
trials
(RCTs)
clinical
investigations,
evaluating
efficacy
in
management.
A
comprehensive
literature
search
was
conducted
across
PubMed,
Scopus,
Cochrane
databases
using
several
keywords,
"probiotic",
"microbiome",
"acne
vulgaris".
Inclusion
criteria
are
RCTs
2009
2024
examining
treatment.
Studies
were
selected,
screened,
analyzed
based
on
population,
intervention,
design,
results.
Descriptive
statistics
used
summarize
characteristics.
Fifteen
811
participants
met
inclusion
criteria.
The
tested
various
oral
topical
probiotics,
Lactobacillus,
Bifidobacterium,
Bacillus
,
Enterococcus
strains,
over
treatment
periods
ranging
4
12
weeks.
results
showed
that
reduced
lesions,
improved
barrier
function,
decreased
inflammatory
markers.
Both
balancing
reducing
severity.
Some
reported
outcomes
comparable
conventional
treatments,
benzoyl
peroxide.
However,
there
variability
individual
responses
different
probiotic
effects,
though
rare,
have
been
some
cases.
Probiotics
presented
natural,
effective
future
needed
determine
optimal
protocols.
Keywords:
microbiome,
vulgaris,
bacterial
imbalance,
conditions
