Fabrication of Biomedical Scaffolds Using Biodegradable Polymers

Chemical Reviews, Journal Year: 2021, Volume and Issue: 121(18), P. 11238 - 11304

Published: April 15, 2021

Degradable polymers are used widely in tissue engineering and regenerative medicine. Maturing capabilities additive manufacturing coupled with advances orthogonal chemical functionalization methodologies have enabled a rapid evolution of defect-specific form factors strategies for designing creating bioactive scaffolds. However, these scaffolds, especially when utilizing degradable as the base material, present processing challenges that distinct unique from other classes materials. The goal this review is to provide guide fabrication biodegradable polymer-based scaffolds includes complete pathway starting selecting materials, choosing correct method, considering requirements specific applications scaffold.

Language: Английский

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Application of Artificial Intelligence in Medicine: An Overview

Current Medical Science, Journal Year: 2021, Volume and Issue: 41(6), P. 1105 - 1115

Published: Dec. 1, 2021

Artificial intelligence (AI) is a new technical discipline that uses computer technology to research and develop the theory, method, technique, application system for simulation, extension, expansion of human intelligence. With assistance AI technology, traditional medical environment has changed lot. For example, patient's diagnosis based on radiological, pathological, endoscopic, ultrasonographic, biochemical examinations been effectively promoted with higher accuracy lower workload. The treatments during perioperative period, including preoperative preparation, surgical postoperative recovery have significantly enhanced better effects. In addition, also played crucial role in drug production, management, education, taking them into direction. purpose this review introduce medicine provide an outlook future trends.

Language: Английский

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3D bioprinting: current status and trends—a guide to the literature and industrial practice

Bio-Design and Manufacturing, Journal Year: 2021, Volume and Issue: 5(1), P. 14 - 42

Published: Dec. 2, 2021

Abstract The multidisciplinary research field of bioprinting combines additive manufacturing, biology and material sciences to create bioconstructs with three-dimensional architectures mimicking natural living tissues. high interest in the possibility reproducing biological tissues organs is further boosted by ever-increasing need for personalized medicine, thus allowing establish itself biomedical research, attracting extensive efforts from companies, universities, institutes alike. In this context, paper proposes a scientometric analysis critical review current literature industrial landscape provide clear overview its fast-changing complex position. scientific patenting results 2000–2020 are reviewed critically analyzed retrieving 9314 papers 309 international patents order draw picture terms top countries, institutions, journals, authors topics, identifying technology hubs worldwide. This offers guide researchers interested or those who simply want understand emerging trends manufacturing 3D bioprinting. Graphic abstract

Language: Английский

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Functionalizing bioinks for 3D bioprinting applications

Drug Discovery Today, Journal Year: 2018, Volume and Issue: 24(1), P. 198 - 205

Published: Sept. 20, 2018

Language: Английский

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Hyaluronic acid as a bioactive component for bone tissue regeneration: Fabrication, modification, properties, and biological functions

Nanotechnology Reviews, Journal Year: 2020, Volume and Issue: 9(1), P. 1059 - 1079

Published: Jan. 1, 2020

Abstract Hyaluronic acid (HA) is widely distributed in the human body, and it heavily involved many physiological functions such as tissue hydration, wound repair, cell migration. In recent years, HA its derivatives have been used advanced bioactive polymers for bone regeneration. Many medical products containing developed because this natural polymer has proven to be nontoxic, noninflammatory, biodegradable, biocompatible. Moreover, HA-based composite scaffolds shown good potential promoting osteogenesis mineralization. Recently, biomaterials fabricated regeneration by combining with electrospinning 3D printing technology. review, structures, processing, properties, applications engineering are summarized. The challenges prospects of also discussed.

Language: Английский

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Applications of 3D Bioprinting in Tissue Engineering and Regenerative Medicine

Journal of Clinical Medicine, Journal Year: 2021, Volume and Issue: 10(21), P. 4966 - 4966

Published: Oct. 26, 2021

Regenerative medicine is an emerging field that centers on the restoration and regeneration of functional components damaged tissue. Tissue engineering application regenerative seeks to create tissue whole organs. Using 3D printing technologies, native mimics can be created utilizing biomaterials living cells. Recently, has begun employ bioprinting methods highly specialized models improve upon conventional methods. Here, we review use in advancement by describing process its advantages over other Materials techniques are also reviewed, addition future clinical applications, challenges, directions field.

Language: Английский

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AI-Optimized Technological Aspects of the Material Used in 3D Printing Processes for Selected Medical Applications

Materials, Journal Year: 2020, Volume and Issue: 13(23), P. 5437 - 5437

Published: Nov. 29, 2020

While the intensity, complexity, and specificity of robotic exercise may be supported by patient-tailored three-dimensional (3D)-printed solutions, their performance can still compromised non-optimal combinations technological parameters material features. The main focus this paper was computational optimization 3D-printing process in terms features selection order to achieve maximum tensile force a hand exoskeleton component, based on artificial neural network (ANN) genetic algorithms (GA). creation selected component achieved using Cura 0.1.5 software 3D-printed fused filament fabrication (FFF) technology. To optimize we compared ten two distinct printing materials (polylactic acid (PLA), PLA+) ANN GA built trained MATLAB environment. determine exoskeleton, samples were tested an INSTRON 5966 universal testing machine. balance between technical requirements user safety constraints requires further analysis, PLA-based have been optimized. Additive manufacturing support successful usable/functional components. indicated which should selected: Namely PLA+. AI-based play key role increasing final product supporting constraint satisfaction solutions.

Language: Английский

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A 3D Food Printing Process for the New Normal Era: A Review

Processes, Journal Year: 2021, Volume and Issue: 9(9), P. 1495 - 1495

Published: Aug. 25, 2021

Owing to COVID-19, the world has advanced faster in era of Fourth Industrial Revolution, along with 3D printing technology that achieved innovation personalized manufacturing. Three-dimensional been utilized across various fields such as environmental fields, medical systems, and military materials. Recently, food printer global market shown a high annual growth rate is huge industry approximately one billion dollars. can be applied ranges based on advantages designing existing suit one’s taste purpose. Currently, many countries worldwide produce printers, developing special foods combat food, space restaurants, floating elderly food. Many people are unaware utilization it its early stages. There cases using parts world. expected become new trend normal after COVID-19. Compared other industries, relatively small overall size because problems insufficient institutionalization limitation standardized materials for printing. In this review, current industrial status was investigated suggestions improvement era.

Language: Английский

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Review of Low-Cost 3D Bioprinters: State of the Market and Observed Future Trends

SLAS TECHNOLOGY, Journal Year: 2021, Volume and Issue: 26(4), P. 333 - 366

Published: June 17, 2021

Three-dimensional (3D) bioprinting has become mainstream for precise and repeatable high-throughput fabrication of complex cell cultures tissue constructs in drug testing regenerative medicine, food products, dental medical implants, biosensors, so forth. Due to this tremendous growth demand, an overwhelming amount hardware manufacturers have recently flooded the market with different types low-cost bioprinter models-a price segment that is most affordable typical-sized laboratories. These machines range sophistication, type underlying printing technology, possible add-ons/features, which makes selection process rather daunting (especially a nonexpert customer). Yet, review articles available literature mostly focus on technical aspects printer technologies under development, as opposed explaining differences what already market. In contrast, paper provides snapshot fast-evolving niche, well reputation profiles (relevant delivery time, part quality, adherence specifications, warranty, maintenance, etc.) companies selling these machines. Specifically, models spanning three dominant technologies-microextrusion, droplet-based/inkjet, light-based/crosslinking-are reviewed. Additionally, representative examples high-end competitors (including up-and-coming microfluidics-based bioprinters) are discussed highlight their major advantages relative models. Finally, forecasts made based trends observed during survey, anticipated trickling down printers. Overall, insight guiding buyers limited budget toward making informed purchasing decisions fast-paced

Language: Английский

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Biomaterial-based 3D bioprinting strategy for orthopedic tissue engineering

Acta Biomaterialia, Journal Year: 2022, Volume and Issue: 156, P. 4 - 20

Published: Aug. 10, 2022

Language: Английский

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