Journal of Oral Biology and Craniofacial Research,
Journal Year:
2024,
Volume and Issue:
14(2), P. 230 - 235
Published: March 1, 2024
Hyaluronic
acid
(HA)
is
found
in
different
locations
the
periodontium,
including
mineralized
tissues
(i.e.,
cementum
and
alveolar
bone)
non-mineralized
gingiva
periodontal
ligament).
In
addition,
it
seems
to
play
an
essential
part
regulating
underlying
mechanisms
involved
tissue
inflammatory
reactions
wound
healing.
HA
has
potential
regulate
regeneration
treat
disease.
The
current
review
of
literature
was
conducted
assess
how
plays
its
therapy
examine
contemporary
literature's
viewpoint
on
use
regeneration.
a
multifunctional
character
regeneration,
healing
appears
provide
promising
outcomes
regenerative
applications.
International Journal of Molecular Sciences,
Journal Year:
2023,
Volume and Issue:
24(12), P. 10296 - 10296
Published: June 18, 2023
Hyaluronic
acid
(HA)
is
a
glycosaminoglycan
widely
distributed
in
the
human
body,
especially
body
fluids
and
extracellular
matrix
of
tissues.
It
plays
crucial
role
not
only
maintaining
tissue
hydration
but
also
cellular
processes
such
as
proliferation,
differentiation,
inflammatory
response.
HA
has
demonstrated
its
efficacy
powerful
bioactive
molecule
for
skin
antiaging
atherosclerosis,
cancer,
other
pathological
conditions.
Due
to
biocompatibility,
biodegradability,
non-toxicity,
non-immunogenicity,
several
HA-based
biomedical
products
have
been
developed.
There
an
increasing
focus
on
optimizing
production
achieve
high-quality,
efficient,
cost-effective
products.
This
review
discusses
HA’s
structure,
properties,
through
microbial
fermentation.
Furthermore,
it
highlights
applications
emerging
sectors
biomedicine.
Gels,
Journal Year:
2023,
Volume and Issue:
9(7), P. 588 - 588
Published: July 21, 2023
Hydrogel-based
bone
tissue
engineering
is
a
potential
strategy
for
treating
abnormalities
and
fractures.
Hyaluronic
acid
(HA)
natural
polymer
that
widely
distributed
in
the
human
body
plays
significant
role
numerous
physiological
processes
such
as
cell
migration,
hydration,
wound
healing.
Hydrogels
based
on
HA
its
derivatives
have
gained
popularity
treatments
bone-related
diseases.
HA-based
hydrogels
been
extensively
studied
their
ability
to
mimic
extracellular
matrix
of
provide
suitable
microenvironment
support
regeneration.
The
physical
chemical
properties
can
be
modified
improve
mechanical
strength,
biocompatibility,
osteogenic
potential.
Moreover,
combined
with
other
biomaterials
presence
or
absence
bioactive
agents
investigated
means
improving
bioactivity
hydrogel
scaffold.
Therefore,
shown
great
promise
due
activity,
tissue.
Overall,
this
review
provides
comprehensive
overview
current
state
art
engineering,
highlighting
key
advances,
challenges,
future
directions
rapidly
evolving
field.
ACS Applied Bio Materials,
Journal Year:
2024,
Volume and Issue:
7(8), P. 5082 - 5106
Published: July 15, 2024
In
view
of
their
exceptional
approach,
excellent
inherent
biocompatibility
and
biodegradability
properties,
interaction
with
the
local
extracellular
matrix,
protein-based
polymers
have
received
attention
in
bone
tissue
engineering,
which
is
a
multidisciplinary
field
that
repairs
regenerates
fractured
bones.
Bone
multihierarchical
complex
structure,
it
performs
several
essential
biofunctions,
including
maintaining
mineral
balance
structural
support
protecting
soft
organs.
Protein-based
gained
interest
developing
ideal
scaffolds
as
emerging
biomaterials
for
healing
regeneration,
challenging
to
design
substitutes
perfect
biomaterials.
Several
polymers,
collagen,
keratin,
gelatin,
serum
albumin,
etc.,
are
potential
materials
due
cytocompatibility,
controlled
biodegradability,
high
biofunctionalization,
tunable
mechanical
characteristics.
While
numerous
studies
indicated
encouraging
possibilities
proteins
BTE,
there
still
major
challenges
concerning
stability
physiological
conditions,
continuous
release
growth
factors
bioactive
molecules.
Robust
derived
from
can
be
used
replace
broken
or
diseased
biocompatible
substitute;
proteins,
being
biopolymers,
provide
engineering.
Herein,
recent
developments
protein
cutting-edge
engineering
addressed
this
review
within
3–5
years,
focus
on
significant
future
perspectives.
The
first
section
discusses
fundamentals
anatomy
scaffolds,
second
describes
fabrication
techniques
scaffolds.
third
highlights
importance
applications
BTE.
Hence,
development
state-of-the-art
has
been
discussed,
highlighting
Pharmaceutics,
Journal Year:
2022,
Volume and Issue:
14(2), P. 306 - 306
Published: Jan. 27, 2022
Tissue
regeneration
is
an
auto-healing
mechanism,
initiating
immediately
following
tissue
damage
to
restore
normal
structure
and
function.
This
falls
in
line
with
survival
instinct
being
the
most
dominant
for
any
living
organism.
Nevertheless,
process
slow
not
feasible
all
tissues,
which
led
emergence
of
engineering
(TE).
TE
aims
at
replacing
damaged
tissues
new
ones.
To
do
so,
either
cultured
vitro
then
implanted,
or
stimulants
are
implanted
into
target
site
enhance
endogenous
formation.
Whichever
approach
used,
a
matrix
used
support
growth,
known
as
‘scaffold’.
In
this
review,
overall
look
scaffolds
fabrication
discussed,
starting
design
considerations
different
biomaterials
used.
Following,
highlights
conventional
advanced
techniques
attentively
presented.
The
future
ever
promising,
likes
nanotechnology
investigated
scaffold
integration.
constant
evolvement
organoids
biofluidics
eventual
inclusion
organ-on-a-chip
has
shown
promising
prospect
what
technology
might
lead
to.
Perhaps
closest
market
4D
successful
implementation
printing
other
fields.
International Journal of Molecular Sciences,
Journal Year:
2021,
Volume and Issue:
22(13), P. 7077 - 7077
Published: June 30, 2021
Hyaluronan
(HA)
is
a
natural
glycosaminoglycan
present
in
many
tissues
of
all
vertebrates.
HA
has
various
biological
functions,
which
are
dependent
on
its
molar
mass.
High-molar-mass
anti-angiogenic,
immunosuppressive
and
anti-inflammatory
properties,
while
low-molar-mass
opposite
effects.
also
antioxidative
however
the
other
hand
it
can
be
readily
degraded
by
reactive
oxygen
species.
For
years
been
used
treatment
osteoarthritis,
cosmetics
ophthalmology.
In
last
there
growing
interest
to
applied
fields
medicine
such
as
skin
wound
healing,
tissue
engineering,
dentistry
gene
delivery.
this
review
we
summarize
information
modes
administration,
properties
effects
including
recent
progress
investigation
HA.
