3‐Dimensional Printing of Hydrogel‐Based Nanocomposites: A Comprehensive Review on the Technology Description, Properties, and Applications DOI Creative Commons

Sanaz Soleymani Eil Bakhtiari,

Hamid Reza Bakhsheshi‐Rad, Saeed Karbasi

et al.

Advanced Engineering Materials, Journal Year: 2021, Volume and Issue: 23(10)

Published: Sept. 20, 2021

Increasing demand for customized implants and tissue scaffolds requires advanced biomaterials fabricating processes three‐dimensional (3D) structures that resemble the complexity of extracellular matrix (ECM). Lately, biofabrication approaches such as cell‐laden (soft) hydrogel 3D printing (3DP) have been increasing interest in development functional environments similar to natural tissues organs. Hydrogels biological ECMs can provide mechanical support signaling cues cells control their behavior. Although capability hydrogels produce artificial regulate cellular behavior, one major drawbacks working with is inferior properties. Therefore, keeping enhancing integrity fabricated has become an essential matter structures. Herein, 3D‐printed hydrogel‐based nanocomposites (NCs) are evaluated systematically terms introducing novel techniques 3DP materials, properties, biomedical applications.

Language: Английский

Natural Hydrogel-Based Bio-Inks for 3D Bioprinting in Tissue Engineering: A Review DOI Creative Commons
Ahmed Fatimi, Oseweuba Valentine Okoro, Daria Podstawczyk

et al.

Gels, Journal Year: 2022, Volume and Issue: 8(3), P. 179 - 179

Published: March 14, 2022

Three-dimensional (3D) printing is well acknowledged to constitute an important technology in tissue engineering, largely due the increasing global demand for organ replacement and regeneration. In 3D bioprinting, which a step ahead of biomaterial printing, ink employed impregnated with cells, without compromising printability. This allows immediate scaffold cellularization generation complex structures. The use cell-laden inks or bio-inks provides opportunity enhanced cell differentiation fabrication Recognizing importance such bio-inks, current study comprehensively explores state art utilization based on natural polymers (biopolymers), as cellulose, agarose, alginate, decellularized matrix, bioprinting. Discussions regarding progress techniques approaches bioprinting polymers, limitations prospects concerning future trends human-scale are also presented.

Language: Английский

Citations

171

Additive manufacturing of sustainable biomaterials for biomedical applications DOI Creative Commons
Zia Ullah Arif, Muhammad Yasir Khalid,

Reza Noroozi

et al.

Asian Journal of Pharmaceutical Sciences, Journal Year: 2023, Volume and Issue: 18(3), P. 100812 - 100812

Published: April 27, 2023

Biopolymers are promising environmentally benign materials applicable in multifarious applications. They especially favorable implantable biomedical devices thanks to their excellent unique properties, including bioactivity, renewability, bioresorbability, biocompatibility, biodegradability and hydrophilicity. Additive manufacturing (AM) is a flexible intricate technology, which widely used fabricate biopolymer-based customized products structures for advanced healthcare systems. Three-dimensional (3D) printing of these sustainable applied functional clinical settings wound dressing, drug delivery systems, medical implants tissue engineering. The present review highlights recent advancements different types biopolymers, such as proteins polysaccharides, employed develop by using extrusion, vat polymerization, laser inkjet 3D techniques addition normal bioprinting four-dimensional (4D) techniques. This also incorporates the influence nanoparticles on biological mechanical performances 3D-printed scaffolds. work addresses current challenges well future developments friendly polymeric manufactured through AM Ideally, there need more focused research adequate blending biodegradable biopolymers achieving useful results targeted areas. We envision that composites have potential revolutionize sector near future.

Language: Английский

Citations

156

Chitosan based-nanoparticles and nanocapsules: Overview, physicochemical features, applications of a nanofibrous scaffold, and bioprinting DOI
Kamel R. Shoueir,

Nagwa El-Desouky,

Moataz M. Rashad

et al.

International Journal of Biological Macromolecules, Journal Year: 2020, Volume and Issue: 167, P. 1176 - 1197

Published: Nov. 14, 2020

Language: Английский

Citations

148

Chitosan-Based Biomaterials for Tissue Regeneration DOI Creative Commons

Yevgeniy Kim,

Zharylkasyn Zharkinbekov, Kamila Raziyeva

et al.

Pharmaceutics, Journal Year: 2023, Volume and Issue: 15(3), P. 807 - 807

Published: March 1, 2023

Chitosan is a chitin-derived biopolymer that has shown great potential for tissue regeneration and controlled drug delivery. It numerous qualities make it attractive biomedical applications such as biocompatibility, low toxicity, broad-spectrum antimicrobial activity, many others. Importantly, chitosan can be fabricated into variety of structures including nanoparticles, scaffolds, hydrogels, membranes, which tailored to deliver desirable outcome. Composite chitosan-based biomaterials have been demonstrated stimulate in vivo the repair various tissues organs, but not limited to, bone, cartilage, dental, skin, nerve, cardiac, other tissues. Specifically, de novo formation, resident stem cell differentiation, extracellular matrix reconstruction were observed multiple preclinical models different injuries upon treatment with formulations. Moreover, proven efficient carriers medications, genes, bioactive compounds since they maintain sustained release these therapeutics. In this review, we discuss most recently published organ well delivery

Language: Английский

Citations

121

Chitosan as a matrix of nanocomposites: A review on nanostructures, processes, properties, and applications DOI Creative Commons
Angelo Oliveira Silva, Ricardo Sousa Cunha, Dachamir Hotza

et al.

Carbohydrate Polymers, Journal Year: 2021, Volume and Issue: 272, P. 118472 - 118472

Published: July 22, 2021

Language: Английский

Citations

115

A review on four-dimensional (4D) bioprinting in pursuit of advanced tissue engineering applications DOI
Zia Ullah Arif, Muhammad Yasir Khalid, Waqas Ahmed

et al.

Bioprinting, Journal Year: 2022, Volume and Issue: 27, P. e00203 - e00203

Published: March 30, 2022

Language: Английский

Citations

90

Recent Advances in the Additive Manufacturing of Stimuli‐Responsive Soft Polymers DOI Creative Commons
Ali Tariq, Zia Ullah Arif, Muhammad Yasir Khalid

et al.

Advanced Engineering Materials, Journal Year: 2023, Volume and Issue: 25(21)

Published: Aug. 29, 2023

Stimuli‐responsive polymers (SRPs) are special types of soft materials, which have been extensively used for developing flexible actuators, robots, wearable devices, sensors, self‐expanding structures, and biomedical thanks to their ability change shapes functional properties in response external stimuli including light, humidity, heat, pH, electric field, solvent, magnetic field or combinations two more these stimuli. In recent years, additive manufacturing (AM) aka 3D printing technology SRPs, also known as 4D printing, has gained phenomenal attention different engineering fields, its unique develop complex, personalized, innovative undergo twisting, elongating, swelling, rolling, shrinking, bending, spiraling, other complex morphological transformations. Herein, an effort made provide insightful information about the AM techniques, type applications including, but not limited tissue engineering, bionics, construction, smart textiles. This article incorporates current challenges prospects, hoping basis utilization this fields. It is expected that amalgamation with SRPs would unparalleled advantages arenas.

Language: Английский

Citations

84

Chitosan Derivatives as Carriers for Drug Delivery and Biomedical Applications DOI
Sreejan Manna, Arnab Seth,

Prajna Gupta

et al.

ACS Biomaterials Science & Engineering, Journal Year: 2023, Volume and Issue: 9(5), P. 2181 - 2202

Published: April 10, 2023

Over the past few decades, chitosan (CS) has gained attention of researchers investigating newer biomaterial-based carriers for drugs in pharmaceutical and biomedical research. Combined with its nontoxic behavior, biodegradability, biocompatibility, found widespread applications fields drug delivery, tissue engineering, cosmetics. As a novel carrier, is regarded as one promising biomaterials industry. The extensive use this cationic biopolysaccharide delivery therapeutic agents brought limitations into limelight. Various chemical modifications can minimize these improve efficacy carrier. effectiveness several chemically modified derivatives, including trimethyl chitosan, thiolated PEGylated other been investigated by many controlled target specific therapeutics. derivatives exhibited greater importance current scenario on due to their solubility wide range media along interaction pharmaceutically active ingredients. Chitosan have also attracted fields, wound healing, hyperthermia therapy, bioadhesives. present review narrates sources common physicochemical properties important synthetic obtain chitosans target-specific applications.

Language: Английский

Citations

77

Polysaccharide 3D Printing for Drug Delivery Applications DOI Creative Commons
Alexandra Zamboulis, Georgia Michailidou, Ioanna Koumentakou

et al.

Pharmaceutics, Journal Year: 2022, Volume and Issue: 14(1), P. 145 - 145

Published: Jan. 7, 2022

3D printing, or additive manufacturing, has gained considerable interest due to its versatility regarding design as well in the large choice of materials. It is a powerful tool field personalized pharmaceutical treatment, particularly crucial for pediatric and geriatric patients. Polysaccharides are abundant inexpensive natural polymers, that already widely used food industry excipients cosmetic formulations. Due their intrinsic properties, such biocompatibility, biodegradability, non-immunogenicity, etc., polysaccharides largely investigated matrices drug delivery. Although an increasing number interesting reviews on manufacturing delivery being published, there gap concerning printing polysaccharides. In this article, we will review recent advances focused applications. Among family polysaccharides, present focus cellulose derivatives, chitosan sodium alginate, printed by fused deposition modeling extrusion-based printing.

Language: Английский

Citations

75

3D printing of stimuli-responsive hydrogel materials: Literature review and emerging applications DOI Creative Commons
Zia Ullah Arif, Muhammad Yasir Khalid, Ali Tariq

et al.

Giant, Journal Year: 2023, Volume and Issue: 17, P. 100209 - 100209

Published: Nov. 15, 2023

Additive manufacturing (AM) aka three-dimensional (3D) printing has been a well-established and unparalleled technology, which is expanding the boundaries of materials science exhibiting an enormous potential to fabricate intricate geometries for healthcare, electronics, construction sectors. In contemporary era, combination AM technology stimuli-responsive hydrogels (SRHs) helps create dynamic functional structures with extreme accuracy, are capable changing their shape, functional, or mechanical properties in response environmental cues such as humidity, heat, light, pH, magnetic field, electric etc. 3D SRHs permits creation on-demand dynamically controllable shapes excellent control over various self-repair, self-assembly, multi-functionality, These accelerate researchers think unthinkable applications. Additively manufactured objects have shown applications like tissue engineering, drug delivery, soft robots, sensors, other biomedical devices. The current review provides recent progress SRHs, more focus on techniques, stimuli mechanisms, shape morphing behaviors, Finally, trends future roadmap additively smart different also presented, will be helpful research. This holds great promise providing fundamental knowledge about diverse

Language: Английский

Citations

71