Amelioration of Cancer Employing Chitosan, Its Derivatives, and Chitosan-Based Nanoparticles: Recent Updates

Polymers, Journal Year: 2023, Volume and Issue: 15(13), P. 2928 - 2928

Published: July 1, 2023

The limitations associated with the conventional treatment of cancer have necessitated design and development novel drug delivery systems based mainly on nanotechnology. These include various kinds nanoparticles, such as polymeric solid lipid nanostructured carriers, hydrogels, micelles. Among systems, chitosan-based nanoparticles attracted attention researchers to treat cancer. Chitosan is a polycationic polymer generated from chitin characteristics biocompatibility, biodegradability, non-toxicity, mucoadhesiveness, making it an ideal fabricate systems. However, chitosan poorly soluble in water acidic aqueous solutions. Furthermore, owing presence reactive amino groups, can be chemically modified improve its physiochemical properties. derivatives employed which are used most frequently pharmaceutical sector due their possession nanosize, appropriate pharmacokinetic pharmacodynamic properties, non-immunogenicity, improved stability, loading capacity. capable delivering nucleic acids, chemotherapeutic medicines, bioactives using chitosan. derivative-based targeted specific sites via active passive mechanisms. Based many anticancer drugs now better effectiveness, potency, cytotoxicity, or biocompatibility. tailored derivatives, well use therapy, will examined this review.

Language: Английский

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Design and Nanoengineering of Photoactive Antimicrobials for Bioapplications: from Fundamentals to Advanced Strategies

Advanced Functional Materials, Journal Year: 2024, Volume and Issue: 34(38)

Published: April 23, 2024

Abstract Currently, microbial infections have posed an arduous challenge to global public health, whereas the rise of antibiotic resistance is rendering traditional therapies futile, prompting development new antimicrobial technologies. Photoactive nanomaterials thus garnered a thriving interest for disinfection owing their superior antibacterial efficaciousness, favorable biosafety, and rapidness spatiotemporal precision in excreting bactericidal actions. The review summarizes recent advances emerging trends design, nanoengineering, bioapplications photoactive antimicrobials. It commences by elaborating fundamental theories on bacterial resistance, mechanisms phototherapy. Subsequently, regulation effectiveness comprehensively discussed, centering criteria strategies tuning photoabsorption spectra, photothermal conversion, photocatalytic efficiency, alongside tactics enabling synergistic therapies. This followed comparative analyses techniques modalities synthesizing engineering with diverse structures, forms, functionalities. Thereafter, state‐of‐the‐art applications phototherapies across various medical sectors are portrayed, key challenges opportunities finally discussed spur future innovations translation. envisaged provide useful guidance devising developing nanomaterials‐based photoresponsive antimicrobials application‐specific materials properties biological functions.

Language: Английский

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Thermal analysis and entropy generation of magnetic Eyring-Powell nanofluid with viscous dissipation in a wavy asymmetric channel

International Journal of Numerical Methods for Heat &amp Fluid Flow, Journal Year: 2022, Volume and Issue: 33(5), P. 1609 - 1636

Published: Dec. 2, 2022

Purpose This study aims to deal with entropy generation and thermal analysis of magnetic hybrid nanofluid containing silver gold as nanoparticles (Au-Ag/NPs) in the Eyring–Powell fluid. Design/methodology/approach The blood is used a base fluid rheological effects wavy asymmetric channel. effect viscous dissipation also taken into account. mathematical model developed using lubrication technique. perturbation method solve nondimensional nonlinear differential equations, whereas pumping properties have been analyzed numerical integration. Findings impact generation, Brinkman number, Hartmann volume fraction, Grashof number parameter examined on velocity profile, temperature profile characteristics. It observed that introduction boosts field smaller segment rises for increasing values nanoparticle fractions while restrained by parameter. rate all sections increase; however, has reverse effect. trapping boluses significantly affected parameter, Originality/value results are original contribute discover role under influence fields. Pharmaceutical technology may use this research things like better mucoadhesive drug delivery systems more productive peristaltic micropumps.

Language: Английский

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PMMA-Based Nanocomposites for Odontology Applications: A State-of-the-Art

International Journal of Molecular Sciences, Journal Year: 2022, Volume and Issue: 23(18), P. 10288 - 10288

Published: Sept. 7, 2022

Polymethyl methacrylate (PMMA), a well-known polymer of the family, is extensively used in biomedicine, particularly odontological applications including artificial teeth, dentures and denture bases, obturators, provisional or permanent crowns, so forth. The exceptional PMMA properties, aesthetics, inexpensiveness, simple manipulation, low density, adjustable mechanical make it perfect candidate field dentistry. However, presents some deficiencies, weakness regarding hydrolytic degradation, poor fracture toughness, lack antibacterial activity. To further enhance its properties solve these drawbacks, different approaches can be performed, incorporation nanofillers. In this regard, types metallic nanoparticles, metal oxide nanofillers, carbon-based nanomaterials have been recently integrated into matrices with aim to reduce water absorption improve their performance, namely thermal flexural properties. review, recent studies development PMMA-based nanocomposites for odontology are summarized future perspectives highlighted.

Language: Английский

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Magnetic Nanoparticles: Current Advances in Nanomedicine, Drug Delivery and MRI

Chemistry, Journal Year: 2022, Volume and Issue: 4(3), P. 872 - 930

Published: Aug. 27, 2022

Magnetic nanoparticles (MNPs) have evolved tremendously during recent years, in part due to the rapid expansion of nanotechnology and their active magnetic core with a high surface-to-volume ratio, while surface functionalization opened door plethora drug, gene bioactive molecule immobilization. Taming reactivity was achieved by various techniques, producing MNPs tailored for diagnosis treatment cardiovascular or neurological disease, tumors cancer. Superparamagnetic iron oxide (SPIONs) are established at drug-delivery systems could act as efficient agents MFH (magnetic fluid hyperthermia). Depending on intrinsic morphological features, now cover broad scope which current review aims overview. Considering exponential field, will be limited roughly past three years.

Language: Английский

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Graphene-Based Polymer Composites for Flexible Electronic Applications

Micromachines, Journal Year: 2022, Volume and Issue: 13(7), P. 1123 - 1123

Published: July 16, 2022

Graphene-based nanomaterials have gained a lot of interest over the last years in flexible electronics due to their exceptional electrical, mechanical, and optoelectronic properties, as well potential surface modification. Their flexibility processability make them suitable for electronic devices that require bending, folding, stretching, which cannot be fulfilled by conventional electronics. These can assembled with various types organic materials, including polymers, biomolecules, generate variety nanocomposites greater stretchability healability, higher stiffness, electrical conductivity, thermal stability lighting display technologies. This article summarizes main characteristics synthesis methods graphene, its oxidized form graphene oxide (GO), reduced GO derivative, corresponding polymeric composites, provides brief overview about some recent examples these applications, electrodes solar cells supercapacitors, textiles, transistors.

Language: Английский

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Machine Learning for Property Prediction and Optimization of Polymeric Nanocomposites: A State-of-the-Art

International Journal of Molecular Sciences, Journal Year: 2022, Volume and Issue: 23(18), P. 10712 - 10712

Published: Sept. 14, 2022

Recently, the field of polymer nanocomposites has been an area high scientific and industrial attention due to noteworthy improvements attained in these materials, arising from synergetic combination properties a polymeric matrix organic or inorganic nanomaterial. The enhanced performance those materials typically involves superior mechanical strength, toughness stiffness, electrical thermal conductivity, better flame retardancy higher barrier moisture gases. Nanocomposites can also display unique design possibilities, which provide exceptional advantages developing multifunctional with desired for specific applications. On other hand, machine learning (ML) recognized as powerful predictive tool data-driven multi-physical modelling, leading unprecedented insights exploration system’s beyond capability traditional computational experimental analyses. This article aims brief overview most important findings related application ML rational nanocomposites. Prediction, optimization, feature identification uncertainty quantification are presented along different algorithms used property prediction, selected examples discussed. Finally, conclusions future perspectives highlighted.

Language: Английский

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Development of Polyvinylpyrrolidone-Based nanomaterials for biosensors applications: A Review

Inorganic Chemistry Communications, Journal Year: 2023, Volume and Issue: 152, P. 110714 - 110714

Published: April 14, 2023

Language: Английский

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Chitosan-Based Nano-Smart Drug Delivery System in Breast Cancer Therapy

Pharmaceutics, Journal Year: 2023, Volume and Issue: 15(3), P. 879 - 879

Published: March 8, 2023

Despite recent advances, cancer remains the primary killer on a global scale. Numerous forms of research have been conducted to discover novel and efficient anticancer medications. The complexity breast is major challenge which coupled with patient-to-patient variations heterogeneity between cells within tumor. Revolutionary drug delivery expected provide solution that challenge. Chitosan nanoparticles (CSNPs) prospects as revolutionary system capable enhancing activity reducing negative impacts normal cells. use smart systems (SDDs) delivering materials improve bioactivity NPs understand intricacies has garnered significant interest. There are many reviews about CSNPs present various points view, but they not yet described series in therapy from cell uptake death. With this description, we will more complete picture for designing preparations SDDs. This review describes SDDSs, targeting stimulus response using their mechanism. Multimodal chitosan SDDs medication therapeutic results.

Language: Английский

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Osteoimmunomodulatory Nanoparticles for Bone Regeneration

Nanomaterials, Journal Year: 2023, Volume and Issue: 13(4), P. 692 - 692

Published: Feb. 10, 2023

Treatment of large bone fractures remains a challenge for orthopedists. Bone regeneration is complex process that includes skeletal cells such as osteoblasts, osteoclasts, and immune to regulate formation resorption. Osteoimmunology, studying this complicated process, has recently been used develop biomaterials advanced regeneration. Ideally, biomaterial shall enable timely switch from early stage inflammatory (to recruit osteogenic progenitor cells) later-stage anti-inflammatory promote differentiation terminal mineralization model the microstructure tissue) in cells, especially M1-to-M2 phenotype macrophage populations, Nanoparticle (NP)-based drug delivery systems can controlled release therapeutic reagents therapeutics into specific cell types, thereby benefiting through osteoimmunomodulation. In review, we briefly describe significance osteoimmunology regeneration, advancement NP-based approaches application NPs macrophage-targeting

Language: Английский

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