International Journal of Biological Macromolecules, Journal Year: 2024, Volume and Issue: 282, P. 137352 - 137352
Published: Nov. 8, 2024
Language: Английский
Pharmaceutics, Journal Year: 2024, Volume and Issue: 16(1), P. 93 - 93
Published: Jan. 10, 2024
Wounds and chronic wounds can be caused by bacterial infections lead to discomfort in patients. To solve this problem, scientists are working create modern wound dressings with antibacterial additives, mainly because traditional materials cannot meet the general requirements for complex promote healing. This demand is met material engineering, through which we electrospun dressings. Electrospun dressings, as well those based on hydrogels incorporated compounds, these requirements. manuscript reviews recent used discussing their formation, application, functionalization. The focus presenting hydrogels. In contrast, advancements care have highlighted potential of thermoresponsive dynamic These contain adaptable polymers that offer targeted drug delivery show promise managing various types while addressing infections. way, article intended serve a compendium knowledge researchers, medical practitioners, biomaterials engineers, providing up-to-date information state art, possibilities innovative solutions, challenges area
Language: Английский
Citations
19
Polymers, Journal Year: 2024, Volume and Issue: 16(17), P. 2526 - 2526
Published: Sept. 5, 2024
Skin, the largest organ of human body, accounts for protecting against external injuries and pathogens. Despite possessing inherent self-regeneration capabilities, repair skin lesions is a complex time-consuming process yet vital to preserving its critical physiological functions. The dominant treatment involves application dressing protect wound, mitigate risk infection, decrease likelihood secondary injuries. Pursuing solutions accelerating wound healing has resulted in groundbreaking advancements materials science, from hydrogels hydrocolloids foams micro-/nanofibers. Noting convenience flexibility design, nanofibers merit high surface-area-to-volume ratio, controlled release therapeutics, mimicking extracellular matrix, excellent mechanical properties. Core-shell bring even further prospects realm dressings upon separate compartments with independent functionality, adapted profiles bioactive agents, better moisture management. In this review, we highlight core-shell applications featuring survey on common synthesis methods. Our discussion embodies process, optimal characteristics, current organic inorganic material repertoire multifunctional nanofibers, techniques fabricate proper coaxial structures. We also provide an overview antibacterial nanomaterials emphasis their crystalline structures, properties, conclude outlook potential offered by toward more advanced design effective healing.
Language: Английский
Citations
16
International Journal of Biological Macromolecules, Journal Year: 2024, Volume and Issue: 266, P. 131187 - 131187
Published: March 28, 2024
Language: Английский
Citations
15
Micromachines, Journal Year: 2024, Volume and Issue: 15(10), P. 1226 - 1226
Published: Sept. 30, 2024
Non-invasive medical nanofiber technology, characterized by its high specific surface area, biocompatibility, and porosity, holds significant potential in various domains, including tissue repair biosensing. It is increasingly becoming central to healthcare offering safer more efficient treatment options for contemporary medicine. Numerous studies have explored non-invasive nanofibers recent years, yet a comprehensive overview of the field remains lacking. In this paper, we provide summary applications electrospun fields, considering multiple aspects perspectives. Initially, introduce electrospinning nanofibers. Subsequently, detail their health, health monitoring, personal protection, thermal regulation, wound care, highlighting critical role improving human health. Lastly, paper discusses current challenges associated with offers insights into future development trajectories.
Language: Английский
Citations
14
Nanocomposites, Journal Year: 2024, Volume and Issue: 10(1), P. 254 - 267
Published: May 30, 2024
The research project focuses on conducting an in vitro comparison between sodium alginate and chitosan electrospun nanofibers for moist wound management. These fabricated were incorporated with levofloxacin (Lev) as a model drug to investigate their release behavior. study included comprehensive examination of the physicochemical, thermal, antibacterial, cytocompatibility properties these nanofibers. Both (SA-L) (CS-L) successfully produced homogeneous defect-free structure. XRD FTIR analyses conducted validate incorporation Lev In terms liquid absorption capacity, it was observed that outperformed nanofibers, exhibiting capacities 5.9, 5.88, 7.1 g/g PBS, solution A, DI, respectively, SA-L, compared 5.27, 4.42, 5.3 CS-L This superior ability SA-L may be attributed inherent gel-forming aqueous environments. Furthermore, kinetics indicated exhibited faster which could alginate's natural tendency mediums. demonstrated remarkable efficacy against Staphylococcus aureus (S. aureus) Pseudomonas aeruginosa (P. aeruginosa), displaying larger inhibition zones agar diffusion tests due chitosan's antibacterial properties. Moreover, assessments using HaCat cell line revealed prepared biocompatible non-toxic. Interestingly, proliferation when potentially positively charged amine groups enhance migration negatively keratinocytes.
Language: Английский
Citations
12
Carbohydrate Polymer Technologies and Applications, Journal Year: 2025, Volume and Issue: unknown, P. 100706 - 100706
Published: Feb. 1, 2025
Language: Английский
Citations
2
Journal of Polymers and the Environment, Journal Year: 2025, Volume and Issue: unknown
Published: March 6, 2025
Language: Английский
Citations
2
Journal of Science Advanced Materials and Devices, Journal Year: 2025, Volume and Issue: unknown, P. 100862 - 100862
Published: Feb. 1, 2025
Language: Английский
Citations
1
APL Bioengineering, Journal Year: 2025, Volume and Issue: 9(1)
Published: Feb. 25, 2025
The high incidence and prevalence of diabetic foot ulcers (DFUs) present a substantial clinical economic burden, necessitating innovative therapeutic approaches. Fibroblasts, characterized by their intrinsic cellular plasticity multifunctional capabilities, play key roles in the pathophysiological processes underlying DFUs. Hyperglycemic conditions lead to cascade biochemical alterations that culminate dysregulation fibroblast phenotype function, which is primary cause impaired wound healing Biomaterials, particularly those engineered at nanoscale, hold significant promise for enhancing DFU treatment outcomes. Electrospun nanofiber scaffolds, with structural compositional similarities natural extracellular matrix, serve as an effective substrate adhesion, proliferation, migration. This review comprehensively summarizes biological behavior fibroblasts DFUs mechanism mediating healing. At same time, materials, especially electrospun improve effect regulating activity was also discussed. By highlighting latest advancements applications, we aim provide clear perspective on future direction strategies centered fibroblast-targeted therapies.
Language: Английский
Citations
1
International Journal of Biological Macromolecules, Journal Year: 2025, Volume and Issue: 307, P. 142084 - 142084
Published: March 13, 2025
Language: Английский
Citations
1