Synthesis and Characterization of Photocurable Difunctional Monomers for Medical Applications DOI Open Access
Gökhan Demirci, Agata Goszczyńska, Martyna Sokołowska

et al.

Polymers, Journal Year: 2024, Volume and Issue: 16(24), P. 3584 - 3584

Published: Dec. 21, 2024

Photocurable materials offer a rapid transition from liquid to solid state, and have recently received great interest in the medical field. However, while dental resins are very popular, only few been developed for soft tissue repair. This study aims synthesize difunctional methacrylate monomer using dibutyltin dilaurate which is suitable photocuring of materials. These were compared with PhotoBioCure® (Szczecin, Poland) material similar molecular weight, Mn ~7000 g/mol on average. Infrared spectroscopy was used monitor two-step synthesis catalyzed dilaurate, spectroscopic chromatographic methods determine chemical structure weight monomers. Photopolymerization kinetics under varying light intensities explored nitrogen atmosphere representative The mechanical testing resulting elastomeric films confirmed tensile strength modulus values consistent parameters range 3–4 MPa. 3D printability macromonomers also assessed. Additionally, cytotoxicity assessments cultured cells showed high cell viability (97%) all new Overall, we demonstrate that monomers converted flexible solids during photopolymerization show potential biomedical applications.

Language: Английский

Applications of 3D Bioprinting Technology to Brain Cells and Brain Tumor Models: Special Emphasis to Glioblastoma DOI Creative Commons
Ilkay Irem Ozbek, Hale Saybaşılı, Kutlu Ö. Ülgen

et al.

ACS Biomaterials Science & Engineering, Journal Year: 2024, Volume and Issue: 10(5), P. 2616 - 2635

Published: April 26, 2024

Primary brain tumor is one of the most fatal diseases. The malignant type among them, glioblastoma (GBM), has low survival rates. Standard treatments reduce life quality patients due to serious side effects. Tumor aggressiveness and unique structure render removal tumors development new therapies challenging. To elucidate characteristics examine their response drugs, realistic systems that mimic environment cellular crosstalk are desperately needed. In past decade, 3D GBM models have been presented as excellent platforms they allowed investigation phenotypes testing innovative therapeutic strategies. scope, bioprinting technology offers utilities such fabricating bioprinted structures in a layer-by-layer manner precisely controlled deposition materials cells, can be integrated with other technologies like microfluidics approach. This Review covers studies investigated models, especially using techniques essential parameters affect result study frequently used physical hydrogel, conditions, cross-linking methods, characterization techniques.

Language: Английский

Citations

7
Light‐Assisted 3D‐Printed Hydrogels for Antibacterial Applications DOI Creative Commons
Liwen Zhang,

Naufal Kabir Ahamed Nasar,

Xumin Huang

et al.

Small Science, Journal Year: 2024, Volume and Issue: 4(8)

Published: May 23, 2024

Light‐assisted 3D printing technology, which uses a light source to solidify photopolymerizable prepolymer solution, has shown great potential in the development of antibacterial hydrogels with high‐resolution, specific features and functionalities. 3D‐printed customized structures functions are widely used tissue engineering, regenerative medicine, wound healing, implants advance modeling treatment diseases. In current review, an overview light‐assisted technologies is first provided for hydrogels. Novel strategies involving integration inorganic nanomaterials, antibiotics, functional polymers into enhancement effects then discussed. Finally, perspective advanced design using artificial intelligence machine learning proposed, providing comprehensive yet succinct examination purposes.

Language: Английский

Citations

6
Bioprinting of hepatic tissue using 3D technology: Transitioning beyond laboratory models to real-world applications in medical treatments DOI
S. Logesh Kumar, Rishabha Malviya

Applied Materials Today, Journal Year: 2024, Volume and Issue: 39, P. 102307 - 102307

Published: July 8, 2024

Language: Английский

Citations

6
Bioprinting of gelatin-based materials for orthopedic application DOI Creative Commons
Yusuf Olatunji Waidi, Ishaq Kariim, Sudipto Datta

et al.

Frontiers in Bioengineering and Biotechnology, Journal Year: 2024, Volume and Issue: 12

Published: March 13, 2024

Bio-printed hydrogels have evolved as one of the best regenerative medicine and tissue engineering platforms due to their outstanding cell-friendly microenvironment. A correct hydrogel ink formulation is critical for creating desired scaffolds that better fidelity after printing. Gelatin its derivatives sparked intense interest in various biomedical sectors because biocompatibility, biodegradability, ease functionalization, rapid gelling tendency. As a result, this report emphasizes relevance gelatin-based fabricating bio-printed orthopedic applications. Starting with what bio-printing are all about. We further summarized different techniques explored applications, including few recent studies. also discussed suitability gelatin biopolymer both 3D 4D printing materials. extrusion most widely used gelatin-based, we summarize rheological features bio-ink. Lastly, elaborate on studies orthopedics potential clinical translation issues, research possibilities.

Language: Английский

Citations

4
Using Three-Dimensional Bioprinting to Generate Realistic Models of Wound Healing DOI

Giselle Y. Díaz,

Victor Allisson da Silva,

Farnoosh Kalantarnia

et al.

Advances in Wound Care, Journal Year: 2025, Volume and Issue: unknown

Published: March 5, 2025

Significance: The skin serves as the primary defense against external stimuli, making it vulnerable to damage. Injuries can cause a dysregulated environment, resulting in chronic inflammation and inhibition of cell proliferation migration, which delays recovery. Innovative approaches, such three-dimensional (3D) bioprinting, foster controlled healing environment by promoting synergy between microbiome cells. Recent Advances: Traditional approaches wound have focused on fostering an conducive interplay cells, extracellular proteins, growth factors. 3D manufacturing technology with applications tissue engineering, deposits biomaterial-based bioink containing living cells fabricate custom-designed scaffolds layer-by-layer fashion. This process controls architecture composition construct, producing multilayered complex structures skin. Critical Issues: selection biomaterials for has been challenge when engineering. While prioritizing mechanical properties, current often lack ability interact environmental stimuli pH, temperature, or oxygen levels. Employing smart that integrate bioactive molecules adapt conditions could overcome these limitations. innovation would enable create sustainable wound-healing balance, reducing inflammation, facilitating cellular recovery restoration, addressing critical gaps existing care solutions. Future Directions: Novel formulations injury are improving long-term viability, proliferation, vascularization, immune integration. Efficient using potential microenriched environments support restore regulation. promising direction future research aims improve patient outcomes care.

Language: Английский

Citations

0
3D bioprinting for bile duct tissue engineering: current status and prospects DOI Creative Commons
Bo Gao

Frontiers in Bioengineering and Biotechnology, Journal Year: 2025, Volume and Issue: 13

Published: April 14, 2025

Bile duct disorders, including cholangiocarcinoma, primary sclerosing cholangitis, and iatrogenic injuries, pose significant clinical challenges due to limited regenerative capacity the complexity of biliary tree. In recent years, 3D bioprinting has emerged as a promising approach for bile tissue engineering by providing patient-specific geometries facilitating spatial organization cells, scaffolding materials, bioactive factors. This review presents comprehensive overview techniques engineering, focusing on fundamental principles, biomaterial selection, current achievements, key challenges, future perspectives. We systematically discuss latest technological breakthroughs, highlight emerging innovations such organoid-based strategies microfluidic-assisted printing, evaluate prospects translation. Finally, we outline main challenges—such biocompatibility vascularization, immunological barriers, standardization protocols, regulatory hurdles—and propose directions research, emphasizing multidisciplinary collaboration translational studies.

Language: Английский

Citations

0
Light-Based 3D Bioprinting Techniques for Illuminating the Advances of Vascular Tissue Engineering DOI Creative Commons
Wei Li, Jinhua Li, Chen Pan

et al.

Materials Today Bio, Journal Year: 2024, Volume and Issue: 29, P. 101286 - 101286

Published: Oct. 2, 2024

Vascular tissue engineering faces significant challenges in creating

Language: Английский

Citations

1
Advances in 3D Bioprinting Technologies for Cardiovascular Intervention and Regeneration Therapeutics DOI Creative Commons
S. J. Kim, Jinah Jang

Journal of Cardiovascular Intervention, Journal Year: 2024, Volume and Issue: 4

Published: Dec. 5, 2024

Language: Английский

Citations

0
State of the Art in Purkinje Bioengineering DOI

Ravi K. Birla

Tissue and Cell, Journal Year: 2024, Volume and Issue: 90, P. 102467 - 102467

Published: July 9, 2024

Language: Английский

Citations

0
Strategies To Enhance Biocompatibility of Bone Scaffold for Tissue Engineering Applications DOI Creative Commons

S.A.P. Sughanthy,

M.N.M. Ansari,

Angela Ng Min Hwei

et al.

Jurnal Kejuruteraan, Journal Year: 2024, Volume and Issue: 36(4), P. 1385 - 1398

Published: July 30, 2024

Tissue engineering (TE) is a modern approach to improve or restore tissues that has been diseased damaged by combining the factors in growth signaling and appropriate cells form compatible biomaterial scaffold. Bone repair major global health challenge recent decades. transplantation widely used as an effective clinical treatment for this purpose. However, there are several serious issues with transplantation, including shortage of autologous bone, immune rejection, risk virus transmission allogeneic postoperative complications. In years, scaffolds bone tissue have emerged promising alternative repair. These porous structures mimic extracellular matrix, which can enhance migration, proliferation, differentiation osteoblasts. This process accelerates defects.The usage bioactive materials become important tool regenerative medicine application they mechanically, chemically, physically. Polymeric scaffold provides numerous advantageous since physicochemical properties such porosity, pore size, solubility biocompatibility be controlled. Therefore, research works were carried out explore potential various producing technology. As both newcomers experts, review paper will help them find information on types biomaterials imparting enhancing their biological biocompatibility, bacterial inhibition, regeneration cell growth, bio inertness, resorbability application.

Language: Английский

Citations

0