Biomaterials Mimicking Mechanobiology: A Specific Design for a Specific Biological Application DOI Open Access

Leonardo Donati,

Maria Luisa Valicenti,

Samuele Giannoni

et al.

International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(19), P. 10386 - 10386

Published: Sept. 26, 2024

Mechanosensing and mechanotransduction pathways between the Extracellular Matrix (ECM) cells form essential crosstalk that regulates cell homeostasis, tissue development, morphology, maintenance, function. Understanding these mechanisms involves creating an appropriate support elicits signals to guide cellular functions. In this context, polymers can serve as ideal molecules for producing biomaterials designed mimic characteristics of ECM, thereby triggering responsive closely resemble those induced by a natural physiological system. The generated specific stimuli depend on different or synthetic origins polymers, chemical composition, assembly structure, physical surface properties biomaterials. This review discusses most widely used their customization develop with tailored properties. It examines how biomaterials-based be harnessed replicate functions biological cells, making them suitable biomedical biotechnological applications.

Language: Английский

Bioprinting of Cells, Organoids and Organs-on-a-Chip Together with Hydrogels Improves Structural and Mechanical Cues DOI Creative Commons
Claudia Tanja Mierke

Cells, Journal Year: 2024, Volume and Issue: 13(19), P. 1638 - 1638

Published: Oct. 1, 2024

The 3D bioprinting technique has made enormous progress in tissue engineering, regenerative medicine and research into diseases such as cancer. Apart from individual cells, a collection of organoids, can be printed combination with various hydrogels. It hypothesized that will even become promising tool for mechanobiological analyses organoids their matrix environments highly defined precisely structured environments, which the mechanical properties cell environment individually adjusted. Mechanical obstacles or bead markers integrated bioprinted samples to analyze deformations forces within these constructs, perform biophysical analysis complex systems, are still not standard techniques. review highlights advances 4D printing technologies integrating cues so next step detailed key future directions organoid generation development disease model regeneration drug testing perspective. Finally, hydrogels, pure natural synthetic hydrogels mixtures, organoid–cell co-cultures, organ-on-a-chip systems organoid-organ-on-a chip combinations introduces use assembloids determine mutual interactions different types cell–matrix interferences specific biological environments.

Language: Английский

Citations

6
Advancements in nanotheranostics for glioma therapy DOI

Liza Sahoo,

Safal Kumar Paikray,

Nigam Sekhar Tripathy

et al.

Naunyn-Schmiedeberg s Archives of Pharmacology, Journal Year: 2024, Volume and Issue: unknown

Published: Oct. 31, 2024

Language: Английский

Citations

4
Title Actuated Hydrogel Platforms To Study Brain Cell Behavior DOI Creative Commons
Kirill E. Zhurenkov, Darren Svirskis, Bronwen Connor

et al.

Advanced Healthcare Materials, Journal Year: 2025, Volume and Issue: unknown

Published: March 16, 2025

Abstract The human brain is a highly complex organ characterized by intricate neural networks, biochemical signaling, and unique mechanical properties. soft dynamic viscoelastic extracellular matrix (ECM) plays crucial role in supporting different types of cells influencing their behavior. Understanding how respond to stimuli within this environment essential for unraveling fundamental mechanisms healthy, unhealthy, regenerative functions the central nervous system. This requires development advanced materials techniques study interplay between cues cell responses. Hydrogels have become research, mimicking brain's ECM both chemical composition Conventional hydrogels, while helpful, are static lack stimulation. On other hand, hydrogels provide reversible, stimulation, closely replicating review discusses current hydrogel platforms used investigate function health disease, focusing on traumatic injury (TBI)‐like conditions tumors. These offer sophisticated tools understanding mechanobiology developing new therapeutic approaches.

Language: Английский

Citations

0
Effect of graphene oxide on Fe3O4/TiO2 nanocomposite and their characterization for drug delivery applications DOI

Noshin Salimi,

Ebrahim Mohammadi‐Manesh

Inorganic Chemistry Communications, Journal Year: 2025, Volume and Issue: unknown, P. 114387 - 114387

Published: March 1, 2025

Language: Английский

Citations

0
4D Bioprinting for Personalized Medicine, Innovations in Implant Fabrication and Regenerative Therapies DOI

Senthil Maharaj Kennedy,

Manigandan Sekar,

A. Vasanthanathan

et al.

Polymer-Plastics Technology and Materials, Journal Year: 2025, Volume and Issue: unknown, P. 1 - 26

Published: March 30, 2025

Language: Английский

Citations

0
3-Dimensional printing and bioprinting in neurological sciences: applications in surgery, imaging, tissue engineering, and pharmacology and therapeutics DOI Creative Commons

S K Dhar,

Faraz Ahmad, Aditi Deshpande

et al.

Journal of Materials Science Materials in Medicine, Journal Year: 2025, Volume and Issue: 36(1)

Published: April 9, 2025

Abstract The rapid evolution of three-dimensional printing (3DP) has significantly impacted the medical field. In neurology for instance, 3DP been pivotal in personalized surgical planning and education. Additionally, it facilitated creation implants, microfluidic devices, optogenetic probes, offering substantial implications research applications. 3D printed nasal casts are showing great promise targeted brain drug delivery. also aided creating “phantoms” aligning with advancements neuroimaging, design intricate objects investigating neurobiology sensory perception. Furthermore, emergence bioprinting (3DBP), a fusion cell biology, created new avenues neural tissue engineering. Effective ethical tissue-like biomimetic constructs enabled mechanistic, regenerative, therapeutic evaluations. While individual reviews have explored applications or 3DBP, comprehensive review encompassing success stories across multiple facets both technologies neurosurgery, neuro-regeneration lacking. This aims to consolidate recent achievements 3DBP various neurological science domains encourage interdisciplinary among neurologists, neurobiologists, engineers, order promote further exploration methodologies novel areas practice. Graphical abstract

Language: Английский

Citations

0
Three-dimensional bioprinted in vitro glioma tumor constructs for synchrotron microbeam radiotherapy dosimetry and biological study using gelatin methacryloyl hydrogel DOI Creative Commons
John Paul O. Bustillo, E. Engels,

Vincent de Rover

et al.

Scientific Reports, Journal Year: 2025, Volume and Issue: 15(1)

Published: April 22, 2025

Language: Английский

Citations

0
Biomaterials Mimicking Mechanobiology: A Specific Design for a Specific Biological Application DOI Open Access

Leonardo Donati,

Maria Luisa Valicenti,

Samuele Giannoni

et al.

International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(19), P. 10386 - 10386

Published: Sept. 26, 2024

Mechanosensing and mechanotransduction pathways between the Extracellular Matrix (ECM) cells form essential crosstalk that regulates cell homeostasis, tissue development, morphology, maintenance, function. Understanding these mechanisms involves creating an appropriate support elicits signals to guide cellular functions. In this context, polymers can serve as ideal molecules for producing biomaterials designed mimic characteristics of ECM, thereby triggering responsive closely resemble those induced by a natural physiological system. The generated specific stimuli depend on different or synthetic origins polymers, chemical composition, assembly structure, physical surface properties biomaterials. This review discusses most widely used their customization develop with tailored properties. It examines how biomaterials-based be harnessed replicate functions biological cells, making them suitable biomedical biotechnological applications.

Language: Английский

Citations

2