Journal of Polymers and the Environment, Journal Year: 2025, Volume and Issue: unknown
Published: March 6, 2025
Language: Английский
ACS Biomaterials Science & Engineering, Journal Year: 2024, Volume and Issue: 10(7), P. 4114 - 4144
Published: June 3, 2024
Nanofiber scaffolds have gained significant attention in the field of bone tissue engineering. Electrospinning, a straightforward and efficient technique for producing nanofibers, has been extensively researched. When used engineering scaffolds, electrospun nanofibers with suitable surface properties promote new growth enhance cell adhesion. Recent advancements electrospinning technology provided innovative approaches scaffold fabrication This review comprehensively examines utilization evaluates relevant literature. The begins by presenting fundamental principles methodologies electrospinning. It then discusses various materials production nanofiber engineering, including natural synthetic polymers, as well certain inorganic materials. challenges associated these are also described. focuses on novel techniques construction such multilayer multifluid electrospinning, integration other methods. enabled precisely aligned nanoscale architectures. These methods facilitate biomimetic structures, wherein bioactive substances can be incorporated released controlled manner drug delivery purposes. Moreover, they address issues encountered traditional mechanical characteristics biocompatibility. Consequently, development implementation technologies revolutionized
Language: Английский
Citations
22
Nanomaterials, Journal Year: 2025, Volume and Issue: 15(4), P. 290 - 290
Published: Feb. 13, 2025
Gum Arabic (GA), or acacia gum, refers to the dried exudate produced by certain Acacia trees. GA is composed mainly of a mixture polysaccharides and glycoproteins, with proportions that can slightly differ from one species another. It commonly utilized in food pharmaceutical industries as stabilizer an emulsifier owing its biocompatibility, hydrophilicity, antibacterial properties. In addition, be manipulated it possesses many functional groups used grafting, cross-linking, chemical modifications add new feature developed material. this review, we highlight recent GA-based formulations, including nanoparticles, hydrogels, nanofibers, membranes, scaffolds, their possible applications tissue regeneration, cancer therapy, wound healing, biosensing, bioimaging, packaging, antimicrobial antifouling membranes.
Language: Английский
Citations
2
The Chemical Record, Journal Year: 2025, Volume and Issue: unknown
Published: March 4, 2025
Abstract The escalating global waste crisis necessitates innovative solutions. This study investigates the sustainable production of nanocellulose from biomass and its biomedical applications. Cellulose‐rich materials–including wood, textiles, agricultural residues, food by‐products–were systematically processed using alkaline, acid, oxidative pretreatments to enhance fiber accessibility. Mechanical techniques, such as grinding homogenization, combined with chemical methods like acid hydrolysis 2,2,6,6‐Tetramethylpiperidin‐1‐yl‐oxyl (TEMPO) oxidation, were employed successfully isolate nanocellulose. Post‐treatment modifications, including surface coating cross‐linking, further tailored properties for specific results demonstrated nanocellulose's biocompatibility, biodegradability, functional versatility. In wound healing, it enhanced moisture management exhibited antimicrobial properties. Its high area facilitated efficient drug loading controlled release in delivery Nanocellulose bioinks supported cell proliferation 3D bioprinting tissue engineering. Additional applications biosensors personal care products also identified. advances materials science, aligning resource conservation circular economy principles address sector needs.
Language: Английский
Citations
2
Journal of Drug Delivery Science and Technology, Journal Year: 2024, Volume and Issue: 99, P. 105958 - 105958
Published: July 9, 2024
Language: Английский
Citations
16
Macromolecular Materials and Engineering, Journal Year: 2024, Volume and Issue: 309(5)
Published: March 12, 2024
Abstract Silk fibroin (SF), a natural protein derived from silkworms, has emerged as promising biomaterial due to its biocompatibility, biodegradability, degradation rate, and tunable mechanical properties. This review delves into the intrinsic attributes of SF that make it an attractive candidate for scaffold development in tissue engineering regenerative medicine. The distinctiveness this comprehensive resides detailed exploration recent advancements fabrication techniques SF‐based fibrous scaffolds, namely electrospinning, freeze‐drying, 3D printing. An in‐depth analysis these is conducted illustrate their versatility customizing essential characteristics, such porosity, fiber diameter, strength. article meticulously discusses process parameters, advantages, challenges each technique, highlighting innovative made respective field. Furthermore, goes beyond provide overview latest biomedical applications research endeavors utilizing SF‐derived scaffolds. From nerve regeneration wound healing drug delivery, bone regeneration, vascular engineering, diverse underscore adopting various challenges. Finally, emphasizes need standardized characterization techniques, scalable manufacturing processes, long‐term vivo studies.
Language: Английский
Citations
10
IntechOpen eBooks, Journal Year: 2024, Volume and Issue: unknown
Published: May 23, 2024
Conventional therapeutic models based on the premise of a universal solution are facing decrease in efficiency, emphasized by large number patients who show resistance or do not respond positively to classic treatments. This perspective highlights urgency for more precise approaches personalized treatments that adaptable specific complexities and unique challenges faced each patient. Hydrogels biocompatible biodegradable systems well-controlled targeted administration agents, being formed 3D reticulated networks water-soluble polymeric biomaterials, natural, synthetic, hybrid origin, with intrinsic extrinsic properties. Due easily adjustable porous structure, hydrogels allow encapsulation macromolecular drugs, proteins, small molecules, cells, hormones, growth factors gel matrix their subsequent controlled release. The biomaterials used, crosslinking methods, design, functionalization strategies obtaining improved properties presented. different possibilities application described transdermally, as dressing materials, oral, ocular, spray-able, injectable, up intracellular level. chapter extensively investigates advances advantages enable effective, noninvasive, provide greater patient comfort wide range applications.
Language: Английский
Citations
10
Polymer Bulletin, Journal Year: 2024, Volume and Issue: unknown
Published: Sept. 30, 2024
Language: Английский
Citations
10
Frontiers in Bioscience-Landmark, Journal Year: 2024, Volume and Issue: 29(6)
Published: June 24, 2024
Mesenchymal stem/stromal cells (MSCs) have emerged as a promising therapeutic approach for variety of diseases due to their immunomodulatory and tissue regeneration capabilities. Despite potential, the clinical application MSC therapies is hindered by limited cell retention engraftment at target sites. Electrospun scaffolds, with high surface area-to-volume ratio tunable physicochemical properties, can be used platforms delivery. However, synthetic polymers often lack bioactive cues necessary optimal cell-scaffold interactions. Integrating electrospun scaffolds biological polymers, such polysaccharides, proteins, composites, combines mechanical integrity materials bioactivity natural represents strategic enhance The molecular interactions between MSCs blended or functionalized been examined in recent studies, it has shown that integration adhesion, proliferation, paracrine secretion through activation multiple signaling pathways, FAK/Src, MAPK, PI3K/Akt, Wnt/β-catenin, YAP/TAZ. Preclinical studies on small animals also reveal enhancing delivery efficacy context regenerating bone, cartilage, muscle, cardiac, vascular, nervous tissues. Future research should concentrate identifying distinct characteristics niche, investigating processes involved MSC-scaffold interactions, applying new technologies stem treatment biofabrication scaffold design. Research large animal models collaboration among scientists, engineers, physicians are crucial translating these advancements into use.
Language: Английский
Citations
9
RSC Advances, Journal Year: 2025, Volume and Issue: 15(5), P. 3259 - 3272
Published: Jan. 1, 2025
Optimizing solvent systems for electrospun PLGA tissue scaffolds enables control over mechanical properties. Hansen solubility theory helps identify key effects, enabling the design of tunable, high-performance biomedical use.
Language: Английский
Citations
1
RSC Advances, Journal Year: 2024, Volume and Issue: 14(36), P. 26183 - 26197
Published: Jan. 1, 2024
Recently, the design of polymer nanofibers using electrospinning process has attracted much interest. Particularly use natural polymers promoted many advantages in their biomedical applications. However, combination multiple remains a great challenge terms electrospun production and applied performance. From this perspective, current investigation highlights study preparation nanomaterial scaffolds based on combined for improved wound healing First, we have synthesized crosslinked by reacting microcrystalline cellulose (MC) chitosan (CS) biopolymer
Language: Английский
Citations
6