Emerging Polymer-Based Nanosystem Strategies in the Delivery of Antifungal Drugs

Pharmaceutics, Journal Year: 2023, Volume and Issue: 15(7), P. 1866 - 1866

Published: July 1, 2023

Nanosystems-based antifungal agents have emerged as an effective strategy to address issues related drug resistance, release, and toxicity. Among the diverse materials employed for delivery, polymers, including polysaccharides, proteins, polyesters, gained significant attention due their versatility. Considering complex nature of fungal infections varying sites, it is crucial researchers carefully select appropriate polymers based on specific scenarios when designing agent delivery nanosystems. This review provides overview various types nanoparticles used in systems, with a particular emphasis used. The focuses application systems release behavior these systems. Furthermore, summarizes critical physical properties relevant information utilized polymer nanomedicine briefly discusses prospects

Language: Английский

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Extraction of proteinaceous components and biominerals from cold water fish fileting side streams: a review

Frontiers in Sustainable Food Systems, Journal Year: 2024, Volume and Issue: 7

Published: Jan. 9, 2024

Fileting is a popular form of processing methods and in addition to being sold fresh or frozen, filets are used for preparation products battered breaded filets. This generates considerable amount side streams like skin, frames, cut-offs which forms around 30–70% the total body weight. The European Waste Framework Directive 2008 recent amendments [EU WFD (2018/851)] stipulates comprehensive regulations manufacturers must follow while handling generated during processing. demands detailed compilation information regarding yield, classification valorization potential associated with fileting operations cold-water finfishes. rich source proteins including structural collagen biominerals such as hydroxyapatite find multiple application food pharmaceutical industry. Previously, recovery these components was performed by extensive chemical treatment acids bases, subsequent washing steps. Nowadays, green extraction methods, defined technologies reduced energy consumption, should be considered achieve shift Nevertheless, industrial upscaling refinement isolated compounds further evaluated improved order industry using side-stream derived ingredients. Moreover, legislations well national international evaluated. Even though number articles recently available seafood stream valorization, this review focus on predominantly from cold water fish species also discusses sustainable included process.

Language: Английский

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Chitosan-Based Hierarchical Scaffolds Crosslinked with Genipin

Journal of Composites Science, Journal Year: 2024, Volume and Issue: 8(3), P. 85 - 85

Published: Feb. 24, 2024

Osteochondral defects present significant challenges for effective tissue regeneration due to the complex composition of bone and cartilage. To address this challenge, study presents fabrication hierarchical scaffolds combining chitosan/β-tricalcium phosphate (β-TCP) simulate a bone-like layer, interconnected with silk fibroin layer mimic cartilage, thus replicating cartilage-like native osteochondral architecture. The were produced by freeze-drying then crosslinking genipin. They have degree up 24%, which promotes structural rearrangement improved connection between different layers. Micro-CT analysis demonstrated that structures distinct porosity values on their top (up 84%), interface 65%), bottom 77%) are dependent concentration β-tricalcium used. Both layers confirmed be clearly defined distribution components throughout constructs, showing adequate mechanical properties biomedical use. exhibited lower weight loss 7%, 15 days) after enzymatic degradation combined effects genipin β-TCP incorporation. In vitro studies showed constructs supported ATDC5 chondrocyte-like cells MC3T3 osteoblast-like in duo culture conditions, providing suitable environment cell adhesion proliferation 14 days. Overall, physicochemical biological results developed phosphate/silk bilayered suggest they may potential candidates strategies.

Language: Английский

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The Phenomenon of Marine Bioprospecting

Biology Bulletin Reviews, Journal Year: 2024, Volume and Issue: 14(1), P. 115 - 132

Published: Feb. 1, 2024

Language: Английский

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Evaluation of the efficiency of sorbents for accidental oil spill response in the Arctic waters

Journal of Mining Institute, Journal Year: 2023, Volume and Issue: Online first

Published: March 23, 2023

The development and operation of new oil fields on the Arctic shelf increases risks spills, which require use spill response tools materials that are efficient in harsh climatic conditions. question actual efficiency sorbents for reducing level pollution conditions subarctic waters is relevant. work aimed at a comparative study mineral organic origin used by coastal enterprises Kola Bay as well sorbent based chitin model systems simulating real sea waters. characteristics sorption agents were determined applying ASTM F716-18 procedure. Sorption capacity was evaluated respect ARCO grade oil, diesel fuel marine oil. estimated “sea water – oil” temperature corresponding to average annual surface Barents Sea. Actual data commercial “Lessorb”, “Novosorb”, vermiculite relation potential pollutants obtained. dynamics saturation with products –0.5 (±1) 10 °С determined. It shown higher concentration column (in presence an film surface) four times than low temperature. Kinetic dependences obtained describe content near-surface layer studied 5 °C, A method proposed evaluating from values regression coefficients characterizing dependence character duration its action.

Language: Английский

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