Marine Invertebrate Antimicrobial Peptides and Their Potential as Novel Peptide Antibiotics

Marine Drugs, Journal Year: 2023, Volume and Issue: 21(10), P. 503 - 503

Published: Sept. 23, 2023

Marine invertebrates constantly interact with a wide range of microorganisms in their aquatic environment and possess an effective defense system that has enabled existence for millions years. Their lack acquired immunity sets marine apart from other animals. Invertebrates could rely on innate immunity, providing the first line defense, survival, thriving. The immune includes various biologically active compounds, specifically, antimicrobial peptides. Nowadays, there is revive interest these peptides due to urgent need discover novel drugs against antibiotic-resistant bacterial strains, pressing global concern modern healthcare. Modern technologies offer extensive possibilities development innovative based which can act bacteria, fungi, protozoa, viruses. This review focuses structural peculiarities, biological functions, gene expression, biosynthesis, mechanisms action, regulatory activities, prospects therapeutic use derived invertebrates.

Language: Английский

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Novel Insights into the Nobilamide Family from a Deep-Sea Bacillus: Chemical Diversity, Biosynthesis and Antimicrobial Activity Towards Multidrug-Resistant Bacteria

Marine Drugs, Journal Year: 2025, Volume and Issue: 23(1), P. 41 - 41

Published: Jan. 14, 2025

With rising concerns about antimicrobial resistance, the identification of new lead compounds to target multidrug-resistant bacteria is essential. This study employed a fast miniaturized screening simultaneously cultivate and evaluate 300 marine strains for biosurfactant antibacterial activities, leading selection deep-sea Bacillus halotolerans BCP32. The integration tandem mass spectrometry molecular networking bioassay-guided fractionation unveiled this strain as prolific factory surfactins nobilamides. Particularly, 84 nobilamide congeners were identified in bacterial exometabolome, 71 them being novel metabolites. Among these, four major isolated, including known TL-119 I, well two nobilamides T1 S1. S1 exhibited potent antibiotic activity against various Staphylococcus other Gram-positive pathogens, foodborne pathogen Listeria monocytogenes. Finally, silico analysis BCP32 genome revealed biosynthesis be directed by previously unknown heptamodular nonribosomal peptide synthetase.

Language: Английский

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Marine bioactive peptides with anticancer potential, a narrative review

International Journal of Biochemistry and Molecular Biology, Journal Year: 2024, Volume and Issue: 15(4), P. 118 - 126

Published: Jan. 1, 2024

In this paper, we explore marine bioactive peptides with anticancer potential sourced from various organisms, including tunicates, sea sponges, and mollusks. Peptides like Stylisin Papuamides have been isolated, identified, modified to enhance their activity, many advancing clinical trials due diverse biological activities, promising prospects in medicine. Enzymatic hydrolysis is a favored method for extracting proteins, particularly sponges known rich compounds. Compounds such as Jaspamide Homophymins exhibit potent cytotoxic activity against cancer cells, underscoring therapeutic potential. Additionally, ascidians mollusks, Aplidine Kahalalide F, demonstrate significant properties. This study also explores influencing apoptosis, microtubule dynamics, angiogenesis, providing insights into mechanisms treatment. While Neovastat mycothiazole target pathways, others patellamides act through unknown mechanisms, highlighting the intricate interactions of cells. Overall, marine-derived show promise valuable candidates developing novel therapies.

Language: Английский

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Dinuclear Titanium(III)-Catalyzed Radical-Type Kinetic Resolution of Epoxides for the Enantioselective Synthesis of cis-Glycidic Esters

Journal of the American Chemical Society, Journal Year: 2024, Volume and Issue: 146(19), P. 13546 - 13557

Published: May 1, 2024

Glycidic esters represent pivotal constituents in synthetic chemistry, offering enhanced versatility for tailoring toward a diverse array of molecular targets comparison with simple epoxides. While considerable progress has been made the asymmetric synthesis trans- and trisubstituted glycidic esters, achieving enantioselective preparation cis-glycidic remained long-standing challenge. Here, we demonstrate selectivity-predictable modular platform via novel dinuclear (salen)titanium(III)-catalyzed radical-type kinetic resolution (KR) approach. This radical KR protocol operates under mild conditions demonstrates wide substrate scope, facilitating alkyl- aryl-substituted high levels regioselectivity enantioselectivity, along hydroxy ester byproducts representing synthetically valuable motifs as well. study presents unique exploration applied to epoxides, effectively overcoming steric challenges inherent conventional nucleophilic-type methodologies typically employed epoxide chemistry.

Language: Английский

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Discovery of potent antiosteoporotic cyclic depsipeptides with an unusual nitrile hydroxy acid from Microascus croci

Bioorganic Chemistry, Journal Year: 2025, Volume and Issue: 155, P. 108133 - 108133

Published: Jan. 5, 2025

Language: Английский

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Isolation and Bioassay of Linear Veraguamides from a Marine Cyanobacterium (Okeania sp.)

Molecules, Journal Year: 2025, Volume and Issue: 30(3), P. 680 - 680

Published: Feb. 4, 2025

Marine cyanobacteria have gained momentum in recent years as a source of novel bioactive small molecules. This paper describes the structure elucidation and pharmacological evaluation two new (veraguamide O (1) veraguamide P (2)) one known C (3)) analogs isolated from cyanobacterial collection made Las Perlas Archipelago Panama. We hypothesized that these compounds would be cytotoxic cancer cell lines. The were screened against HEK-293, estrogen receptor positive (MCF-7), triple-negative breast (MDA-MB-231) cells well broad panel membrane-bound receptors. planar structures determined based on NMR MS data along with comparison to previously analogs. Phylogenetic analysis suggests it an Okeania sp., similar species cyanobacterium reported produce other veraguamides. Veraguamide shows no cytotoxicity (greater than 100 μM) ER-positive (MCF-7) 13 μM IC50 MDA-MB-231 TNBC cells. Interestingly, show affinity for sigma2/TMEM-97 receptor, making them potential leads development non-toxic sigma 2 targeting ligands.

Language: Английский

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A building blocks perspective on protein emergence and evolution

Current Opinion in Structural Biology, Journal Year: 2025, Volume and Issue: 91, P. 102996 - 102996

Published: Feb. 6, 2025

Language: Английский

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Investigation of Aged-related Metabolites in the Marine Polychaete (Marphysa moribidii) Using 1H NMR Metabolomics and LC-MS/MS Analysis

Pertanika journal of science & technology, Journal Year: 2025, Volume and Issue: 33(3)

Published: April 22, 2025

Marphysa moribidii (marine polychaetes) exhibits distinct age-related characteristics based on body width in the initial seven chaetigers, excluding parapodia or bristles that are classified into three age classes: Class Ι (body ranging from 3–5 mm), ΙΙ (6–8 and ΙΙΙ (9–11 mm). Despite its potential, exploration of metabolites marine worms, particularly through metabolomics, remains limited. The aim this study is to identify metabolite profile depict metabolic pathways different classes M. utilising proton nuclear magnetic resonance spectroscopy (1H NMR) metabolomics liquid chromatography with tandem mass spectrometry (LC-MS/MS) analysis. A total 35 were identified using 1H NMR including amino acids, carbohydrates, fatty glycerol, nitrogenous compounds, organic vitamins. LC-MS/MS analysis also discovered 36 can be categorised phenolic acids. II emerged have highest concentration chemicals originating making it ideal for harvesting. Comparing profiles across groups could provide valuable insights physiological processes, dynamics, potential bioactive compounds present at various developmental stages.

Language: Английский

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Recent Advances in Marine-Derived Bioactives Towards Cancer Therapy

International Journal of Translational Medicine, Journal Year: 2024, Volume and Issue: 4(4), P. 740 - 781

Published: Dec. 6, 2024

The increase in cancer incidence recent years necessitates urgent exploration of novel and alternative sources natural bioactives for targeted therapy. Approximately 75% the Earth’s surface is covered by oceans, which are thought to harbor untapped physiologically active compounds with potential efficacy against cancer. Recently, a growing focus has been on isolating investigating bioactive derived from marine sources. Bioactive metabolites diverse chemical structures, isolated various species such as algae, mollusks, actinomycetes, demonstrate wide range cancers. To our knowledge, this one articles that reviewed papers application marine-derived This study aims showcase some most current developments therapy have identified

Language: Английский

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Modular, Atroposelective Total Synthesis of Micitide 982

Published: May 15, 2024

A modular, atroposelective total synthesis of micitide 982 (1) is reported. The feature this report the gram-scale C-H biarylation N-phthaloyl-L-alanine followed by Larock macrocyclization. This modular approach allowed construction a highly strained atrop-Tyr-Trp cross-linkage with unprecedented atropisomerism, as well first (1).

Language: Английский

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