Japanese Journal of Infectious Diseases,
Journal Year:
2024,
Volume and Issue:
unknown
Published: Oct. 30, 2024
The
aim
of
this
study
was
to
describe
the
clinical,
histopathological,
and
immunohistochemical
characteristics
MPX
offer
meaningful
insights
into
clinicopathology
MPX.
We
recruited
eight
men
who
had
sex
with
diagnosed
based
on
positive
results
from
Virus
(MPXV)-specific
polymerase
chain
reaction.
Skin
biopsies
were
obtained
four
selected
lesions,
including
typical
atypical
lesions.
Histopathological
examinations
solitary
ulceration
revealed
infiltrating
inflammatory
cells
predominantly
composed
plasma
lymphocytes,
forming
a
"sleeve"
around
superficial
vessels
dermis.
These
features
might
be
misinterpreted
as
indicative
cutaneous
syphilis
infection.
Meanwhile,
pustular
lesions
displayed
central
necrotic
epidermis
accompanied
by
perivascular
infiltrate
dominated
neutrophils,
well
ballooning
reticular
degeneration
keratinocytes.
Additionally,
multinucleated
keratinocytes
eosinophilic
cytoplasmic
inclusions
known
Guarnieri's
bodies
also
observed.
Importantly,
represented
pioneering
report
detection
MPXV
A29
A35
proteins
in
skin
distinguishing
it
previous
studies
that
focused
detecting
vaccinia
virus
protein.
anti-MPXV
antibody
exhibited
robust
staining
specifically
within
affected
both
adjacent
hair
follicles,
thereby
could
contribute
diagnosis
MPX,
especially
for
cases
Signal Transduction and Targeted Therapy,
Journal Year:
2023,
Volume and Issue:
8(1)
Published: Dec. 27, 2023
In
2022,
a
global
outbreak
of
Mpox
(formerly
monkeypox)
occurred
in
various
countries
across
Europe
and
America
rapidly
spread
to
more
than
100
regions.
The
World
Health
Organization
declared
the
be
public
health
emergency
international
concern
due
rapid
virus.
Consequently,
nations
intensified
their
efforts
explore
treatment
strategies
aimed
at
combating
infection
its
dissemination.
Nevertheless,
available
therapeutic
options
for
virus
remain
limited.
So
far,
only
few
numbers
antiviral
compounds
have
been
approved
by
regulatory
authorities.
Given
high
mutability
virus,
certain
mutant
strains
shown
resistance
existing
pharmaceutical
interventions.
This
highlights
urgent
need
develop
novel
drugs
that
can
combat
both
drug
potential
threat
bioterrorism.
Currently,
there
is
lack
comprehensive
literature
on
pathophysiology
Mpox.
To
address
this
issue,
we
conducted
review
covering
physiological
pathological
processes
infection,
summarizing
latest
progress
anti-Mpox
drugs.
Our
analysis
encompasses
currently
employed
clinical
settings,
as
well
newly
identified
small-molecule
antibody
displaying
efficacy
against
Furthermore,
gained
valuable
insights
from
process
development,
including
repurposing
drugs,
discovery
targets
driven
artificial
intelligence,
preclinical
development.
purpose
provide
readers
with
overview
current
knowledge
Small Structures,
Journal Year:
2025,
Volume and Issue:
unknown
Published: Feb. 19, 2025
To
effectively
address
crisis
emergence
of
new
virus
such
as
monkeypox,
a
collective
and
collaborative
effort
between
scientists,
engineers,
innovators,
artists
from
all
ages,
regions,
diverse
fields
is
required.
This
review
explores
holistic
approach
to
addressing
the
monkeypox
by
integrating
nanobiosensors,
artificial
intelligence,
visual
arts,
humanities,
social
sciences.
Traditional
diagnostic
methods
are
often
limited
time,
accessibility,
accuracy,
but
advancement
point‐of‐care
smart
nanobiosensors
offers
promising
shift
toward
rapid,
precise,
accessible
diagnostics.
They
enhance
ability
screen,
diagnose,
monitor
infections
efficiently,
contributing
better
disease
management.
Beyond
technological
innovation,
essential
role
sciences
in
fostering
public
engagement,
understanding,
acceptance
tools
emphasized.
Visual
arts
can
illustrate
scientific
concepts,
making
them
more
relatable,
while
storytelling
through
various
media
reduce
stigma
promote
preventive
measures.
Social
provide
insights
into
cultural
attitudes,
behaviors,
health
challenges,
ensuring
that
solutions
integrated
communities.
By
combining
these
disciplines,
this
presents
comprehensive
framework
for
resilient
global
system
aligns
with
One
Health
principles,
emphasizing
interconnectedness
human,
animal,
environmental
health.
Viruses,
Journal Year:
2024,
Volume and Issue:
16(2), P. 237 - 237
Published: Feb. 2, 2024
Middle
East
respiratory
syndrome
coronavirus
(MERS-CoV)
is
a
zoonotic
virus
with
high
contagion
and
mortality
rates.
Heparan
sulfate
proteoglycans
(HSPGs)
are
ubiquitously
expressed
on
the
surface
of
mammalian
cells.
Owing
to
its
negatively
charged
property,
heparan
(HS)
host
cells
used
by
many
viruses
as
cofactor
facilitate
viral
attachment
initiate
cellular
entry.
Therefore,
inhibition
interaction
between
HS
could
be
promising
target
inhibit
infection.
In
current
study,
receptor-binding
domain
(RBD)
MERS-CoV
heparin
was
exploited
assess
inhibitory
activity
various
sulfated
glycans
such
glycosaminoglycans,
marine-sourced
(sulfated
fucans,
fucosylated
chondroitin
sulfates,
fucoidans,
rhamnan
sulfate),
pentosan
polysulfate,
mucopolysaccharide
using
Surface
Plasmon
Resonance.
We
believe
this
study
provides
valuable
insights
for
development
glycan-based
inhibitors
potential
antiviral
agents.
SCRIPTA MEDICA,
Journal Year:
2025,
Volume and Issue:
56(1), P. 185 - 197
Published: Jan. 1, 2025
Monkeypox
virus
(MPXV)
is
a
close
relative
of
the
Variola
(smallpox)
virus,
which
was
formerly
prevalent
throughout
West
and
Central
Africa.
Nonetheless,
instances
have
lately
been
verified
outside
Africa
in
several
nonendemic
nations.
Considering
COVID-19
pandemic,
World
Health
Organization
(WHO)
defined
recent
monkeypox
spread
health
emergency
for
public
global
significance
on
23
July
2022.
This
worldwide
community
may
be
danger
because
increased
number
confirmed
cases.
The
(MPXV),
etiologic
agent,
isolated
from
diseased
monkeys
1959,
its
pathogenicity
humans
first
documented
1970s,
primarily
Western
African
endemic
countries.
But
2022,
this
disease
shows
extreme
return
at
never-before-seen
rate,
raising
concerns
about
communicative
expansion
non-endemic
areas
potential
human-to-human
transmission.
Healthcare
professionals,
regulators
general
people
around
world
must
possess
substantial
expertise
such
relatively
unknown
viral
diseases
to
mitigate
situation.
Here,
thorough
current
pathogenesis
overview,
epidemiology
clinical
characteristics,
along
with
therapy
presented.
review
also
covers
future
research
fields,
vaccine
advancements
preventive
control
methods
reemerging
that
currently
recognised
as
crisis
health.
MedComm,
Journal Year:
2024,
Volume and Issue:
5(8)
Published: Aug. 1, 2024
Abstract
A
global
outbreak
of
monkeypox
(mpox)
caused
by
the
mpox
virus
(MPXV)
has
posed
a
serious
threat
to
public
health
worldwide,
thus
calling
for
urgent
development
antivirals
and
vaccines
curb
its
further
spread.
In
this
study,
we
screened
41
anhydride‐modified
proteins
found
that
3‐hydroxyphthalic
β‐lactoglobulin
(3HP‐β‐LG),
clinically
used
anti‐HPV
agent,
was
highly
effective
in
inhibiting
infection
vaccinia
Tiantan
strain
(VACV‐VTT)
MPXV.
Mechanistic
studies
demonstrated
3HP‐β‐LG
bound
virus,
not
host
cell,
targeting
early
stage
entry,
possibly
through
interaction
between
amino
acids
with
negatively
charges
key
positive
target
region
A29L,
surface
protein
synergistic
effect
observed
when
combined
tecovirimat,
small‐molecule
antiviral
drug
approved
United
States
Food
Drug
Administration
European
Medicine
Agency
treatment
smallpox
mpox.
Because
proven
safety
stability,
shows
promise
as
prophylactic
agent
prevent
sexual
transmission
