Gut microbiota, immune cells, and chronic sinusitis: A Mendelian randomization analysis DOI Creative Commons
Junwei Huang, Xiao Fang Zhu,

Junxia Yao

et al.

Medicine, Journal Year: 2025, Volume and Issue: 104(3), P. e41093 - e41093

Published: Jan. 17, 2025

Allergic rhinitis (AR) is a common allergic inflammatory disease that affects the upper respiratory tract. Although previous research suggests potential association between gut microbiota alterations and AR, causal relationship remains unclear. This study employs Mendelian randomization (MR) to reduce confounding factors reverse causality. By using genetic variants as instrumental variables, MR approach aims provide more reliable evidence of microbiota, immune-related antibodies, AR. utilized large-scale genome-wide data from FINRISK 2002 cohort UK Biobank systematically investigate relationships antibody immune responses, AR through 2-sample approach. We applied inverse variance weighting method assess mediating role responses in interaction analysis identified 17 microbiomes significantly associated with chronic rhinosinusitis (CRS) risk. Specifically, increased abundances CAG-884 UBA1407 species were linked higher CRS risk, while greater levels Atopobiaceae Bacteroides thetaiotaomicron reduced In addition, 29 cell types correlated CRS, 12 found increase it. Notably, indirectly influenced risk by affecting proportion TD double negative (CD4−CD8−) % T cells, effect ratio 36.4%. Our findings confirm cells relation underscoring this interaction.

Language: Английский

Complete Genome Sequencing, Annotation, and Mutational Profiling of the Novel Clade I Human Mpox Virus, Kamituga Strain DOI Creative Commons

Leandre Murhula Masirika,

Anuj Kumar,

Mansi Dutt

et al.

The Journal of Infection in Developing Countries, Journal Year: 2024, Volume and Issue: 18(04), P. 600 - 608

Published: April 30, 2024

Introduction: Human Mpox (formerly monkeypox) infection is an emerging zoonotic disease caused by the virus (MPXV). We describe complete genome annotation, phylogeny, and mutational profile of a novel, sustained Clade I outbreak in city Kamituga Eastern Democratic Republic Congo (DRC). Methodology: A cross-sectional, observational, cohort study was performed among patients all ages admitted to Hospital with symptoms between late September 2023 January 2024. DNA isolated from swabbed lesions sequenced followed phylogenetic analysis, profiling. Results: ongoing Kamituga, South Kivu Province, Congo. Whole-genome sequencing viral RNA samples revealed, on average, 201.5 snps, 28 insertions, 81 deletions, 2 indels, 312.5 total variants, 158.3 amino acid changes, 81.66 intergenic 72.16 synonymous mutations, 106 missense 41.16 frameshift 3.33 inframe deletions across six samples. By assigning mutations at proteome level for MPXV sequences, we observed that seven proteins, namely, C9L (OPG047), I4L (OPG080), L6R (OPG105), A17L (OPG143), A25R (OPG151), A28L (OPG153), B21R (OPG210) have emerged as hot spot based consensuses acids substitutions. Based outcome found deletion D14L (OPG032) gene Following analysis whole assembly, determined this cluster infections genetically distinct previously reported outbreaks, thus propose represents novel subgroup (subgroup VI) MPXV. Conclusions: Here report first time. This presents oubtreaks, suggesting (we term VI). These findings underscore need vigilance continued threats endemic regions.

Language: Английский

Citations

20
Dynamics of Mpox in an HIV endemic community: A mathematical modelling approach DOI Creative Commons
Andrew Omame, Sarafa A. Iyaniwura, Qing Han

et al.

Mathematical Biosciences & Engineering, Journal Year: 2025, Volume and Issue: 22(2), P. 225 - 259

Published: Jan. 1, 2025

<p>During the 2022 monkeypox (Mpox) outbreak in non-endemic countries, sexual transmission was identified as dominant mode of transmission, and particularly affected community men who have sex with (MSM). This experienced highest incidence Mpox cases, exacerbating public health burden they already face due to disproportionate impact HIV. Given simultaneous spread HIV within MSM community, it is crucial understand how these diseases interact. Specifically, since endemic this population, understanding its influence on control essential. In study, we analyze a mechanistic mathematical model explore potential dynamics community. The considered work incorporates two diseases, including antiretroviral therapy (ART) for We assumed that population at onset outbreak. Through our analysis, derived invasion reproduction number an HIV-endemic setting established existence local asymptotic stability Mpox-free equilibrium under conditions. Furthermore, demonstrated Mpox-endemic regime. Notably, findings revealed exhibits backward bifurcation, phenomenon may not occurred absence population. significance results presence could hinder efforts Mpox, allowing disease become even when below one. Additionally, found might be more challenging scenarios where increases susceptibility Mpox. Finally, consistent previous studies, analysis confirms reducing contact can effective controlling community.</p>

Language: Английский

Citations

2
A critical review of mpox outbreaks, risk factors, and prevention efforts in Africa: lessons learned and evolving practices DOI Creative Commons
Godfrey Musuka, Enos Moyo, Nigel Tungwarara

et al.

IJID Regions, Journal Year: 2024, Volume and Issue: 12, P. 100402 - 100402

Published: July 6, 2024

In recent years, mpox, a zoonotic disease caused by the mpox virus, has transcended its primary association with Central and West Africa, emerging as global public health concern. The virus poses substantial threat, particularly, to vulnerable demographics such young children individuals compromised immune systems. This critical literature review aimed comprehensively evaluate burden, risk factors, current management strategies associated in Africa.

Language: Английский

Citations

10
Evolutionary trajectory and characteristics of Mpox virus in 2023 based on a large-scale genomic surveillance in Shenzhen, China DOI Creative Commons
Shengjie Zhang, Fuxiang Wang, Yun Peng

et al.

Nature Communications, Journal Year: 2024, Volume and Issue: 15(1)

Published: Aug. 28, 2024

The global epidemic of Mpox virus (MPXV) continues, and a local outbreak has occurred in Shenzhen city since June 2023. Herein, the evolutionary trajectory characteristics MPXV 2023 were analyzed using 92 sequences from available genomes GISAID GenBank databases. Phylogenetic tracing MPXVs suggests that may have multiple sources importation, two main transmission chains been established. combination phylogenetic relationships, epidemiological features, mutation supports emergence new lineage C.1.1. Together with B.1 diverging A.1 lineage, C.1.1 C.1 serve as another significant events MPXV. Moreover, increasing apolipoprotein B mRNA-editing catalytic polypeptide-like 3 (APOBEC3) related mutations, higher rate missense less mutations non-coding regions shown during evolution. Host regulation proteins accumulated considerable amino acid lineage-defining APOBEC3-related disrupts N2L gene encoding viral innate immune modulator identified lineage. In summary, our study provides compelling evidence for ongoing evolution specific features.

Language: Английский

Citations

9
Mpox Virus as a Global Public Health Emergency: A Scoping Review DOI Creative Commons
Sathish Sankar, Pachamuthu Balakrishnan, Yean K. Yong

et al.

Canadian Journal of Infectious Diseases and Medical Microbiology, Journal Year: 2025, Volume and Issue: 2025(1)

Published: Jan. 1, 2025

The monkeypox (Mpox) virus has emerged as a global public health emergency of international concern recently. that was endemic in West and Central Africa now been reported with chains transmission to several countries. A scoping review carried out from the relevant literature available PubMed, Scopus Web Science. This comprehensive analysis describes epidemiology, pathogenesis, clinical manifestations, complications including secondary bacterial infections, diagnosis, treatment vaccination. article underscores significance key viral immune mediators infection discusses updated recommendations on therapeutic strategies

Language: Английский

Citations

1
Mpox: emergence following smallpox eradication, ongoing outbreaks and strategies for prevention DOI
Amy E. Bryant,

Stanford T. Shulman

Current Opinion in Infectious Diseases, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 29, 2025

Purpose of review This focuses on the temporal relationship between discontinuation global smallpox eradication effort with rise mpox in Africa and worldwide. It also discusses 2022 clade II epidemic current 2024 I outbreak. Newer findings viral evolution pathogenesis, plus future strategies for disease prevention, are reviewed. Recent The association incidence World Health Organization's Global Smallpox Eradication Program (GSEP) is presented. discussed. data show that IIb monkeypox virus (MPXV)-2022 has novel genetic features supporting a greater propensity mutations may be responsible enhanced human-to-human transmissibility, increased severity accelerated evolution. In 2023, another outbreak began Africa, this time due to potentially more virulent MPXV Ib strains. remains ongoing cases have recently been reported elsewhere including United States Great Britain. Organization deemed public health emergency. Two vaccines approved prevention States; third vaccine an improved diagnostic test received WHO Emergency Use authorization. mRNA-based evolving orthopoxvirus infections Summary Vaccination prevent provides immunologic cross-protection against infection other members genus Orthopoxvirus , mpox. Discontinuation program 1980s subsequent waning herd immunity contributed multinational human infections. A second ongoing. gold standard however newer multiepitope development hold promise outbreaks.

Language: Английский

Citations

1
Establishment of an animal model for monkeypox virus infection in dormice DOI Creative Commons
Gaojie Song, Lingling Cheng, Jun Liu

et al.

Scientific Reports, Journal Year: 2025, Volume and Issue: 15(1)

Published: Feb. 3, 2025

This study aims to establish an animal model of monkeypox virus (MPXV) infection in dormice through intranasal inoculation. Male aged 4-5 months were selected as experimental subjects and administered different titers MPXV (103.5 PFU, 104.5 105.5 respectively) via nasal instillation. Within 14 days post-infection, clinical indicators such survival rate, body weight changes, respiratory status, mental state continuously monitored. Additionally, tissue samples from the lungs, liver, spleen, trachea each group collected on 5th 10th for titer detection, histopathological analysis was performed lung days. Dormice infected with exhibited typical symptoms appetite loss, continuous reduction, aggravated difficulties, accompanied by lethargy, chills, other manifestations similar human infection. Virological tests further confirmed distribution multiple vital organs dormice, including trachea, particularly significant pathological damage observed tissue. An successfully established inoculation a PFU MPXV, which can be used studying mechanism pharmacology MPXV.

Language: Английский

Citations

1
Plant-derived molecules in monkeypox management: insight and alternative therapeutic strategies DOI Creative Commons
Martin Ndayambaje, Emmanuel Munyeshyaka,

Olive Dieumerci

et al.

Beni-Suef University Journal of Basic and Applied Sciences, Journal Year: 2025, Volume and Issue: 14(1)

Published: Feb. 19, 2025

Abstract The WHO and CDC recently declared monkeypox virus (MPXV) a zoonotic disease known as (Mpox) Public Health Emergency of International Concern. According to the CDC, no treatment is specifically approved for Mpox infections. Medicinal plants are crucial in healthcare economic development, particularly low- middle-income countries. This review offers valuable insights into pathogenesis management through therapeutic approaches vaccination strategies using plant-based molecules. Core structural proteins necessary both viral entry immune response, including A29, H3L, L1R, involved MPXV. Potential targets vaccines include like A35R B6R, which essential propagation viruses. MPXV evades system by concealing its DNA, suppressing interferon limiting T NK cell activation, preventing apoptosis, complicating vaccine development. Antivirals (tecovirimat, brincidofovir) vaccinations (JYNNEOS, ACAM2000) manage Mpox. A recent study revealed early clinical trial results, indicating that antiviral drug tecovirimat, well-known conventional treatment, more effective than placebo against clade I type Research gaps, low effectiveness, availability challenges. novel perspective on combating global threat investigating alternative centered plant-derived compounds. Graphical

Language: Английский

Citations

1
Interdisciplinary Approach to Monkeypox Prevention: Integrating Nanobiosensors, Nanovaccines, Artificial Intelligence, Visual Arts, and Social Sciences DOI Creative Commons
Vishal Chaudhary,

Lucky Lucky,

Harsh Sable

et al.

Small Structures, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 19, 2025

To effectively address crisis emergence of new virus such as monkeypox, a collective and collaborative effort between scientists, engineers, innovators, artists from all ages, regions, diverse fields is required. This review explores holistic approach to addressing the monkeypox by integrating nanobiosensors, artificial intelligence, visual arts, humanities, social sciences. Traditional diagnostic methods are often limited time, accessibility, accuracy, but advancement point‐of‐care smart nanobiosensors offers promising shift toward rapid, precise, accessible diagnostics. They enhance ability screen, diagnose, monitor infections efficiently, contributing better disease management. Beyond technological innovation, essential role sciences in fostering public engagement, understanding, acceptance tools emphasized. Visual arts can illustrate scientific concepts, making them more relatable, while storytelling through various media reduce stigma promote preventive measures. Social provide insights into cultural attitudes, behaviors, health challenges, ensuring that solutions integrated communities. By combining these disciplines, this presents comprehensive framework for resilient global system aligns with One Health principles, emphasizing interconnectedness human, animal, environmental health.

Language: Английский

Citations

1
The Resurgence of Monkeypox: Epidemiology, Clinical Features, and Public Health Implications in the Post-Smallpox Eradication Era DOI Creative Commons
Parminder Singh, Sathvik Belagodu Sridhar, Javedh Shareef

et al.

New Microbes and New Infections, Journal Year: 2024, Volume and Issue: 62, P. 101487 - 101487

Published: Sept. 24, 2024

Language: Английский

Citations

8