International Journal of Oceanography & Aquaculture,
Journal Year:
2023,
Volume and Issue:
7(4), P. 1 - 4
Published: Jan. 1, 2023
Marine
microbes
are
defined
by
their
habitat
as
microorganisms
living
in
the
sea
or
ocean.
The
term
“marine
microbes”
includes
viruses,
protozoa
and
fungi.
This
microbial
life
constitutes
70%
To
90%
of
marine
biomass.
More
than
15000
bioactive
compounds
have
been
isolated
from
fungi,
other
organisms
used
anti-inflammatory,
anticancer
leads.
Among
marine,
bacteria
least
explored
ones.
actinobacteria
adapted
to
high
hydrostatic
pressure,
concentration
Sodium
Chloride,
low
organic
matter,
temperature.
phylum
is
a
Gram-positive,
nonmotile,
aerobic
bacteria.
Streptomyces
Actinomycetes
studied
largely
this
due
ability
produce
wide
array
extracellular
enzymes
secondary
metabolites.
Examples
active
include
Fijimycins,
etamycin
A,
Chlorinated
bisindole
pyrroles,
dynamics
A–E.
There
may
be
diverse
extremo
hidden
shadows
that
currently
unknown
and,
if
discovered,
open
up
interesting
new
methods
for
production
use
novel
antimicrobials.
In
pharmaceutical
research,
very
small
fraction
such
studied.
If
discovered
ingenious,
cost-effective
many
anti-microbials.
Biomolecules,
Journal Year:
2024,
Volume and Issue:
14(9), P. 1162 - 1162
Published: Sept. 16, 2024
Microbial
exopolysaccharides
(EPSs)
are
receiving
growing
interest
today,
owing
to
their
diversity
in
chemical
structure
and
source,
multiple
functions,
immense
potential
applications
many
food
non-food
industries.
Their
health-promoting
benefits
for
humans
deserve
particular
attention
because
of
various
biological
activities
physiological
functions.
The
aim
this
paper
is
provide
a
comprehensive
review
microbial
EPSs,
covering
(1)
biochemical
diversity,
including
composition,
biosynthesis,
bacterial
sources
belonging
mainly
lactic
acid
bacteria
(LAB)
or
probiotics;
(2)
technological
analytical
aspects,
especially
production
mode
characterization;
(3)
aspects
based
on
functions;
(4)
current
future
uses
medical
pharmaceutical
fields,
particularly
prebiotic,
anticancer,
immunobiotic
properties,
as
well
other
industrial
agricultural
sectors.
International Journal of Molecular Sciences,
Journal Year:
2023,
Volume and Issue:
24(13), P. 10980 - 10980
Published: July 1, 2023
Pellicle
biofilm-forming
bacteria
Bacillus
amyloliquefaciens
are
the
major
spoilage
microorganisms
of
soy
products.
Due
to
their
inherent
resistance
antibiotics
and
disinfectants,
pellicle
biofilms
formed
difficult
eliminate
represent
a
threat
food
safety.
Here,
we
assessed
linalool’s
ability
prevent
two
B.
strains.
The
minimum
biofilm
inhibitory
concentration
(MBIC)
linalool
against
DY1a
DY1b
was
4
μL/mL
8
μL/mL,
respectively.
MBIC
had
considerable
eradication
rate
77.15%
83.21%
on
strains,
Scanning
electron
microscopy
observations
revealed
that
less
wrinkly
thinner
medium
supplemented
with
1/2
1/4
linalool.
Also,
inhibited
cell
motility
production
extracellular
polysaccharides
proteins
matrix.
Furthermore,
exposure
reduced
surface
hydrophobicity,
zeta
potential,
auto-aggregation
amyloliquefaciens.
Molecular
docking
analysis
demonstrated
interacted
strongly
quorum-sensing
ComP
receptor
matrix
assembly
TasA
through
intermolecular
hydrogen
bonds,
hydrophobic
contacts,
van
der
Waals
forces
interacting
site
residues.
Overall,
our
findings
suggest
may
be
employed
as
potential
antibiofilm
agent
control
RSC Advances,
Journal Year:
2023,
Volume and Issue:
13(39), P. 27363 - 27384
Published: Jan. 1, 2023
The
current
trend
in
fighting
bacteria
is
attacking
the
virulence
and
quorum-sensing
(QS)
signals
that
control
bacterial
communication
factors,
especially
biofilm
formation.
This
study
reports
new
Schiff
bases
tetracyclic
rings
based
on
a
pyridine
pharmacophore
by
two
methods:
green
approach
using
CAN
conventional
method.
structure
of
designed
derivatives
was
confirmed
different
spectroscopies
(IR
1H/13C
NMR)
elemental
analysis.
exhibited
good
to
moderate
inhibition
zones
against
fungal
pathogens.
In
addition,
six
compounds
2a,b,
3a,b,
6a,b
displayed
potency
tested
pathogens
with
eligible
MIC
MBC
values
compared
standard
antimicrobial
agents.
Compound
2a
15.6
μg
mL-1
Gentamicin
(MIC
=
250
K.
pneumoniae),
while
compound
6b
super-potent
activity
P.
aeruginosa,
pneumoniae
62.5
125
mL-1,
as
well
31.25
mL-1),
respectively.
Surprisingly,
these
revealed
bactericidal
fungicidal
remarkable
anti-biofilm
could
significantly
reduce
formation
MRSA,
E.
coli,
C.
albicans.
Furthermore,
most
active
reduced
LasR
gene's
production
between
10-40%
at
1/8
MICs
untreated
aeruginosa.
Besides,
they
demonstrated
promising
safety
profile
Vero
cells
(normal
cell
lines)
IC50
ranging
(175.17
±
3.49
344.27
3.81
mL-1).
silico
ADMET
prediction
carried
out
results
be
used
oral
bioavailability
low
toxicity
when
administered
candidate
drug.
Finally,
molecular
docking
simulation
performed
inside
predicted
key
binding
interactions
responsible
for
corroborated
biological
results.
Langmuir,
Journal Year:
2025,
Volume and Issue:
unknown
Published: March 3, 2025
In
aquatic
environments,
conditioning
layers
play
a
crucial
role
in
modulating
the
adhesion
and
aggregation
of
planktonic
bacteria,
ultimately
facilitating
biofilm
formation
irreversible
onset
biofouling.
This
study
reports
construction
simplified
layer
using
extracellular
polymeric
substances
(EPS)
secreted
by
Bacillus
licheniformis
its
influence
on
adherence
behaviors
bacteria.
The
results
reveal
that
EPS
remarkably
inhibits
Staphylococcus
aureus
yet
promotes
Escherichia
coli.
surface
shows
flat
morphology
with
highest
height
approximately
12.9
nm.
alters
physicochemical
properties
substrate
materials
their
surfaces,
water
contact
angles
changing
from
61.23°
to
8.76°
zeta
potential
-1.0
-25.0
mV.
Despite
these
changes,
overall
effect
bacterial
was
found
be
minimal.
Further
investigation
two
main
components
EPS,
namely,
polysaccharides
bacitracin,
affect
behaviors.
Bacitracin
plays
predominant
inhibiting
attachment,
promote
coli
aggregation.
These
findings
would
give
inspiring
insight
into
developing
environmentally
friendly
efficient
biological
measures
for
combating
worldwide
persisting
Current Issues in Molecular Biology,
Journal Year:
2025,
Volume and Issue:
47(3), P. 175 - 175
Published: March 7, 2025
Marine-derived
biomaterials
are
emerging
as
promising
candidates
for
tissue
regeneration
due
to
their
sustainability,
biocompatibility,
bioactivity,
and
unique
chemical
structure.
This
review
provides
an
overview
of
different
marine-derived
inorganic
organic
materials,
such
calcium
carbonate,
magnesium
salts,
silica,
polysaccharides,
bioactive
peptides,
lipid-based
compounds,
effects
in
promoting
osteogenesis.
Specifically,
the
osteoinductive,
osteoconductive,
osteointegrative
activities
traditional
innovative
materials
that
influence
key
molecular
pathways
BMP/Smad
Wnt/β-catenin
signaling
underlying
bone
formation
will
be
evaluated.
also
prospects
approaches,
i.e.,
phage
display
technology,
optimize
peptides
targeted
regeneration.
In
context
sustainable
this
suggests
some
interesting
applications
unusual
able
overcome
limitations
conventional
ones
stimulate
cellular
by
activating
specific
pathways.
