bioRxiv (Cold Spring Harbor Laboratory),
Journal Year:
2024,
Volume and Issue:
unknown
Published: June 1, 2024
Abstract
The
role
of
foods
is
shifting
from
focusing
on
the
provision
energy
and
basic
nutrients
to
also
include
bioactive
compounds
that
prevent
development
chronic
age-related
diseases.
Microalgae
offer
a
source
nutritional
with
important
health
effects,
have
potential
for
production
health-promoting
products,
without
increasing
agricultural
land
use
negatively
impacting
environment.
Here
we
investigate
effects
microalgal
extracts
high
levels
colourless
carotenoid
phytoene.
Phytoene
widely
available
dietary
sources
can
be
detected
across
different
tissues
in
human
body.
However,
it
usually
regarded
as
precursor
synthesis
other
carotenoids,
rather
than
molecule.
We
utilised
model
organism
C.
elegans
show
phytoene-rich
Chlorella
sorokiniana
Dunaliella
bardawil
anti-ageing
properties.
protect
against
oxidative
damage
amyloid-β
42
proteotoxicity
(a
major
pathology
Alzheimer’s
disease),
extends
lifespan.
pure
phytoene
has
these
suggesting
molecule
positive
ageing
longevity.
Pharmaceuticals,
Journal Year:
2024,
Volume and Issue:
17(7), P. 960 - 960
Published: July 18, 2024
Fucoxanthin,
a
carotenoid
widely
studied
in
marine
microalgae,
is
at
the
heart
of
scientific
research
because
its
promising
bioactive
properties
for
human
health.
Its
unique
chemical
structure
and
specific
biosynthesis,
characterized
by
complex
enzymatic
conversion
organisms,
have
been
examined
depth
this
review.
The
antioxidant,
anti-inflammatory,
anti-cancer
activities
fucoxanthin
rigorously
supported
data
from
vitro
vivo
experiments
early
clinical
trials.
Additionally,
review
explores
emerging
strategies
to
optimize
stability
efficacy
fucoxanthin,
aiming
increase
solubility
bioavailability
enhance
therapeutic
applications.
However,
despite
these
potential
benefits,
challenges
persist,
such
as
limited
technological
obstacles
hindering
large-scale
production.
medical
exploitation
thus
requires
an
innovative
approach
continuous
optimization
overcome
barriers.
Although
further
needed
refine
use,
offers
development
natural
therapies
aimed
improving
By
integrating
knowledge
about
mechanisms
action,
beneficial
effects,
future
studies
could
open
new
perspectives
treatment
cancer
other
chronic
diseases.
Heliyon,
Journal Year:
2024,
Volume and Issue:
10(17), P. e36832 - e36832
Published: Aug. 24, 2024
Important
marine
microorganisms
are
resources
of
renewable
energy
that
may
face
global
population
growth
and
needs.
The
application
biomass
metabolites,
such
as
carotenoids
their
derivatives,
solve
some
agro-food
health
problems.
Herein,
a
new
halophilic
Archaea
Halobacterium
salinarum
producing
carotenoid
was
screened
from
Tunisian
solar
Saltworks
(Sfax).
identification
the
pigments
carried
out
using
HPLC-MS/MS.
predominant
produced
by
this
were
bacterioruberin
its
derivatives
production
found
to
be
21.51
mg/mL.
Moreover,
data
revealed
extract
exhibited
high
antioxidant
activity
across
four
oxidizing
assays.
present
results
suggested
extracted
interesting
sources
natural
antioxidants
for
future
innovative
applications
in
agro-food,
cosmetic
fields.Graphical
abstract
Seaweeds,
also
known
as
marine
algae,
have
gained
attention
a
promising
source
of
bioactive
compounds
with
potential
applications
in
drug
discovery.
This
review
explores
the
emerging
field
seaweed-based
discovery
and
highlights
diverse
range
found
seaweeds,
including
polysaccharides,
phlorotannins,
pigments,
peptides.
These
exhibit
various
pharmacological
activities
such
antioxidant,
anti-inflammatory,
antimicrobial,
antiviral,
anticancer
effects.
Seaweeds
demonstrated
particular
promise
areas
cancer
research,
certain
species
showing
potent
antitumor
properties.
Additionally,
their
neuroprotective
has
captured
scientific
interest
treatment
chronic
diseases
neurodegenerative
disorders.
However,
challenges
related
to
compound
identification,
extraction
methods,
scalability
seaweed
cultivation,
understanding
mechanisms
action
still
need
be
addressed.
As
researchers
employ
advanced
technologies
dive
deeper
into
chemical
composition
untapped
these
organisms
awaits
further
exploration
holds
significant
for
future
therapeutic
advancements.
Molecules,
Journal Year:
2024,
Volume and Issue:
29(6), P. 1228 - 1228
Published: March 9, 2024
Carotenoids
are
hydrophobic
pigments
produced
exclusively
by
plants,
fungi,
and
specific
microbes.
Microalgae
well
suited
for
the
production
of
valuable
carotenoids
due
to
their
rapid
growth,
efficient
isoprenoid
pathway,
ability
store
these
compounds
within
cells.
The
possible
markets
bio-products
range
from
feed
additives
in
aquaculture
agriculture
pharmaceutical
uses.
microalgae
is
affected
several
environmental
conditions,
which
can
be
utilized
enhance
productivity.
current
study
focused
on
optimizing
extraction
parameters
(time,
temperature,
number)
maximize
yield
carotenoids.
Additionally,
impact
various
nitrogen
sources
(ammonia,
nitrate,
nitrite,
urea)
lutein
loroxanthin
Scenedesmus
obliquus
was
examined.
To
isolate
carotenoids,
0.20
g
biomass
added
CaCO3
10.0
mL
ethanol
solution
containing
0.01%
(w/v)
pyrogallol.
Subsequently,
performed
using
an
ultrasonic
bath
a
duration
10
min
at
temperature
30
°C.
This
followed
four-hour
saponification
process
10%
methanolic
KOH
solution.
concentration
measured
HPLC–DAD
446
nm,
with
flow
rate
1.0
mL/min
Waters
YMC
C30
Carotenoid
column
(4.6
×
250
mm,
5
μm).
confirmation
after
isolation
preparative
chromatography
achieved
liquid
chromatography–tandem
mass
spectrometry
(LC–MS/MS)
atmospheric
pressure
chemical
ionization
(APCI)
probe
UV–vis
spectroscopy.
In
summary,
S.
shows
significant
promise
large-scale
loroxanthin.
findings
this
provide
strong
support
application
technology
other
species.
bioRxiv (Cold Spring Harbor Laboratory),
Journal Year:
2024,
Volume and Issue:
unknown
Published: June 1, 2024
Abstract
The
role
of
foods
is
shifting
from
focusing
on
the
provision
energy
and
basic
nutrients
to
also
include
bioactive
compounds
that
prevent
development
chronic
age-related
diseases.
Microalgae
offer
a
source
nutritional
with
important
health
effects,
have
potential
for
production
health-promoting
products,
without
increasing
agricultural
land
use
negatively
impacting
environment.
Here
we
investigate
effects
microalgal
extracts
high
levels
colourless
carotenoid
phytoene.
Phytoene
widely
available
dietary
sources
can
be
detected
across
different
tissues
in
human
body.
However,
it
usually
regarded
as
precursor
synthesis
other
carotenoids,
rather
than
molecule.
We
utilised
model
organism
C.
elegans
show
phytoene-rich
Chlorella
sorokiniana
Dunaliella
bardawil
anti-ageing
properties.
protect
against
oxidative
damage
amyloid-β
42
proteotoxicity
(a
major
pathology
Alzheimer’s
disease),
extends
lifespan.
pure
phytoene
has
these
suggesting
molecule
positive
ageing
longevity.
