Pharmaceutics, Journal Year: 2024, Volume and Issue: 16(1), P. 69 - 69
Published: Jan. 2, 2024
The development of a pharmaceutical product consists giving drug an optimal dosage form (a certain state aggregation, consistency, structural, mechanical, physicochemical, and functional properties), which ensure stability, the possibility accurate dosage, required pharmacological effect, ease administration with minimal side effects [...].
Language: Английский
International Journal of Biological Macromolecules, Journal Year: 2024, Volume and Issue: 268, P. 131853 - 131853
Published: April 26, 2024
Language: Английский
Citations
14
International Journal of Biological Macromolecules, Journal Year: 2025, Volume and Issue: 299, P. 140127 - 140127
Published: Jan. 21, 2025
Language: Английский
Citations
1
Molecular Pharmaceutics, Journal Year: 2025, Volume and Issue: unknown
Published: Jan. 27, 2025
The development of malignant tumors is a complex process that involves the tumor microenvironment (TME). An immunosuppressive TME presents significant challenges to current cancer therapies, serving as key mechanism through which cells evade immune detection and play crucial role in progression metastasis. This impedes optimal effectiveness immunotherapeutic approaches, including cytokines, checkpoint inhibitors, vaccines. Tumor-associated macrophages (TAMs), major component tumor-infiltrating cells, exhibit dual functionalities: M1-like TAMs suppress tumorigenesis, while M2-like promote growth Consequently, various nanocarriers aimed at polarizing phenotypes distinct mechanisms has emerged promising therapeutic strategy inhibit escape enhance antitumor responses. Review covers origin types TAMs, common pathways regulating macrophage polarization, progression, strategies targeting aiming provide comprehensive understanding guidance for future research clinical applications.
Language: Английский
Citations
1
Comprehensive Reviews in Food Science and Food Safety, Journal Year: 2024, Volume and Issue: 23(4)
Published: June 25, 2024
Abstract Seaweed polysaccharides are natural biomacromolecules with unique physicochemical properties (e.g., good gelling, emulsifying, and film‐forming properties) diverse biological activities anticoagulant, antioxidant, immunoregulatory, antitumor effects). Furthermore, they nontoxic, biocompatible biodegradable, abundant in resources. Therefore, have been widely utilized food, cosmetics, pharmaceutical industries. However, their bioactivities sometimes not satisfactory for some purposes. Modification of can impart the amphiphilicity new functions to biopolymers change structure conformation, thus effectively improving functional so as meet requirement targeted applications. This review outlined modification methods representative red algae (carrageenan agar), brown (fucoidan, alginate, laminaran), green (ulvan) that potential food applications, including etherification, esterification, degradation, sulfation, phosphorylation, selenylation, on. The improved modified seaweed applications also summarized.
Language: Английский
Citations
8
Journal of Functional Foods, Journal Year: 2024, Volume and Issue: 119, P. 106303 - 106303
Published: June 15, 2024
Brown seaweed polysaccharides (BSPs) are potential alternative sources of bioactive compounds. The food and pharmaceutical industries have a great interest in BSPs because their various bioactivities, such as anticancer, antioxidant, immunomodulatory activities. Studies demonstrated that the bioactivities significantly influenced by structural characteristics chemical constitution; but, specific conformational relationships complex required further study. However, systematic reviews biological activities mechanisms action currently inadequate. Thus, this paper summarizes recent studies on physicochemical features, characterization methods, activities, related from different sources. Based these findings, future prospects include following three aspects. More advanced research techniques need to be developed identify exact main branch structure BSPs; in-depth detailed needed elucidate between clinical trials should conducted verify effectiveness prevention treatment diseases. information provided here aims offer theoretical foundation for properties, mechanism action, applications well as, increase economic value extend application range.
Language: Английский
Citations
5
Physics of Fluids, Journal Year: 2025, Volume and Issue: 37(1)
Published: Jan. 1, 2025
The linear and nonlinear rheological behavior of alginate/Ca2+ gels made through slow solubilization CaCO3 using gluconic acid-δ-lactone was studied. Rheological modulus follows a power law at the critical point; exponents (n = 0.60–0.65) decrease slightly, increasing Ca2+ ions. These values agree with those reported in literature similar mannuronic/guluronic residue ratios total polymer concentration. strain-hardening matured investigated large amplitude oscillatory shear. Blatz–Sharda–Tschoegl scaling model used to estimate their fractal dimension, whose were 1.23–1.31; dimension is not sensible Lissajous–Bowditch curves show higher nonlinearity constitute fingerprint these gels. geometrical decomposition intracycle strain terms thickening stiffening shows weak formation temporary network junctions during breaking process due convexity curves. Diffusion wave spectroscopy determine mean square displacement microspheres embedded solution exhibiting subdiffusive process, two slopes: m ∼ 0.3 short times 1 long times. diffusive region section decreases as gelation progresses disappears when are formed. Gelation time estimated identify terminal relaxation time, evolution almost same exponential curve for high concentration many multiple egg-box structures. After 24 h gelation, an apparent plateau, indicating important particle confinement.
Language: Английский
Citations
0
Fermentation, Journal Year: 2025, Volume and Issue: 11(1), P. 34 - 34
Published: Jan. 16, 2025
Algin is the most abundant substance in alga. Alginate lyase degrades algin and produces monosaccharides, disaccharides, oligosaccharides, which are widely used bioenergy, food, medicine, other fields. In this study, one Exiguobacterium strain isolated from rotten kelp exhibited a robust ability to degrade The sequencing of revealed presence three different types alginate lyase. Nevertheless, expression genes Escherichia coli lower activity compared that original strain. After codon optimization, gene with highest was successfully expressed Pichia pastoris produce recombinant EbAlg664. enzyme 5 L high-density fermentation reached 1306 U/mg protein, 3.9 times results enzymatic analysis optimal temperature pH range EbAlg664 were narrower Additionally, Cu2+ Co2+ enhanced activity, whereas Mg2+ Fe3+ inhibitory effects on study offers theoretical practical foundation for industrial-scale production engineered high activity.
Language: Английский
Citations
0
European Journal of General Dentistry, Journal Year: 2025, Volume and Issue: unknown
Published: Jan. 20, 2025
Abstract Objectives Dental alginate is one of the impression materials used in dentistry to reproduce intra- and extraoral structures. Alginate a quite affordable easy-to-use material, but because its lower tear strength, it still has limitations terms accuracy. One way increase strength by adding fillers. Polymethyl methacrylate (PMMA) an example organic filler that can be utilized as alternative reinforcement could effectively dimensional stability. Thus, purpose this study was evaluate alginate's following addition PMMA Materials Methods This experimental research consisted four group samples. Sample A served controls, while sample B included treated samples with varying additions 3wt% (B1), 5wt% (B2), 7wt% (B3). Each had five The test conducted according ISO Standard 21563:2021 using Universal Testing Machine, which followed characterization Scanning Electron Microscope (SEM) Fourier Transform Infra-Red (FTIR) spectroscopy. Statistical Analysis results were then evaluated One-Way Variance (ANOVA) Tukey's (p < 0.05). Results control (A) 0.540 N/mm. Meanwhile, strengths 0.612 N/mm 0.663 0.596 There difference between fillers These are supported SEM FTIR related physical closure or blocking porous structure slight changes functional group. Conclusion dental provides increases. impact accuracy especially when material quickly removed from oral Additional investigation may assess biocompatibility attributes further.
Language: Английский
Citations
0
Engineering materials, Journal Year: 2025, Volume and Issue: unknown, P. 19 - 57
Published: Jan. 1, 2025
Language: Английский
Citations
0
Chemical Engineering Journal, Journal Year: 2025, Volume and Issue: unknown, P. 160785 - 160785
Published: Feb. 1, 2025
Language: Английский
Citations
0