Biomedicine & Pharmacotherapy,
Journal Year:
2024,
Volume and Issue:
172, P. 116250 - 116250
Published: Feb. 5, 2024
Non-alcoholic
fatty
liver
disease
(NAFLD)
is
a
substantial
global
health
issue
owing
to
its
high
prevalence
and
the
lack
of
effective
therapies.
Fermentation
medicinal
herbs
has
always
been
considered
feasible
strategy
for
enhancing
efficacy
in
treating
various
ailments.
This
study
aimed
investigate
potential
benefits
Lactobacillus
casei-fermented
Amomum
xanthioides
(LAX)
on
NAFLD
high-fat
diet
model.
HFD-fed
C57BL6/j
mice
were
administered
with
200
mg/kg
LAX
or
unfermented
(AX)
100
metformin
6
weeks
from
4th
week.
The
10-week
HFD-induced
alterations
hepatic
lipid
accumulation
inflammation
significantly
attenuated
by
dominantly
(more
than
AX
metformin),
which
evidenced
pathohistological
findings,
contents,
inflammatory
cytokines
including
tumor
necrosis
factor
(TNF)-α,
interleukin
(IL)−
IL-1β,
oxidative
parameters
such
as
reactive
oxygen
species
(ROS)
malondialdehyde
(MDA),
molecular
changes
reversely
between
lipogenic
proteins
glycerol-3-phosphate
acyltransferase
(GPAM)
sterol
regulatory
element-binding
protein
(SREBP)−
1,
lipolytic
peroxisome
proliferator-activated
receptor
(PPAR-α)
AMP-activated
kinase
(AMPK)-α
tissues.
In
addition,
abnormal
serum
(triglyceride,
total
cholesterol
LDL-cholesterol)
notably
ameliorated
LAX.
conclusion,
these
findings
support
promising
plant-derived
remedy
NAFLD.
International Journal of Molecular Sciences,
Journal Year:
2024,
Volume and Issue:
25(3), P. 1429 - 1429
Published: Jan. 24, 2024
Acute
colitis
is
a
complex
disease
that
can
lead
to
dysregulation
of
the
gut
flora,
inducing
more
parenteral
diseases.
Dandelion
polysaccharides
(DPSs)
may
have
potential
preventive
and
therapeutic
effects
on
enteritis.
In
this
study,
LPS
was
used
induce
enteritis
VC
as
positive
drug
control
explore
DPS
The
results
showed
could
repair
intestinal
barrier,
down-regulate
expression
TNF-α,
IL-6,
IL-1β,
other
pro-inflammatory
factors,
up-regulate
IL-22
anti-inflammatory
factor,
improve
antioxidant
capacity
body,
structure
flora.
It
proved
effectively
prevent
treat
LPS-induced
acute
play
role
in
promoting
health.
Biomedicine & Pharmacotherapy,
Journal Year:
2024,
Volume and Issue:
172, P. 116250 - 116250
Published: Feb. 5, 2024
Non-alcoholic
fatty
liver
disease
(NAFLD)
is
a
substantial
global
health
issue
owing
to
its
high
prevalence
and
the
lack
of
effective
therapies.
Fermentation
medicinal
herbs
has
always
been
considered
feasible
strategy
for
enhancing
efficacy
in
treating
various
ailments.
This
study
aimed
investigate
potential
benefits
Lactobacillus
casei-fermented
Amomum
xanthioides
(LAX)
on
NAFLD
high-fat
diet
model.
HFD-fed
C57BL6/j
mice
were
administered
with
200
mg/kg
LAX
or
unfermented
(AX)
100
metformin
6
weeks
from
4th
week.
The
10-week
HFD-induced
alterations
hepatic
lipid
accumulation
inflammation
significantly
attenuated
by
dominantly
(more
than
AX
metformin),
which
evidenced
pathohistological
findings,
contents,
inflammatory
cytokines
including
tumor
necrosis
factor
(TNF)-α,
interleukin
(IL)−
IL-1β,
oxidative
parameters
such
as
reactive
oxygen
species
(ROS)
malondialdehyde
(MDA),
molecular
changes
reversely
between
lipogenic
proteins
glycerol-3-phosphate
acyltransferase
(GPAM)
sterol
regulatory
element-binding
protein
(SREBP)−
1,
lipolytic
peroxisome
proliferator-activated
receptor
(PPAR-α)
AMP-activated
kinase
(AMPK)-α
tissues.
In
addition,
abnormal
serum
(triglyceride,
total
cholesterol
LDL-cholesterol)
notably
ameliorated
LAX.
conclusion,
these
findings
support
promising
plant-derived
remedy
NAFLD.
