Frontiers in Pharmacology,
Journal Year:
2025,
Volume and Issue:
16
Published: March 19, 2025
Neurodegenerative
diseases
such
as
Alzheimer’s,
Parkinson’s,
and
Huntington’s
are
on
the
rise
pose
significant
challenges
due
to
lack
of
effective
treatments.
This
review
critically
examines
neuroprotective
effects
various
natural
products
derived
from
plants,
marine
organisms,
fungi.
Natural
have
long
been
used
in
traditional
medicine
gaining
attention
modern
drug
discovery
for
their
unique
properties.
The
explains
how
these
can
protect
neurons
by
influencing
key
biological
pathways
involved
neurodegeneration.
It
discusses
mechanisms
including
antioxidant
effects,
anti-inflammatory
actions,
modulation
cellular
signalling,
support
mitochondrial
function.
A
systematic
literature
search
was
conducted
minimize
bias
ensure
rigorous
study
selection.
Preclinical
studies
using
animal
models
cell
cultures
show
that
secondary
metabolites
like
polyphenols,
alkaloids,
terpenoids
significantly
reduce
neuronal
damage.
Some
clinical
trials
shown
promising
results.
However,
bioavailability,
standardization,
dosage
must
be
addressed
translate
findings
into
practice.
also
evaluates
potential
synergy
combining
with
conventional
treatments,
offering
a
complementary
therapeutic
approach.
represent
avenue
developing
innovative
treatments
neurodegenerative
diseases.
highlights
research
gaps
proposes
future
directions.
Future
should
focus
overcoming
existing
refining
improve
efficacy
safety
settings.
application
knowledge
has
enhance
quality
life
individuals
affected
Advances in medical technologies and clinical practice book series,
Journal Year:
2024,
Volume and Issue:
unknown, P. 235 - 264
Published: Aug. 30, 2024
Alzheimer's
disease
(AD)
remains
a
significant
healthcare
issue,
and
novel
treatment
approaches
are
needed.
Due
to
their
structural
variety
pharmacological
potential,
marine
metabolites
excellent
sources
for
drug
development.
In
recent
years,
nanotheranostics,
merger
of
therapeutic
diagnostic
functions
inside
nanoscale
platforms,
have
received
increased
attention
potential
in
precision
medicine.
This
chapter
will
focus
on
the
integration
into
these
nanotheranostic
systems,
allowing
early
illness
identification
real-time
monitoring
responses.
Finally,
this
book
highlights
promise
bioengineering
metabolite-based
nanotheranostics
as
option
disease.
By
leveraging
synergistic
interaction
bioresources
nanotechnology,
new
platforms
show
enormous
addressing
unmet
needs
patients,
ultimately
leading
medicine
paradigms
neurodegenerative
illnesses.
Frontiers in Neuroanatomy,
Journal Year:
2024,
Volume and Issue:
18
Published: Oct. 16, 2024
The
objective
of
this
review
was
to
verify
the
therapeutic
effect
polysaccharides
derived
from
algae
in
neurodegenerative
disease
models
involving
basal
ganglia.
To
achieve
goal,
a
literature
search
conducted
PubMed,
Science
Direct,
Scopus,
Web
Science,
Embase,
and
Google
Scholar
databases.
descriptors
“neuroprotective
or
neural
regenerative
immunomodulatory
activity
neuroprotection,”
“polysaccharide
carbohydrate
polymers,”
“marine
seaweed,”
“basal
ganglia”
according
Preferred
Reporting
Items
for
Systematic
reviews
Meta-Analyses
(PRISMA)
methodology
were
used.
This
involved
steps
searching,
pre-selection,
inclusion
articles.
A
total
737
records
identified.
Following
data
analysis,
698
studies
excluded,
resulting
final
sample
8
studies.
Species
such
as
Turbinaria
decurrens
,
Gracilaria
cornea
Chlorella
pyrenoidosa
Arthrospira
(Spirulina)
platensis
Fucus
vesiculosus
Laminaria
japonica
have
demonstrated
significant
neuroprotective
effects.
suggests
that
marine
possess
potential
neuroprotection,
modulation
inflammation,
amelioration
functional
deficits.
Their
use
warrants
further
consideration.
