Published: Jan. 1, 2024
Language: Английский
Nutrients, Journal Year: 2024, Volume and Issue: 16(8), P. 1123 - 1123
Published: April 10, 2024
This review delves into the burgeoning field of seaweed proteins as promising alternative sources protein. With global demand escalating and concerns over traditional protein sources' sustainability ethics, emerges a viable solution, offering high content minimal environmental impacts. Exploring nutritional composition, extraction methods, functional properties, potential health benefits proteins, this provides comprehensive understanding. Seaweed contains essential amino acids, vitamins, minerals, antioxidants. Its ranges from 11% to 32% dry weight, making it valuable for diverse dietary preferences, including vegetarian vegan diets. Furthermore, underscores advantages production compared sources. cultivation requires resources, mitigating issues like ocean acidification. As specific types, methodologies, highlights versatility in various food products, plant-based meats, dairy alternatives, supplements. Additionally, discusses associated with such their unique acid profile bioactive compounds. Overall, aims provide insights proteins' applications role addressing needs sustainably.
Language: Английский
Citations
16
International Journal of Translational Medicine, Journal Year: 2024, Volume and Issue: 4(4), P. 740 - 781
Published: Dec. 6, 2024
The increase in cancer incidence recent years necessitates urgent exploration of novel and alternative sources natural bioactives for targeted therapy. Approximately 75% the Earth’s surface is covered by oceans, which are thought to harbor untapped physiologically active compounds with potential efficacy against cancer. Recently, a growing focus has been on isolating investigating bioactive derived from marine sources. Bioactive metabolites diverse chemical structures, isolated various species such as algae, mollusks, actinomycetes, demonstrate wide range cancers. To our knowledge, this one articles that reviewed papers application marine-derived This study aims showcase some most current developments therapy have identified
Language: Английский
Citations
7
Marine Drugs, Journal Year: 2024, Volume and Issue: 22(10), P. 478 - 478
Published: Oct. 19, 2024
Macroalgae are known as abundant sources of phytochemicals, which offer a plethora beneficial biological properties. Besides being the most notable classes compounds found in macroalgae, phlorotannins, bromophenols, and terpenoids comprise some relevant for their Phlorotannins, mainly prevalent brown algae structurally characterized complex polyphenolic derived from phloroglucinol units, possess robust antioxidant, anti-inflammatory, antitumor, cytotoxic activities, modulated by factors such degree polymerization environmental conditions. Bromophenols, halogenated other marine organisms, exhibit significant antioxidant antiviral Their diverse structures bromination patterns contribute to potential therapeutic chemical defense agents. Pigments (chemically described primary terpenoids) play critical role light absorption energy transfer macroalgae divided into three main groups: (i) carotenoids, primarily provide photoprotective benefits; (ii) chlorophylls, facilitating conversion energy; (iii) phycobilins, mostly red important roles transfer, besides providing remarkable health benefits. Finally, secondary terpenoids, particularly (e.g., Rhodomelaceae family) central cellular interactions antimicrobial, antidiabetic, anti-inflammatory This study represents detailed analysis biosynthesis, structural diversity, activities these metabolites, emphasizing
Language: Английский
Citations
5
Marine Drugs, Journal Year: 2024, Volume and Issue: 22(7), P. 304 - 304
Published: June 28, 2024
From sea shores to the abysses of deep ocean, marine ecosystems have provided humanity with valuable medicinal resources. The use organisms is discussed in ancient pharmacopoeias different times and geographic regions still deeply rooted traditional medicine. Thanks present-day, large-scale bioprospecting rigorous screening for bioactive metabolites, ocean coming back as an untapped resource natural compounds therapeutic potential. This renewed interest drugs propelled by a burgeoning research field investigating molecular mechanisms which newly identified intervene pathophysiology human diseases. Of great clinical relevance are molecules endowed anti-inflammatory immunomodulatory properties emerging applications management chronic inflammatory disorders, autoimmune diseases, cancer. Here, we review historical development pharmacology Eastern Western worlds describe status drug discovery. Finally, discuss importance conducting sustainable exploitation resources through biotechnology.
Language: Английский
Citations
4
Food Chemistry, Journal Year: 2024, Volume and Issue: 469, P. 142602 - 142602
Published: Dec. 21, 2024
Language: Английский
Citations
4
Medicina, Journal Year: 2025, Volume and Issue: 61(1), P. 165 - 165
Published: Jan. 20, 2025
Background and Objectives: Persistent exposure to airborne fine dust (FD) particles contributing air pollution has been linked various human health issues, including respiratory inflammation, allergies, skin diseases. We aimed identify potential seaweed anti-inflammatory bioactive reagents determine their effects on systemic inflammatory responses induced by FD particles. Materials Methods: While exploring reagents, we purified compounds with from the extracts of Ecklonia cava, stolonifera, Codium fragile. Structural analyses siphonaxanthin (Sx), fucoxanthin (Fx), dieckol (Dk), phlorofucofuroeckol-A (PFF-A) were performed using NMR LC-MS/MS. Results: Notably, these compounds, especially PFF-A, showed significant protective against FD-induced in RAW 264.7 cells without cytotoxicity. Further investigation inflammatory-associated signaling demonstrated that PFF-A inhibited IL-1β expression modulating NF-κB/MAPK signal pathway cells. Additionally, gene profiling revealed early activation signature genes involved production cytokines chemokines profiling. Treatment markedly reduced levels pro-inflammatory apoptosis-related even elevated Bmp families. Conclusions: These results suggested is a natural therapeutic candidate for managing response.
Language: Английский
Citations
0
PLoS ONE, Journal Year: 2025, Volume and Issue: 20(2), P. e0318781 - e0318781
Published: Feb. 11, 2025
The identification of multifunctional peptides derived from marine byproducts represents a significant challenge in the field. In Thailand, fisheries industry exports salted jellyfish, which results low-value primarily employed for animal feed. Previous studies have indicated bioactivities jellyfish protein hydrolysates Lobonema smitthii ; however, properties Rhopilema hispidum remain largely unexplored. This research aimed to characterize synthetic bioactive sourced ( R. ), with specific emphasis on their antioxidant, angiotensin-I-converting enzyme (ACE) inhibitory, and anti-inflammatory activities. hydrolysate obtained umbrella portion, subjected pepsin treatment at 3:20 enzyme-to-substrate ratio 48 h 37 °C, demonstrated highest levels antioxidant activity (DPPH = 1.85 ± 0.05 mM TE/mg protein, ABTS 7.28 0.03 FRAP 3.04 0.12 FeSO 4 /mg protein). Following purification, 18 novel exhibiting high scores (FRS+CHEL > 0.48) were identified synthesized. Notably, peptide MVVACVLPEA exhibited 56.07 protein), ACE inhibitory (91.69%), activities (NO release 34.59 µ M) without cytotoxic effects, although it is important note that two other did demonstrate cytotoxicity. investigation reports total 16 synthesized possess triple functional activities—antioxidant, anti-inflammatory—without cytotoxicity, thus highlighting potential applications health-related fields.
Language: Английский
Citations
0
Revista Brasileira de Farmacognosia, Journal Year: 2025, Volume and Issue: unknown
Published: March 15, 2025
Language: Английский
Citations
0
Deleted Journal, Journal Year: 2025, Volume and Issue: 2(1)
Published: June 2, 2025
Language: Английский
Citations
0
International Journal of Biological Macromolecules, Journal Year: 2024, Volume and Issue: 276, P. 133776 - 133776
Published: July 9, 2024
Language: Английский
Citations
1