Characterizing gene expression profiles of various tissue states in stony coral tissue loss disease using a feature selection algorithm DOI Creative Commons
Kelsey M. Beavers, Daniela Gutierrez-Andrade, Emily W. Van Buren

et al.

bioRxiv (Cold Spring Harbor Laboratory), Journal Year: 2024, Volume and Issue: unknown

Published: Nov. 8, 2024

ABSTRACT Stony coral tissue loss disease (SCTLD) remains a substantial threat to reef diversity already threatened by global climate change. Restoration efforts and effective treatment of SCTLD requires an in-depth understanding its pathogenesis in the holobiont as well mechanisms resistance. Here, we present supervised machine learning framework describe progression major reef-building coral, Montastraea cavernosa , dominant algal endosymbiont, Cladocopium goreaui . Utilizing support vector recursive feature elimination (SVM-RFE) conjunction with differential expression analysis, identify subset biologically relevant genes that exhibit highest classification performance across three types tissues collected from natural environment: apparently healthy on colony, SCTLD-affected lesion colony. By analyzing gene signatures associated these health states both host endosymbiont (family Symbiodiniaceae), key processes involved resistance within holobiont. Our findings further evidence causes dysbiosis between Symbiodinaiceae additionally describes metabolic immune shifts occur transitions diseased state. This offers novel approach accurately assess endangered species brings us closer developing solutions for monitoring intervention. AUTHOR SUMMARY Coral reefs are under increasing due change, rising ocean temperatures outbreaks accelerating degradation. has been particularly destructive, leading widespread mortality Florida’s Reef wider Caribbean since emergence 2014. While cause unknown, rapid decline highlights urgent need innovative approaches threats health. In this study, applied approach, previously used cancer research, symbiotic algae, which relies meet nutritional requirements. patterns representing different states, find affects interactions their symbionts signaling pathways, even colony appears be healthy. study presents applying research could lead new methods combatting SCTLD.

Language: Английский

Marine natural products DOI Creative Commons
Anthony R. Carroll, Brent R. Copp, Tanja Grkovic

et al.

Natural Product Reports, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 1, 2025

A comprehensive review of 1220 new MNPs including a novel sex inducing pheromone from the diatom Seminavis robusta .

Language: Английский

Citations

2
A review of organophosphonates, their natural and anthropogenic sources, environmental fate and impact on microbial greenhouse gases emissions – Identifying knowledge gaps DOI
Adam Furtak, Anna Szafranek-Nakonieczna, Karolina Furtak

et al.

Journal of Environmental Management, Journal Year: 2024, Volume and Issue: 355, P. 120453 - 120453

Published: March 1, 2024

Language: Английский

Citations

5
Immunomodulatory Compounds from the Sea: From the Origins to a Modern Marine Pharmacopoeia DOI Creative Commons
Edoardo Andrea Cutolo, Rosanna Campitiello, Roberto Caferri

et al.

Marine Drugs, Journal Year: 2024, Volume and Issue: 22(7), P. 304 - 304

Published: June 28, 2024

From sea shores to the abysses of deep ocean, marine ecosystems have provided humanity with valuable medicinal resources. The use organisms is discussed in ancient pharmacopoeias different times and geographic regions still deeply rooted traditional medicine. Thanks present-day, large-scale bioprospecting rigorous screening for bioactive metabolites, ocean coming back as an untapped resource natural compounds therapeutic potential. This renewed interest drugs propelled by a burgeoning research field investigating molecular mechanisms which newly identified intervene pathophysiology human diseases. Of great clinical relevance are molecules endowed anti-inflammatory immunomodulatory properties emerging applications management chronic inflammatory disorders, autoimmune diseases, cancer. Here, we review historical development pharmacology Eastern Western worlds describe status drug discovery. Finally, discuss importance conducting sustainable exploitation resources through biotechnology.

Language: Английский

Citations

4
Photobiota of the Tropical Red Sea: Fatty Acid Profile Analysis and Nutritional Quality Assessments DOI Creative Commons

Sarah A. Gozai-Alghamdi,

Samir M. Aljbour,

Sapta Priyana Amin

et al.

Molecules, Journal Year: 2025, Volume and Issue: 30(3), P. 621 - 621

Published: Jan. 31, 2025

Photosynthetic organisms are primary sources of marine-derived molecules, particularly ω3 fatty acids (FAs), which influence the quality marine foods. It is reported that tropical possess lower FA nutritional than those from colder oceans. However, high biodiversity known for areas may help compensate this deficiency by producing a diversity molecules with benefits ecosystem. Here we addressed aspect analyzing profiles 20 photosynthetic salty and warm Red Sea, hot spot, including cyanobacteria, eukaryotic microalgae, macroalgae, mangrove leaves, as well three selected reef's photosymbiotic zooxanthellate corals jellyfish. Using direct transesterification, gas chromatography-mass spectrometry, absolute quantification, indexes, evaluated their lipid qualities. We observed interspecific strain-specific variabilities in qualities, unique environmental conditions Sea to explain. Generally, microalgae exhibited highest quality. The previously unanalyzed diatoms Leyanella sp. Minutocellus had eicosapentaenoic acid (EPA) contents. bioprospected photobiota pharmaceutical nutraceutical potential. By sourcing quantifying these bioactive compounds, highlight untapped rich showcase opportunities harness potentials.

Language: Английский

Citations

0
Diet of deep-sea octocorals from the Emperor Seamount Chain inferred by fatty acid trophic markers DOI

Rodkina S.A,

D. N.

Deep Sea Research Part II Topical Studies in Oceanography, Journal Year: 2025, Volume and Issue: unknown, P. 105462 - 105462

Published: Feb. 1, 2025

Language: Английский

Citations

0
Moderate levels of dissolved iron stimulate cellular growth and increase lipid storage in Symbiodinium sp. DOI Creative Commons
Walter Dellisanti, Swathi Murthy, Elena Bollati

et al.

Journal of Phycology, Journal Year: 2025, Volume and Issue: unknown

Published: March 30, 2025

Abstract Dinoflagellates in the family Symbiodiniaceae are fundamental coral reef ecosystems and facilitate essential processes such as photosynthesis, nutrient cycling, calcium carbonate production. Iron (Fe) is an element for physiological of Symbiodiniaceae, yet its role remains poorly understood context cellular development metabolic health. Here, we investigated effect iron availability—0–100 nM Fe(III)—on Symbiodinium sp. ITS2 type A1 cultures quantified content using flow cytometry holotomography. Moderate levels dissolved Fe (50 nM) enhanced growth rates sp., including lipids proteins. We observed distinct patterns, pigment concentrations, morphology under increasing indicating influence availability on physiology. Nondestructive, label‐free holotomographic microscopy enabled single‐cell vivo imaging, revealing higher intracellular lipid accumulation (+57%) response to 50 Fe(III) enrichment. Our findings contribute a deeper understanding relationship between development, with potential implications health resilience face environmental stressors.

Language: Английский

Citations

0
The effect of depth on the composition and saturation of total fatty acids present within the tissues and skeletons of two reef-building corals DOI Creative Commons
Nora S. H. von Xylander, Laëtitia Hédouin, Terry Smith

et al.

Marine Biology, Journal Year: 2025, Volume and Issue: 172(5)

Published: April 3, 2025

Language: Английский

Citations

0
Metagenomic and metabolomic analysis of the effect of bleaching on unsaturated fatty acid synthesis pathways in coral symbionts DOI
Fulin Sun,

Hongqiang Yang,

Xiyang Zhang

et al.

The Science of The Total Environment, Journal Year: 2023, Volume and Issue: 912, P. 169487 - 169487

Published: Dec. 22, 2023

Language: Английский

Citations

7
Bioactive Diepoxy Metabolites and Highly Oxygenated Triterpenoids from Marine and Plant-Derived Bacteria and Fungi DOI Creative Commons
Valery M. Dembitsky

Microbiology Research, Journal Year: 2023, Volume and Issue: 15(1), P. 66 - 90

Published: Dec. 21, 2023

This article explores the diverse array of biologically active compounds derived from microbial symbionts, particularly focusing on isolation and characterization diepoxides, highly oxygenated triterpenoids, secosteroids, ergostane-type steroids, meroterpenoids various marine plant-derived fungi. We highlight significant discoveries such as vitamin D variants fungal species, unique sesterterpenoids mangrove endophytic fungi, secosteroids with potential medicinal applications. The study delves into structural uniqueness bioactivities these compounds, including their anti-inflammatory, antibacterial, antifungal, antiviral, cytotoxic effects. Notable findings include activity against cancer cell lines, inhibition acetylcholinesterase, promising antifouling properties. work underscores symbionts a rich source novel bioactive therapeutic applications, highlighting importance biodiversity in drug discovery development.

Language: Английский

Citations

3
Impact of seawater warming and nutrient deprivation on the physiology and energy metabolism of corals DOI Creative Commons
Chloé A. Pupier,

Renaud Grover,

Cécile Rottier

et al.

Frontiers in Marine Science, Journal Year: 2024, Volume and Issue: 11

Published: Oct. 1, 2024

Seawater temperature and the availability of dissolved inorganic nutrients (DINut) have a major influence on stability symbiosis between corals Symbiodiniaceae. In particular, seawater warming or DINut depletion can lead to coral bleaching, loss Symbiodiniaceae from tissue. However, combined effects heat stress deficiency energy metabolism are still understudied. Here, we investigated physiological energetic responses octocoral Heteroxenia fuscescens hexacoral Stylophora pistillata exposed two levels in (control, depleted) temperatures, 25°C (control) 30°C (high temperature), crossed factorial design. Our results show that thermal both decreased photosynthesis respiration ratio species induced bleaching H. . While nutrient deprivation had little effect corals’ metabolism, led higher concentrations macromolecules such as carbohydrates lipids, well anaerobic ATP production Given intensity frequency marine heatwaves will significantly increase future, there is an urgent need investigate processes by which overcome starvation.

Language: Английский

Citations

0