Astaxanthin Prevents Oxidative Damage and Cell Apoptosis Under Oxidative Stress Involving the Restoration of Mitochondrial Function DOI

Jia‐Xin Yu,

Miao Lin,

W.R. Zhang

et al.

Cell Biochemistry and Function, Journal Year: 2024, Volume and Issue: 42(8)

Published: Dec. 1, 2024

ABSTRACT Oxidative stress (OS) is one of the factors that result in cell damage and development neurological diseases such as Alzheimer's disease (AD). Astaxanthin (ASTA), a natural compound known for its potent antioxidant properties, shows biological activities anti‐apoptosis antitumor. However, specific mechanism on mitochondrial function remains unclear. This study investigated effects ASTA regulation apoptosis under OS induced by hydrogen peroxide (H 2 O ). The results demonstrated (0.1, 1, 10 μmol/L) protected cells form H ‐induced through pathway. significantly reduced dysfunctions restored intracellular reactive oxygen species (ROS), membrane potential, respiratory capacity. These findings suggest ASTA's properties can benefit neurons maintaining alleviating oxidative .

Language: Английский

Plant Secondary Metabolites as Modulators of Mitochondrial Health: An Overview of Their Anti-Oxidant, Anti-Apoptotic, and Mitophagic Mechanisms DOI Open Access

Julia Anchimowicz,

Piotr Zielonka, Sławomir Jakieła

et al.

International Journal of Molecular Sciences, Journal Year: 2025, Volume and Issue: 26(1), P. 380 - 380

Published: Jan. 4, 2025

Plant secondary metabolites (PSMs) are a diverse group of bioactive compounds, including flavonoids, polyphenols, saponins, and terpenoids, which have been recognised for their critical role in modulating cellular functions. This review provides comprehensive analysis the effects PSMs on mitochondrial health, with particular emphasis therapeutic potential. Emerging evidence shows that these improve function by reducing oxidative stress, promoting biogenesis, regulating key processes such as apoptosis mitophagy. Mitochondrial dysfunction, hallmark many pathologies, neurodegenerative disorders, cardiovascular diseases, metabolic syndrome, has shown to benefit from protective PSMs. Recent studies show can dynamics, stabilise membranes, enhance bioenergetics, offering significant promise prevention treatment mitochondrial-related diseases. The molecular mechanisms underlying effects, modulation signalling pathways direct interactions proteins, discussed. integration into strategies is highlighted promising avenue improving efficacy while minimising side commonly associated synthetic drugs. also highlights need future research elucidate specific roles individual synergistic within complex plant matrices, may further optimise utility. Overall, this work valuable insights health potential natural agents targeting dysfunction.

Language: Английский

Citations

3
Oral Delivery of Astaxanthin via Carboxymethyl Chitosan-Modified Nanoparticles for Ulcerative Colitis Treatment DOI Creative Commons
Wen Zhang, Xinping Zhang,

Xinyi Lv

et al.

Molecules, Journal Year: 2024, Volume and Issue: 29(6), P. 1291 - 1291

Published: March 14, 2024

The oral delivery strategy of natural anti-oxidant and anti-inflammatory agents has attracted great attention to improve the effectiveness ulcerative colitis (UC) treatment. Herein, we developed a novel orally deliverable nanoparticle, carboxymethyl chitosan (CMC)-modified astaxanthin (AXT)-loaded nanoparticles (CMC-AXT-NPs), for UC CMC-AXT-NPs were evaluated by appearance, morphology, particle size, ζ-potential, encapsulation efficiency (EE). results showed that nearly spherical in shape with size 34.5 nm ζ-potential -30.8 mV, EE was as high 95.03%. exhibited preferable storage stability over time well-controlled drug-release properties simulated intestinal fluid. Additionally, vitro studies revealed remarkably inhibited cytotoxicity induced LPS demonstrated superior antioxidant abilities Raw264.7 cells. Furthermore, effectively alleviated clinical symptoms dextran sulfate sodium salt (DSS), including maintaining body weight, inhibiting colon shortening, reducing fecal bleeding. Importantly, suppressed expression pro-inflammatory cytokines like TNF-α, IL-6, IL-1β ameliorated DSS-induced oxidative damage. Our potential CMC-modified an system suggested these AXT could be promising

Language: Английский

Citations

5
Astaxanthin in cancer therapy and prevention (Review) DOI Open Access
Chiara Copat, Claudia Favara, Marianna Flora Tomasello

et al.

Biomedical Reports, Journal Year: 2025, Volume and Issue: 22(4)

Published: Feb. 14, 2025

Astaxanthin (AXT), a carotenoid primarily derived from marine organisms such as shrimp, krill and the microalga Haematococcus pluvialis, has gained significant attention for its potent antioxidant, anti‑inflammatory anti‑proliferative properties. The present comprehensive review explored role of AXT in cancer prevention treatment, emphasizing cytotoxic mechanisms modulation key molecular pathways involved progression. demonstrated efficacy across variety types, including nervous system, breast gastrointestinal cancers, through ability to induce apoptosis, inhibit metastasis disrupt cell growth. detailed both in vitro vivo studies highlighting effectiveness sensitizing cells chemotherapy, thereby enhancing therapeutic outcomes potentially reducing treatment‑related side effects. incorporation nanoparticle‑based delivery systems further improved bioavailability targeted action, showcasing potential advanced therapies. However, despite promising experimental results, more clinical trials are necessary validate safety human populations. Such research would help standardize dosing, confirm interactions with conventional treatments support integration into oncology natural, complementary approach existing treatments.

Language: Английский

Citations

0
Identification of Polyphenols in Mallotus peltatus (Geiseler) Mull. Arg. Based on UPLC‐MS/MS and Their Protective Effects on H2O2‐Induced Liver Injury DOI Creative Commons

Ying-Jing Zhang,

Jinxin Li,

Kaili Hao

et al.

Journal of Food Biochemistry, Journal Year: 2025, Volume and Issue: 2025(1)

Published: Jan. 1, 2025

Background: Liver cells are particularly susceptible to mitochondrial dysfunction due external stimuli, leading excess reactive oxygen species (ROS) and redox imbalance. The aim of this study was extract purify the polyphenolic fractions Mallotus peltatus (Geiseler) Mull. Arg. evaluate their potential protective effect against H 2 O ‐induced oxidative stress injury in hepatocytes. Methods: extraction process polyphenols MPMA optimized by response surface method. Then, we purified crude extracts with macroporous resin HPD600 obtain MPMAP‐I, MPMAP‐II, MPMAP‐III. physical properties component composition samples were analyzed FT‐IR UPLC‐MS/MS. An vitro model hepatocytes established investigate MPMAP‐I on L02 cells. assessed measuring cell survival rate, enzyme activities, intracellular ROS levels, apoptosis membrane potential, mRNA expression related signaling pathways. Results: results showed that conditions 60% ethanol, 140 min, 85°C, liquid‐to‐solid ratio 30 mL/g. All three contained different (such as kaempferol 3‐O‐sophoroside, corilagin, cirsiliol) had great antioxidant activities. treatment could increase activities SOD, CAT, GPx cells, reduce content MDA, transaminases, production ROS, rate apoptosis, restore function. Furthermore, these effects might be inactivation Bcl2/Bax/caspase‐3 apoptotic pathway activation Nrf2/γ‐GCL pathway. Conclusion: Our provided a theoretical basis for liver injury, which is helpful improve development application medicine healthcare products.

Language: Английский

Citations

0
The Polyphenols from <i>Mallotus Peltatus</i> (Geiseler) Mull. Arg. Protect Against H <sub>2</sub>O <sub>2</sub>-Induced Liver Injury in L02 Cells DOI

Ying-Jing Zhang,

Kexin Hao, Jian‐Guo Jiang

et al.

Published: Jan. 1, 2024

Language: Английский

Citations

0
Carotenoids as modulators of the PI3K/Akt/mTOR pathway: innovative strategies in cancer therapy DOI

Biswajit Kumar Utpal,

Zerrouki Dehbia,

B. M. Redwan Matin Zidan

et al.

Medical Oncology, Journal Year: 2024, Volume and Issue: 42(1)

Published: Nov. 16, 2024

Language: Английский

Citations

0
Optimization of Culture Conditions for High Cell Productivity and Astaxanthin Accumulation in Vietnam’s Green Microalgae Haematococcus pluvialis HB and a Neuroprotective Activity of Its Astaxanthin DOI Creative Commons
Nguyen Cam Ha,

Luu Thi Tam,

Hoang Thi Minh Hien

et al.

Bioengineering, Journal Year: 2024, Volume and Issue: 11(12), P. 1176 - 1176

Published: Nov. 21, 2024

Background: Haematococcus pluvialis, a green microalga, is rich source of natural astaxanthin and potent antioxidant with high commercial value. This study investigates the biological characteristics potential H. pluvialis HB isolated from Hoa Binh, Vietnam, for growth accumulation using two-phase culture method. Methods: was cultured in C/RM medium at 25 °C, morphological were examined. NMR spectroscopy used to determine structure astaxanthin, which extracted Soxhlet Results: After 22 days, highest cell density (4.96 × 106 cells mL−1) achieved under optimized light ultraviolet conditions. Nutrient deprivation followed by bicarbonate supplementation resulted maximal 48.8 mg g−1 dry weight within two days. The demonstrated activity (IC50: 3.74 compared ascorbic acid 18.53 µg exhibited strong acetylcholinesterase inhibition 297.99 mL−1). It also showed neuroprotective effects against H2O2 amyloid beta-induced neurotoxicity C6 cells. Conclusions: highlights as promising large-scale production applications health products.

Language: Английский

Citations

0
Astaxanthin Prevents Oxidative Damage and Cell Apoptosis Under Oxidative Stress Involving the Restoration of Mitochondrial Function DOI

Jia‐Xin Yu,

Miao Lin,

W.R. Zhang

et al.

Cell Biochemistry and Function, Journal Year: 2024, Volume and Issue: 42(8)

Published: Dec. 1, 2024

ABSTRACT Oxidative stress (OS) is one of the factors that result in cell damage and development neurological diseases such as Alzheimer's disease (AD). Astaxanthin (ASTA), a natural compound known for its potent antioxidant properties, shows biological activities anti‐apoptosis antitumor. However, specific mechanism on mitochondrial function remains unclear. This study investigated effects ASTA regulation apoptosis under OS induced by hydrogen peroxide (H 2 O ). The results demonstrated (0.1, 1, 10 μmol/L) protected cells form H ‐induced through pathway. significantly reduced dysfunctions restored intracellular reactive oxygen species (ROS), membrane potential, respiratory capacity. These findings suggest ASTA's properties can benefit neurons maintaining alleviating oxidative .

Language: Английский

Citations

0