Bioactive potency of extracts from Stylissa carteri and Amphimedon chloros with silver nanoparticles against cancer cell lines and pathogenic bacteria DOI Open Access
Moath Alqaraleh, Khaled M. Khleifat, Ali Al‐Samydai

et al.

Biomedical Reports, Journal Year: 2024, Volume and Issue: 22(2)

Published: Dec. 19, 2024

Silver nanoparticles (AgNPs) are spherical particles with a number of specific and unique physical (such as surface plasmon resonance, high electrical conductivity thermal stability) well chemical (including antimicrobial activity, catalytic efficiency the ability to form conjugates biomolecules) properties. These properties allow AgNPs exhibit desired interactions biological system make them prospective candidates for use in antibacterial anticancer activities. have quenching capacity, which produces reactive oxygen species disrupts cellular processes reducing function mitochondria, damaging cell membrane, inhibiting DNA replication altering protein synthesis). In addition, sponge extracts contain biologically active substances therapeutic effects. Therefore, concurrent these agents may present potential development novel antitumor drugs. The study investigated cytotoxic effects combined from species, Stylissa carteri or Amphimedon chloros, against various cancer lines pathogenic bacterial strains. was it provided further understanding cytotoxicity underlying mechanisms AgNPs. Alterations properties, such size, charge polydispersity index, were demonstrated after lyophilization. Scanning electron microscopy revealed submicron‑sized particles. across lung, colorectal, breast pancreatic lines, demonstrated, especially when extracts, suggested synergistic effect. Analysis using liquid chromatography‑mass spectrometry key components molecular docking simulations indicated inhibition between extract epidermal growth factor receptor tyrosine kinase A. Synergistic several Staphylococcus xylosus, Klebsiella oxytoca, Enterobacter aerogenes, Micrococcus spp. Escherichia coli, observed ethyl acetate extracts. results application marine‑derived compounds nanotechnology combating infections. Future research should elucidate mechanistic pathways investigate in vivo efficacy.

Language: Английский

Natural Compounds for Preventing Age-Related Diseases and Cancers DOI Open Access
Mi‐Ran Ki,

Sol Youn,

Dong Hyun Kim

et al.

International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(14), P. 7530 - 7530

Published: July 9, 2024

Aging is a multifaceted process influenced by hereditary factors, lifestyle, and environmental elements. As time progresses, the human body experiences degenerative changes in major functions. The external internal signs of aging manifest various ways, including skin dryness, wrinkles, musculoskeletal disorders, cardiovascular diseases, diabetes, neurodegenerative cancer. Additionally, cancer, like aging, complex disease that arises from accumulation genetic epigenetic alterations. Circadian clock dysregulation has recently been identified as an important risk factor for cancer development. Natural compounds herbal medicines have gained significant attention their potential preventing age-related diseases inhibiting progression. These demonstrate antioxidant, anti-inflammatory, anti-proliferative, pro-apoptotic, anti-metastatic, anti-angiogenic effects well circadian regulation. This review explores cancers, specific natural targeting key features these conditions.

Language: Английский

Citations

8
A comprehensive review of marine sponge metabolites, with emphasis on Neopetrosia sp. DOI
Noora Barzkar, Станислав Сухих, Olga Babich

et al.

International Journal of Biological Macromolecules, Journal Year: 2024, Volume and Issue: unknown, P. 135823 - 135823

Published: Sept. 1, 2024

Language: Английский

Citations

5
Recent Advances in Marine-Derived Bioactives Towards Cancer Therapy DOI Creative Commons
Nafisa Nawar Tamzi, Md. Motiur Rahman, Subhadeep Das

et al.

International Journal of Translational Medicine, Journal Year: 2024, Volume and Issue: 4(4), P. 740 - 781

Published: Dec. 6, 2024

The increase in cancer incidence recent years necessitates urgent exploration of novel and alternative sources natural bioactives for targeted therapy. Approximately 75% the Earth’s surface is covered by oceans, which are thought to harbor untapped physiologically active compounds with potential efficacy against cancer. Recently, a growing focus has been on isolating investigating bioactive derived from marine sources. Bioactive metabolites diverse chemical structures, isolated various species such as algae, mollusks, actinomycetes, demonstrate wide range cancers. To our knowledge, this one articles that reviewed papers application marine-derived This study aims showcase some most current developments therapy have identified

Language: Английский

Citations

3
Isoechinulin B, a natural product from Antarctic fungus, attenuates acute liver injury by inhibiting excessive cell adhesion DOI
Han Sun,

Xu Pang,

Jianrui Li

et al.

European Journal of Pharmacology, Journal Year: 2024, Volume and Issue: unknown, P. 177065 - 177065

Published: Oct. 1, 2024

Language: Английский

Citations

0
Mechanism of luteolin against non-small-cell lung cancer: a study based on network pharmacology, molecular docking, molecular dynamics simulation, and in vitro experiments DOI Creative Commons

Jihang Zhang,

Changling Li,

Wenyi Li

et al.

Frontiers in Oncology, Journal Year: 2024, Volume and Issue: 14

Published: Nov. 8, 2024

Luteolin, a naturally occurring flavonoid compound, demonstrates promising anti-cancer properties. However, its mechanism against non-small-cell lung cancer (NSCLC) remains unknown. This study employed network pharmacology, molecular docking, dynamics simulation (MDS), and

Language: Английский

Citations

0
Bioactive potency of extracts from Stylissa carteri and Amphimedon chloros with silver nanoparticles against cancer cell lines and pathogenic bacteria DOI Open Access
Moath Alqaraleh, Khaled M. Khleifat, Ali Al‐Samydai

et al.

Biomedical Reports, Journal Year: 2024, Volume and Issue: 22(2)

Published: Dec. 19, 2024

Silver nanoparticles (AgNPs) are spherical particles with a number of specific and unique physical (such as surface plasmon resonance, high electrical conductivity thermal stability) well chemical (including antimicrobial activity, catalytic efficiency the ability to form conjugates biomolecules) properties. These properties allow AgNPs exhibit desired interactions biological system make them prospective candidates for use in antibacterial anticancer activities. have quenching capacity, which produces reactive oxygen species disrupts cellular processes reducing function mitochondria, damaging cell membrane, inhibiting DNA replication altering protein synthesis). In addition, sponge extracts contain biologically active substances therapeutic effects. Therefore, concurrent these agents may present potential development novel antitumor drugs. The study investigated cytotoxic effects combined from species, Stylissa carteri or Amphimedon chloros, against various cancer lines pathogenic bacterial strains. was it provided further understanding cytotoxicity underlying mechanisms AgNPs. Alterations properties, such size, charge polydispersity index, were demonstrated after lyophilization. Scanning electron microscopy revealed submicron‑sized particles. across lung, colorectal, breast pancreatic lines, demonstrated, especially when extracts, suggested synergistic effect. Analysis using liquid chromatography‑mass spectrometry key components molecular docking simulations indicated inhibition between extract epidermal growth factor receptor tyrosine kinase A. Synergistic several Staphylococcus xylosus, Klebsiella oxytoca, Enterobacter aerogenes, Micrococcus spp. Escherichia coli, observed ethyl acetate extracts. results application marine‑derived compounds nanotechnology combating infections. Future research should elucidate mechanistic pathways investigate in vivo efficacy.

Language: Английский

Citations

0