Harnessing artificial intelligence for predictive modelling in oral oncology: Opportunities, challenges, and clinical Perspectives DOI Creative Commons
Vishnu Priya Veeraraghavan,

Shikhar Daniel,

Arun Kumar Dasari

et al.

Oral Oncology Reports, Journal Year: 2024, Volume and Issue: 11, P. 100591 - 100591

Published: June 29, 2024

Artificial intelligence (AI) has emerged as a promising tool in oral oncology, particularly the field of prediction. This review provides comprehensive outlook on role AI predicting cancer, covering key aspects such data collection and preprocessing, machine learning techniques, performance evaluation validation, challenges, future prospects, implications for clinical practice. Various algorithms, including supervised learning, unsupervised deep approaches, have been discussed context cancer Additionally, challenges interpretability, accessibility, regulatory compliance, legal are addressed along with research directions potential impact oncology care.

Language: Английский

Optimizing Prognostic Assessment in High‐Risk Head and Neck Squamous Cell Carcinomas: The Impact of Tumor Budding and a Novel Histomorphological Scoring System DOI Creative Commons

Moritz Knebel,

Jan Philipp Kühn, Sandrina Körner

et al.

Cancer Medicine, Journal Year: 2025, Volume and Issue: 14(4)

Published: Feb. 1, 2025

ABSTRACT Background Head and neck squamous cell carcinomas (HNSCC) pose significant clinical challenges, particularly in high‐risk cases with positive lymph node status. Current prognostic biomarkers are often costly methodologically demanding. In this regard, histomorphological such as tumor buds (TB) poorly differentiated clusters (PDC) represent promising, cost‐effective indicators that relatively straightforward to implement. Methods The significance of TB PDC, conjunction stromal tumor‐infiltrating lymphocytes (sTILs) the tumor‐stroma ratio (TSR), was evaluated a cohort 50 high‐risk, nodal‐positive HNSCC patients. Histomorphological features were assessed using standard hematoxylin eosin (H&E) staining, while HPV association PD‐L1 expression determined by means immunohistochemistry (IHC) and/or PCR. All variables collected subsequently correlated traditional histopathological parameters. Finally, novel scoring system incorporating PDC developed, its overall survival (OS) analyzed. Results both demonstrated impact on patients' OS (TB Log‐rank test, p = 0.0499, 0.0235). A based these had strong (Log‐rank 0.0200) contrast conventional routinely performed grading system, which evaluates degree differentiation within neoplastic cells 0.3325). not associated formation. HPV‐negative status higher number buds. Conclusion This study reveals potential value HNSCC, may offer practical alternative markers. Our proposed practicable employable significantly correlates OS, suggesting benefit practice. These findings advocate for further validation enhance accuracy guide treatment strategies HNSCC.

Language: Английский

Citations

1
Age-Related Oral and Para-Oral Tissue Disorders: The Evolving Therapeutic and Diagnostic Potential of Exosomes DOI Creative Commons
Mohamed Khaled Mohamed Maria,

Esraa Mohamed Abdel Moniem,

Ahmed Khaled Hanafy

et al.

Dentistry Journal, Journal Year: 2025, Volume and Issue: 13(3), P. 106 - 106

Published: Feb. 27, 2025

This review highlights the key molecular and cellular mechanisms contributing to aging, such as DNA damage, mitochondrial dysfunction, telomere shortening, protein defective autophagy. These biological are involved in various oral health conditions prevalent elderly, including periodontal disease, cancer, xerostomia, dental caries, temporomandibular joint disorders. Exosomes generated by mesenchymal stem cells possess substantial therapeutic potential. exosomes nanosized extracellular vesicles derived from essential intercellular communication tissue homeostasis. The exosome-based therapies proved superior traditional cell-based approaches, due lower immunogenicity, ease of storage, avoidance complications associated with cell transplantation. Furthermore, diagnostic potential non-invasive biomarkers for aging processes age-related diseases offers insights into disease diagnosis, staging, monitoring. Among challenges future perspectives translating exosome research preclinical studies clinical applications is need standardized procedures fully harness capabilities exosomes.

Language: Английский

Citations

1
Management approaches for recurrent or metastatic head and neck squamous cell carcinoma after anti-PD-1/PD-L1 immunotherapy DOI
Makoto Tahara, Wan‐Teck Lim,

Bhumsuk Keam

et al.

Cancer Treatment Reviews, Journal Year: 2025, Volume and Issue: unknown, P. 102938 - 102938

Published: April 1, 2025

Language: Английский

Citations

1
Tongue tumor and prognostic factors: Could a diagnostic procedure influence patient outcomes? DOI
Marta Tagliabue, Rita De Berardinis,

Giulia Doi

et al.

Oral Oncology, Journal Year: 2025, Volume and Issue: 165, P. 107298 - 107298

Published: April 22, 2025

Language: Английский

Citations

1
Statins in Cancer Prevention and Therapy DOI Open Access
Natalia Ricco, Stephen J. Kron

Cancers, Journal Year: 2023, Volume and Issue: 15(15), P. 3948 - 3948

Published: Aug. 3, 2023

Statins, a class of HMG-CoA reductase inhibitors best known for their cholesterol-reducing and cardiovascular protective activity, have also demonstrated promise in cancer prevention treatment. This review focuses on potential applications head neck (HNC), common malignancy which established treatment often fails despite incurring debilitating adverse effects. Preclinical clinical studies suggested that statins may enhance HNC sensitivity to radiation other conventional therapies while protecting normal tissue, but the underlying mechanisms remain poorly defined, likely involving both cholesterol-dependent -independent effects diverse cancer-related pathways. brings together recent discoveries concerning anticancer activity relevant HNC, highlighting anti-inflammatory impacts DNA-damage response. We explore molecular targets discuss integrate into regimens improve patient outcomes.

Language: Английский

Citations

19
Optimization of the Production Process of Clinical-Grade Human Salivary Gland Organoid-Derived Cell Therapy for the Treatment of Radiation-Induced Xerostomia in Head and Neck Cancer DOI Creative Commons

Jacoba van Zanten,

Annelies Jorritsma‐Smit,

Hans H. Westra

et al.

Pharmaceutics, Journal Year: 2024, Volume and Issue: 16(3), P. 435 - 435

Published: March 21, 2024

Head and neck cancer is a common worldwide. Radiotherapy has an essential role in the treatment of head cancers. After irradiation, early effects reduced saliva flow hampered water secretion are seen, along with cell loss decline amylase production. Currently, there no curative for radiation-induced hyposalivation/xerostomia. This study aimed to develop optimize validated manufacturing process salivary gland organoid cells containing stem/progenitor using patient biopsies as starting material. The should comply GMP requirements ensure clinical applicability. A laboratory-scale was further developed into good practice (GMP) process. Clinical-grade batches complying set acceptance stability criteria were manufactured. results showed that manufactured gland-derived able self-renew, differentiate, show functionality. describes optimization innovative promising novel cell-based therapy.

Language: Английский

Citations

8
Developments and future prospects of personalized medicine in head and neck squamous cell carcinoma diagnoses and treatments DOI Creative Commons
Shalindu Malshan Jayawickrama, Piyumi Madhushani Ranaweera,

Roshan Pradeep

et al.

Cancer Reports, Journal Year: 2024, Volume and Issue: 7(3)

Published: March 1, 2024

Abstract Background Precision healthcare has entered a new era because of the developments in personalized medicine, especially diagnosis and treatment head neck squamous cell carcinoma (HNSCC). This paper explores dynamic landscape medicine as applied to HNSCC, encompassing both current future prospects. Recent Findings The integration strategies into HNSCC is driven by utilization genetic data biomarkers. Epigenetic biomarkers, which reflect modifications DNA that can influence gene expression, have emerged valuable indicators for early detection risk assessment. Treatment approaches within framework are equally promising. Immunotherapy, silencing, editing techniques, including RNA interference CRISPR/Cas9, offer innovative means modulate expression correct aberrations driving HNSCC. stem research with presents opportunities tailored regenerative approaches. synergy between technological advancements exemplified artificial intelligence (AI) machine learning (ML) applications. These tools empower clinicians analyze vast datasets, predict patient responses, optimize unprecedented accuracy. Conclusion prospects transformative approach managing this complex malignancy. By harnessing insights, immunotherapy, editing, therapies, advanced technologies like AI ML, holds key enhancing outcomes ushering precision oncology.

Language: Английский

Citations

8
Review of Current and Future Medical Treatments in Head and Neck Squamous Cell Carcinoma DOI Open Access
Aaron M. Lee, Alice N. Weaver,

Phillip Acosta

et al.

Cancers, Journal Year: 2024, Volume and Issue: 16(20), P. 3488 - 3488

Published: Oct. 15, 2024

Head and neck squamous cell carcinoma (HNSCC) is a complex cancer requiring multidisciplinary approach. For patients with locally or regionally advanced disease, surgery and/or radiation are the cornerstones of definitive treatment. Medical therapy plays an important adjunct role in this setting, typically consisting platinum-based regimen given as induction, concurrent, adjuvant While relapsed/metastatic HNSCC has historically been difficult-to-treat disease poor outcomes, options have considerably improved incorporation biologics immune checkpoint inhibitors. Clinical trials ongoing to investigate novel approaches, including new combination immunotherapies, targeted therapies, therapeutic vaccines, antibody-drug conjugates, cellular therapies. The results thus far mixed, highlighting knowledge gaps that continue challenge medical oncologist treating HNSCC. Here, we present most updated broad review current treatment landscape both locoregional metastatic discuss expansive future therapies under investigation.

Language: Английский

Citations

8
Pathogenesis and Therapy of Oral Carcinogenesis DOI Open Access
Marko Tarle, Ivica Lukšić

International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(12), P. 6343 - 6343

Published: June 8, 2024

Oral squamous cell carcinoma (OSCC) is the most common malignant tumor of head and neck with an extremely poor five-year survival rate approximately 50 to 55%, despite significant advances in diagnostic therapeutic procedures over past three decades [...]

Language: Английский

Citations

7
Relationship between XPA, XPB/ERCC3, XPF/ERCC4, and XPG/ERCC5 Polymorphisms and the Susceptibility to Head and Neck Carcinoma: A Systematic Review, Meta-Analysis, and Trial Sequential Analysis DOI Creative Commons
Mohammad Moslem Imani,

Masoumeh Basamtabar,

S Akbari

et al.

Medicina, Journal Year: 2024, Volume and Issue: 60(3), P. 478 - 478

Published: March 14, 2024

Background and Objectives: Nucleotide Excision Repair (NER), the most extensively researched DNA repair mechanism, is responsible for repairing a variety of damages, Xeroderma Pigmentosum (XP) genes participate in NER. Herein, we aimed to update previous results with meta-analysis evaluating association XPA, XPB/ERCC3, XPF/ERCC4, XPG/ERCC5 polymorphisms susceptibility HNC. Materials Methods: PubMed/Medline, Web Science, Scopus, Cochrane Library databases were searched without any restrictions until 18 November 2023 find relevant studies. The Review Manager 5.3 (RevMan 5.3) software was utilized compute effect sizes, which expressed as odds ratio (OR) 95% confidence interval (CI). Results: Nineteen articles involved systematic review that included thirty-nine studies involving ten polymorphisms. reported CC genotype rs17655 polymorphism showed significantly decreased risk HNC recessive model (OR: 0.89; 95%CI: 0.81, 0.99; p-value 0.03). In addition, CT 0.65; 0.48, 0.008) rs751402 associated risk, T allele 1.28; 1.05, 1.57; 0.02), TT 1.74; 1.10, 2.74; + 2.22; 1.04, 4.74; 0.04) genotypes an increased Conclusions: analysis identified two polymorphisms, rs751402, being study underscored influence various factors, such type cancer, ethnicity, source control, sample size on these associations.

Language: Английский

Citations

6