Clinical & Translational Oncology, Journal Year: 2024, Volume and Issue: unknown
Published: Dec. 23, 2024
Language: Английский
Bioconjugate Chemistry, Journal Year: 2025, Volume and Issue: unknown
Published: Feb. 12, 2025
Brain tumors, particularly glioblastomas, represent the most complicated cancers to treat and manage due their highly invasive nature protective barriers of brain, including blood-brain barrier (BBB). The efficacy currently available treatments, viz., radiotherapy, chemotherapy, immunotherapy, are frequently limited by major side effects, drug resistance, restricted penetration into brain. Lipid nanoparticles (LNPs) have emerged as a promising targeted delivery system for brain tumors. nanocarriers gained tremendous attention tumor therapeutics multiple encapsulation abilities, controlled release, better biocompatibility, ability cross BBB. Herein, detailed analysis design, mechanisms, therapeutic benefits LNPs in treatment is discussed. Moreover, we also discuss safety issues clinical developments current future challenges. Further, focused on transformation therapy eliminating effects engineering overcome related biological barriers, which provide personalized, affordable, low-risk options.
Language: Английский
Citations
2
International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(11), P. 5694 - 5694
Published: May 23, 2024
According to the WHO 2016 classification, glioblastoma is most prevalent primary tumor in adult central nervous system (CNS) and categorized as grade IV. With an average lifespan of about 15 months from diagnosis, has a poor prognosis presents significant treatment challenge. Aberrant angiogenesis, which promotes neovascularization prospective target for molecular treatment, one its unique aggressive characteristics. Recently, existence glioma stem cells (GSCs) within tumor, are tolerant chemotherapy radiation, been linked highly form glioblastoma. Anti-angiogenic medications have not significantly improved overall survival (OS), despite various preclinical investigations clinical trials demonstrating encouraging results. This suggests need discover new options. Glioblastoma numerous cancers metformin, anti-hyperglycemic medication belonging Biguanides family, used first-line therapy type 2 diabetes mellitus (T2DM), it shown both vitro vivo anti-tumoral activity. Based on these findings, repurposed, inhibition many oncopromoter mechanisms and, result, identified pathways involved. Metformin inhibits cancer cell growth by blocking LKB1/AMPK/mTOR/S6K1 pathway, leading selective death GSCs inhibiting proliferation CD133+ cells. It minimal impact differentiated normal human The systematic retrieval information was performed PubMed. A total 106 articles were found search metformin Out six Meta-analyses, Randomized Controlled Trials, trials, Systematic Reviews. rest Literature review articles. These years 2011 2024. Appropriate studies isolated, important each them understood entered into database this article. use searched clinicaltrials.gov. In article, we examine evaluate metformin's possible effects glioblastoma, determining whether or may appropriately function anti-angiogenic substance be safely added management patients.
Language: Английский
Citations
10
Cancers, Journal Year: 2024, Volume and Issue: 16(11), P. 2089 - 2089
Published: May 30, 2024
Background: The study aims to investigate the role of hypoxia-inducible factors (HIFs) in development, progression, and therapeutic potential glioblastomas. Methodology: study, following PRISMA guidelines, systematically examined hypoxia HIFs glioblastoma using MEDLINE (PubMed), Web Science, Scopus. A total 104 relevant studies underwent data extraction. Results: Among studies, global contributions were diverse, with China leading at 23.1%. most productive year was 2019, accounting for 11.5%. Hypoxia-inducible factor 1 alpha (HIF1α) frequently studied, followed by 2 (HIF2α), osteopontin, cavolin-1. Commonly associated pathways include glucose transporter (GLUT1) 3 (GLUT3) receptors, vascular endothelial growth (VEGF), phosphoinositide 3-kinase (PI3K)-Akt-mechanistic target rapamycin (mTOR) pathway, reactive oxygen species (ROS). HIF expression correlates various hallmarks, including survival, neovascularization, metabolism, migration, invasion. Conclusion: Overcoming challenges such as treatment resistance absence biomarkers is critical effective integration HIF-related therapies into aim optimizing patient outcomes.
Language: Английский
Citations
5
Clinical & Translational Oncology, Journal Year: 2025, Volume and Issue: unknown
Published: Feb. 1, 2025
Language: Английский
Citations
0
Cancer Letters, Journal Year: 2025, Volume and Issue: unknown, P. 217601 - 217601
Published: March 1, 2025
Language: Английский
Citations
0
Frontiers in Pharmacology, Journal Year: 2025, Volume and Issue: 16
Published: March 17, 2025
Glioblastoma multiform (GBM) is considered the deadliest brain cancer. Standard therapies are followed by poor patient's survival outcomes, so novel and more efficacious therapeutic strategies imperative to tackle this scourge. Metformin has been reported have anti-cancer effects. However, precise mechanism underlying these effects remains elusive. A better understanding of its will inform future experimental designs exploring metformin as a potential adjuvant therapy for GBM. This research aimed elucidate molecular in GBM integrating proteomics transcriptomics. The study examined on cell lines using various methods. U87, U251 HA1800 were cultured modified through PER2 knockdown overexpression. Cell viability was assessed CCK8 assay, G6PDH activity intracellular NADPH+ levels measured with specific kits. ROS levels, mitochondrial membrane potential, cycle distribution apoptosis analyzed flow cytometry. RNA extracted transcriptomic analysis sequencing, while proteomic performed total protein from treated cells. WB detected proteins, RT-qPCR quantified gene expression. In vivo experiments, xenograft nude mice combining radiotherapy evaluated received IHC TUNEL staining expression assessment. Statistical analyses conducted Prism software identify significant group differences. We found that differential expressional genes proteins relating circadian rhythm enriched or transcriptomic. PER2, key gene, up-regulated when metformin. Furthermore, silent information regulator 2(SIRT2) down-regulated, G6PD just slightly increased lines. Meanwhile, production enzyme significantly decreased. Further validated inhibited growth up-regulating SIRT2/G6PD signaling pathway, enhancing radiotherapy(RT) sensitivity. also inhibition SIRT2 caused mediated PER2. pivotal role an effective regulator. Targeting clock modify rescue dysfunctional cells at level might be innovative way administer cancer chronotherapy maintain metabolic homeostasis real world practice.
Language: Английский
Citations
0
Antioxidants, Journal Year: 2025, Volume and Issue: 14(3), P. 351 - 351
Published: March 18, 2025
Curcumin, a polyphenol found in turmeric, demonstrates multifaceted anti-cancer activity against glioblastoma. Its therapeutic potential stems from its ability to modulate various molecular pathways implicated glioblastoma development and progression, enhance the effectiveness of radiation therapy, induce cancer cell death through diverse mechanisms, including apoptosis, autophagy, cycle arrest. These combined actions make curcumin promising candidate for treatment, warranting further investigation into clinical application. In this review, we summarize latest research on analogs' therapy.
Language: Английский
Citations
0
Journal of Functional Biomaterials, Journal Year: 2025, Volume and Issue: 16(4), P. 114 - 114
Published: March 24, 2025
Cancer significantly impacts human quality of life and expectancy, with an estimated 20 million new cases 10 cancer-related deaths worldwide every year. Standard treatments including chemotherapy, radiotherapy, surgical removal, for aggressive cancers, such as glioblastoma, are often ineffective in late stages. Glioblastoma, example, is known its poor prognosis post-diagnosis, a median survival time approximately 15 months. Novel therapies using local electric fields have shown anti-tumour effects glioblastoma by disrupting mitotic spindle assembly inhibiting cell growth. However, constant application poses risks like patient burns. Wireless stimulation via piezoelectric nanomaterials offers safer alternative, requiring ultrasound activation to induce therapeutic effects, altering voltage-gated ion channel conductance depolarising membrane potentials. This review highlights the mechanism, drug delivery, activation, current technologies cancer therapy, emphasising need further research address limitations biocompatibility whole systems. The goal underscore these areas inspire avenues overcome barriers developing nanoparticle-based therapies.
Language: Английский
Citations
0
Published: July 9, 2024
Background: Glioblastoma (GBM) is a highly aggressive, invasive, and growth-factor-independent grade IV glioma. Survival following the diagnosis generally poor, with median survival of approximately 15 months, it considered most aggressive lethal central nervous system tumor. Conventional treatments based on surgery, chemotherapy, radiation therapy only delay progression, death inevitable. Malignant glioma cells are resistant to traditional therapies, potentially due subpopulation stem that invasive capable rapid regrowth. Methods: Systematic retrieval information was performed PubMed. Specified keywords were used in PubMed articles published peer-reviewed scientific journals associated brain GBM cancer, sodium iodide symporter (NIS). Additionally, words 'radionuclide therapy', 'radioiodine', 'iodine-131', 'molecular imaging', 'gene 'translational imaging' used. Other such as ‘glioblastoma', 'targeted', 'theranostic', 'symporter', 'virus', 'solid tumor', 'combined 'pituitary', or 'plasmid' also appropriate literature databases search engines. 19 found this Mesenchymal Stem Cell Sodium Iodide Symporter GBM. \ These from years 2000 2024. Appropriate studies isolated, important each them understood entered into database which article. Results: For long they express functional NIS, mesenchymal systemically repress T B cells; however, after that, largely replaced by generated embryonic functionally competent. As result their natural capacity identify malignancies, MSC employed tumor vehicles. Because MSCs may be transplanted several methods, have been proposed ideal vehicles for NIS gene transfer. Conclusion: Non-invasive imaging-based detection presents an alternate means monitor diagnose evaluate recurrence. The iodine specific variety human thyroid disease functions move cell. In recent years, increasing number related reported tumors therapeutic vectors imaging therapy. Gene nuclear medicine provide new direction.
Language: Английский
Citations
3
Biomedicines, Journal Year: 2024, Volume and Issue: 12(11), P. 2429 - 2429
Published: Oct. 23, 2024
Studies increasingly support the role of gut microbiota in glioma development and treatment, although exact mechanisms remain unclear. Research indicates that can influence progression, response to therapies, effectiveness treatments like immunotherapy, with certain microbial compositions being linked better outcomes. Additionally, impacts tumor microenvironment, affecting both growth treatment. This review will explore glioma, microbiota, how their interaction shapes therapy responses. this examines metabolites, such as short-chain fatty acids (SCFAs) tryptophan, on It also explores microbiome signaling via pattern recognition receptors, molecular mimicry between antigens glioblastoma, if these interactions affect
Language: Английский
Citations
3