Investigating the Relationship between Obstructive Sleep Apnoea, Inflammation and Cardio-Metabolic Diseases

International Journal of Molecular Sciences, Journal Year: 2023, Volume and Issue: 24(7), P. 6807 - 6807

Published: April 6, 2023

Obstructive sleep apnoea (OSA) is a prevalent underdiagnosed disorder whose incidence increases with age and weight. Uniquely characterised by frequent breathing interruptions during sleep-known as intermittent hypoxia (IH)-OSA disrupts the circadian rhythm. Patients OSA have repeated episodes of reoxygenation, leading to systemic consequences. consequences range from apparent symptoms like excessive daytime sleepiness, neurocognitive deterioration decreased quality life pathological complications elevated biomarkers linked endocrine-metabolic cardiovascular changes. well-recognized risk factor for cerebrovascular diseases. Furthermore, other conditions that worsen outcomes, such obesity. The relationship between obesity complex reciprocal, involving interaction biological lifestyle factors. pathogenesis both involve oxidative stress, inflammation metabolic dysregulation. current medical practice uses continuous positive airway pressure (CPAP) gold standard tool manage OSA. It has been shown improve cardiac function, reduce normalise biomarkers. Nonetheless, full understanding factors involved in deleterious effects best methods eliminate their occurrence are still poorly understood. In this review, we present evidence linking increased conditions.

Language: Английский

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Association between glucose metabolism, the circadian cycle and hypoxia: Evaluation of the NPAS2 and Rev-Erb-α protein serum levels in obstructive sleep apnea patients – a pilot study

Dental and Medical Problems, Journal Year: 2024, Volume and Issue: 61(3), P. 465 - 469

Published: May 28, 2024

Background.Obstructive sleep apnea (OSA) is one of the risk factors for diabetes mellitus type 2 (DM2).As OSA associated with disruption circadian rhythm, it affects clock proteins, including neuronal PAS domain protein (NPAS2) and nuclear receptor subfamily 1 group D member (Rev-Erb-α).These proteins have been shown to be related metabolic abnormalities, i.a., insulin resistance.Objectives.The present pilot study aimed investigate NPAS2 Rev-Erb-α serum levels in groups patients severe OSA+DM2 comparison healthy controls, taking into account correlations polysomnography (PSG) parameters (e.g., oxygen saturation (SpO ) variables). Material methods.A total 40 participants were included study.They split 3 as follows: (n = 17; apnea-hypopnea index (AHI) >30, no DM2); 7; AHI > 30 control 16; < 5, DM2).All underwent a nocturnal PSG examination had their blood collected following morning.The assessed using enzyme-linked immunosorbent assay (ELISA). Results.The mean level was significantly lower compared individuals (p 0.017).Additionally, presented group, but only tendency observed 0.094).No differences concentration noticed.Furthermore, negative correlation between during rapid eye movement (REM) (r -0.478;p 0.002).Conclusions.Serum might involved dysregulation among patients, while mechanism itself may REM sleep.

Language: Английский

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Association Between Shift Work and Acute Coronary Syndrome According to Alcohol Intake and Smoking

Medicina, Journal Year: 2025, Volume and Issue: 61(3), P. 373 - 373

Published: Feb. 21, 2025

Background and Objectives: Shift work is associated with an increased risk of acute coronary syndrome (ACS) higher rates smoking alcohol consumption. This study examines how intake may influence the effect shift on ACS risk, indicating a complex interaction among these factors in individuals engaged work. Materials Methods: investigation utilized data from Korean Genome Epidemiology Study (KoGES). was primary exposure, main outcome ACS, defined as either myocardial infarction or angina pectoris diagnosed 2003 to 2020. Cox proportional regression analysis employed assess impact work, smoking, incidence. Additionally, we performed examine effects conjunction Results: Out 10,038 participants enrolled during period, 3696 (36.8%) met inclusion criteria. The incidence rate 11.88 per 1000 person-years group compared 5.96 non-shift group. Using logistic regression, found be hazard ratio (HR) 1.74 (95% CI, 1.20, 2.53) Smoking consumption did not exhibit significant HR for incidence, HRs 1.31 0.98, 1.75) 0.83 0.65, 1.07), respectively. In model, after adjusting other covariates, significantly current smokers (HR 1.05, 95% CI 0.49, 2.23). However, non-current smokers, emerged factor 2.26, 1.44, 3.55) (p < 0.01). No between relation Conclusions: independent (ACS), particularly smokers. finding highlights need address both lifestyle occupational when developing strategies mitigate workers. Employers policymakers should consider implementing targeted workplace interventions reduce this risk. These include optimizing schedules minimize circadian disruption, providing regular health screenings focused cardiovascular health, promoting healthy habits such balanced nutrition, physical activity, stress management programs. wellness initiatives could focus reducing modifiable factors, resources cessation limiting exposure stressors. Integrating into policies can contribute early detection prevention ultimately improving

Language: Английский

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Evaluation of SIRT1 Protein Levels and SIRT1/rs7895833 Distributions in Turkish Patients With Obstructive Sleep Apnea

Journal of Clinical Laboratory Analysis, Journal Year: 2025, Volume and Issue: unknown

Published: March 10, 2025

ABSTRACT Objective Obstructive Sleep Apnea (OSA) is a common heterogeneous sleep disorder that significantly impacts the quality of individuals and leads to severe complications. Patients with OSA often experience disrupted circadian rhythm, hyperactive hypoxia response, endothelial dysfunction, yet underlying molecular mechanism remains poorly known. Recent research suggests promising evidence potential role SIRT1 in etiology OSA, warranting further investigation. Methods We investigated associations promoter variant (rs7895833A > G) severity 199 who underwent an overnight polysomnography at clinic. Results The minor allele frequency was observed as 0.309 males ( n = 149) 0.310 females 50). No significant were between genotypes apnea‐hypopnea index (AHI) entire sample. However, we association p 0.034) rs7895833‐G stratified by AHI. Additionally, found statistically inverse correlations age protein levels total sample 0.013) male group 0.018), suggesting age‐related expression SIRT1. Our analysis also confirmed published literature, showing AHI clinical parameters such age, BMI, Epworth sleepiness scale, neck circumference. Conclusions Overall, may indirectly affect pathogenesis, which might be influenced gender. Further detailed involving large population‐based biobanks, especially focusing on gender‐based differences, will improve our understanding management.

Language: Английский

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Analysis of the efficacy of the ZJU index and triglyceride‒glucose product index in identifying obstructive sleep apnea hypoventilation syndrome in patients with metabolic syndrome

HORMONES, Journal Year: 2025, Volume and Issue: unknown

Published: March 21, 2025

Language: Английский

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Assessment of continuous positive airway pressure effect on the circadian clock signaling pathway in obstructive sleep apnea patients

Scientific Reports, Journal Year: 2025, Volume and Issue: 15(1)

Published: April 2, 2025

Obstructive sleep apnea (OSA) is associated with circadian rhythm dysregulation plausibly through affecting clock genes. The study's purpose was to investigate the effect of one-night continuous positive airway pressure treatment (CPAP treatment) on genes: BMAL1, CLOCK, CRY1, and PER1 at mRNA protein levels. study included 30 OSA patients, who underwent diagnostic polysomnography (PSG) next a effective CPAP PSG monitoring (CPAP). blood collected in evening before morning after CPAP. Protein levels expression were measured using ELISA qRT-PCR, respectively. increase observed compared (p = 0.005); additionally, level decreased 0.035). In CLOCK significant changes observed: an 0.049), 0.006), difference between vs. 0.012). Obtained results suggest that even short-term might reverse signaling pathway disruption OSA.

Language: Английский

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Exploring differences in signaling pathways of the circadian clock and neuromodulators in obstructive sleep apnea

Scientific Reports, Journal Year: 2025, Volume and Issue: 15(1)

Published: April 26, 2025

Obstructive sleep apnea (OSA) is a prevalent disorder characterized by recurring upper airway obstructions, leading to disrupted and systemic complications. The complexity of OSA suggests intricate interactions between neuromodulators circadian clock genes. This study aimed explore the expression levels rhythm genes neurotrophins (NTs) in patients compared controls. Participants (166 patients, 64 controls) were enrolled. Blood samples collected post-polysomnography (PSG), underwent RNA extraction from peripheral blood lymphocytes RT-PCR was performed for gene analysis. In group, BMAL1, CLOCK, CRY1, PER1, NPAS2, NR1D1, HIF-1β positively correlated with BDNF (p < 0.05 all). Conversely, control only PER1 mRNA showed correlation (R = 0.280, p 0.017). NF-κβ demonstrated positive HIF-1α, expressions both groups HIF-1α HIF1-β NR1D1 regardless presence underscores among genes, NTs, transcription factors OSA, providing basis potential targeted therapeutic interventions.

Language: Английский

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The Protective Role of Leptin in Neurological Damage Induced by Chronic Intermittent Hypoxia

Molecular Neurobiology, Journal Year: 2025, Volume and Issue: unknown

Published: May 7, 2025

Language: Английский

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Association of serum uric acid with all-cause and cardiovascular mortality in obstructive sleep apnea

Scientific Reports, Journal Year: 2023, Volume and Issue: 13(1)

Published: Nov. 10, 2023

The study investigated the association between Serum Uric Acid (SUA) levels and all-cause as well cardiovascular mortality in patients with Obstructive Sleep Apnea (OSA). This prospective cohort enrolled participants OSA from four cycles of National Health Nutrition Examination Survey (NHANES) conducted 2005 2008, 2015-2018. A weighted Cox proportional hazards model was used to assess adjusted hazard ratios (aHRs) their corresponding 95% confidence intervals (CI) for mortality. Additionally, multivariable logistic regression restricted cubic splines (RCS) models were employed examine nonlinear relationships SUA Among 5,584 included study, covering NHANES a median follow-up 4.333 years, total 537 deaths observed, including 108 attributed disease. Comparing fourth quartile (Q4) uric acid levels, both fifth (Q5) (aHRs = 1.51, CI [1.08, 2.12]) second (Q2) 1.53, [1.04, 2.25]) independently associated an increased risk Furthermore, comparing 2.40, 5.35]) RCS demonstrated U-shaped pattern OSA, inflection point observed at 5.83 mg/dl. findings this suggest serum nonlinearity Further studies are warranted determine causal relationship

Language: Английский

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The role of microRNAs in pathophysiology and diagnostics of metabolic complications in obstructive sleep apnea patients

Frontiers in Molecular Neuroscience, Journal Year: 2023, Volume and Issue: 16

Published: July 21, 2023

Obstructive sleep apnea (OSA) is one of the most common disorders, which characterized by recurrent apneas and/or hypopneas occurring during due to upper airway obstruction. Among a variety health consequences, OSA patients are particularly susceptible developing metabolic complications, such as syndrome and diabetes mellitus type 2. MicroRNAs (miRNAs) epigenetic modulators promising particles in both understanding pathophysiology prediction complications. This review describes role miRNAs development OSA-associated Moreover, it summarizes usefulness biomarkers predicting aforementioned

Language: Английский

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