International Journal of Molecular Sciences,
Journal Year:
2024,
Volume and Issue:
25(24), P. 13494 - 13494
Published: Dec. 17, 2024
Cardiovascular
diseases
(CVDs)
are
the
leading
cause
of
death
worldwide,
and
effectively
repairing
heart
following
myocardial
injuries
remains
a
significant
challenge.
Research
has
increasingly
shown
that
exosomes
derived
from
mesenchymal
stem
cells
(MSC-Exo)
can
ameliorate
improve
outcomes
after
such
injuries.
The
therapeutic
benefits
MSC-Exo
largely
due
to
their
capacity
deliver
specific
cargo,
including
microRNAs
proteins.
modulate
various
signaling
pathways
provide
several
beneficial
effects,
cytoprotection,
inflammation
modulation,
angiogenesis
promotion
help
repair
damaged
myocardium.
In
this
review,
we
summarize
cardioprotective
effects
in
injury,
underlying
molecular
mechanism
involved
process,
approaches
studied
enhance
efficacy
based
on
recent
findings.
Advanced Science,
Journal Year:
2024,
Volume and Issue:
11(30)
Published: June 14, 2024
Abstract
In
recent
decades,
research
on
Extracellular
Vesicles
(EVs)
has
gained
prominence
in
the
life
sciences
due
to
their
critical
roles
both
health
and
disease
states,
offering
promising
applications
diagnosis,
drug
delivery,
therapy.
However,
inherent
heterogeneity
complex
origins
pose
significant
challenges
preparation,
analysis,
subsequent
clinical
application.
This
review
is
structured
provide
an
overview
of
biogenesis,
composition,
various
sources
EVs,
thereby
laying
groundwork
for
a
detailed
discussion
contemporary
techniques
preparation
analysis.
Particular
focus
given
state‐of‐the‐art
technologies
that
employ
microfluidic
non‐microfluidic
platforms
EV
processing.
Furthermore,
this
discourse
extends
into
innovative
approaches
incorporate
artificial
intelligence
cutting‐edge
electrochemical
sensors,
with
particular
emphasis
single
proposes
current
outlines
prospective
avenues
future
research.
The
objective
motivate
researchers
innovate
expand
methods
analysis
fully
unlocking
biomedical
potential.
Frontiers in Cell and Developmental Biology,
Journal Year:
2025,
Volume and Issue:
13
Published: Jan. 24, 2025
Exosomes,
as
key
mediators
of
intercellular
communication,
have
been
increasingly
recognized
for
their
role
in
the
oncogenic
processes,
particularly
facilitating
drug
resistance.
This
article
delves
into
emerging
evidence
linking
exosomal
lncRNAs
to
modulation
resistance
mechanisms
cancers
such
ovarian,
cervical,
and
endometrial
cancer.
It
synthesizes
current
research
findings
on
how
these
influence
cancer
cell
survival,
tumor
microenvironment,
chemotherapy
efficacy.
Additionally,
review
highlights
potential
therapeutic
strategies
targeting
lncRNAs,
proposing
a
new
frontier
overcoming
By
mapping
interface
resistance,
this
aims
provide
comprehensive
understanding
that
could
pave
way
innovative
treatments
improved
patient
outcomes
female
reproductive
system
cancers.
International Journal of Molecular Sciences,
Journal Year:
2023,
Volume and Issue:
24(21), P. 15677 - 15677
Published: Oct. 27, 2023
Exosomes,
as
potent
intercellular
communication
tools,
have
garnered
significant
attention
due
to
their
unique
cargo-carrying
capabilities,
which
enable
them
influence
diverse
physiological
and
pathological
functions.
Extensive
research
has
illuminated
the
biogenesis,
secretion,
functions
of
exosomes.
These
vesicles
are
secreted
by
cells
in
different
states,
exerting
either
protective
or
harmful
biological
Emerging
evidence
highlights
role
cardiovascular
disease
(CVD)
mediating
comprehensive
interactions
among
cell
types.
This
review
delves
into
impacts
exosomes
on
CVD
under
stress
conditions,
including
coronary
artery
(CAD),
myocardial
infarction,
heart
failure,
other
cardiomyopathies.
Focusing
cellular
signaling
mechanisms,
we
explore
how
mediate
multifaceted
interactions,
particularly
contributing
endothelial
dysfunction,
oxidative
stress,
apoptosis
pathogenesis.
Additionally,
show
great
promise
biomarkers,
reflecting
differential
expressions
NcRNAs
(miRNAs,
lncRNAs,
circRNAs),
therapeutic
carriers
for
targeted
treatment.
However,
specific
regulatory
mechanisms
governing
remain
incomplete,
necessitating
further
exploration
characteristics
roles
various
CVD-related
contexts.
aims
provide
novel
insights
implications
offer
innovative
perspectives
diagnosis
treatment
CVD.
Biomaterials Research,
Journal Year:
2023,
Volume and Issue:
27(1)
Published: Feb. 9, 2023
Abstract
Background
In
recent
years,
cardiovascular
disease
in
particular
myocardial
infarction
(MI)
has
become
the
predominant
cause
of
human
disability
and
mortality
clinical
setting.
The
restricted
capacity
adult
cardiomyocytes
to
proliferate
restore
function
infarcted
sites
is
a
challenging
issue
after
occurrence
MI.
application
stem
cells
byproducts
such
as
exosomes
(Exos)
paved
way
for
alleviation
cardiac
tissue
injury
along
with
conventional
medications
clinics.
However,
short
lifespan
activation
alloreactive
immune
response
Exos
are
main
issues
patients
Therefore,
there
an
urgent
demand
develop
therapeutic
approaches
minimum
invasion
restoration
function.
Main
body
Here,
we
focused
on
data
associated
Exo-loaded
hydrogels
ischemic
tissue.
Whether
how
advances
engineering
modalities
have
increased
efficiency
whole-based
therapies
under
conditions.
integration
nanotechnology
nanobiology
designing
novel
smart
biomaterials
outcomes
was
highlighted.
Conclusion
Hydrogels
can
provide
suitable
platforms
transfer
Exos,
small
molecules,
drugs,
other
bioactive
factors
direct
injection
into
damaged
myocardium.
Future
studies
should
focus
improvement
physicochemical
properties
Exo-bearing
hydrogel
translate
standard
treatment
options.
Graphical
Cancers,
Journal Year:
2025,
Volume and Issue:
17(6), P. 940 - 940
Published: March 10, 2025
Exosomes
have
emerged
as
pivotal
players
in
precision
oncology,
offering
innovative
solutions
to
longstanding
challenges
such
metastasis,
therapeutic
resistance,
and
immune
evasion.
These
nanoscale
extracellular
vesicles
facilitate
intercellular
communication
by
transferring
bioactive
molecules
that
mirror
the
biological
state
of
their
parent
cells,
positioning
them
transformative
tools
for
cancer
diagnostics
therapeutics.
Recent
advancements
exosome
engineering,
artificial
intelligence
(AI)-driven
analytics,
isolation
technologies
are
breaking
barriers
scalability,
reproducibility,
clinical
application.
Bioengineered
exosomes
being
leveraged
CRISPR-Cas9
delivery,
while
AI
models
enhancing
biomarker
discovery
liquid
biopsy
accuracy.
Despite
these
advancements,
key
obstacles
heterogeneity
populations
lack
standardized
protocols
persist.
This
review
synthesizes
pioneering
research
on
biology,
molecular
translation,
emphasizing
dual
roles
both
mediators
tumor
progression
intervention.
It
also
explores
emerging
areas,
including
microbiome–exosome
interactions
integration
machine
learning
exosome-based
medicine.
By
bridging
innovation
with
translational
strategies,
this
work
charts
a
forward-looking
path
integrating
into
next-generation
care,
setting
it
apart
comprehensive
guide
overcoming
technological
hurdles
rapidly
evolving
field.
Analytical Chemistry,
Journal Year:
2025,
Volume and Issue:
unknown
Published: March 25, 2025
Extracellular
vesicles
(EVs)
play
crucial
roles
in
intercellular
communication
and
hold
great
promise
as
biomarkers
for
noninvasive
disease
diagnosis.
Intensive
research
efforts
have
been
devoted
to
discovering
the
EV
subpopulations
responsible
specific
functions
or
with
enhanced
effectiveness
markers,
through
extensive
purification
content
analysis.
However,
their
high
heterogeneity
size
cargo
composition
poses
significant
challenges
reaching
such
goals.
Isolation
methods
like
ultracentrifugation
size-exclusion
chromatography,
well
analysis
approaches
polymerase
chain
reaction
enzyme-linked
immunosorbent
assay,
made
contributions
improving
our
understanding
of
biology.
Nonetheless,
these
face
limitations
isolation
efficiency,
purity,
detection
sensitivity
specificity
due
issues
large
sample
consumption,
unsatisfactory
insufficient
resolution
subtyping.
Microfluidic
technology
presents
promising
solutions
challenges,
leveraging
intrinsic
capabilities
precise
flow
external
energy
field
manipulation,
compartmentalization,
signal
enhancement
at
micro-
nanoscale.
Hence,
this
review
summarizes
recent
developments
microfluidics-enabled
analysis,
paying
special
attention
unique
microfluidic
features
exploited.
Strategies
viscoelastic
inertial
flow,
fluid
mixing,
external-field-assisted
purification,
compartmentalization
micro/nanostructures
enhancing
detection,
are
examined.
Furthermore,
current
potential
future
directions
discussed
inspire
advancements
rapidly
developing
field.
Ultrastructural Pathology,
Journal Year:
2025,
Volume and Issue:
unknown, P. 1 - 9
Published: April 23, 2025
We
previously
reported
that
human
hypertension
is
associated
with
ultrastructural
remodeling
of
systemic
resistance
arteries.
Endothelial
and
smooth
muscle
cells
(SMC)
displayed
mitochondrial
sarco-endoplasmic
reticulum
stress,
accompanied
by
SMC
migration
toward
the
intima.
Exosomes,
nano-sized
phospholipid
bilayer-enclosed
vesicles
released
from
upon
fusion
multivesicular
bodies
(MVB)
plasma
membrane,
are
thought
to
be
involved
in
endothelial-to-SMC
communication
regulating
these
adaptations.
However,
there
a
dearth
studies
on
microvascular
exosomes
during
hypertension.
Therefore,
we
characterized
quantified
omental
resistance-sized
arteries
(200-400
μm),
obtained
surgery
19
women
(9
hypertensive),
mean
age
42
y
(SE
1).
The
number
MVBs
was
around
7-fold
higher
hypertensives,
mean,
3.8
0.2)/cell
vs
0.5
(0.1)
normotensives,
shift
scant
dispersion
intracellular
prominent
abluminal
endothelial
location
hypertensives.
also
contained
significantly
more
7.9
(0.2)
5.0
(0.2)/MVB
normotensives.
