A Narrative Review on Plant Extracts for Metabolic Syndrome: Efficacy, Safety, and Technological Advances

Nutrients, Journal Year: 2025, Volume and Issue: 17(5), P. 877 - 877

Published: Feb. 28, 2025

Metabolic syndrome, a global health concern, is characterized by visceral obesity, hyperglycemia, dyslipidemia, hypertension, and chronic low-grade inflammation. Current therapeutic options are limited their varying efficacy significantly adverse side effects, fueling interest in natural products, particularly plant extracts, as potential preventive interventions for high-risk individuals. This review examines the role of extracts mitigating metabolic syndrome risk factors, addressing safety concerns exploring associated technological advancements. The literature indicates that hold promise pathophysiology dysfunction. However, challenges such concerns, lack standardized regulation, drug-plant interactions currently limit clinical application. Rigorous, long-term trials necessary to confirm before they can be established strategy managing syndrome.

Language: Английский

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METFORMIN MITIGATES SEPSIS-ASSOCIATED PULMONARY FIBROSIS BY PROMOTING AMPK ACTIVATION AND INHIBITING HIF-1α–INDUCED AEROBIC GLYCOLYSIS

Shock, Journal Year: 2023, Volume and Issue: 61(2), P. 283 - 293

Published: Nov. 15, 2023

ABSTRACT Recent research has revealed that aerobic glycolysis a strong correlation with sepsis-associated pulmonary fibrosis (PF). However, at present, the mechanism and pathogenesis remain unclear. We aimed to test hypothesis adenosine monophosphate-activated protein kinase (AMPK) activation suppression of hypoxia-inducible factor 1α (HIF-1α)–induced play central role in septic fibrogenesis. Cellular experiments demonstrated lipopolysaccharide increased fibroblast through AMPK inactivation, HIF-1α induction, alongside an augmentation glycolysis. By contrast, effects were reversed by or inhibition. In addition, pretreatment metformin, which is activator, suppresses expression alleviates PF associated sepsis, caused glycolysis, mice. Hypoxia-inducible knockdown similar protective vivo . Our implies targeting HIF-1α–induced metformin might be practical useful therapeutic alternative for PF.

Language: Английский

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The Influence of Catechin on Adiponectin and Insulin Resistance in Obese Rats

Kufa Journal For Veterinary Medical Sciences, Journal Year: 2024, Volume and Issue: 15(1), P. 34 - 42

Published: June 30, 2024

Obesity represented as an abnormal accumulation of visceral fat. The synthesis adiponectin has been linked to fat accumulation. Obesity, and cardiovascular disease have all decreased levels adiponectin. This study included the effect catechin administration for 30 days on lipid profile, glucose, insulin serum well IR obese female rats. Twenty rats were conducted experiment where divide four equal groups as; negative normal group received diet time (60 days); positive control high (HFD) GTC-fed fed HFD; ATV-fed this ATV cholesterol lowering drug. significant differences considered at (p < 0.05 with 95% CI). revealed that Total-Ch, triglycerides glucose significantly higher in than group. Additionally, a level Catechin treatment Moreover, reduction means obtained compared groups. Furthermore, difference between HDL-C also differed In conclusion exposed influence obesity lethal factors such cholesterol, hyperglycemia, concentration

Language: Английский

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Green Tea Kombucha Impacts Inflammation and Salivary Microbiota in Individuals with Excess Body Weight: A Randomized Controlled Trial

Nutrients, Journal Year: 2024, Volume and Issue: 16(18), P. 3186 - 3186

Published: Sept. 20, 2024

Background: Green tea kombucha (GTK) is a fermented beverage with promising health benefits, but few studies proved its impact on human health. Thus, we aimed to investigate the of GTK weight loss, inflammation, and salivary microbiota in individuals excess body weight. Methods: This randomized controlled clinical trial that lasted 10 weeks two groups weight: control (CG; n = 29; caloric restriction) (KG; 30; restriction + 200 mL GTK). Body composition, anthropometry, saliva, blood collection were performed beginning end intervention. Plasma interleukins determined by flow cytometry. Salivary was analyzed 16S rRNA sequencing. Results: Both decreased weight, BMI, fat (p < 0.001) after intervention, there no differences between groups. The KG reduced lipid accumulation product (LAP) 0.029). IL-1β IL-8, IL-6 increased CG 0.023) compared group. Alpha beta diversity KG. Moreover, presented lower Bacillota/Bacteroidota ratio 0.028), BMI positively associated Bacillota phylum. Conclusions: did not enhance it LAP. helped inflammatory profile induced positive changes oral composition.

Language: Английский

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Global hotspots and trends in tea anti-obesity research: a bibliometric analysis from 2004 to 2024

Frontiers in Nutrition, Journal Year: 2024, Volume and Issue: 11

Published: Nov. 13, 2024

Background The prevalence of obesity and its related ailments is on the rise, posing a substantial challenge to public health. Tea, widely enjoyed for flavors, has shown notable potential in mitigating obesity. Yet, there remains lack exhaustive bibliometric studies this domain. Methods We retrieved analyzed multidimensional data concerning tea from January 2004 June 2024, using Web Science Core Collection database. This investigation utilized tools such as Bibliometrix, CiteSpace, VOSviewer gather analyze geographical distribution, leading institutions, prolific authors, impactful journals, citation patterns, prevalent keywords. Results There been significant surge publications relevant field within last two decades. Notably, China, Hunan Agricultural University, journal Food Function have emerged contributors terms country, institution, publication medium, respectively. Zhonghua Liu University distinction most publications, whereas Joshua D. Lambert State New Jersey cited author. Analyses co-citations frequently used keywords identified critical focus areas anti-obesity research. Current are primarily aimed at understanding roles components regulating gut microbiota, boosting fat oxidation, increasing metabolic rate. research trajectory progressed preliminary mechanism clinical trials more sophisticated investigations into mechanisms, particularly focusing tea’s regulatory effects microbiota. Conclusion study offers an intricate overview prevailing conditions, principal areas, developmental trends role against It delivers comprehensive summary discourse recent progress field, emphasizing study’s core findings pivotal insights. Highlighting efficacy prevention treatment, also points out need continued area.

Language: Английский

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The potential efficacy of Artemisia anuua L. extract nanoparticles in mitigating obesity-related-metabolic complications in hypercaloric diet-fed rats

Egyptian Journal of Basic and Applied Sciences, Journal Year: 2024, Volume and Issue: 11(1), P. 183 - 212

Published: March 27, 2024

Obesity-related health problems are worsening in various societies worldwide. Artemisia anuua L. (AA) has distinctive benefits, including anti-inflammatory, antioxidant, and insulin-sensitizing properties. Nanoformulation of herbal extracts is a new approach to enhance the bioavailability natural products. This study aimed evaluate efficacy AA extract, either conventional extract (AAE) or its nano-form (AAEN), modulating obesity-related metabolic complications hypercaloric (high-fat/high-sucrose) diet-induced obese rats. Forty-eight rats were divided into two groups fed basal diet for twelve weeks. Starting from eighth week, each main group was subdivided three subgroups treated orally with saline, AAE, AAEN until end experiment. Both AAE exerted antiadipogenic effects. They reduced body weight epididymal fat, mitigated dyslipidemia, improved glucose utilization insulin resistance, hyperleptinemia, increased serum adiponectin, decreased oxidative stress inflammatory markers. These results mediated by regulating SIRT-1, PGC-1α, SREBP-1, PPAR-γ, FAS, LPL, IRS 1, GLUT4 gene expression, suggesting an effect on de novo lipogenesis utilization. The produced more expressive ameliorating effects than extract. administration ameliorated obesity-associated induced feeding diet, implying that this may be used as complementary treatment option obesity consequences. effectiveness enhanced nanoformulation, nanoparticle system can applied boost other medicine effectiveness.

Language: Английский

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Formulation and Characterization of Nanoparticle-Protein Sirtuin 1 (NPS1) by Nanoprecipitation Technique

Biomedical & Pharmacology Journal, Journal Year: 2024, Volume and Issue: 17(2), P. 751 - 756

Published: June 25, 2024

Atherosclerosis is a cardiovascular disease caused by endothelial dysfunction. This situation will trigger the bone marrow to immediately replace it with new progenitor cells (EPC) cells. However, some studies suggest that EPC can experience premature senescence. Sirtuin-1 (SIRT1) cellular post-translational protein has task of repairing dysfunctional Studies have tried develop SIRT1 activation, but currently, there are no attempted increase levels in Nanoparticles (NPS) one methods nanomedicine, which advantage being drug carrier. So, further research needed on adding exogenous levels, NPS, improve quality and prevent study aims report formulation characterization stages nanoparticles carrying (NPS1) different solvents, such as ethanol aquadest. The method used this uses nanoprecipitation. at stage included organoleptic tests, pH quantifying using Nanodrops determining presence adsorbed proteins. test showed NPS1 was acidic (K1 = 5.412 ± 0.73; K2 3.624 0.45; F1 5.418 0.55; F2 4.182 0.07), yellow color, had characteristic odor. Thus, characteristics be development for anti-senescence therapy research, both vitro, vivo, evaluation preparations still very possible developed.

Language: Английский

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Natural Lipase Inhibitors in Recent Years: A Review

ChemistrySelect, Journal Year: 2024, Volume and Issue: 9(33)

Published: Aug. 30, 2024

Abstract Obesity is a condition caused by abnormal fat accumulation. The prevalence of obesity and related diseases increasing globally, efforts to find solutions are ongoing. In addition diet, exercise, surgery, drug therapy recommended for individuals seeking solution. Current anti‐obesity drugs target central peripheral pathways. However, targeting the nervous system have serious side effects. Therefore, one approaches in treatment inhibit pancreatic lipase (PL), which acts on Currently, only clinically approved PL inhibitor Orlistat, but this semi‐synthetic has also been associated with unwanted Recently, there extensive research natural sources products derived from these as potential inhibitors fewer This article reviews recent vitro studies inhibiting enzyme extracts plants, fungi, algae, well extracts. addition, review presents molecular docking vivo demonstrating inhibitors.

Language: Английский

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The Potential Efficacy of Artemisia Anuua L. Extract Nanoparticles in Mitigating Obesity-Related-Metabolic Complications in Hypercaloric Diet-Fed Rats

Research Square (Research Square), Journal Year: 2023, Volume and Issue: unknown

Published: Oct. 19, 2023

Abstract Obesity-related health problems are getting worse in various societies worldwide. Artemisia anuua L. (AA) has distinctive benefits, including anti-inflammatory, antioxidant, and insulin-sensitizing properties; however, its major constituents' limitedsolubility bioavailability constrain absorption. This study aimed to use a sonochemical technique nano-formulate the AA ethanolic extract (AAE) produce AAE nanoparticles (AAEN) compare their efficacy modulating obesity-related complications hypercaloric (high-fat /high-sucrose, HF/HS) diet-induced obese rats. Forty-eight Sprague Dawley adult rats were divided into two main groups fed basal or diet for twelve weeks. Starting from eighth week, each group was subdivided three subgroups treated orally with either saline, AAE, AAEN till end of experiment (12 weeks). exerted antiadipogenic effects. They reduced body weight epididymal fat, mitigated dyslipidemia, improved glucose utilization, insulin resistance hyperleptinemia, increased serum adiponectin, decreased oxidative stress andinflammatory markers. These results mediated by controlling expression critical genes contributing lipids carbohydrate metabolism.AAEN produced more expressive ameliorating effects than conventional extract. In conclusion, nanoformulation annua boosted efficacy.

Language: Английский

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