Effects of Globularia cordifolia on colon cancer cells: antioxidant activity, inflammatory cytokine analysis and molecular docking studies DOI Open Access
Emine İncilay Torunoğlu, Erdi Can Aytar, Betül Aydın

et al.

Journal of the Science of Food and Agriculture, Journal Year: 2024, Volume and Issue: unknown

Published: Dec. 27, 2024

Abstract BACKGROUND The present study aimed to comprehensively evaluate the anticancer, anti‐inflammatory, and antioxidant properties of Globularia cordifolia L. samples. plant material was collected extracted using maceration method. Antioxidant activities were assessed through DPPH (i.e. 2,2‐diphenyl‐1‐picrylhydrazyl) iron chelation assays, whereas phenolic flavonoid contents measured spectrophotometric methods. Gas chromatography‐mass spectrometry analysis performed identify biologically active compounds. cytotoxic effect on colon cancer cells evaluated MTT [i.e. 2,3‐bis‐(2‐methoxy‐4‐nitro‐5‐sulfophenyl)‐2H‐tetrazolium‐5‐carboxanilide] inflammatory cytokine levels an enzyme‐linked immunosorbent assay. Molecular docking studies investigated interactions bioactive compounds with 4UYA protein, ADME absorption, distribution, metabolism, excretion toxicity) modeling predicted their toxicity. RESULTS revealed that extract exhibited strong activity a median 50% inhibitory concentration (IC 50 ) value 39.48 ± 2.15 μg mL −1 in assay effective capacity IC 4.28 0.19 mg . total content 662.51 20.95 gallic acid equivalents g , 114.99 0.51 quercetin demonstrating extract's richness Significant antiproliferative effects observed at dose 250 Inflammatory indicated reduction pro‐inflammatory responses. showed binding affinities between suggesting mechanisms action. CONCLUSION findings indicate G. exhibits antioxidant, anti‐inflammatory properties, making it promising biomolecular agent for therapy. high contents, combined compounds' key molecular targets, underscore its potential therapeutic applications. © 2024 Society Chemical Industry.

Language: Английский

Impact of nanopollution on plant growth, photosynthesis, toxicity, and metabolism in the agricultural sector: An updated review DOI
Muthu Thiruvengadam, Hee Yong Youn, Seung‐Hyun Kim

et al.

Plant Physiology and Biochemistry, Journal Year: 2024, Volume and Issue: 207, P. 108370 - 108370

Published: Jan. 14, 2024

Language: Английский

Citations

19

Unlock Laboratory Waste Potential to Turn into Sustainable Bi-metallic Nanoparticles with Dyes Degradation and Therapeutic Activities DOI
Selma Hamimed,

Mohammed Zakaria Khelifati,

Rayene Hamimed

et al.

Journal of Inorganic and Organometallic Polymers and Materials, Journal Year: 2025, Volume and Issue: unknown

Published: March 21, 2025

Language: Английский

Citations

1

Nanoparticles as Elicitors and Harvesters of Economically Important Secondary Metabolites in Plants DOI
Sanchaita Lala

Reference series in phytochemistry, Journal Year: 2025, Volume and Issue: unknown, P. 1191 - 1240

Published: Jan. 1, 2025

Language: Английский

Citations

1

De Novo synthesis of selenium-doped CeO2@Fe3O4 nanoparticles for improving secondary metabolite biosynthesis in Carthamus tinctorius cell suspension culture DOI
Kamran Ashraf, Zebo Liu, Qamar uz Zaman

et al.

Chemical Engineering Journal, Journal Year: 2025, Volume and Issue: unknown, P. 159705 - 159705

Published: Jan. 1, 2025

Language: Английский

Citations

0

Biological Effects of Green Synthesized Al-ZnO Nanoparticles Using Leaf Extract from Anisomeles indica (L.) Kuntze on Living Organisms DOI Creative Commons

S. K. Johnsy Sugitha,

R. Latha,

Raja Venkatesan

et al.

Nanomaterials, Journal Year: 2024, Volume and Issue: 14(17), P. 1407 - 1407

Published: Aug. 28, 2024

The synthesis of Al-ZnO nanoparticles (NPs) was achieved using a green approach, utilizing leaf extract from Anisomeles indica (L.) in straightforward co-precipitation method. goal this study to investigate the production through reduction and capping method extract. powder X-ray diffraction, UV spectroscopy, Fourier transform infrared scanning electron microscopy with EDAX analysis were used analyze nanoparticles. diffraction confirmed presence spherical structures an average grain size 40 nm diameter, while UV–visible spectroscopy revealed prominent absorption peak at 360 nm. FTIR spectra demonstrated stretching vibrations associated O-H, N-H, C=C, C-N, C=O as well C-Cl groups indicating their involvement stabilization SEM image spongy, spherical, porous agglomerated nanoparticles, confirming chemical composition use technique. showed increased bactericidal activity against both Gram-positive Gram-negative bacteria. antioxidant property synthesized by DPPH radical scavenging IC50 value 23.52 excellent capability. Green shown vivo studies on HeLa cell lines be effective for cancer treatment. Additionally, α-amylase inhibition assay α-glucosidase potent anti-diabetic activities. Moving forward, current methodology suggests that phenolic groups, flavonoids, amines exhibit significant promise eliciting biological responses, including effects, realms biomedical pharmaceutical applications.

Language: Английский

Citations

3

Nanoparticles as new elicitors for the production of bioactive and phytochemicals in vitro and in vivo plant culture DOI

Mahsa Darbahani,

M. Ghiyasi,

Mahdi Rahaie

et al.

Phytochemistry Reviews, Journal Year: 2024, Volume and Issue: unknown

Published: Sept. 19, 2024

Language: Английский

Citations

3

Changes in Growth and Secondary Metabolite Production in Cannabis Sativa L. in Response to Simultaneous Treatment with Plasma Activated water, Melatonin and Nano-Zinc DOI
Hakimeh Oloumi,

Fatemeh Nasibi,

Zakie Poorsheikhali

et al.

BioNanoScience, Journal Year: 2025, Volume and Issue: 15(2)

Published: April 4, 2025

Language: Английский

Citations

0

Biosynthesized sulfur nanoparticles: a novel strategy to enhance antioxidant secondary metabolites in Lotus arabicus L. callus cultures DOI Creative Commons
Sherien E. Sobhy, Asmaa M. Khalifa, E. S. E. Hafez

et al.

BMC Plant Biology, Journal Year: 2025, Volume and Issue: 25(1)

Published: May 7, 2025

Abstract Background Secondary metabolites are distinct compounds with significant medicinal value, yet their production and chemical synthesis present considerable challenges. This necessitates the development of innovative strategies to improve yield. study investigated potential biosynthesized sulfur nanoparticles (SNPs) as an eco-friendly elicitor enhance antioxidant secondary in Lotus arabicus L. callus cultures. Results After seven weeks, induced calli L were transferred MS media supplemented SNPs at different concentrations (0, 25, 50, 100, 200 mg/l). The results indicated that (100 mg/l) significantly higher profiles for biomass metabolite compared control treatments. Enzyme activities related biosynthesis, specifically phenylalanine ammonia lyase (PAL) polyphenol oxidase (PPO) enhanced a dose-dependent manner, greatest increases observed 100 mg/l SNPs. also modulated oxidative stress markers (MDA H 2 O ), generally improving growth conditions by reducing stress, except highest concentration mg/l. Additionally, application markedly upregulated expression levels six crucial genes biosynthesis pathway ( chalcone synthase CHS), PAL), flavonol FLS), isomerase CHI) , hydroxycinnamoyl CoA quinate transferase (HQT) deoxyxylulose phosphate reductoisomerase DXR )). Quantitative HPLC profiling 16 phenolic flavonoid revealed supplementation resulted noticeable boots majority measured SNP supplementation. Conclusion Overall, culture positively influenced molecular physiological levels, increasing its use.

Language: Английский

Citations

0

Evaluation and efficacy of plant extracts in eradicating medically important mosquitoes: a review DOI
K. Dass

Toxicology and Environmental Health Sciences, Journal Year: 2024, Volume and Issue: 16(4), P. 413 - 458

Published: April 21, 2024

Language: Английский

Citations

2

Upregulated synthesis and production of bioactive compounds in Lotus arabicus L. by in vitro feeding with dried powder of date palm seeds DOI Creative Commons
Doaa E. Elsherif, Fatmah Ahmed Safhi, Asmaa M. Khalifa

et al.

BMC Plant Biology, Journal Year: 2024, Volume and Issue: 24(1)

Published: March 27, 2024

Abstract Background Plants are considered the primary source of many principal bioactive compounds that have been utilized in a wide range applications including pharmaceutical and biotechnological industries. Therefore, there is an imperative need to modulate production natural components. The present study aimed determine importance dried pulverized date palm seeds (DPS) as elicitor for synthesis secondary metabolites Lotus arabicus L. Results presence various antioxidant compounds, simple sugars, amino acids, fatty acids reasonable mineral contents was distinct phytochemical characterization DPS. major components detected DPS analysis were 5-(hydroxymethyl) furfural 2,3-dihydro-3,5-dihydroxy-6-methyl-4H-pyranone. induced callus (seven weeks old) supplemented with at different concentrations (0, 2, 4, 8 10 g/l) culture media. Treatment g/l highest capacity, ascorbic acid content (total phenolics flavonoids) produced callus. Stress biomarkers (hydrogen peroxide malondialdehyde) found control ranges except expression patterns key genes involoved metabolism modulation, such phenylalanine ammonia lyase ( PAL ), chalcone synthase CHS isomerase CHI flavonol FLS ) deoxyxylulose phosphate reductoisomerase DXR triggered after treatments. Moreover, quantitative profiling phenolic flavonoid showed supplementation DPS, especially g/l, led pronounced increases most measured compounds. Conclusion marked upregulation eliciting-responsive overproduction provide molecular-based evidence intensifying pathways phenylpropanoid, terpenoid biosynthesis. Overall, vitro highlights stimulating capacity utilization improve physiological molecular levels, enhancing its potential medicinal herb.

Language: Английский

Citations

1