Targeting natural antioxidant polyphenols to protect neuroinflammation and neurodegenerative diseases: a comprehensive review

Frontiers in Pharmacology, Journal Year: 2025, Volume and Issue: 16

Published: Jan. 24, 2025

Polyphenols, naturally occurring phytonutrients found in plant-based foods, have attracted significant attention for their potential therapeutic effects neurological diseases and neuroinflammation. These compounds possess diverse neuroprotective capabilities, including antioxidant, anti-inflammatory, anti-amyloid properties, which contribute to mitigating the progression of neurodegenerative conditions such as Alzheimer's Disease (AD), Parkinson's (PD), Dementia, Multiple Sclerosis (MS), Stroke, Huntington's (HD). Polyphenols been extensively studied ability regulate inflammatory responses by modulating activity pro-inflammatory genes influencing signal transduction pathways, thereby reducing neuroinflammation neuronal death. Additionally, polyphenols shown promise various cellular signaling pathways associated with viability, synaptic plasticity, cognitive function. Epidemiological clinical studies highlight polyphenol-rich diets decrease risk alleviate symptoms disorders Furthermore, demonstrated through regulation key Akt, Nrf2, STAT, MAPK, play critical roles neuroprotection body's immune response. This review emphasizes growing body evidence supporting combating neurodegeneration neuroinflammation, well enhancing brain health. Despite substantial promising hypotheses, further research investigations are necessary fully understand role establish them advanced targets age-related neuroinflammatory conditions.

Language: Английский

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The Neurometabolic Function of the Dopamine–Aminotransferase System

Metabolites, Journal Year: 2025, Volume and Issue: 15(1), P. 21 - 21

Published: Jan. 6, 2025

The neurometabolic function is controlled by a complex multi-level physiological system that includes neurochemical, hormonal, immunological, sensory, and metabolic components. Functional disorders of monoamine systems are often detected in clinical practice together with dysfunctions. An important part the mentioned pathological conditions associated disturbances protein metabolism, some most biomarkers which aminotransferases transcription factors regulate direct reactions. Another energy metabolism dopamine-mediated regulation metabolism. review describes research results into mechanism humans animals. Particular attention paid to mechanisms dopamine-aminotransferase separate, independent, regulatory diagnostically significant biochemical pathway hormonal system, key hormone cortisol, neurotransmitter dopamine, factor CREB, enzymes alanine aminotransferase, aspartate tyrosine aminotransferase. This presents an original study describing discovery new for A this system.

Language: Английский

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Advances in Understanding Biomarkers and Treating Neurological Diseases -Role of the Cerebellar Dysfunction and Emerging Therapies

Ageing Research Reviews, Journal Year: 2024, Volume and Issue: unknown, P. 102519 - 102519

Published: Sept. 1, 2024

Language: Английский

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Advancing CNS Therapeutics: Enhancing Neurological Disorders with Nanoparticle-Based Gene and Enzyme Replacement Therapies

International Journal of Nanomedicine, Journal Year: 2025, Volume and Issue: Volume 20, P. 1443 - 1490

Published: Feb. 1, 2025

Abstract: Given the complexity of central nervous system (CNS) and diversity neurological conditions, increasing prevalence disorders poses a significant challenge to modern medicine. These disorders, ranging from neurodegenerative diseases psychiatric not only impact individuals but also place substantial burden on healthcare systems society. A major obstacle in treating these conditions is blood-brain barrier (BBB), which restricts passage therapeutic agents brain. Nanotechnology, particularly use nanoparticles (NPs), offers promising solution this challenge. NPs possess unique properties such as small size, large surface area, modifiable characteristics, enabling them cross BBB deliver drugs directly affected brain regions. This review focuses application gene therapy enzyme replacement (ERT) for disorders. Gene involves altering or manipulating expression can be enhanced by designed carry various genetic materials. Similarly, improve efficacy ERT lysosomal storage (LSDs) facilitating delivery brain, overcoming issues like immunogenicity instability. Taken together, explores potential revolutionizing treatment options highlighting their advantages future directions rapidly evolving field. Keywords: system, nanoparticle, therapy,

Language: Английский

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Phytochemical Composition of Ziziphus lotus (L.) Lam and Its Impact on the Metabolic Syndrome: A Review

Advances in Pharmacological and Pharmaceutical Sciences, Journal Year: 2025, Volume and Issue: 2025(1)

Published: Jan. 1, 2025

The long‐term pathological state known as metabolic syndrome is characterized by hypertension, insulin resistance diabetes, abdominal obesity, and hyperlipidemia. Seeking healthcare strategies with fewer side effects, such herbal remedies, preferable in terms of mitigating the negative consequences synthetic medications. Ziziphus lotus (L.) (Rhamnaceae) or wild jujube, commonly “Sedra,” one best choices it contains a variety phytochemicals biologically active compounds. Several flavonoids stilbenes have been recognized primary bioactive components including rutin, hyperin, isoquercitrin, resveratrol. These polyphenols are pharmacologically broad‐spectrum beneficial effects for reducing risk factors associated syndrome. They exhibit antioxidant anti‐inflammatory properties, regulate lipid metabolism, possess antiobesity, antihypertensive, antidiabetic characteristics. However, there certain limitations to their therapeutic application, low bioavailability. Various proposed enhance pharmacokinetic profile potential future use. main goal this review explore underlying mechanisms related jujube its compounds treatment prevention

Language: Английский

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Harnessing nutrition to combat MASLD: a comprehensive guide to food-based therapeutic strategies

Food and Agricultural Immunology, Journal Year: 2025, Volume and Issue: 36(1)

Published: May 6, 2025

Language: Английский

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Can excessive perspiration contribute to the development of skin tags? A review of the underlying mechanisms and clinical implications

Deleted Journal, Journal Year: 2024, Volume and Issue: 1(1)

Published: Nov. 11, 2024

This study investigated whether excessive sweating or hyperhidrosis contributes to the formation of skin tags (acrochordons). aimed explore underlying mechanisms and clinical significance this potential association, focusing on interaction between tag development. A review was conducted using PubMed, Cochrane Library, Scopus identify studies evaluating association tags, with data extraction statistical analysis performed according standardized protocols. Statistical analyses, including logistic regression chi-squared tests, were used evaluate occurrence tags. Participants included individuals all ages, adjusted for confounding factors such as obesity, diabetes, metabolic conditions. The sample sizes ranged from 100 5,000 participants, a median age 45 years. prevalence significantly higher in (64%) (p < 0.001). Logistic revealed that independently associated an increased risk development (Odds Ratio [OR] = 2.8, 95% Confidence Interval [CI] 1.5–5.2, p 0.002) after adjusting body mass index (BMI), fasting plasma glucose (FPG), lipid profiles. also showed mean systolic blood pressure 0.004) diastolic 0.006). Additionally, total cholesterol 0.015) triglyceride 0.021) levels observed group, suggesting link hyperhidrosis, dysregulation. These findings suggest is potentially owing prolonged moisture friction areas prone hyperhidrosis. emphasizes importance recognizing contributing factor particularly syndrome.

Language: Английский

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Effect of Diet on HDL in Obesity

Molecules, Journal Year: 2024, Volume and Issue: 29(24), P. 5955 - 5955

Published: Dec. 17, 2024

Alterations of plasma lipoprotein levels and oxidative stress are frequently observed in obese patients, including low high-density (HDL) cholesterol (HDL-C) alterations HDL composition. Dysfunctional with lower antioxidant anti-inflammatory properties have also been demonstrated obesity. There is increasing evidence that white adipose tissue (WAT) participates several metabolic activities modulates HDL-C function. In subjects, the changes morphology function lead to impaired regulatory associated a state low-grade chronic inflammation, increased release pro-inflammatory adipokines cytokines. These may affect metabolism functions; thus, considered potential target for prevention treatment A cornerstone obesity therapy lifestyle modification through dietary changes, which reflected modulation metabolism. Some components metabolites directly composition structure modulate its vasoprotective properties. The aims review summarize crosstalk between adipocytes dysfunction human highlight recent discoveries on beneficial patterns as well nutritional inflammation

Language: Английский

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Efficacy and safety of combined Chinese and western medicine in the treatment of metabolic syndrome: A network meta-analysis of randomized controlled trials

Heliyon, Journal Year: 2024, Volume and Issue: 10(16), P. e35811 - e35811

Published: Aug. 1, 2024

To comprehensively analyze the randomized controlled clinical trials of integrated traditional Chinese medicine (TCM) and western in treatment metabolic syndrome (MetS), to explore efficacy safety different TCM combined with for MetS. The purpose this study is provide specific suggestions guidance

Language: Английский

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The Relationship between the Mediterranean Diet and Vascular Stiffness, Metabolic Syndrome, and Its Components in People over 65 Years of Age

Nutrients, Journal Year: 2024, Volume and Issue: 16(20), P. 3464 - 3464

Published: Oct. 12, 2024

The aim of the study was to examine relationship between Mediterranean diet (MD) and vascular stiffness metabolic syndrome (MetS), as well its components in individuals over age 65, overall by sex.

Language: Английский

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