Hybrid Digital-Droplet Microfluidic Chip for Applications in Droplet Digital Nucleic Acid Amplification: Design, Fabrication and Characterization

Sensors, Journal Year: 2023, Volume and Issue: 23(10), P. 4927 - 4927

Published: May 20, 2023

Microfluidic-based platforms have become a hallmark for chemical and biological assays, empowering micro- nano-reaction vessels. The fusion of microfluidic technologies (digital microfluidics, continuous-flow droplet just to name few) presents great potential overcoming the inherent limitations each approach, while also elevating their respective strengths. This work exploits combination digital microfluidics (DMF) (DrMF) on single substrate, where DMF enables mixing further acts as controlled liquid supplier high-throughput nano-liter generator. Droplet generation is performed at flow-focusing region, operating dual pressure: negative pressure applied aqueous phase positive oil phase. We evaluate droplets produced with our hybrid DMF-DrMF devices in terms volume, speed, production frequency compare them standalone DrMF devices. Both types enable customizable (various volumes circulation speeds), yet yield more achieving throughputs that are similar These up four per second, which reach maximum speed close 1540 µm/s low 0.5 nL.

Language: Английский

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Plane-symmetric co-flow capillary for the generation of monodisperse droplets

Microfluidics and Nanofluidics, Journal Year: 2023, Volume and Issue: 28(2)

Published: Dec. 29, 2023

Language: Английский

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Editorial for the Special Issue on Droplet-Based Microfluidics: Design, Fabrication, and Applications

Micromachines, Journal Year: 2023, Volume and Issue: 14(3), P. 693 - 693

Published: March 21, 2023

Microfluidics is a rapidly growing field of research that involves the manipulation and analysis fluids in small-scale channels, usually with dimensions ranging from sub-micrometer to sub-millimeter [...].

Language: Английский

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