The Effects of Propolis on Viral Respiratory Diseases

Molecules, Journal Year: 2023, Volume and Issue: 28(1), P. 359 - 359

Published: Jan. 1, 2023

Propolis remains an interesting source of natural chemical compounds that show, among others, antibacterial, antifungal, antiviral, antioxidative and anti-inflammatory activities. Due to the growing incidence respiratory tract infections caused by various pathogenic viruses, complementary methods prevention therapy supporting pharmacotherapy are constantly being sought out. The properties propolis may be important in treatment diseases viruses such as severe acute syndrome coronavirus 2, influenza parainfluenza virus rhinoviruses. One main challenges recent years has been 2 (SARS-CoV-2), causing COVID-19. Recently, increasing number studies focusing on activity preparations against SARS-CoV-2 adjuvant for this infection. shown a few key mechanisms anti-SARS-CoV-2 action as: inhibition interaction S1 spike protein ACE-2 protein; decreasing replication diminishing synthesis RNA transcripts cells; particles coronaviruses. anti-viral effect is observed not only with extracts but also single biologically active found (e.g., apigenin, caffeic acid, chrysin, kaempferol, quercetin). Moreover, effective hyperglycemia, which increases risk infections. aim literature review was summarize from PubMed database evaluating antiviral terms (in vitro, vivo, clinical trials). Based upon review, it have focused mainly assessment effectiveness its components exerts wide-spectrum antimicrobial activities; thus, can option co-infections associated tract.

Language: Английский

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Chitosan-based films with nanocellulose and propolis as active packaging materials

Industrial Crops and Products, Journal Year: 2024, Volume and Issue: 219, P. 119112 - 119112

Published: July 10, 2024

The increasing interest in sustainable materials has led to a growing exploration of natural biopolymers as matrices for these materials. Chitosan, valued its biocompatibility and biodegradability, is valuable raw material eco-friendly products. This study assessed the impact incorporating cellulose nanofibrils (CNF) propolis extract (EEP) on mechanical, physical, structural, gas barrier, antimicrobial properties chitosan-based films, especially within scope their prospective use packaging industry. addition chitosan matrix did not affect tensile strength elongation at break obtained films compared with pure film. CNF EEP had effect barrier (water vapor transmission rate, carbon dioxide rate oxygen rate) films. inclusion chitosan-nanocellulose film caused antibacterial activity (against Bacillus subtilis Listeria monocytogenes) produced lack against probiotic bacterial strains (Lacticaseibacillus rhamnosus Lactiplantibacillus plantarum). findings provide insights into development intended food, addressing environmental concerns.

Language: Английский

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Characterization and Antifungal Activity of Pullulan Edible Films Enriched with Propolis Extract for Active Packaging

Foods, Journal Year: 2022, Volume and Issue: 11(15), P. 2319 - 2319

Published: Aug. 3, 2022

Active pullulan films with the addition of 3, 5 or 10% propolis extract produced by casting method were tested in study. Propolis extracts from Bochnia County, Siedlce County and Ełk (Poland) used. The appearance was characterized, as well physical parameters (thickness, moisture content, water solubility), tensile strength (TS), elongation at break (EB), optical characteristics (light transparency, UV barrier, color) antifungal properties. activity disc diffusion against yeast (Candida albicans, C. krusei, Saccharomyces cerevisiae, Rhodotorula mucilaginosa) mold (Alternaria solani, Fusarium Rhizopus stolonifer, Colletotrichum gloeosporioides, cladosporioides, Aspergillus niger, A. ochraceus, Mucor mucedo, Penicillium expansum, P. chrysogenum). origin influenced color solubility films. increasing concentrations increased film thickness intensity yellow color, extended dissolution time reduced values TS EB. improved radiation protection but decreased light transparency. significantly concentration film, regardless propolis. Molds showed greater sensitivity to containing than yeasts. In general, made can be considered natural active packaging protect growth fungi food.

Language: Английский

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LC‐ESI‐MS/MS Chemical Characterization, Antioxidant and Antidiabetic Properties of Propolis Extracted with Organic Solvents from Eastern Anatolia Region

Chemistry & Biodiversity, Journal Year: 2023, Volume and Issue: 20(5)

Published: March 28, 2023

Geographic conditions (altitude, climate, and local flora) lead to significant differences in the chemical composition of propolis. Therefore, more research is needed for propolis different geographical regions. So, aim this study was evaluate phenolic profile, total content, antioxidant, antidiabetic properties Pülümür from Turkey. Methanol (MeOH), chloroform (CHCl3 ), hexane extracts were analyzed. LC-ESI-MS/MS analysis showed that most abundant compound caffeic acid MeOH extract (2943.12±11.12 μg phenolics/g extract), while on other hand, CHCl3 had highest content (125.75±1.02 mg GAE/g extract). Antioxidant activity measured using ABTS DPPH assays, whereas (IC50 =6.35±0.11 28.84±0.10 μg/mL, respectively) =5.04±0.07 28.80±0.09 relatively high antioxidant activity. The better than standard compound, acarbose =0.544 0.805 mg/mL, respectively).

Language: Английский

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Natural Substances as Valuable Alternative for Improving Conventional Antifungal Chemotherapy: Lights and Shadows

Journal of Fungi, Journal Year: 2024, Volume and Issue: 10(5), P. 334 - 334

Published: May 5, 2024

Fungi are eukaryotic organisms with relatively few pathogenic members dangerous for humans, usually acting as opportunistic infections. In the last decades, several life-threatening fungal infections have risen mostly associated worldwide extension of chronic diseases and immunosuppression. The available antifungal therapies cannot combat this challenge because arsenal compounds is scarce displays low selective action, significant adverse effects, increasing resistance. A growing isolation outbreaks triggered by species formerly considered innocuous being recorded. From ancient times, natural substances harvested from plants been applied to folk medicine some them recently emerged promising antifungals. most used briefly revised herein. Combinations chemotherapeutic drugs products obtain more efficient gentle treatments also revised. Nevertheless, considerable research work still necessary before their clinical use can be generally accepted. Many a highly complex chemical composition, active principles partially unknown. Here, we survey field underlying lights shadows both groups. More studies involving strains necessary, but illustrate matter discussing potential applications combined carnosic acid plus propolis formulations.

Language: Английский

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Ephedra mediated green synthesis of gold nanoparticles (AuNPs) and evaluation of its antioxidant, antipyretic, anti-asthmatic, and antimicrobial properties

Arabian Journal of Chemistry, Journal Year: 2022, Volume and Issue: 16(1), P. 104353 - 104353

Published: Oct. 26, 2022

The eco-friendly green bio-synthesis of Ephedra-AuNPs was constructed from Ephedra plant extract. synthesis process optimized using different volumes Ephedra-extract, 10-3M (HAuCl4·3H2O) solution, reaction temperature, time, and pH the solution. Where, 4 mL 6 solution at 25 °C for 3 h a are showed optimum parameters respectively. characterization AuNPs verified by UV–vis. spectrophotometer, FTIR, microscopic techniques (TEM, HRTEM), Zeta potential, X-ray (XRD, EDX, XPS). nanoparticles extremely important materials in emerging future sustainable technologies living beings. were employed biological assays where ABTS assay used to investigate antioxidant activity. in-vivo study executed anti-pyretic anti-asthma activities Ephedra-AuNPs. 1.3 nm 15.6 size achieved which have as importance proficient bind with systems. prepared exploiting Ephedra-extract is considered be influential agent antipyretic reduced fever 83.3 % 32μg/g/day. Further scrutinize anti-bacterial Staphylococcus aureus, Listeria moncytogenes, Bacillus subtilis, Escherichia coli, Pseudomonas aeruginosa, Salmonella typhimurium, anti-fungal on Candida albicans, Aspergillus nigra flavus. synthesized exhibited great potential comparable standard drugs case albicans zone inhibition ± 0.5 nm, 26 0.6 24 0.7 It believed that hopeful option intended diverse applications.

Language: Английский

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The Role of Bee Products in the Control of Antimicrobial Resistance and Biofilm Formation

Kafkas Universitesi Veteriner Fakultesi Dergisi, Journal Year: 2024, Volume and Issue: unknown

Published: Jan. 1, 2024

The discovery of antibiotics saved many lives.Infections were not as deadly a problem for clinicians they once were.However, due to inappropriate and excessive use antibiotics, antibiotic resistance has increased dramatically worldwide.Infectious diseases are becoming more challenging control, cause morbidity mortality.Also, significant risk human health is posed by infections associated with biofilms.To combat these drug-resistant microorganisms, several novel alternative strategies have been identified.Bee products such honey, bee pollen, propolis, royal jelly, venom, wax, bread the potential being used antimicrobial or antibiofilm agents in various industrial medical applications.Although some restrictions their varying complex composition, possess field practices viable alternatives antibiotics.They offer solution issue resistance.The objective this review was comprehensive analysis evaluation based on that currently employed suggested against resistance.

Language: Английский

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Biological Activity and Chemical Composition of Propolis Extracts with Potential Use in Vulvovaginal Candidiasis Management

International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(5), P. 2478 - 2478

Published: Feb. 20, 2024

Environmental sustainability is an increasing challenge in the pharmaceutical field, leading to search for eco-friendly active ingredients. Among natural ingredients, propolis arises as excellent alternative, being a complex substance with pharmacological properties. This work aims explore potential of new ingredient replacement conventional vulvovaginal antifungals. Propolis extracts were obtained by Ultrasound-Assisted Extraction using different solvents (water, water/ethanol (50:50, v/v), and ethanol). Afterwards, characterized regarding total phenolic content (TPC), antioxidant/antiradical activities, radical scavenging capacity, antifungal activity against strains Candida species, viability effect on two female genital cell lines. The aqueous extract achieved best TPC result well highest activities ability capture reactive oxygen species. A 38 compounds identified quantified HPLC, among which ferulic acid, phloridzin myricetin predominated. Regarding anti-Candida spp. activity, hydroalcoholic outcomes (with MIC values ranging between 128 512 μg/mL). assays confirmed that presented mild selectivity, while alcoholic showed higher toxicities. These results attest has deep candidiasis management, supporting its economic valorization.

Language: Английский

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Propolis suppresses atopic dermatitis through targeting the MKK4 pathway

BioFactors, Journal Year: 2024, Volume and Issue: 51(1)

Published: Aug. 20, 2024

Propolis is a natural resinous substance made by bees through mixing various plant sources. has been widely recognized as functional food due to its diverse range of beneficial bioactivities. However, the therapeutic effects consuming propolis against atopic dermatitis (AD) remain largely unknown. The current study aimed investigate potential efficacy AD and explore active compound well direct molecular target. In HaCaT keratinocytes, inhibited TNF-α-induced interleukin (IL)-6 IL-8 secretion. It also led reduction in chemokines such monocyte chemoattractant protein-1 (MCP-1) macrophage-derived chemokine (MDC), while restoring levels barrier proteins, filaggrin involucrin. exhibited similar AD-like human skin, leading suppression markers restoration proteins. DNCB-induced mice, oral administration attenuated symptoms, improved function, reduced scratching frequency transepidermal water loss (TEWL). addition, reversed mRNA AD-related mouse dorsal skin. These were attributed caffeic acid phenethyl ester (CAPE), identified comparing major components propolis. Mechanistic studies revealed that CAPE could directly selectively target MKK4. Collectively, these findings demonstrate may be used agent for treatment AD.

Language: Английский

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Propolis: Biological Activity and Its Role as a Natural Indicator of Pollution in Mining Areas

Environments, Journal Year: 2025, Volume and Issue: 12(4), P. 105 - 105

Published: March 30, 2025

Pollution in mining areas represents a major environmental issue, significantly impacting ecosystems and human health. This study highlights propolis as an efficient natural bioindicator for detecting assessing the degree of contamination these areas. The objective this is to determine levels metals (Pb, Cd, As, Cr, Fe, Mn, Cu, Zn) from exploitation Romania, specifically counties Alba, Hunedoara, Maramureș, Caraș-Severin. Although operations are closed, anthropogenic impact varies due differences surface zones affected, occupied by waste heaps, local hydrological conditions, partial ecological rehabilitation efforts. To highlight contamination, reference area considered unaffected activities was used benchmark each county. values obtained investigated were compared with those control zone specific pollution. Maximum recorded Roșia Montană Pb (9.27 mg·kg−1), Cd (0.17 As (0.87 mg·kg−1); Băile Borșa Fe (150.23 mg·kg−1) Zn (2.9 Certeju de Sus Cu (6 Cr (7.01 Moldova Nouă Mn (25.43 mg·kg−1). maximum content phenols (189.49 mg·kg−1 Alba County) flavonoids (88.06 Caraș-Severin) recorded, well minimum IC50 antioxidant activity (0.33 µg·mL−1). Propolis showed antimicrobial against five bacterial strains (Staphylococcus aureus, Escherichia coli, Pseudomonas aeruginosa, Enterococcus faecalis, Streptococcus mutans) fungal (Candida albicans, Aspergillus niger, flavus, Cryptococcus neoformans, Penicillium chrysogenum), although such antifungal more intense unpolluted present reveals that indicator heavy metal pollution These data support usefulness its high capacity accumulate reflect contaminants.

Language: Английский

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