Microbes, macrophages, and melanin: a unifying theory of disease as exemplified by cancer DOI Creative Commons

Stacie Z. Berg,

Jonathan Berg

Frontiers in Immunology, Journal Year: 2025, Volume and Issue: 15

Published: Feb. 6, 2025

It is widely accepted that cancer mostly arises from random spontaneous mutations triggered by environmental factors. Our theory challenges the idea of somatic mutation (SMT). The SMT does not fit well with Charles Darwin's evolution in same relatively few would occur so frequently and these lead to death rather than survival fittest. However, it under evolution, if we were look at vantage point pathogens their supporting microbial communities colonizing humans mutating host cells for own benefit, as give them an evolutionary advantage they are capable selecting genes mutate inserting DNA or RNA into hosts. In this article, provide evidence tumors actually complex composed various microorganisms living within biofilms encapsulated a hard matrix; what cause genetic seen control angiogenesis; spread hiding tumor M2 M2-like macrophages other phagocytic immune traveling inside distant sites camouflaged platelets, which also reprogram, prepare site metastasis; risk factors sources energy able utilize; that, accordance our previous unifying disease, utilize melanin building sustaining metastasis. We propose paradigm shift understanding is, and, thereby, different trajectory avenues treatment prevention.

Language: Английский

Phosphate-Solubilizing Bacteria: Advances in Their Physiology, Molecular Mechanisms and Microbial Community Effects DOI Creative Commons
Lin Pan, Baiyan Cai

Microorganisms, Journal Year: 2023, Volume and Issue: 11(12), P. 2904 - 2904

Published: Dec. 1, 2023

Phosphorus is an essential nutrient for all life on earth and has a major impact plant growth crop yield. The forms of phosphorus that can be directly absorbed utilized by plants are mainly HPO42- H2PO4-, which known as usable phosphorus. At present, the total content soils worldwide 400-1000 mg/kg, only 1.00-2.50% plant-available, seriously affects development agriculture, resulting in high level scarcity available Traditional methods applying fertilizer cannot address deficiency problems; they harm environment ore material nonrenewable natural resource. Therefore, it imperative to find alternative environmentally compatible economically viable strategies scarcity. Phosphorus-solubilizing bacteria (PSB) convert insoluble soil into plants, thus improving uptake utilization plants. However, there no clear systematic report mechanism action PSB. this paper summarizes discovery process, species, distribution PSB, focusing physiological mechanisms outlining processes acidolysis, enzymolysis, chelation complexation reactions related genes regulating PSB acidolysis enzymatic well phosphate transport molecular direction its pathway examined. effects structure abundance microbial communities also described, illustrating how interact with microorganisms indirectly increase amount soil. And three perspectives considered further exploring utilizing synergistic multi-omics approach, PSB-related regulatory different levels investigating application fungicide. This aims provide theoretical support providing optimal management elemental future.

Language: Английский

Citations

68
The Potential Applications of Commercial Arbuscular Mycorrhizal Fungal Inoculants and Their Ecological Consequences DOI Creative Commons
Sulaimon Basiru, Mohamed Hijri

Microorganisms, Journal Year: 2022, Volume and Issue: 10(10), P. 1897 - 1897

Published: Sept. 23, 2022

Arbuscular mycorrhizal fungal (AMF) inoculants are sustainable biological materials that can provide several benefits to plants, especially in disturbed agroecosystems and the context of phytomanagement interventions. However, it is difficult predict effectiveness AMF their impacts on indigenous communities under field conditions. In this review, we examined literature possible outcomes following introduction AMF-based field, including establishment soil plant roots, persistence, effects community. Most studies indicate introduced persist target from a few months years but with declining abundance (60%) or complete exclusion (30%). Further analysis shows inoculation exerts both positive negative native species, suppression (33%), stimulation (38%), (19%), neutral (10% cases). The factors influencing ecological fates inoculants, such as inherent properties inoculum, dosage frequency inoculation, physical factors, further discussed. While important monitor success downstream commercial sampling method molecular tools employed resolve quantify taxa need be improved standardized eliminate bias towards certain strains reduce discrepancies among studies. Lastly, inoculant producers must focus selecting higher chance having little negligible impacts.

Language: Английский

Citations

40
Plant-microbe interactions in the rhizosphere for smarter and more sustainable crop fertilization: the case of PGPR-based biofertilizers DOI Creative Commons
Mónica Yorlady Alzate Zuluaga,

Roberto Fattorini,

Stefano Cesco

et al.

Frontiers in Microbiology, Journal Year: 2024, Volume and Issue: 15

Published: Aug. 8, 2024

Biofertilizers based on plant growth promoting rhizobacteria (PGPR) are nowadays gaining increasingly attention as a modern tool for more sustainable agriculture due to their ability in ameliorating root nutrient acquisition. For many years, most research was focused the screening and characterization of PGPR functioning nitrogen (N) or phosphorus (P) biofertilizers. However, with increasing demand food using far fewer chemical inputs, new investigations have been carried out explore potential use such bacteria also potassium (K), sulfur (S), zinc (Zn), iron (Fe) In this review, we update biofertilizers smarter crop production deliberate prospects microbiome engineering-based methods tools shed light improvement mineral nutrition. The current era omics revolution has enabled design synthetic microbial communities (named

Language: Английский

Citations

15
Functional and Genomic Potential of Burkholderia contaminans PB_AQ24 Isolate for Boosting the Growth of Bamboo Seedlings in Heavy Metal Contaminated Soils DOI

Poonam Bhanse,

Lal Singh, Asifa Qureshi

et al.

Applied Biochemistry and Biotechnology, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 4, 2025

Language: Английский

Citations

2
Restoring soil quality in semi-arid mining-degraded soils: Effects of different combinations of organic amendments on microbial nutrient cycling after 40 months of application DOI
Natalia Rodríguez-Berbel, Aaron Fox, Raúl Ortega

et al.

Journal of Environmental Management, Journal Year: 2025, Volume and Issue: 378, P. 124733 - 124733

Published: March 2, 2025

Language: Английский

Citations

2
Application of Indigenous Rhizospheric Microorganisms and Local Compost as Enhancers of Lettuce Growth, Development, and Salt Stress Tolerance DOI Creative Commons
Redouane Ouhaddou, Raja Ben-Laouane, Rachid Lahlali

et al.

Microorganisms, Journal Year: 2022, Volume and Issue: 10(8), P. 1625 - 1625

Published: Aug. 11, 2022

This study aimed to mitigate salt stress effects on lettuce by using native biostimulants (arbuscular mycorrhizal fungi (M, consortium), plant growth-promoting rhizobacteria (R, Z2, and Z4 strains), compost (C)) applied alone or in combination under salinity (0, 50, 100 mM NaCl). Physiological, biochemical, nutritional, mycorrhizal, growth, soil characteristics were evaluated. Results revealed that growth physiological traits negatively affected salinity. However, colonization was enhanced NaCl after application. The biostimulants, particularly M and/or R improved the tolerance of increasing dry biomass 119% 113% NaCl, respectively, for MR treatments. Similarly, stomatal conductance (47%), water content (260%), total chlorophyll (130%), phosphorus (363%), reduced malondialdehyde (54%) hydrogen peroxide (78%) compared control. Moreover, peroxidase activity (76%) sugar (36%) CM treatment, while protein (111%) proline (104%) contents significantly boosted treatment NaCl. Furthermore, glomalin severe In conclusion, might help tolerate enhance its production degraded areas.

Language: Английский

Citations

31
Secondary Metabolites, Osmolytes and Antioxidant Activity as the Main Attributes Enhanced by Biostimulants for Growth and Resilience of Lettuce to Drought Stress DOI
Redouane Ouhaddou, Lahoucine Ech-chatir, Mohamed Anli

et al.

Gesunde Pflanzen, Journal Year: 2023, Volume and Issue: 75(5), P. 1737 - 1753

Published: Jan. 16, 2023

Language: Английский

Citations

23
Prospects of phosphate solubilizing microorganisms in sustainable agriculture DOI
Harmanjit Kaur, Rakeeb Ahmad Mir,

Sofi Javed Hussain

et al.

World Journal of Microbiology and Biotechnology, Journal Year: 2024, Volume and Issue: 40(10)

Published: Aug. 6, 2024

Language: Английский

Citations

9
Cultural techniques capture diverse phosphate-solubilizing bacteria in rock phosphate-enriched habitats DOI Creative Commons
Amandine Ducousso‐Détrez,

Zakaria Lahrach,

Joël Fontaine

et al.

Frontiers in Microbiology, Journal Year: 2024, Volume and Issue: 15

Published: Feb. 7, 2024

Phosphorus (P) deficiency is a common problem in croplands where phosphate-based fertilizers are regularly used to maintain bioavailable P for plants. However, due their limited mobility the soil, there has been an increased interest microorganisms that can convert insoluble into form, and use develop phosphate-solubilizing bioinoculants as alternative conventional of fertilizers. In this study, we proposed two independent experiments explored entirely different habitats trap bacteria (PSBs). first experiment, PSBs were isolated from rhizoplane native plant species grown rock-phosphate (RP) mining area. A subset 24 bacterial isolates 210 morphotypes was selected inorganic phosphate solubilizing activities using tricalcium (TCP) sole source. second innovative experimental setup select mycohyphospheric associated arbuscular mycorrhizal fungal hyphae, indigenous soils agronomic have trapped membrane bag filled with RP. 25 44 tested activities. These subsets then screened additional growth-promoting (PGP) traits, 16S rDNA sequencing performed identification. Overall, isolation resulted diverse phylogenetic affiliations PSB collection, showing only 4 genera (24%) 5 (17%) shared between communities, thus underlining value protocols, including isolate selection method, selecting greater biodiversity cultivable PSB. All positive ammonia production. Indol-3-acetic acid (IAA) production observed 13 20 isolates, respectively among PSB, ranging, respectively, 32.52 330.27 μg mL −1 41.4 963.9 . Only five 12 positively N 2 fixation. Four identified siderophore producers, while none were. The phenotype one isolate, assigned Pseudomonas , showed four additive PGP Some strains belonging dominant Bacillus could be considered potential candidates further formulation biofertilizer order bioinoculant consortia promote nutrition growth RP-enriched soils.

Language: Английский

Citations

8
Isolation and Identification of Acer truncatum Endophytic Fungus Talaromyces verruculosus and Evaluation of Its Effects on Insoluble Phosphorus Absorption Capacity and Growth of Cucumber Seedlings DOI Creative Commons

Qingpan Zeng,

Jiawei Dong,

Xiaoru Lin

et al.

Journal of Fungi, Journal Year: 2024, Volume and Issue: 10(2), P. 136 - 136

Published: Feb. 8, 2024

The symbiosis between endophytic fungi and plants can promote the absorption of potassium, nitrogen, phosphorus, other nutrients by plants. Phosphorus is one indispensable nutrient elements for plant growth development. However, content available phosphorus in soil very low, which limits Phosphorus-soluble microorganisms improve utilization rate insoluble phosphorus. In this study, Talaromyces verruculosus (T. verruculosus), a potential phosphorus-soluble fungus, was isolated from Acer truncatum, with strong stress resistance, its ability relation to cucumber seedlings under different treatment conditions determined. addition, morphological, physiological, biochemical indexes were assessed. results show that T. could solubilize tricalcium phosphate (TCP) lecithin, solubilization effect lecithin higher than TCP. After application verruclosus, leaf photosynthetic index increased significantly. system damage caused low alleviated, root morphological increased. height, stem diameter, area treated also significantly those without treatment. Therefore, it shown beneficial fungus resistance. This study will provide useful reference further research on

Language: Английский

Citations

7