Journal of Fungi,
Journal Year:
2023,
Volume and Issue:
9(3), P. 355 - 355
Published: March 15, 2023
Commonly
found
colonizing
the
human
microbiota,
Candida
albicans
is
a
microorganism
known
for
its
ability
to
cause
infections,
mainly
in
vulvovaginal
region,
and
responsible
85%
90%
of
candidiasis
(VVC)
cases.
The
development
drug
resistance
C.
isolates
after
long-term
therapy
with
fluconazole
an
important
complication
solve
new
therapeutic
strategies
are
required
target
this
organism
pathogenicity.
In
present
study,
phenyllactic
acid
(PLA)
broad-spectrum
antimicrobial
compound
was
investigated
antifungal
antivirulence
activities
against
clinical
albicans.
Previously
characterized
strains
from
women
VVC
ATCC90028
were
used
evaluate
time
dependent
killing
assay
activity
PLA
showing
MIC
7.5
mg
mL-1
complete
reduction
viable
cells
detected
by
kinetics
4
h
treatment
PLA.
Additionally,
significantly
reduced
biomass
metabolic
biofilms
impaired
biofilm
formation
also
changes
ERG11,
ALS3,
HWP1
genes
expression
as
qPCR.
eradicated
pre-formed
showed
confocal
laser
scanning
microscopy
(CLSM)
observations.
Furthermore,
prolonged
survival
rate
Galleria
mellonella
infected
isolates.
These
results
indicate
that
promising
candidate
novel
safe
agents
candidiasis.
Plants,
Journal Year:
2023,
Volume and Issue:
12(2), P. 358 - 358
Published: Jan. 12, 2023
Candida
auris
represents
an
emerging
pathogen
that
results
in
nosocomial
infections
and
is
considered
a
serious
global
health
problem.
The
aim
of
this
work
was
to
evaluate
the
vitro
antifungal
efficacy
Cinnamomum
cassia
essential
oil
(CC-EO)
pure
or
formulated
polycaprolactone
(PCL)
nanoparticles
against
ten
clinical
strains
C.
auris.nanoparticles
PCL
were
produced
using
CC-EO
(nano-CC-EO)
cinnamaldehyde
(CIN)
through
nanoprecipitation
method.
chemical
profile
both
nano-CC-EO
evaluated
SPME
sampling
followed
by
GC-MS
analysis.
Micro-broth
dilution
tests
performed
fungistatic
fungicidal
effectiveness
CIN,
nano-formulated.
Furthermore,
checkerboard
synergistic
action
with
micafungin
fluconazole
conducted.
Finally,
biofilm
disrupting
activity
formulations
evaluated.GC-MS
analysis
shows
different
composition
between
nano-CC-EO.
Moreover,
microbiological
analyses
do
not
show
any
variation
either
towards
planktonic
form
(MICCC-EO
=
0.01
±
MICnano-CC-EO
0.02
0.01)
form.
No
drugs
tested
found.both
same
antimicrobial
are
potential
assets
fight
auris.
Antibiotics,
Journal Year:
2022,
Volume and Issue:
11(12), P. 1743 - 1743
Published: Dec. 2, 2022
Infectious
diseases
caused
by
various
nosocomial
microorganisms
affect
worldwide
both
immunocompromised
and
relatively
healthy
persons.
Bacteria
fungi
have
different
tools
to
evade
antimicrobials,
such
as
hydrolysis
damaging
the
drug,
efflux
systems,
formation
of
biofilm
that
significantly
complicates
treatment
infection.
Here,
we
show
myrtenol
potentiates
antimicrobial
biofilm-preventing
activity
conventional
drugs
against
S.
aureus
C.
albicans
mono-
dual-species
cultures.
In
our
study,
two
optical
isomers,
(−)-myrtenol
(+)-myrtenol,
been
tested
either
antibacterials,
antifungals,
or
enhancers
drugs.
(+)-Myrtenol
demonstrated
a
synergistic
effect
with
amikacin,
fluconazole,
benzalkonium
chloride
on
64–81%
clinical
isolates
albicans,
including
MRSA
fluconazole-resistant
fungi,
while
increased
properties
amikacin
fluconazole
repress
in
half
isolates.
Furthermore,
was
able
potentiate
up
sixteen-fold
planktonic
cells
an
aureus–C.
mixed
culture
repressed
adhesion
aureus.
The
mechanism
(+)-myrtenol
synergy
apparently
driven
membrane
damage
since
terpenes
led
significant
drop
potential
similar
action
chloride.
Thus,
due
low
toxicity
myrtenol,
it
seems
be
promising
agent
increase
efficiency
infections
bacteria
genus
Candida
well
fungal–bacterial
infections,
resistant
strains.
Antibiotics,
Journal Year:
2024,
Volume and Issue:
13(1), P. 80 - 80
Published: Jan. 15, 2024
The
opportunistic
human
fungal
pathogen
Candida
albicans
produces
and
releases
into
the
surrounding
medium
extracellular
vesicles
(EVs),
which
are
involved
in
some
processes
as
communication
between
cells
host–pathogen
interactions
during
infection.
Here,
we
have
conducted
isolation
of
EVs
produced
by
a
clinical
isolate
C.
biofilm
formation
proved
their
effect
towards
ability
Gram-negative
bacterial
Klebsiella
pneumoniae
to
adhere
HaCaT
form
vitro.
results
represent
first
evidence
an
antagonistic
action
against
bacteria.
Journal of Fungi,
Journal Year:
2024,
Volume and Issue:
10(6), P. 424 - 424
Published: June 16, 2024
Two
new
polyketide
derivatives,
penirubenones
A
and
B
(1
2),
two
naturally
rare
amino-bis-tetrahydrofuran
penirubenamides
(3
4),
together
with
nine
known
compounds
(5–13)
were
isolated
from
the
marine-derived
fungus
Penicillium
rubens
BTBU20213035.
The
structures
identified
by
HRESIMS
1D
2D
NMR
analyses,
their
absolute
configurations
determined
a
comparison
of
experimental
calculated
electronic
circular
dichroism
(ECD)
spectroscopy
13C
data.
We
found
that
6
exhibited
antibacterial
activity
against
Staphylococcus
aureus,
an
MIC
value
3.125
μg/mL,
1
2
showed
synergistic
antifungal
Candida
albicans
at
12.5
50
μg/mL
0.0625
rapamycin.
Molecules,
Journal Year:
2025,
Volume and Issue:
30(8), P. 1738 - 1738
Published: April 13, 2025
Nowadays,
the
spread
of
foodborne
diseases
and
growing
concerns
about
antibiotic
resistance
have
shifted
focus
researchers
towards
use
substances
natural
origin.
Phenyllactic
acid
(PLA),
a
naturally
produced
compound,
has
already
demonstrated
antimicrobial
properties
against
pathogenic
microorganisms
those
responsible
for
food
spoilage.
This
study
examines
antibacterial
antibiofilm
PLA
pathogens
such
as
Salmonella
enterica
Derby
Escherichia
coli
O26.
The
showed
that
effectively
inhibited
both
biofilm
formation
bacterial
planktonic
growth,
with
minimal
inhibitory
concentrations
(MICs)
ranging
from
2
to
2.75
mg
mL−1.
A
dose-dependent
inhibition
was
observed,
reaching
approximately
90%
strains
50%
E.
at
1.5
cytotoxicity
evaluation
on
Caco-2
cells
well-tolerated
up
PLA’s
effectiveness
also
in
real
matrices,
where
its
application
minced
beef
stored
4
°C
significantly
reduced
microbial
populations,
unlike
untreated
samples
counts
increased.
good
ability
inhibit
eradicate
mature
biofilm,
measuring
total
biomass.
Additionally,
found
be
biocompatible
cells,
confirming
it
poses
no
health
risk
tested
concentrations.
observed
adhesion
intestinal
suggesting
potential
preventing
colonization.
These
results
highlight
promising
agent
preservation,
applications
sustainable
packaging
controlling
contamination
processing.
Future
studies
should
further
explore
long-term
stability
interactions
complex
environments.
