Elsevier eBooks, Journal Year: 2025, Volume and Issue: unknown, P. 151 - 197
Published: Jan. 1, 2025
Language: Английский
Microorganisms, Journal Year: 2023, Volume and Issue: 11(5), P. 1276 - 1276
Published: May 12, 2023
Endophytic fungi and bacteria live asymptomatically within plant tissues. In recent decades, research on endophytes has revealed that their significant role in promoting plants as been shown to enhance nutrient uptake, stress tolerance, disease resistance the host plants, resulting improved crop yields. Evidence shows can provide tolerances salinity, moisture, drought conditions, highlighting capacity farm them marginal land with use of endophyte-based strategies. Furthermore, offer a sustainable alternative traditional agricultural practices, reducing need for synthetic fertilizers pesticides, turn risks associated chemical treatments. this review, we summarise current knowledge agriculture, potential solution improving productivity general health. This review outlines key nutrient, environmental, biotic stressors, providing examples mitigating effects stress. We also discuss challenges agriculture further fully realise potential.
Language: Английский
Citations
44
Biomolecules, Journal Year: 2023, Volume and Issue: 13(7), P. 1038 - 1038
Published: June 25, 2023
The seminal discovery of paclitaxel from endophytic fungus Taxomyces andreanae was a milestone in recognizing the immense potential fungi as prolific producers bioactive secondary metabolites use medicine, agriculture, and food industries. Following paclitaxel, research community has intensified efforts to harness putative lead molecules with anticancer, anti-inflammatory, antimicrobial, antioxidant, cardio-protective, immunomodulatory properties. Endophytic have been valuable source compounds over last three decades. Compounds such taxol, podophyllotoxin, huperzine, camptothecin, resveratrol effectively isolated characterized after extraction fungi. These findings expanded applications medicine related fields. In present review, we systematically compile analyze several important derived fungi, encompassing period 2011 2022. Our systematic approach focuses on elucidating origins exploring structural diversity biological activities exhibited by these compounds, giving special emphasis pharmacological mechanism action certain compounds. We highlight tremendous alternate sources metabolites, implications for combating major global diseases. This underscores significant role that can play development novel therapeutic agents address challenges posed prevalent diseases worldwide.
Language: Английский
Citations
40
International Journal of Molecular Sciences, Journal Year: 2023, Volume and Issue: 24(19), P. 14897 - 14897
Published: Oct. 4, 2023
The misuse of antibiotics and antimycotics accelerates the emergence antimicrobial resistance, prompting need for novel strategies to combat this global issue. Metallic nanoparticles have emerged as effective tools combating various resistant microbes. Numerous studies highlighted their potential in addressing antibiotic-resistant fungi bacterial strains. Understanding mechanisms action these nanoparticles, including iron-oxide, gold, zinc oxide, silver is a central focus research within life science community. Various hypotheses been proposed regarding how exert effects. Some suggest direct targeting microbial cell membranes, while others emphasize release ions from nanoparticles. most compelling mechanism involves oxidative damage caused by nanoparticles-generated reactive oxygen species. This review aims consolidate knowledge, discuss properties metallic underscore alternatives enhance efficacy existing medications against infections antimicrobial-resistant pathogens.
Language: Английский
Citations
38
Plant Biotechnology Reports, Journal Year: 2023, Volume and Issue: 17(4), P. 427 - 457
Published: March 14, 2023
Language: Английский
Citations
31
RSC Advances, Journal Year: 2023, Volume and Issue: 13(12), P. 8049 - 8089
Published: Jan. 1, 2023
Microorganisms still remain the main hotspots in global drug discovery avenue. In particular, fungi are highly prolific producers of vast structurally diverse specialized secondary metabolites, which have displayed a myriad biomedical potentials. Intriguingly, isocoumarins is one distinctive class fungal natural products polyketides, demonstrated numerous remarkable biological and pharmacological activities. This review article provides comprehensive state-of-the-art over period 2000-2022 about discovery, isolation, classifications, therapeutic potentials exclusively reported from fungi. Indeed, list 351 were documented classified according to their sources [16 order/28 family/55 genera] where they been originally discovered along with activities wherever applicable. Also, recent insights around proposed experimentally proven biosynthetic pathways also briefly discussed.
Language: Английский
Citations
29
Current Microbiology, Journal Year: 2025, Volume and Issue: 82(2)
Published: Jan. 15, 2025
Language: Английский
Citations
1
Pharmaceutics, Journal Year: 2023, Volume and Issue: 15(2), P. 644 - 644
Published: Feb. 14, 2023
Wound care is a global health issue with financial burden of up to US $96.8 billion annually in the USA alone. Chronic non-healing wounds which show delayed and incomplete healing are especially problematic. Although there more than 3000 dressing types wound management market, new developments efficient dressings will require innovative approaches such as embedding antibacterial additives into wound-dressing materials. The lack novel agents misuse current antibiotics have caused an increase antimicrobial resistance (AMR) estimated cause 10 million deaths by 2050 worldwide. These ongoing challenges clearly indicate urgent need for developing targeting microbial pathogens. Natural products their derivatives long been significant source pharmaceuticals against AMR. Scrutinising data newly approved drugs has identified plants one biggest most important sources development drugs. Some plant-based additives, essential oils plant extracts, previously used dressings; however, another plant-derived i.e., those produced symbiotic endophytic fungi, that great potential applications. Endophytes represent novel, natural, sustainable bioactive compounds therapeutic applications, including chronic dressings. This review examines appraises recent incorporate natural well advances endophyte research treating wounds.
Language: Английский
Citations
21
Journal of Fungi, Journal Year: 2023, Volume and Issue: 9(10), P. 997 - 997
Published: Oct. 8, 2023
The study examines the intricate relationship between plants and endophytic fungi inhabiting their tissues. These harmoniously coexist with plants, forming a distinct symbiotic connection that has caught scientific attention due to its potential implications for plant health growth. diverse range of bioactive compounds produced by these holds significant promise human health. review covers various aspects this topic, starting introducing microorganisms, explaining colonization different parts, illuminating roles in enhancing defense against diseases promoting emphasizes widespread occurrence diversity microorganisms among species while highlighting complexities significance isolating extracting from them. It focuses on benefits compounds, including capacity exhibit antioxidant, anti-inflammatory, antimicrobial, anticancer effects. delves into mechanisms behind health-promoting effects, spotlighting how interact cellular receptors, signaling pathways, gene expression. In conclusion, provides comprehensive overview fungi. outlines multifaceted impact, applications, future research avenues medicine.
Language: Английский
Citations
17
Journal of Fungi, Journal Year: 2024, Volume and Issue: 10(2), P. 136 - 136
Published: Feb. 8, 2024
The symbiosis between endophytic fungi and plants can promote the absorption of potassium, nitrogen, phosphorus, other nutrients by plants. Phosphorus is one indispensable nutrient elements for plant growth development. However, content available phosphorus in soil very low, which limits Phosphorus-soluble microorganisms improve utilization rate insoluble phosphorus. In this study, Talaromyces verruculosus (T. verruculosus), a potential phosphorus-soluble fungus, was isolated from Acer truncatum, with strong stress resistance, its ability relation to cucumber seedlings under different treatment conditions determined. addition, morphological, physiological, biochemical indexes were assessed. results show that T. could solubilize tricalcium phosphate (TCP) lecithin, solubilization effect lecithin higher than TCP. After application verruclosus, leaf photosynthetic index increased significantly. system damage caused low alleviated, root morphological increased. height, stem diameter, area treated also significantly those without treatment. Therefore, it shown beneficial fungus resistance. This study will provide useful reference further research on
Language: Английский
Citations
7
AMB Express, Journal Year: 2023, Volume and Issue: 13(1)
Published: July 6, 2023
Endophytic fungi allied to plants have sparked substantial promise in discovering new bioactive compounds. In this study, propagation of the endophytic fungus Alternaria alternata HE11 obtained from Colocasia esculanta leaves led isolation Ergosterol (1), β-Sitosterol (2), peroxide (3), addition three dimeric naphtho-γ-pyrones, namely Fonsecinone A (4), Asperpyrone C (5), and B (6), which were isolated genus for first time. Structures compounds established on basis extensive 1D 2D NMR and, MS measurements. The ethyl acetate extract, as well 1, 3, 4 6 evaluated their antimicrobial activity using agar well-diffusion broth microdilution assays. Molecular docking study was carried out explore pharmacophoric moieties that governed binding orientation antibacterial active multidrug efflux transporter AcrB ATP site E. coli DNA gyrase MOE software. Results revealed most bind with high affinity phenylalanine-rich cage are surrounded other hydrophobic residues. antiproliferative all vitro human prostatic adenocarcinoma cell lines DU-145, PC-3, PC-3 M, 22Rv1 CWR-R1ca adopting MTT assay. Compound against almost tested lines, IC50 values 28.6, 21.6, 17.1 13.3 respectively.
Language: Английский
Citations
15