History of periodontitis as a risk factor for implant failure and incidence of peri‐implantitis: A systematic review, meta‐analysis, and trial sequential analysis of prospective cohort studies

Clinical Implant Dentistry and Related Research, Journal Year: 2024, Volume and Issue: 26(3), P. 482 - 508

Published: May 8, 2024

Abstract Introduction Dental implants are widely employed as dependable replacements for lost teeth. However, it is crucial to establish, solely through prospective cohort studies, whether a history of periodontitis indeed constitutes significant risk factor implant failure. Methods A systematic literature search was conducted in October 2022 several electronic databases with subsequent manual updates. Only original studies evaluating the (loss) rate ≥1 year after loading were included. Logarithmic ratio and weighted mean differences calculated. Study results summarized using random effects meta‐analyses evaluated by trial sequential analyses. The Newcastle‐Ottawa scale study bias GRADE approach assessed certainty/quality evidence. Results total 14 publications reporting on 12 Low evidence due absence randomized clinical trials revealed significantly greater odds failure patients at follow‐ups both ≤5 years (RR = 1.62; 95% CI: 1.71–2.37; p 0.013) >5 2.26; 1.12–4.53; 0.023). incidence peri‐implantitis 4.09; 1.93–8.58; < 0.001) (WM) marginal bone loss (WM difference 0.75 mm; 0.18–1.31; 0.05) statistically periodontally compromised group, whereas there no between two groups peri‐implant probing depth. Conclusion can be considered incident failure, peri‐implantitis, loss.

Language: Английский

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Microbiota of Peri-Implant Healthy Tissues, Peri-Implant Mucositis, and Peri-Implantitis: A Comprehensive Review

Microorganisms, Journal Year: 2024, Volume and Issue: 12(6), P. 1137 - 1137

Published: June 2, 2024

Understanding the microbiological profiles of peri-implant conditions is crucial for developing effective preventive and therapeutic strategies. This narrative review analyzes microbial associated with healthy sites, mucositis, peri-implantitis, along related sampling analyses. Healthy sites are predominantly colonized by Streptococcus, Rothia, Neisseria, Corynebacterium species, in addition to Gram-positive cocci facultatively anaerobic rods, forming a stable community that prevents pathogenic colonization maintains balance. In contrast, mucositis shows increased diversity, including both health-associated bacteria such as red orange complex bacteria, contributing early tissue inflammation. Peri-implantitis characterized even greater diversity biofilm. Predominant pathogens include Porphyromonas gingivalis, Tannerella forsythia, Treponema denticola, Fusobacterium nucleatum, unique species like Filifactor alocis Fretibacterium fastidiosum. Additionally, less common Staphylococcus Enterobacteriaceae, disease progression through biofilm formation inflammatory response, EBV human cytomegalovirus still not defined role, Candida albicans contribute formation, immune modulation, synergistic inter-kingdom interactions. Future research should standardize diagnostic criteria, employ advanced molecular techniques, integrate data clinical factors, highlight

Language: Английский

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Zirconium phosphate nanonetworks for enhanced soft tissue integration and antibacterial performance of zirconia implant abutments

Chemical Engineering Journal, Journal Year: 2025, Volume and Issue: unknown, P. 163090 - 163090

Published: April 1, 2025

Language: Английский

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Evaluation of the Impact of Periodontitis Susceptibility on Peri-implant Marginal Bone Level Changes: A Longitudinal Retrospective Study

Journal of Dentistry, Journal Year: 2025, Volume and Issue: 157, P. 105757 - 105757

Published: April 12, 2025

Language: Английский

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Linking peri-implantitis to microbiome changes in affected implants, healthy implants, and saliva: a cross-sectional pilot study

Frontiers in Cellular and Infection Microbiology, Journal Year: 2025, Volume and Issue: 15

Published: April 17, 2025

The rising use of dental implants is accompanied by an expected increase in peri-implant diseases, particularly peri-implantitis (PI), which poses a significant threat to implant success and necessitates thorough understanding its pathogenesis for effective management. To gain deeper insights into the role impact microbiome progression PI, we analyzed 100 samples saliva subgingival biofilm from 40 participants with healthy (HI group) or co-occurrence diagnosed PI-affected (PI using shotgun metagenomic sequencing. We identified most discriminative species distinguishing diseased study groups through log ratios differential ranking analyses. Mogibacterium timidum, Schaalia cardiffensis, Parvimonas micra, Filifactor alocis, Porphyromonas endodontalis, gingivalis Olsenella uli were associated biofilm. In contrast, Neisseria sp oral taxon 014, Haemophilus parainfluenzae, Actinomyces naeslundii, Rothia mucilaginosa aeria more prevalent Functional pathways such as arginine polyamine biosynthesis, including putrescine citrulline showed stronger correlations implants. health was characterized predominance involved purine pyrimidine deoxyribonucleotide de novo glucose glucose-1-phosphate degradation, tetrapyrrole biosynthesis. Our findings reveal that PI-free cavities differ significantly microbial composition functional compared co-occurring implants, closely resemble PI-associated profiles. This pattern extended salivary samples, where biomarkers follow similar trends.

Language: Английский

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Do Concurrent Peri-Implantitis and Periodontitis Share Their Microbiotas? A Pilot Study

Dentistry Journal, Journal Year: 2024, Volume and Issue: 12(4), P. 113 - 113

Published: April 18, 2024

The microbial compositions from concurrent peri-implant and periodontal lesions were compared, since the results reported in literature on etiological relationship between these oral pathologies are contradictory. Microbial nine patients evaluated using Illumina MiSeq sequencing of 16S rRNA gene amplicons Principal Components Analysis. Comparisons use curettes or paper points as collection methods bacterial composition both performed. Paper allowed recovery a higher number genera. A diversity was found peri-implantitis compared to samples same patient, while greater operational taxonomic units (OTUs) present corresponding samples. abundance pathogens, such Porphyromonas Treponema, sites. opposite trend observed for Aggregatibacter abundance, which than lesions, suggesting that could be considered different but related diseases. Although analysis would needed, differences regarding provide basis further understating pathogenesis infections.

Language: Английский

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Assessing peri-implant bacterial community structure: the effect of microbiome sample collection method

BMC Oral Health, Journal Year: 2024, Volume and Issue: 24(1)

Published: Aug. 26, 2024

Oral microbiota comprises polymicrobial communities shaped by mutualistic coevolution with the host, contributing to homeostasis and regulating immune function. Nevertheless, dysbiosis of oral bacterial is associated a number clinical symptoms that ranges from infections cancer. Peri-implant diseases are biofilm-associated inflammatory conditions affecting soft hard tissues around dental implants. Characterization identification biofilm community essential for understanding pathophysiology such diseases. For sampling methods should be representative Therefore, there need know effect different strategies on characterization next generation sequencing. With aim selecting an appropriate microbiome procedure periimplant biofilms, sequencing was used characterizing obtained three two months after transepithelial abutment placement: adjacent periodontal crevicular fluid (ToCF), (TACF) (TA). Significant differences in multiple alpha diversity indices were detected at both OTU genus level between procedures. Differentially abundant taxa sample collection strategies, including peri-implant health disease related taxa. At significant also TACF TA ToCF. Moreover, differential network properties association patterns identified. The selection strategy can significantly affect composition structure. This research part randomized trial designed assess surface formation. registered Trial Registration ClinicalTrials.gov under NCT03554876.

Language: Английский

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No association between periodontitis extent, severity, and progression rate with dental implant failure

Journal of Stomatology Oral and Maxillofacial Surgery, Journal Year: 2024, Volume and Issue: unknown, P. 102123 - 102123

Published: Oct. 1, 2024

Language: Английский

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THE EFFECT OF DENTAL IMPLANTS ON INCREASING THE COLONIZATION RATE OF AEROBIC BACTERIA IN THE ORAL CAVITY

Universal Journal of Pharmaceutical Research, Journal Year: 2023, Volume and Issue: unknown

Published: July 15, 2023

Background and aims: Dental implants' principal function is to support artificial teeth. The physiological process by which bones firmly adhere the surface of various ceramics metals, such as titanium, what leads emergence modern dental implants, there may be negative effects these implants on balance in bacterial numbers mouth. Therefore, this study compared colony forming unit (CFU) oral bacteria from buccal mucosa tongue between patients who had healthy volunteers without implants. Methods: In study, 36 people with were both included. Following serial dilutions made distributed blood agar, samples grown Brain Heart Infusion Broth (BHI). When a single layer developed agar at any dilution level, CFU was estimated. Version 7 Epi-info Statistics software used analyze data. each graph, results presented mean standard error (SEM), table, deviation (SD). Collected data normally an independent T-test compare different means control test groups lingual mucosa. Results: For non-implant controls values for counts slightly lower than that implant patient’s There significant correlation increase aerobic colonization where mean±SD 196.8±12.9 CFU/ml greater 183.4±9.1 normal controls; indicating enhancement effect heavy cavity among patient group (p<0.0001). association ≥5 being 214±13.9 CFU/mL vs. 192.85±4.44 two-implant composite patient; p=0.027. Additionally, strong duration 13–24 months since placement decreased 193.2±10.3 209.6±13.8 ≤ 12 months; p=0.005. Conclusion: Patients readings patients, suggesting are more prone plaque adhesion. particularly those associated five or recently placed, increased amount leading heavily colonized cavity. Peer Review History: Received: 11 March 2023; Revised: 26 April; Accepted: 29 June 2023, Available online: 15 July 2023 Academic Editor: Dr. Iman Muhammad Higazy, National Research Center, Egypt, [email protected] Received file: Reviewer's Comments: Average review marks initial stage: 6.0/10 publication 7.0/10 Reviewers: Omnia Momtaz Al-Fakharany, Tanta, University, Eygpt, [email protected] Mohaddese Mahboubi, Alzahra Tehran, Iran, [email protected]

Language: Английский

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The Potential Value of Probiotics after Dental Implant Placement

Microorganisms, Journal Year: 2023, Volume and Issue: 11(7), P. 1845 - 1845

Published: July 20, 2023

Dental implantation is currently the optimal solution for tooth loss. However, health and stability of dental implants have emerged as global public concerns. implant placement, healing surgical site, osseointegration, bone tissues, prevention peri-implant diseases are challenges faced in achieving long-term implants. These been ongoing concerns field oral implantation. Probiotics, beneficial microorganisms, play a significant role body by inhibiting pathogens, promoting tissue homeostasis, facilitating regeneration, modulating immune-inflammatory levels. This review explores potential probiotics addressing post-implantation challenges. We summarize existing research regarding importance managing advocate further into their applications.

Language: Английский

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