Antibacterial and Antibiofouling Activities of Carbon Polymerized Dots/Polyurethane and C60/Polyurethane Composite Films

Journal of Functional Biomaterials, Journal Year: 2024, Volume and Issue: 15(3), P. 73 - 73

Published: March 17, 2024

The cost of treatment antibiotic-resistant pathogens is on the level tens billions dollars at moment. It special interest to reduce or solve this problem using antimicrobial coatings, especially in hospitals other healthcare facilities. bacteria can transfer from medical staff contaminated surfaces patients. In paper, we focused our attention antibacterial and antibiofouling activities two types photodynamic polyurethane composite films doped with carbon polymerized dots (CPDs) fullerene C60. Detailed atomic force, electrostatic force viscoelastic microscopy revealed topology, nanoelectrical nanomechanical properties used fillers composites. A relationship between electronic structure nanocarbon composites was established. Thorough spectroscopic analysis reactive oxygen species (ROS) generation conducted for both films, it found that them were potent agents against nosocomial (Klebsiela pneumoniae, Proteus mirabilis, Salmonela enterica, Enterococcus faecalis, epidermis Pseudomonas aeruginosa). Antibiofouling testing indicated CPDs/PU eradicated almost completely biofilms aeruginosa Staphylococcus aureus about 50% Escherichia coli biofilms.

Language: Английский

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Detection of mecA Genes in Hospital-Acquired MRSA and SOSA Strains Associated with Biofilm Formation

Pathogens, Journal Year: 2024, Volume and Issue: 13(3), P. 212 - 212

Published: Feb. 28, 2024

Methicillin-resistant (MR)

Language: Английский

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Utilizing the biosimulator to analyze the environmental microbiome within the intensive care units of a hospital

BioTechniques, Journal Year: 2025, Volume and Issue: unknown, P. 1 - 10

Published: Feb. 26, 2025

Hospital-acquired infections (HAIs), also known as nosocomial infections, are illnesses contracted during treatment at a healthcare facility and can result in severe or life-threatening complications. HAIs caused by microorganisms that exhibit resistance to standard antibiotics. lead complications, longer stays, increased mortality, particularly vulnerable patients. In our previous study, we demonstrated the ability of an engraved Petri dish, referred "biosimulator," induce adhesion non-adherent cells microbiome. This paper explores use biosimulator elucidate microbiome composition within intensive care units (ICUs) hospital setting. The biosimulator, with nutrient-rich bacterial growth medium, was placed ICUs for 24 h, then incubated three days under aerobic anaerobic conditions. Using 16S rRNA sequencing, profiled ICU from multiple samples. Our findings showed microbiomes closely mirrored those patients, exhibiting stronger interrelationships than control combined profiling offers effective approach analyzing understanding changes settings, high-risk areas, such ICUs.

Language: Английский

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Healthcare-Associated Infections: The Role of Microbial and Environmental Factors in Infection Control—A Narrative Review

Infectious Diseases and Therapy, Journal Year: 2025, Volume and Issue: unknown

Published: April 10, 2025

Language: Английский

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..úNo touch..Ñ methods for health care room disinfection: Focus on clinical trials

American Journal of Infection Control, Journal Year: 2023, Volume and Issue: 51(11), P. A134 - A143

Published: Oct. 25, 2023

Language: Английский

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Gut microbiome dynamics and predictive value in hospitalized COVID-19 patients: a comparative analysis of shallow and deep shotgun sequencing

Frontiers in Microbiology, Journal Year: 2024, Volume and Issue: 15

Published: June 19, 2024

The COVID-19 pandemic caused by SARS-CoV-2 has led to a wide range of clinical presentations, with respiratory symptoms being common. However, emerging evidence suggests that the gastrointestinal (GI) tract is also affected, angiotensin-converting enzyme 2, key receptor for SARS-CoV-2, abundantly expressed in ileum and colon. virus been detected GI tissues fecal samples, even cases negative results reverse transcription polymerase chain reaction tract. have associated an increased risk ICU admission mortality. gut microbiome, complex ecosystem around 40 trillion bacteria, plays crucial role immunological metabolic pathways. Dysbiosis microbiota, characterized loss beneficial microbes decreased microbial diversity, observed patients, potentially contributing disease severity. We conducted comprehensive microbiome study 204 hospitalized patients using both shallow deep shotgun sequencing methods. aimed track microbiota composition changes induced hospitalization, link these alterations procedures (antibiotics administration) outcomes (ICU referral, survival), assess predictive potential prognosis. Shallow was evaluated as cost-effective diagnostic alternative settings. Our demonstrated diverse effects various combinations parameters, profiles, patient metadata on precision outcome prognostication patients. It indicates microbiological data possesses greater reliability forecasting when contrasted or metadata. Furthermore, we established presents viable within environments.

Language: Английский

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Microbe, climate change and marine environment: Linking trends and research hotspots

Marine Environmental Research, Journal Year: 2023, Volume and Issue: 189, P. 106015 - 106015

Published: May 24, 2023

Language: Английский

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Complexation of Terpenes for the Production of New Antimicrobial and Antibiofilm Molecules and Their Encapsulation in Order to Improve Their Activities

Applied Sciences, Journal Year: 2023, Volume and Issue: 13(17), P. 9854 - 9854

Published: Aug. 31, 2023

Microbiological risk associated with abiotic surfaces is one of the most important issues worldwide. Surface contaminations by pathogenic bacterial biofilms or adherent cells affect a number sectors, including medical services, food industries, human and environment. There need to synthesize set up novel biosource-based antimicrobials. Terpenes such as limonene carvacrol are usually found in essential oils have potent antimicrobial activities. However, direct use these molecules often inefficient due their low water solubility, loss volatile compounds, thermal degradation, oxidation, toxicity. The organic synthesis stable metal complexes based on terpene ligands seems be promising issue, since it can allow for promote terpenes challenge drawbacks molecules. Spray drying could suitable method encapsulating protect enhance activity against biofilms. goal this review discuss microbiological biofilm ligands. In addition, explores how improve bioactivities characteristics using formulation encapsulation.

Language: Английский

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Far-UV-C irradiation promotes synergistic bactericidal action against adhered cells of Escherichia coli and Staphylococcus epidermidis

The Science of The Total Environment, Journal Year: 2024, Volume and Issue: 917, P. 170352 - 170352

Published: Jan. 28, 2024

The contamination of indoor areas is a global health problem that can cause the dispersion infectious diseases. In sense, it urgent to find new strategies applying lower concentration traditional chemicals used for cleaning and disinfection. Ultraviolet radiation (UV), in particular far-UV-C (200–225 nm), has emerged as successful, powerful, easy-to-apply, inexpensive approach bacterial eradication still requires scientific assessment. This study investigated disinfection based on (222 nm) combined with chlorine mechanical cleaning, providing an innovative solution using low doses. bactericidal activity was tested at intensity irradiation from 78.4 μW/cm2 597.7 (for 1 min) against Escherichia coli Staphylococcus epidermidis adhered polystyrene microtiter plates. It further combination (ultrasounds free (0.1, 0.5, mg/L 5 min). triple consisting + (0.5 mg/L) (54 mJ/cm2) cells materials found hospital settings other public spaces: polyvinyl chloride (PVC), stainless steel (SS), polyetheretherketone (PEEK). Disinfection 0.5 min allowed total reduction culturable E. logarithmic 2.98 ± 0.03 S. epidermidis. far-UV-C, chlorine, resulted both bacteria. Bacterial adhesion PVC, SS, PEEK occurred distinct extents influenced combination, reductions up three. overall results highlight that, culturability assessment, mg/L; (1 efficient strategy mild conditions. viability assessment recommended detect regrowth events increase effectiveness microbial growth control.

Language: Английский

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Advanced antibacterial materials for the prevention of nosocomial infections

Interdisciplinary Nursing Research, Journal Year: 2024, Volume and Issue: 3(2), P. 97 - 108

Published: May 6, 2024

Abstract Nosocomial infections, as the most common adverse event in health care environments, have become an urgent global challenge. It is of great significance solving nosocomial infections to improve patient survival rates and reduce economic burden on patients. Antibacterial materials play a crucial role prevention treatment infections. Since traditional antibacterial are not sufficient satisfy increasing clinical requirements, advanced widely developed biomedical applications hospital fields, aiming at achieving more efficient, longer-lasting, safer antimicrobial effects. This article outlines construction strategies mechanisms materials, including bacterial adhesion prevention, release agents, contact-kill multistrategy-based sterilization. Meanwhile, latest progress departments public environments summarized explored, dressings, medical sutures, implants, bone cements, catheters, plastics products, ceramics, fiber fabrics. Finally, challenges future directions for researches translations discussed, providing comprehensive reference guidance development system applications.

Language: Английский

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