MORPHOLOGICAL CHANGES OF RATS’ CEREBRAL CORTEX UNDER CONDITIONS OF DMH-INDUCED EXPERIMENTAL CARCINOGENESIS DOI Open Access
Iryna Ivanchuk, N. Ye. Lisnychuk

Clinical anatomy and operative surgery, Journal Year: 2023, Volume and Issue: 22(2), P. 64 - 73

Published: May 25, 2023

Abstract. The progression of the endogenous intoxication syndrome accompanies development any neoplasm. infl uence toxic products leads to signifi cant disruptions in homeostasis, which seriously aff ects central nervous system, specifi cally cortex large hemispheres. Therefore, purpose our study was establish changes morphological reorganization hemispheres rats with DMG-induced adenocarcinoma situ. used 85 mature white male rats. All animals were divided into 2 groups: I – 35 intact and II 50 colon adenocarcinoma.Histological slides brain prepared by generally accepted methodology. drugs studied using a MICROmed SEO SCAN light microscope photo- documented Vision CCD Camera. histological organization cerebral had typical histoarchitectonics. In fi rst three stages experiment, moderate detected compared control group. fourth stage carcinogenesis modeling characterized manifestation changes, decrease number normochromic, an increase hypo- hyperchromic neurocytes, appearance cell alteration signs. Typical for this period also hemodynamic disorders: venous hyperemia, stasis, aggregation erythrocytes («sludge»), perivascular pericellular edema. At 5th 6th violation cytoarchitectonics revealed. Destructive neurocytes increased. Betz cells state tigrolysis, sometimes total one. A Nissl substance neurons confi rmed their impaired functional capacity. Increased permeability capillary walls led severe edema neurocytes. Intracellular most 7th induced presence destructive neurons: hypo-, hyperchromic, sharply fragmentation neurocyte neuroplasm, content them, up its complete absence. Blood capillaries deformed wall cantly enlarged spaces. Consequently, established dynamics alterative caused carcinogenesis. These disorders progressive microcirculation disorders. identifi ed brains ected prove dependence on duration carcinogen exposure.

Language: Английский

Role of the gut microbiota in tumorigenesis and treatment DOI Creative Commons
Qingya Liu,

Yun Yang,

Meng Pan

et al.

Theranostics, Journal Year: 2024, Volume and Issue: 14(6), P. 2304 - 2328

Published: Jan. 1, 2024

The gut microbiota is a crucial component of the intricate microecosystem within human body that engages in interactions with host and influences various physiological processes pathological conditions.In recent years, association between dysbiosis tumorigenesis has garnered increasing attention, as it recognized hallmark cancer scientific community.However, only few microorganisms have been identified potential drivers tumorigenesis, enhancing molecular understanding this process substantial importance clinical relevance for treatment.In review, we delineate impact on treatment multiple types while also analyzing associated mechanisms.Moreover, discuss utility data diagnosis patient stratification.We further outline current research harnessing prospects challenges approach.

Language: Английский

Citations

12
Role of Gut Microbial Metabolites in the Pathogenesis of Primary Liver Cancers DOI Open Access

Maria Pallozzi,

Valeria De Gaetano,

Natalia Di Tommaso

et al.

Nutrients, Journal Year: 2024, Volume and Issue: 16(14), P. 2372 - 2372

Published: July 22, 2024

Hepatobiliary malignancies, which include hepatocellular carcinoma (HCC) and cholangiocarcinoma (CCA), are the sixth most common cancers third leading cause of cancer-related death worldwide. Hepatic carcinogenesis is highly stimulated by chronic inflammation, defined as fibrosis deposition, an aberrant imbalance between liver necrosis nodular regeneration. In this context, gut-liver axis gut microbiota have demonstrated a critical role in pathogenesis HCC, dysbiosis altered intestinal permeability promote bacterial translocation, to inflammation tumorigenesis through several pathways. A few data exist on or bacteria resident biliary tract CCA, some microbial metabolites, such choline bile acids, seem show association. review, we analyze impact its metabolites HCC CCA development biomarker hepatobiliary cancer risk response during anti-tumor therapy. We also discuss future application management.

Language: Английский

Citations

7
Therapeutic Approaches in Pancreatic Cancer: Recent Updates DOI Creative Commons
Lokender Kumar, Sanjay Kumar, Sandeep Kumar

et al.

Biomedicines, Journal Year: 2023, Volume and Issue: 11(6), P. 1611 - 1611

Published: June 1, 2023

Cancer is a significant challenge for effective treatment due to its complex mechanism, different progressing stages, and lack of adequate procedures screening identification. Pancreatic cancer typically identified in advanced progression phase with low survival ~5 years. Among cancers, pancreatic also considered high mortality-causing casualty over other accidental or disease-based mortality, it ranked seventh among all mortality-associated cancers globally. Henceforth, developing diagnostic early detection, understanding cancer-linked mechanisms, various therapeutic strategies are crucial. This review describes the recent development progression, approaches, including molecular techniques biomedicines effectively treating cancer.

Language: Английский

Citations

15
Type 2 Diabetes Mellitus and Liver Disease: Across the Gut–Liver Axis from Fibrosis to Cancer DOI Open Access

Vittoria Manilla,

Francesco Santopaolo, Antonio Gasbarrini

et al.

Nutrients, Journal Year: 2023, Volume and Issue: 15(11), P. 2521 - 2521

Published: May 29, 2023

Type 2 diabetes mellitus is a widespread disease worldwide, and one of the cornerstones metabolic syndrome. The existence strong relationship between progression liver fibrosis has been demonstrated by several studies, using invasive noninvasive techniques. Patients with type (T2DM) nonalcoholic fatty (NAFLD) show faster than patients without diabetes. Many confounding factors make it difficult to determine exact mechanisms involved. What we know so far that both T2DM are expressions dysfunction, recognize similar risk factors. Interestingly, promoted endotoxemia, low-grade inflammatory condition caused increased endotoxin levels linked intestinal dysbiosis permeability. There broad evidence on role gut microbiota in disease, through mechanisms. Therefore, associated can act as modifier natural evolution NAFLD. In addition diet, hypoglycemic drugs play an important this scenario, their benefit also result effects exerted gut. Here, provide overview explain why diabetic more rapid up hepatocellular carcinoma (HCC), focusing especially those involving gut–liver axis.

Language: Английский

Citations

14
Gut Microbiota, LADA, and Type 1 Diabetes Mellitus: An Evolving Relationship DOI Creative Commons
Andrea Piccioni, Federico Rosa, Sergio Mannucci

et al.

Biomedicines, Journal Year: 2023, Volume and Issue: 11(3), P. 707 - 707

Published: Feb. 25, 2023

There is much evidence confirming the crucial role played by gut microbiota in modulating immune system onset of autoimmune diseases. In this article, we focus on relationship between alterations microbiome and diabetes mellitus type 1 LADA, light latest evidence. We will then look at both how appears to be increasingly pathogenesis these disorders aspect may instrumental development new potential therapeutic strategies that modulate microbiota, such as probiotics, prebiotics, fecal transplantation.

Language: Английский

Citations

13
Enhancement of host defense against Helicobacter pylori infection through modulation of the gastrointestinal microenvironment by Lactiplantibacillus plantarum Lp05 DOI Creative Commons
Yao Dong,

Han Mei,

Xianghui Qi

et al.

Frontiers in Immunology, Journal Year: 2025, Volume and Issue: 15

Published: Jan. 17, 2025

This study aimed to assess the impact of Lactiplantibacillus plantarum Lp05 (Lp05) on gastrointestinal microbiome and pathophysiological status mice infected with Helicobacter pylori (H. pylori), exploring its potential as a probiotic treatment for H. infections. In vitro, interaction between was analyzed using laser confocal scanning electron microscopy. vivo, C57BL/6 were treated divided into six groups: control, model, quadruple therapy, three dosage levels (2×107, 2×108, 2×109 CFU/mouse/day). Over weeks, physiological markers assessed. Measurements included digestive enzymes (α-amylase, pepsin, cellulase), inflammatory (interleukin-17A, interleukin-23, interleukin-10, interferon-β, interferon-γ, FoxP3, endothelin, IP-10, TGF-β1), oxidative stress (catalase, malondialdehyde, superoxide dismutase, myeloperoxidase), tissue pathology (via modified Warthin-Starry silver H&E staining). Microbial community structure in stomach intestines evaluated through 16S rRNA gene sequencing. vitro studies showed formed co-aggregates, potentially disrupting cell structure, reducing colonization. significantly lowered gastric mucosal urease activity serum pylori-IgG antibody (p < 0.01). It also mitigated pathological changes duodenum, decreased responses (ET, IL-17A, IL-23, TGF-beta1, p 0.01 all), enhanced antioxidant enzyme activities (CAT SOD, 0.01) while MDA MPO 0.01), combating from infection. intestinal microbiota, increasing beneficial bacteria like Lactobacillus Ligilactobacillus, decreasing harmful such Olsenella, linked conditions. effectively modulates microbiome, reduces inflammation stress, suppresses pylori, promising therapies further research needed refine clinical use.

Language: Английский

Citations

0
Diet-microbiome interactions in cancer DOI
Suhaib K. Abdeen, Ignacio Mastandrea,

Nina Stinchcombe

et al.

Cancer Cell, Journal Year: 2025, Volume and Issue: unknown

Published: April 1, 2025

Language: Английский

Citations

0
Oleanolic acid improved intestinal immune function by activating and potentiating bile acids receptor signaling in E. coli-challenged piglets DOI Creative Commons
Chenyu Xue, Hongpeng Jia,

Rujing Cao

et al.

Journal of Animal Science and Biotechnology/Journal of animal science and biotechnology, Journal Year: 2024, Volume and Issue: 15(1)

Published: May 18, 2024

Abstract Background Infection with pathogenic bacteria during nonantibiotic breeding is one of the main causes animal intestinal diseases. Oleanolic acid (OA) a pentacyclic triterpene that ubiquitous in plants. Our previous work demonstrated protective effect OA on health, but underlying molecular mechanisms remain unclear. This study investigated whether dietary supplementation can prevent diarrhea and immune dysregulation caused by enterotoxigenic Escherichia coli (ETEC) piglets. The key role bile receptor signaling this process has also been explored. Results results alleviated disturbance metabolism ETEC-infected piglets ( P < 0.05). stabilized composition pool regulating enterohepatic circulation acids significantly increased contents UDCA CDCA ileum cecum may explain why maintain stability microbiota structure ETEC-challenged In addition, as natural ligand receptors, reduce severity inflammation enhance strength epithelial cell antimicrobial programs through receptors TGR5 FXR Specifically, inhibited NF-κB-mediated directly activating its downstream cAMP-PKA-CREB pathway Furthermore, enhanced CDCA-mediated MEK-ERK cells upregulating expression 0.05), thereby endogenous defense molecules cells. Conclusions conclusion, our findings suggest OA-mediated regulation plays an important innate response, which provides new diet-based intervention for diseases bacterial infections Graphical

Language: Английский

Citations

2
Revitalizing the Gut Microbiome in Chronic Kidney Disease: A Comprehensive Exploration of the Therapeutic Potential of Physical Activity DOI Creative Commons
Marieke Vandecruys, Stefan De Smet, Jasmine De Beir

et al.

Toxins, Journal Year: 2024, Volume and Issue: 16(6), P. 242 - 242

Published: May 26, 2024

Both physical inactivity and disruptions in the gut microbiome appear to be prevalent patients with chronic kidney disease (CKD). Engaging activity could present a novel nonpharmacological strategy for enhancing mitigating adverse effects associated microbial dysbiosis individuals CKD. This narrative review explores underlying mechanisms through which may favorably modulate health, either direct impact on or interorgan crosstalk. Also, development of its interplay CKD are discussed. Mechanisms interventions restore homeostasis explored.

Language: Английский

Citations

2
Protective role of cells and spores of Shouchella clausii SF174 against fructose-induced gut dysfunctions in small and large intestine DOI Creative Commons
Anella Saggese, Valentina Barrella, Angela Di Porzio

et al.

The Journal of Nutritional Biochemistry, Journal Year: 2024, Volume and Issue: 133, P. 109706 - 109706

Published: July 23, 2024

The oral administration of probiotics is nowadays recognized as a strategy to treat or prevent the consequences unhealthy dietary habits. Here we analyze and compare effects vegetative cells spores Shouchella clausii SF174 in counteracting gut dysfunctions induced by 6 weeks high fructose intake rat model. Gut microbiota composition, tight junction proteins, markers inflammation redox homeostasis were evaluated ileum colon rats fed rich diet supplemented with SF174. Our results show that both effective preventing fructose-induced metabolic damage gut, namely establishment "leaky gut", oxidative damage, thus preserving function. also suggest germination-derived metabolize part ingested at level.

Language: Английский

Citations

2