The oral microbiome of newly diagnosed tuberculosis patients; a pilot study DOI Creative Commons
Muhammad Shahzad, Muhammad Saeed,

Humaira Amin

et al.

Genomics, Journal Year: 2024, Volume and Issue: 116(2), P. 110816 - 110816

Published: Feb. 29, 2024

Changes in oral microbiota composition (dysbiosis) has long been known to play a key role the pathogenesis of and systemic diseases including respiratory diseases. However, till now, no study assessed changes following tuberculosis (TB) infection humans. This is first its kind that aimed investigate microbial dysbiosis newly diagnosed, treatment naïve, TB patients. Oral swab samples were collected from diagnosed patients (n = 20) age, gender ethnicity matched healthy controls 10). DNA was extracted analyzed by sequencing hypervariable (V3–V4) region bacterial 16S rRNA gene using Illumina MiSeq platform. Bioinformatics statistical analyses performed QIIME R. Bacterial richness, diversity community significantly different between controls. The two groups also exhibit differential abundance at phylum, class, genus species levels. LEfSe analysis revealed enrichment (LDA scores (log10) >2, P < 0.05) Firmicutes (especially Streptococcus) Actinobacteriota Rothia) relative Gene function prediction showed upregulation metabolic pathways related carbohydrates (butanoate, galactose) fatty acids metabolism, antibiotics biosynthesis, proteosome immune system signaling. These observations suggest significant variations diversity, functional potential compared thereby suggesting pathogenesis. longitudinal studies powerful metagenomic transcriptomic approaches are crucial identify these findings.

Language: Английский

The Complicated Relationship of Short-Chain Fatty Acids and Oral Microbiome: A Narrative Review DOI Creative Commons
Georgy Leonov, Y. Varaeva, E.N. Livantsova

et al.

Biomedicines, Journal Year: 2023, Volume and Issue: 11(10), P. 2749 - 2749

Published: Oct. 11, 2023

The human oral microbiome has emerged as a focal point of research due to its profound implications for health. involvement short-chain fatty acids in composition, health, and chronic inflammation is gaining increasing attention. In this narrative review, the results early vitro, vivo, pilot clinical studies projects are presented order define boundaries new complicated issue. According results, current data disputable ambiguous. When investigating role SCFAs health disease, it crucial distinguish between their local GI effects systemic influences. Locally, part normal microbiota metabolism, but increased formation usually attribute dysbiosis; excess participate development diseases biota gut colonization dysbiosis. On other hand, number have established positive impact on whole, including reduction inflammation, improvement metabolic processes, decrease some types cancer incidence. Thus, complex sophisticated approach with consideration origin localization SCFA function assessment demanded. Therefore, more research, especially needed investigate relationship disease potential prevention treatment.

Language: Английский

Citations

27
The Roles and Interactions of Porphyromonas gingivalis and Fusobacterium nucleatum in Oral and Gastrointestinal Carcinogenesis: A Narrative Review DOI Creative Commons
Bing Wang, Juan Deng, Valentina Donati

et al.

Pathogens, Journal Year: 2024, Volume and Issue: 13(1), P. 93 - 93

Published: Jan. 20, 2024

Epidemiological studies have spotlighted the intricate relationship between individual oral bacteria and tumor occurrence. Porphyromonas gingivalis Fusobacteria nucleatum, which are known periodontal pathogens, emerged as extensively studied participants with potential pathogenic abilities in carcinogenesis. However, complex dynamics arising from interactions these two pathogens were less addressed. This narrative review aims to summarize current knowledge on prevalence mechanism implications of P. F. nucleatum carcinogenesis squamous cell carcinoma (OSCC), colorectal cancer (CRC), pancreatic ductal adenocarcinoma (PDAC). In particular, it explores clinical experimental evidence interplay affecting gastrointestinal recognized keystone or bridging bacteria, identified multiple simultaneously. The both species correlated development progression, emphasizing impact collaboration. Regrettably, there was insufficient demonstrate synergistic function. We further propose a hypothesis elucidate underlying mechanisms, offering promising avenue for future research this dynamic evolving field.

Language: Английский

Citations

15
Bioinspired green synthesis of ZnO nanoparticles by marine-derived Streptomyces plicatus and its multifaceted biomedicinal properties DOI

Jeesha Soni,

Revathi Duraisamy,

Dhanraj Ganapathy

et al.

Microbial Pathogenesis, Journal Year: 2024, Volume and Issue: 193, P. 106758 - 106758

Published: June 19, 2024

Language: Английский

Citations

14
The Effect of Oral Microbiota on the Severity and Prognosis of Stroke DOI Open Access
F. A. Yusupov, A. A. Yuldashev,

A.A. Yusupov

et al.

Bulletin of Science and Practice, Journal Year: 2025, Volume and Issue: 11(1), P. 124 - 145

Published: Jan. 15, 2025

The microbiome of the oral cavity plays an important role in development and progression various somatic diseases, including stroke. Studies show that bacteria living can enter bloodstream contribute to inflammatory processes, which increases risk cardiovascular disease It was found 79% studied stroke-related blood clots, DNA commonly cavity, such as streptococci Viridans species, found. Periodontal pathogenic microorganisms cause chronic inflammation atherosclerosis, is one main factors for Dysbiosis also associated with increase level proinflammatory cytokines, worsen condition vessels likelihood thrombosis. Thus, maintaining health timely treatment dental diseases have a significant impact on reducing Understanding relationship between state system opens up new horizons preventive measures therapeutic approaches patients at high

Language: Английский

Citations

1
Herbal remedies for oral and dental health: a comprehensive review of their multifaceted mechanisms including antimicrobial, anti-inflammatory, and antioxidant pathways DOI Creative Commons

Mohamed Anwar,

Ghadir A. Sayed,

Dina M. Hal

et al.

Inflammopharmacology, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 5, 2025

Abstract Across diverse cultures, herbal remedies have been used to alleviate oral discomfort and maintain dental hygiene. This review presents studies on with remarkable antimicrobial, anti-inflammatory, antioxidant, anticancer, anticaries, analgesic, healing properties. The manuscripts demonstrate the depth of scientific inquiry into for management various health conditions. These include gingivitis, ulcers, mucositis, periodontitis, pathogens, carcinoma, xerostomia, caries. Researchers investigated phytochemical pharmacological properties plant-derived compounds their extracts evaluated interactions pathogens inflammatory processes. convergence traditional knowledge rigorous investigation offers a compelling narrative, fostering deeper understanding as viable alternatives conventional interventions. work has potential provide patients access gentle, yet effective solutions, simultaneously offer professionals opportunity enrich knowledge, ability personalized, holistic care. highlights symbiotic relationship between medicine understanding, emphasizing importance disseminating this benefit both practitioners patients, enabling evidence-based decision-making in exploration promising alternative, potentially mitigating some these side effects while promoting more natural manner.

Language: Английский

Citations

1
A bibliometric and visualized in oral microbiota and cancer research from 2013 to 2022 DOI Creative Commons

Gu Zhi-Yu,

Yunkun Liu

Discover Oncology, Journal Year: 2024, Volume and Issue: 15(1)

Published: Feb. 1, 2024

Abstract Numerous studies have highlighted the implication of oral microbiota in various cancers. However, no bibliometric analysis has been conducted on relationship between and cancer. This aimed to identify research hotspots cancer research, as well predict future trends. The literature published relating was searched from Web Science Core Collection database (WoSCC) 2013 2022. VOSviewer or Citespace software used perform analysis, focusing countries, institutions, authors, journals, keywords references. A total 1516 publications were included analysis. number related increased annually, reaching its peak 2022 with 287 papers. United States (456) China (370) countries most made significant contributions field. Sears CL Zhou XD productive authors. high frequency revealed key topics, including (colorectal cancer, cancer), ( Fusobacterium nucleatum , Porphyromonas gingivalis ), inflammation (periodontal disease). latest trend F. dysbiosis, prognosis, tumor microenvironment, gastric microbiota, complications survival, suggesting a new hotspot field Our study provides comprehensive revealing an increase recent years. Future directions will continue focus diversity impacted by cancers underlying mechanism connecting them, providing ideas for targeted therapy tumorigenesis.

Language: Английский

Citations

7
The Impact of Oral Microbiome Dysbiosis on the Aetiology, Pathogenesis, and Development of Oral Cancer DOI Open Access
Jasminka Talapko,

Suzana Erić,

Tomislav Meštrović

et al.

Cancers, Journal Year: 2024, Volume and Issue: 16(17), P. 2997 - 2997

Published: Aug. 28, 2024

Oral squamous cell carcinoma (OSCC) is the most common head and neck cancer. Although oral cavity an easily accessible area for visual examination, OSCC more often detected at advanced stage. The global prevalence of around 6%, with increasing trends posing a significant health problem due to increase in morbidity mortality. microbiome has been target numerous studies, findings highlighting role dysbiosis developing OSCC. Dysbiosis can significantly pathobionts (bacteria, viruses, fungi, parasites) that trigger inflammation through their virulence pathogenicity factors. In contrast, chronic bacterial contributes development Pathobionts also have other effects, such as impact on immune system, which alter responses contribute pro-inflammatory environment. Poor hygiene carbohydrate-rich foods risk factors mechanisms are not yet fully understood remain frequent research topic. For this reason, narrative review concentrates issue potential cause OSCC, well underlying involved.

Language: Английский

Citations

6
Understanding Protective Mechanisms of an Oral Probiotic in Reducing Radiation-Induced Oral Mucositis DOI
Hannah R. Wardill, Paolo Bossi, Stephen T. Sonis

et al.

Journal of Clinical Oncology, Journal Year: 2024, Volume and Issue: 42(12), P. 1436 - 1438

Published: March 1, 2024

Language: Английский

Citations

6
How Does Airway Surface Liquid Composition Vary in Different Pulmonary Diseases, and How Can We Use This Knowledge to Model Microbial Infections? DOI Creative Commons
Dean Walsh,

Jennifer Bevan,

Freya Harrison

et al.

Microorganisms, Journal Year: 2024, Volume and Issue: 12(4), P. 732 - 732

Published: April 3, 2024

Growth environment greatly alters many facets of pathogen physiology, including pathogenesis and antimicrobial tolerance. The importance host-mimicking environments for attaining an accurate picture behaviour is widely recognised. Whilst this recognition has translated into the extensive development artificial cystic fibrosis (CF) sputum medium, attempts to mimic growth in other respiratory disease states have been completely neglected. composition airway surface liquid (ASL) different pulmonary diseases far less well characterised than CF sputum, making it very difficult researchers model these infection environments. In review, we discuss components human ASL, how lung pathologies affect ASL composition, pathogens interact with components. This will provide interested mimicking information necessary design a allowing better understanding treat causing

Language: Английский

Citations

5
Oral Microbiome Dysbiosis as a Risk Factor for Stroke: A Comprehensive Review DOI Creative Commons
Georgy Leonov, Diana Salikhova, Antonina V. Starodubova

et al.

Microorganisms, Journal Year: 2024, Volume and Issue: 12(8), P. 1732 - 1732

Published: Aug. 22, 2024

Stroke represents a significant global health burden, with substantial impact on mortality, morbidity, and long-term disability. The examination of stroke biomarkers, particularly the oral microbiome, offers promising avenue for advancing our understanding factors that contribute to risk developing strategies mitigate risk. This review highlights correlations between diseases, such as periodontitis caries, onset stroke. Periodontal pathogens within microbiome have been identified contributing factor in exacerbation stroke, including obesity, dyslipidemia, atherosclerosis, hypertension, endothelial dysfunction. alteration may these conditions, emphasizing vital role prevention cardiovascular disease. integration dental medical practices enhancing efforts improving patient outcomes.

Language: Английский

Citations

5